Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Biometals

• Publication date

  2010-06-05

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1007/s10534-010-9336-yPMID 20524046
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cadmium, environmental exposure, and health outcomes.

  2011cited by this paper
• Cadmium levels in Europe: implications for human health

  2010cited by this paper
• Characterization of the transition-metal-binding properties of hepcidin.

  2010cited by this paper
• Cadmium and transport of ions and substances across cell membranes and epithelia

  2010cited by this paper
• Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs

  2010cited by this paper
• Heavy metal poisoning: the effects of cadmium on the kidney

  2010cited by this paper
• Cadmium exposure in the population: from health risks to strategies of prevention

  2010cited by this paper
• ERK and cell death: cadmium toxicity, sustained ERK activation and cell death

  2010cited by this paper
• Cadmium stress: an oxidative challenge

  2010cited by this paper
• Heavy Metal Poisoning

  2010cited by this paper
• The oxidative stress: endoplasmic reticulum stress axis in cadmium toxicity

  2010cited by this paper
• Mechanisms in cadmium-induced carcinogenicity: recent insights

  2010cited by this paper
• Functional significance of zinc-related signaling pathways in immune cells.

  2009cited by this paper
• Zinc and diabetes--clinical links and molecular mechanisms.

  2009cited by this paper
• Function and biogenesis of iron–sulphur proteins

  2009cited by this paper
• Intracellular Ca2+- and Mn2+-transport ATPases.

  2009cited by this paper
• Coordination dynamics of zinc in proteins.

  2009cited by this paper
• The role of zinc transporters in cadmium and manganese transport in mammalian cells.

  2009cited by this paper
• Cadmium osteotoxicity in experimental animals: mechanisms and relationship to human exposures.

  2009cited by this paper
• Factors influencing intestinal cadmium uptake in pregnant Bangladeshi women--a prospective cohort study.

  2009cited by this paper
• Metal-Responsive Transcription Factor 1 (MTF-1) Activity Is Regulated by a Nonconventional Nuclear Localization Signal and a Metal-Responsive Transactivation Domain

  2009cited by this paper
• The Effects of Metals as Endocrine Disruptors

  2009cited by this paper
• Current status of cadmium as an environmental health problem.

  2009cited by this paper
• Cadmium and cellular signaling cascades: to be or not to be?

  2009cited by this paper
• Role of oxidative stress in cadmium toxicity and carcinogenesis.

  2009cited by this paper
• Cadmium, Environmental Exposure, and Health Outcomes

  2009cited by this paper
• Into the matrix: regulation of the iron regulatory hormone hepcidin by matriptase-2.

  2009cited by this paper
• Dose- and route-dependent hormonal activity of the metalloestrogen cadmium in the rat uterus.

  2009cited by this paper
• Specific iron chelators determine the route of ferritin degradation.

  2009cited by this paper
• Enhanced zinc consumption prevents cadmium-induced alterations in lipid metabolism in male rats.

  2009cited by this paper
• Historical perspectives on cadmium toxicology.

  2009cited by this paper
• Regulation of hepcidin and iron-overload disease.

  2009cited by this paper
• Molecular aspects of human cellular zinc homeostasis: redox control of zinc potentials and zinc signals

  2009cited by this paper
• Cellular iron transport.

  2009cited by this paper
• Long duration exposure to cadmium leads to increased cell survival, decreased DNA repair capacity, and genomic instability in mouse testicular Leydig cells.

  2009cited by this paper
• Prevalence of kidney dysfunction in humans - relationship to cadmium dose, metallothionein, immunological and metabolic factors.

  2009cited by this paper
• Ceruloplasmin alters the tissue disposition and neurotoxicity of manganese, but not its loading onto transferrin.

  2009cited by this paper
• Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver of the rat: effects on the oxidative stress.

  2009cited by this paper
• Erythropoiesis: Model systems, molecular regulators, and developmental programs

  2009cited by this paper
• Cadmium, diabetes and chronic kidney disease.

  2009cited by this paper
• Posttranslational regulation of copper transporters

  2009cited by this paper
• Involvement of DNA hypermethylation in down-regulation of the zinc transporter ZIP8 in cadmium-resistant metallothionein-null cells.

