N-hydroxypipecolic acid and salicylic acid: a metabolic duo for systemic acquired resistance.

Recent research has established that the pipecolate pathway, a three-step biochemical sequence from l-lysine to N-hydroxypipecolic acid (NHP), is central for plant systemic acquired resistance (SAR). NHP orchestrates SAR establishment in concert with the immune signal salicylic acid (SA). Here, we outline the biochemistry of NHP formation from l-Lys and address novel progress on SA biosynthesis in Arabidopsis and other plant species. In Arabidopsis, the pathogen-inducible pipecolate and salicylate pathways are activated by common and distinct regulatory elements and mutual interactions between both metabolic branches exist. The mode of action of NHP in SAR involves direct induction of SAR gene expression, signal amplification, priming for enhanced defense activation and positive interplay with SA signaling to ensure elevated plant immunity.

• Publication year

  2019

• Venue

  Current opinion in plant biology

• Publication date

  2019-03-27

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.pbi.2019.02.006PMID 30927665
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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