The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Oncogene

• Publication date

  2003-09-18

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.onc.1206827PMID 13679861
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cytometry

  2020cited by this paper
• [Oncogene].

  2019influential reference
• Cancer Epidemiol Biomarkers Prev

  2004cited by this paper
• In vitro and in vivo antitumor activity of liposomal fenretinide targeted to human neuroblastoma

  2003cited by this paper
• Bcl-2 on the Endoplasmic Reticulum Regulates Bax Activity by Binding to BH3-only Proteins*

  2003cited by this paper
• Altered Sphingolipid Metabolism inN-(4-Hydroxyphenyl)- retinamide-resistant A2780 Human Ovarian Carcinoma Cells*

  2003cited by this paper
• Disruption of Mitochondrial Networks by the Human Cytomegalovirus UL37 Gene Product Viral Mitochondrion-Localized Inhibitor of Apoptosis

  2003cited by this paper
• All-trans-retinoic acid binds to and inhibits adenine nucleotide translocase and induces mitochondrial permeability transition.

  2003cited by this paper
• Apoptosis: Mitochondrial Membrane Permeabilization – The (W)hole Story?

  2003cited by this paper
• BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis

  2003cited by this paper
• Effect of fenretinide on ovarian carcinoma occurrence.

  2002cited by this paper
• Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.

  2002cited by this paper
• Contributions of mitogen‐activated protein kinase and nuclear factor kappa B to N‐(4‐hydroxyphenyl)retinamide–induced apoptosis in prostate cancer cells

  2002influential reference
• Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.

  2002cited by this paper
• Cyclosporin A enhances the apoptotic effects of N‐(4‐hydroxyphenyl)retinamide in breast cancer cells

  2002cited by this paper
• Ceramide Signaling in Fenretinide-induced Endothelial Cell Apoptosis*

  2002cited by this paper
• Classical and novel retinoids: their targets in cancer therapy

  2002cited by this paper
• Implication of mitochondria-derived ROS and cardiolipin peroxidation in N-(4-hydroxyphenyl)retinamide-induced apoptosis

  2002cited by this paper
• N-(4-hydroxyphenyl)retinamide (4-HPR) modulates GADD45 expression in radiosensitive bladder cancer cell lines.

  2002cited by this paper
• Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma

  2002cited by this paper
• Cytochrome c Oxidase Subunit III

  2002cited by this paper
• Chemotherapy: targeting the mitochondrial cell death pathway

  2002cited by this paper
• Quantitation of mitochondrial alterations associated with apoptosis.

  2002cited by this paper
• Elucidation of Molecular Events Mediating Induction of Apoptosis by Synthetic Retinoids Using a CD437-resistant Ovarian Carcinoma Cell Line*

  2002cited by this paper
• Modulation of cyclophilin gene expression by N‐4‐(hydroxyphenyl)retinamide: Association with reactive oxygen species generation and apoptosis *

  2002cited by this paper
• Mouse models of cell death

  2001influential reference
• Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437

  2001influential reference
• Mitochondrial Respiration Is Uniquely Associated with the Prooxidant and Apoptotic Effects ofN-(4-Hydroxyphenyl)retinamide*

  2001cited by this paper
• The expanding role of mitochondria in apoptosis.

  2001cited by this paper
• Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

  2001cited by this paper
• A review of cancer chemopreventive agents.

  2001cited by this paper
• Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis

  2001cited by this paper
• The sequence and antiapoptotic functional domains of the human cytomegalovirus UL37 exon 1 immediate early protein are conserved in multiple primary strains.

  2001cited by this paper
• Human Immunodeficiency Virus 1 Envelope Glycoprotein Complex-Induced Apoptosis Involves Mammalian Target of Rapamycin/Fkbp12-Rapamycin–Associated Protein–Mediated P53 Phosphorylation

  2001influential reference
• Decrease in drug accumulation and in tumour aggressiveness marker expression in a fenretinide-induced resistant ovarianumour cell line

  2001cited by this paper
• Diet and cancer prevention studies in p53-deficient mice.

  2001cited by this paper
• The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide‐induced apoptosis: significance for the molecular mechanism of Bcl‐2 action

  2001cited by this paper
• Mechanism of fenretinide (4-HPR)-induced cell death

  2001cited by this paper
• Mitochondrion as a novel target of anticancer chemotherapy.