  2009cited by this paper
• Investigation of the biophysical and cell biological properties of ferroportin, a multipass integral membrane protein iron exporter.

  2009cited by this paper
• Identification of the Zn2+ Binding Site and Mode of Operation of a Mammalian Zn2+ Transporter*

  2009cited by this paper
• Zinc, a regulator of islet function and glucose homeostasis

  2009cited by this paper
• Zinc in the physiology and pathology of the CNS

  2009cited by this paper
• Early sensing and gene expression profiling under a low dose of cadmium exposure.

  2009cited by this paper
• A P-type ATPase importer that discriminates between essential and toxic transition metals

  2009cited by this paper
• Cadmium adaptation is regulated by multidrug resistance-associated protein-mediated Akt pathway and metallothionein induction

  2009cited by this paper
• Mammalian zinc transporters: nutritional and physiologic regulation.

  2009influential reference
• Erythropoietin and erythropoiesis.

  2009cited by this paper
• Hepcidin Revisited, Disulfide Connectivity, Dynamics, and Structure

  2009cited by this paper
• Cadmium--a metallohormone?

  2009cited by this paper
• Discovery of ZIP transporters that participate in cadmium damage to testis and kidney.

  2009cited by this paper
• Slc39a14 Gene Encodes ZIP14, A Metal/Bicarbonate Symporter: Similarities to the ZIP8 Transporter

  2008cited by this paper
• Novel roles for ceramides, calpains and caspases in kidney proximal tubule cell apoptosis: lessons from in vitro cadmium toxicity studies.

  2008cited by this paper
• Regulation of haeme oxygenase‐1 for treatment of neuroinflammation and brain disorders

  2008cited by this paper
• Cd{sup 2+} versus Zn{sup 2+} uptake by the ZIP8 HCO{sub 3}{sup -}-dependent symporter: Kinetics, electrogenicity and trafficking

  2008cited by this paper
• Metallothionein redox biology in the cytoprotective and cytotoxic functions of zinc.

  2008cited by this paper
• Early Kidney Damage in a Population Exposed to Cadmium and Other Heavy Metals

  2008cited by this paper
• The co‐evolution of phytoplankton and trace element cycles in the oceans

  2008cited by this paper
• Zinc adaptation and resistance to cadmium toxicity in mammalian cells: Molecular insight by proteomic analysis

  2008cited by this paper
• Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network.

  2008cited by this paper
• Copper sensing function of Drosophila metal-responsive transcription factor-1 is mediated by a tetranuclear Cu(I) cluster

  2008cited by this paper
• The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

  2008cited by this paper
• AtHMA3, a P1B-ATPase Allowing Cd/Zn/Co/Pb Vacuolar Storage in Arabidopsis1[W]

  2008cited by this paper
• Increased hepatic accumulation of ingested Cd is associated with upregulation of several intestinal transporters in mice fed diets deficient in essential metals.

  2008cited by this paper
• Mechanisms for copper acquisition, distribution and regulation.

  2008cited by this paper
• Prevention of cadmium accumulation in retinal pigment epithelium with manganese and zinc.

  2008cited by this paper
• Heavy metal ions inhibit molybdoenzyme activity by binding to the dithiolene moiety of molybdopterin in Escherichia coli

  2008cited by this paper
• Copper and zinc distribution in the human retina: relationship to cadmium accumulation, age, and gender.

  2008cited by this paper
• A zinc-resistant human epithelial cell line is impaired in cadmium and manganese import.

  2008cited by this paper
• Iron-sulfur cluster biogenesis and human disease.

  2008cited by this paper
• Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms

  2008cited by this paper
• Changes in transferrin and hepcidin genes expression in the liver of the fish Pseudosciaena crocea following exposure to cadmium

  2008influential reference
• Subcellular changes of essential metal shown by in-air micro-PIXE in oral cadmium-exposed mice

  2008cited by this paper
• Stimulation of Eryptosis by Cadmium Ions

  2008cited by this paper
• Cd2+ versus Zn2+ uptake by the ZIP8 HCO3--dependent symporter: kinetics, electrogenicity and trafficking.

  2008cited by this paper
• Iron regulatory protein 1 is not an early target of cadmium toxicity in mice, but it is sensitive to cadmium stress in a human epithelial cell line.

  2008cited by this paper
• Cell adhesion molecules in chemically-induced renal injury.

  2007cited by this paper
• Cadmium-responsive Element of the Human Heme Oxygenase-1 Gene Mediates Heat Shock Factor 1-dependent Transcriptional Activation*

  2007cited by this paper
• COMMD proteins: COMMing to the scene

  2007cited by this paper
• Knockdown of endosomal/lysosomal divalent metal transporter 1 by RNA interference prevents cadmium-metallothionein-1 cytotoxicity in renal proximal tubule cells.

  2007cited by this paper
• Iron-regulatory proteins: molecular biology and pathophysiological implications

  2007cited by this paper
• Manganese neurotoxicity: a focus on the neonate.

  2007cited by this paper
• Mechanism and Regulation of Cellular Zinc Transport

  2007cited by this paper
• Cellular Zinc and Redox Buffering Capacity of Metallothionein/Thionein in Health and Disease

  2007cited by this paper
• Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1).

  2007cited by this paper
• Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1).

  2007cited by this paper
• Regulation of metal transporters by dietary iron, and the relationship between body iron levels and cadmium uptake

  2007cited by this paper
• Perturbation of copper (Cu) homeostasis and expression of Cu-binding proteins in cadmium-resistant lung fibroblasts.

  2007cited by this paper
• XIAP: cell death regulation meets copper homeostasis.

  2007cited by this paper
• Manganese and iron transport across pulmonary epithelium.

  2006cited by this paper
• Molecular control of vertebrate iron homeostasis by iron regulatory proteins.

  2006cited by this paper
• Zinc protects renal function during cadmium intoxication in the rat.

  2006cited by this paper
• Cadmium toxicity in animal cells by interference with essential metals.

  2006cited by this paper
• Pescadillo Interacts with the Cadmium Response Element of the Human Heme Oxygenase-1 Promoter in Renal Epithelial Cells*

  2006cited by this paper
• Induction of cellular prion protein gene expression by copper in neurons.

  2006cited by this paper
• Acquired Cadmium Resistance in Metallothionein-I/II(–/–) Knockout Cells: Role of the T-Type Calcium Channel Cacnα1G in Cadmium Uptake

  2006cited by this paper
• Homeostatic and toxic mechanisms regulating manganese uptake, retention, and elimination.

  2006cited by this paper

• Can cadmium toxicity be a driving force for iron deficiency anemia – a systematic review and meta-analysis

  2026cites this paper
• Understanding Molecular Mechanisms Driving Cadmium-Induced Mitochondrial Dysfunction in Human Metabolic Liver Disease.

  2026cites this paper
• OvHMA3 enhances cadmium tolerance in Onobrychis viciifolia by promoting root compartmentalization via active transport.

  2026cites this paper
• Different Impacts of Chelating Agents on Cd Bioavailability in Microbes and Plants

  2025cites this paper
• Two novel phosphatidylinositol phosphate-binding proteins are identified in Neospora caninum with NcPX1 playing a crucial role.

  2025cites this paper
• Biomarker Responses and Trophic Dynamics of Metal(loid)s in Prussian Carp and Great Cormorant: Mercury Biomagnifies; Arsenic and Selenium Biodilute

  2025cites this paper
• Adaptability and stress response mechanisms of abalone Haliotis discus hannai to cadmium in vitro and in vivo

  2025cites this paper
• Targeting mitochondrial damage and ER stress to inhibit ferroptosis in cadmium-induced nephrotoxicity

  2025cites this paper
• Associations between element mixtures and biomarkers of pathophysiologic pathways related to autism spectrum disorder.

  2025cites this paper
• Bitter Taste Receptors TAS2R8 and TAS2R10 Reduce Proton Secretion and Differentially Modulate Cadmium Uptake in Immortalized Human Gastric Cells

  2025cites this paper
• Protective effect of ursodeoxycholic acid in a co-exposure model of cadmium-induced kidney damage

  2025cites this paper
• Molecular insights into cadmium transport and micronutrient crosstalk in rice: Towards minimizing grain Cd.