  2000cited by this paper
• GD3 ganglioside directly targets mitochondria in a bcl‐2‐controlled fashion

  2000cited by this paper
• CD95's deadly mission in the immune system

  2000cited by this paper
• Reactive Oxygen Species (Ros-Induced) Ros Release

  2000cited by this paper
• Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c

  2000cited by this paper
• Mitochondrial control of cell death

  2000cited by this paper
• Structure of Bax: coregulation of dimer formation and intracellular localization.

  2000cited by this paper
• Inducible loss of NF-kappaB activity is associated with apoptosis and Bcl-2 down-regulation in Epstein-Barr virus-transformed B lymphocytes.

  2000cited by this paper
• Mitochondrial permeability transition is a central coordinating event in N-(4-hydroxyphenyl)retinamide-induced apoptosis.

  2000cited by this paper
• Dietary 4-HPR suppresses the development of bone metastasis in vivo in a mouse model of prostate cancer progression

  2000cited by this paper
• Purification and liposomal reconstitution of permeability transition pore complex.

  2000cited by this paper
• Purification of mitochondria for apoptosis assays.

  2000cited by this paper
• FEBS Lett

  2000cited by this paper
• A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.

  1999cited by this paper
• Cell Damage-induced Conformational Changes of the Pro-Apoptotic Protein Bak In Vivo Precede the Onset of Apoptosis

  1999influential reference
• Disruption of p53 in human cancer cells alters the responses to therapeutic agents.

  1999cited by this paper
• 4-(hydroxyphenyl)retinamide selectively inhibits the development and progression of ductal hyperplastic lesions and carcinoma in situ in mammary gland.

  1999cited by this paper
• Superoxide in Apoptosis

  1998cited by this paper
• The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins

  1998influential reference
• The mitochondrial death/life regulator in apoptosis and necrosis.

  1998cited by this paper
• Mitochondria as regulators of apoptosis: doubt no more.

  1998cited by this paper
• Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

  1998cited by this paper
• Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.

  1998cited by this paper
• Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes.

  1998cited by this paper
• Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis.

  1997cited by this paper
• Modulation of the Mitochondrial Permeability Transition Pore by Pyridine Nucleotides and Dithiol Oxidation at Two Separate Sites (*)

  1996cited by this paper
• Chloromethyl-X-Rosamine is an aldehyde-fixable potential-sensitive fluorochrome for the detection of early apoptosis.

  1996cited by this paper
• Br. J. Cancer

  1991cited by this paper
• Blood.

  1989cited by this paper
• Leukemia

  1984cited by this paper
• Carcinogenesis

  1961cited by this paper
• Virology

  1955cited by this paper
• THE CANCER CELL

  1924cited by this paper

• 4HPR nanoformulation regulates MAPKAPK3/3pK signaling to control Bax phosphorylation and mitochondrial translocation to execute apoptosis in neuroblastoma.

  2025cites this paper
• The influence of apigenin on cellular responses to radiation: From protection to sensitization

  2024cites this paper
• Diclofenac Diminished the Unfolded Protein Response (UPR) Induced by Tunicamycin in Human Endothelial Cells

  2022cites this paper
• Retinoids and Reactive Oxygen Species in Cancer Cell Death and Therapeutics

  2021cites this paper
• Identification and functional analyses of a cell-death inhibitor encoded by guinea pig cytomegalovirus gp38.1 in cell culture and in animals.

  2020cites this paper
• Cytotoxicity and molecular activity of fenretinide and metabolites in T-cell lymphoid malignancy, neuroblastoma, and ovarian cancer cell lines in physiological hypoxia

  2019cites this paper
• The expression of galectin-3 in breast cancer and its association with chemoresistance: a systematic review of the literature

  2019cites this paper
• Mechanism of HN-3 cell apoptosis induced by carboplatin: Combination of mitochondrial pathway associated with Ca2+ and the nucleus pathways

  2018cites this paper
• Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice

  2017cites this paper
• Reversal of Beta-Amyloid-Induced Neurotoxicity in PC12 Cells by Curcumin, the Important Role of ROS-Mediated Signaling and ERK Pathway

  2017cites this paper
• Mitochondria as a Favourite Organelle for Invading Viruses

  2016cites this paper
• Bortezomib and fenretinide induce synergistic cytotoxicity in mantle cell lymphoma through apoptosis, cell-cycle dysregulation, and I&kgr;B&agr; kinase downregulation

  2015cites this paper
• HMGB1 Promotes Mitochondrial Dysfunction–Triggered Striatal Neurodegeneration via Autophagy and Apoptosis Activation

  2015cites this paper
• Modulation of fenretinide induced cell death in neuroblastoma

  2014cites this paper
• Thyroid hormone, thyromimetics, and metabolic efficiency.

  2014cites this paper
• Paeoniflorin protects cells from GalN/TNF-α-induced apoptosis via ER stress and mitochondria-dependent pathways in human L02 hepatocytes.

  2014cites this paper
• Selenocystine potentiates cancer cell apoptosis induced by 5-fluorouracil by triggering reactive oxygen species-mediated DNA damage and inactivation of the ERK pathway.

  2013cites this paper
• Viruses as Modulators of Mitochondrial Functions

  2013cites this paper
• Cyanidin reverses cisplatin-induced apoptosis in HK-2 proximal tubular cells through inhibition of ROS-mediated DNA damage and modulation of the ERK and AKT pathways.

  2013cites this paper
• Efficacy of PLGA-loaded apigenin nanoparticles in Benzo[a]pyrene and ultraviolet-B induced skin cancer of mice: mitochondria mediated apoptotic signalling cascades.

  2013cites this paper
• Arsenic trioxide alleviates airway hyperresponsiveness and promotes apoptosis of CD4+ T lymphocytes: evidence for involvement of the ER stress–CHOP pathway

  2013cites this paper
• N‐(4‐hydroxyphenyl)retinamide inhibits breast cancer cell invasion through suppressing NF‐KB activation and inhibiting matrix metalloproteinase‐9 expression

  2012cites this paper
• N-(4-hydroxyphenyl)retinamide promotes apoptosis of resting and proliferating B-cell chronic lymphocytic leukemia cells and potentiates fludarabine and ABT-737 cytotoxicity

  2012cites this paper
• Thyroid Hormone and Energy Expenditure

  2012cites this paper
• In the Huh7 Hepatoma Cells Diclofenac and Indomethacin Activate Differently the Unfolded Protein Response and Induce ER Stress Apoptosis

  2011cites this paper
• Effects of Natural and Synthetic Retinoids on the Differentiation and Growth of Squamous Cancers

  2011cites this paper
• Bryostatin-1, Fenretinide and 1α,25 (OH)2D3 Induce Growth Inhibition, Apoptosis and Differentiation in T and B Cell-Derived Acute Lymphoblastic Leukemia Cell Lines (CCRF-CEM and Nalm-6)

  2011cites this paper
• Preferential involvement of both ROS and ceramide in fenretinide-induced apoptosis of HL60 rather than NB4 and U937 cells.

  2011cites this paper
• ROLE OF MITOCHONDRIA DURING BOVINE ADENOVIRUS 3 INFECTION

  2011cites this paper
• Angioprevention with fenretinide: targeting angiogenesis in prevention and therapeutic strategies.

  2010cites this paper
• Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response

  2010cites this paper
• BESCT (Biology, Education, Screening, Chemoprevention and Treatment) Program

  2010cites this paper
• Induction and intracellular localization of Nur77 dictate fenretinide-induced apoptosis of human liver cancer cells.

  2010cites this paper
• Role for PKC δ in Fenretinide-Mediated Apoptosis in Lymphoid Leukemia Cells

  2010cites this paper
• N-(4-Hydroxyphenyl) retinamide potentiated paclitaxel for cell cycle arrest and apoptosis in glioblastoma C6 and RG2 cells.

  2009cites this paper
• Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma

  2009cites this paper
• Bexarotene activates the p53/p73 pathway in human cutaneous T‐cell lymphoma

  2009cites this paper
• Selective apoptosis induction by the cancer chemopreventive agent N-(4-hydroxyphenyl)retinamide is achieved by modulating mitochondrial bioenergetics in premalignant and malignant human prostate epithelial cells

  2009cites this paper
• Oxidative stress and antioxidant defenses in asthmatic murine model exposed to printer emissions and environmental tobacco smoke.