  2025cites this paper
• Modulation of Adverse Health Effects of Environmental Cadmium Exposure by Zinc and Its Transporters

  2024cites this paper
• Impact of Heavy Metal lead acetate on Hematology of Fresh Water Fish Oreochromis niloticus

  2024cites this paper
• Machine learning model for age-related macular degeneration based on heavy metals: The National Health and Nutrition Examination Survey 2005 to 2008

  2024cites this paper
• The complexometric behavior of selected aroyl-S,N-ketene acetals shows that they are more than AIEgens

  2024cites this paper
• Anthocyanins from Lycium ruthenicum Murray Mitigate Cadmium-Induced Oxidative Stress and Testicular Toxicity by Activating the Keap1/Nrf2 Signaling Pathway

  2024cites this paper
• Redox regulation of proteostasis

  2024cites this paper
• Cadmium exposure induced neuronal ferroptosis and cognitive deficits via the mtROS-ferritinophagy pathway.

  2024cites this paper
• Removal of BPA by Pseudomonas asiatica P1: Synergistic response mechanism of toxicity resistance and biodegradation.

  2024cites this paper
• MicroRNA-129-1-3p protects chicken granulosa cells from cadmium-induced apoptosis by down-regulating the MCU-mediated Ca2+ signaling pathway.

  2024cites this paper
• Changes in Endogenous Essential Metal Homeostasis in the Liver and Kidneys during a Six-Month Follow-Up Period after Subchronic Cadmium Exposure

  2024cites this paper
• Lethal effects and sex-specific tolerance of copper and cadmium in the buff-tailed bumble bee.

  2024cites this paper
• Collembola growth in heavy metal-contaminated soils

  2024cites this paper
• Essential and toxic elements analysis of wild boar tissues from north-eastern Romania and health risk implications

  2024cites this paper
• Cadmium transport by mammalian ATP-binding cassette transporters

  2024cites this paper
• Genomic and transcriptomic analyses reveal insights into cadmium resistance mechanisms of Cupriavidus nantongensis strain E324.

  2024cites this paper
• Iron‐MOFs for Biomedical Applications

  2024cites this paper
• Epigenetic alterations in bioaccumulators of cadmium: Lessons from mammalian kidneys and plants.

  2024cites this paper
• Assessment of Essential and Toxic Element Levels in the Toenails of Children with Autism Spectrum Disorder

  2024cites this paper
• Comparative Responses of Silicon to Reduce Cadmium and Enrich Selenium in Rice Varieties

  2023cites this paper
• Investigation of the role of TmMYB16/123 and their targets (TmMTP1/11) in the tolerance of Taxus media to cadmium.

  2023cites this paper
• Pancreas–Liver–Adipose Axis: Target of Environmental Cadmium Exposure Linked to Metabolic Diseases

  2023cites this paper
• Cadmium, Cellular Senescence, and Cancer

  2023cites this paper
• Cadmium alters whole animal ionome and promotes the re-distribution of iron in intestinal cells of Caenorhabditis elegans

  2023cites this paper
• Divulging the dust: An examination of particle deposition on soft ocular lens during urban commuting.

  2023cites this paper
• Cadmium Toxicity: Insight into Sources, Toxicokinetics, and Effect on Vital Organs and Embryos

  2023cites this paper
• Role of the SLC22A17/lipocalin-2 receptor in renal endocytosis of proteins/metalloproteins: A focus on iron- and cadmium-binding proteins.

  2023cites this paper
• Health management of Cd-contaminated soil using Ca-Al layered double hydroxide: Response of different vegetables

  2023cites this paper
• Heavy metal deposition and parameter change of soft contact lenses by exposure to particulate matter

  2023cites this paper
• Evidences of metabolic alterations and cellular damage in different tissues of scallops Aequipecten tehuelchus exposed to cadmium.

  2023cites this paper
• Chronic Exposure to Drinking Water As, Pb, and Cd at Provisional Guideline Values Reduces Weight Gain in Male Mice via Gut Microflora Alterations and Intestinal Inflammation.

  2023cites this paper
• Novel oligonucleotide-based sorbent for the selective extraction of cadmium from serum samples.

  2023cites this paper
• Renal glucose transporters play a role in removal of cadmium from kidney cells mediated by GMDTC – A novel metal chelator

  2023cites this paper
• Direct Effects of Toxic Divalent Cations on Contractile Proteins with Implications for the Heart: Unraveling Mechanisms of Dysfunction

  2023cites this paper
• Metal Profiles in Autism Spectrum Disorders: A Crosstalk between Toxic and Essential Metals

  2022cites this paper
• Salinity variation modulates cellular stress response to ZnO nanoparticles in a sentinel marine bivalve, the blue mussel Mytilussp.

  2022cites this paper
• Nanosized titanium dioxide elevates toxicity of cationic metals species for Daphnia – have aging and natural organic matter an unexpected impact?

  2022cites this paper
• Ferroptosis as a mechanism of non-ferrous metal toxicity

  2022cites this paper
• Toxic and essential trace element concentrations in Pacific walrus (Odobenus rosmarus divergens) skeletal muscle varies by location and reproductive status

  2022cites this paper
• Toxic Effects of Cadmium on Fish

  2022cites this paper
• Exposure to High Concentrations of Cadmium Which Delay Development of Ostrinia Nubilalis Hbn. Larvae Affected the Balance of Bioelements

  2022cites this paper
• CD4 cell activation with the CD8 marker and metallothionein expression in the gills of cadmium-exposed mosquito fish (Gambusia affinis Baird and Girard 1853) juveniles

  2022cites this paper
• Significance of chemical affinity on metal subcellular distribution in yellow perch (Perca flavescens) livers from lake Saint-Pierre (QUeBEC, Canada).

  2022cites this paper
• Zinc and selenium mitigated heavy metals mixture (Pb, Al, Hg and Mn) mediated hepatic-nephropathy via modulation of oxido-inflammatory status and NF‑kB signaling in female albino rats.

  2022cites this paper
• Honokiol reduces cadmium-induced oxidative injury and endosomal/lysosomal vacuolation via protecting mitochondrial function in Coturnix japonicas liver tissues.

  2022cites this paper
• Distinct adverse outcomes and lipid profiles of erythrocytes upon single and combined exposure to cadmium and microplastics.

  2022cites this paper
• Cadmium Body Burden and Inflammatory Arthritis: A Pilot Study in Patients from Lower Silesia, Poland

  2022cites this paper
• Synoviocytes from pigmented villonodular synovitis are less sensitive to cadmium-induced cell death than synoviocytes from rheumatoid arthritis

  2022cites this paper
• Cadmium chloride generates cytotoxic reactive species that cause oxidative damage and morphological changes in human erythrocytes.

  2022cites this paper
• Effects of multi‐metal exposure on the risk of diabetes mellitus among people aged 40–75 years in rural areas in southwest China

  2022cites this paper
• Gestational Cd Exposure in the CD-1 Mouse Sex-Specifically Disrupts Essential Metal Ion Homeostasis

  2021cites this paper
• Cadmium-Induced Kidney Injury: Oxidative Damage as a Unifying Mechanism

  2021cites this paper
• Metal-Specificity Divergence between Metallothioneins of Nerita peloronta (Neritimorpha, Gastropoda) Sets the Starting Point for a Novel Chemical MT Classification Proposal

  2021cites this paper
• The Impact of Trace Elements on Osteoarthritis

  2021cites this paper
• IMMUNOMODULATION BY HEAVY METALS AS A CONTRIBUTING FACTOR TO INFLAMMATORY DISEASES AND AUTOIMMUNE REACTIONS: CADMIUM AS AN EXAMPLE.

  2021cites this paper
• Comparative and Systematic Omics Revealed Low Cd Accumulation of Potato StMTP9 in Yeast: Suggesting a New Mechanism for Heavy Metal Detoxification

  2021cites this paper
• Transcriptional analysis reveals specific niche factors and response to environmental stresses of enterohemorrhagic Escherichia coli O157:H7 in bovine digestive contents

  2021cites this paper
• Cadmium-induced toxicity to amphibian tadpoles might be exacerbated by alkaline not acidic pH level.

  2021cites this paper
• A benchmark dose analysis for urinary cadmium and type 2 diabetes mellitus.

  2021cites this paper
• Role of hepcidin in oxidative stress and cell death of cultured mouse renal collecting duct cells: protection against iron and sensitization to cadmium

  2021influential citation
• Protective Role of the Essential Trace Elements in the Obviation of Cadmium Toxicity: Glimpses of Mechanisms

  2021cites this paper
• Prescribing sea water quality criteria for arsenic, cadmium and lead through species sensitivity distribution.

  2021cites this paper
• Selenium protection against cadmium and lead-induced oxidative stress

  2021cites this paper
• EFFECTS OF SUBLETHAL COPPER EXPOSURE ON NUCLEIC ACID LEVELS IN FISH, OREOCHROMIS MOSSAMBICUS (PETERS)

  2021cites this paper
• The Relationship between the Urinary Cadmium Concentration and Cause-Specific Mortality in Subjects without Severe Renal Damage: A 35-Year Follow-Up Study in a Cadmium-Polluted Area of Japan

  2021cites this paper
• Cadmium: A Threatening Agent for Plants

  2020cites this paper
• First evidence of the protective role of melatonin in counteracting cadmium toxicity in the rat ovary via the mTOR pathway.

  2020cites this paper
• Responsiveness of metallothionein and hemocyanin genes to cadmium and copper exposure in the garden snail Cornu aspersum

  2020cites this paper
• Nonessential metals and their brain pathology

  2020cites this paper
• Effect of Cadmium Exposure on Zinc Levels in Normal Non-Diabetic and Diabetic Rats Induced by Streptozotocin

  2020cites this paper
• Cellular Dynamics of Transition Metal Exchange on Proteins: A Challenge but a Bonanza for Coordination Chemistry

  2020cites this paper
• Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data

  2020cites this paper
• Epigenetic influence of environmentally neurotoxic metals.

  2020cites this paper
• Tobacco smoking induces metabolic reprogramming of renal cell carcinoma.

  2020cites this paper
• Effects of nickel toxicity on expression of genes associated with nickel resistance in white spruce (Picea glauca): Nickel translocation in plant tissues. By

  2020influential citation
• Cadmium and Lead Exposure, Nephrotoxicity, and Mortality

  2020cites this paper
• Cell organelles as targets of mammalian cadmium toxicity

  2020influential citation
• Relief of Cadmium-Induced Intestinal Motility Disorder in Mice by Lactobacillus plantarum CCFM8610

  2020cites this paper
• Environmental Cadmium and Mortality from Influenza and Pneumonia in U.S. Adults

  2020cites this paper
• Dietary supplementation of garlic, propolis, and wakame improves recuperation in cadmium exposed Japanese medaka fish (Oryzias latipes)

  2020cites this paper
• Mechanisms of Cadmium Accumulation in Plants

  2020cites this paper
• Overexpression of a Defensin-Like Gene CAL2 Enhances Cadmium Accumulation in Plants

  2020cites this paper
• Iron and Cadmium Entry Into Renal Mitochondria: Physiological and Toxicological Implications

  2020cites this paper
• Promotion of cadmium uptake and cadmium-induced toxicity by the copper transporter CTR1 in HepG2 and ZFL cells

  2020influential citation
• Essential and nonessential metal effects on extracellular Leishmania amazonensis in vitro.

  2019cites this paper
• Cadmium and High-Fat Diet Disrupt Renal, Cardiac and Hepatic Essential Metals

  2019cites this paper
• The Effect of Cd Stress in Mineral Nutrient Uptake in Plants

  2019cites this paper
• Autophagic elimination of Trypanosoma cruzi in the presence of metals

  2019cites this paper
• Pollution of Water Bodies in Latin America: Impact of Contaminants on Species of Ecological Interest

  2019cites this paper