  2009cites this paper
• Cancer chemoprevention and mitochondria: targeting apoptosis in transformed cells via the disruption of mitochondrial bioenergetics/redox state.

  2009cites this paper
• Identification of ADP-ribosylation factor 4 as a suppressor of N-(4-hydroxyphenyl)retinamide-induced cell death.

  2009cites this paper
• p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum

  2009cites this paper
• Cationic poly(amidoamine) dendrimer induces lysosomal apoptotic pathway at therapeutically relevant concentrations.

  2009cites this paper
• Hepatocyte growth factor prevents advanced glycation end products-induced injury and oxidative stress through a PI3K/Akt-dependent pathway in human endothelial cells.

  2009cites this paper
• Down‐regulation of Bcl‐2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum

  2009cites this paper
• Interplay between bax, reactive oxygen species production, and cardiolipin oxidation during apoptosis.

  2008cites this paper
• Fenretinide induces autophagic cell death in caspase-defective breast cancer cells

  2008cites this paper
• Selenocystine induces apoptosis of A375 human melanoma cells by activating ROS-mediated mitochondrial pathway and p53 phosphorylation

  2008cites this paper
• BAY 11-7082 induces cell death through NF-kappaB-independent mechanisms in the Ewing's sarcoma family of tumours.

  2008cites this paper
• The PERK/eIF2 alpha signaling pathway of Unfolded Protein Response is essential for N-(4-hydroxyphenyl)retinamide (4HPR)-induced cytotoxicity in cancer cells.

  2008cites this paper
• HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches

  2008cites this paper
• Cancer chemoprevention: a radical perspective.

  2008cites this paper
• The sensitivity of the Ewing's sarcoma family of tumours to fenretinide-induced cell death is increased by EWS-Fli1-dependent modulation of p38MAPK activity

  2008cites this paper
• Identification of cytochrome c oxidase subunit 6A1 as a suppressor of Bax-induced cell death by yeast-based functional screening.

  2008cites this paper
• Reduction of mitochondrial oxidative damage and improved mitochondrial efficiency by administration of crocetin against benzo[a]pyrene induced experimental animals.

  2008cites this paper
• Mitochondrial membrane permeabilization in cell death.

  2007cites this paper
• Ethyl 2- [N-p-chlorobenzyl- (2'-methyl)] anilino-4-oxo-4,5-dihydrofuran-3-carboxylate (JOT01007)induces apoptosis in human cervical cancer Ca Ski cells.

  2007cites this paper
• Reactive oxygen species mediate N-(4-hydroxyphenyl)retinamide-induced cell death in malignant T cells and are inhibited by the HTLV-I oncoprotein Tax

  2007cites this paper
• Antioxidants tiron and N-acetyl-L-cysteine differentially mediate apoptosis in melanoma cells via a reactive oxygen species-independent NF-kappaB pathway.

  2007cites this paper
• Induction of endoplasmic reticulum stress by the pro-apoptotic retinoid N-(4-Hydroxyphenyl)retinamide via a reactive oxygen species-dependent mechanism in human head and neck cancer cells

  2007cites this paper
• Novel cell death pathways induced by N-(4-hydroxyphenyl)retinamide: therapeutic implications

  2007cites this paper
• Ethyl 2- [N-m-chlorobenzyl- (2'-methyl)] anilino-4-oxo-4,5-dihydrofuran-3-carboxylate (JOT01006) induces apoptosis in human cervical cancer HeLa cells.

  2007cites this paper
• 4-HPR-mediated leukemia cell cytotoxicity is triggered by ceramide-induced mitochondrial oxidative stress and is regulated downstream by Bcl-2

  2007cites this paper
• Mitochondria as therapeutic targets for cancer chemotherapy

  2006cites this paper
• BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways.

  2006cites this paper
• Experimental Confirmation of Global Murine Cytomegalovirus Open Reading Frames by Transcriptional Detection and Partial Characterization of Newly Described Gene Products

  2006cites this paper
• Mechanism of 4-HPR-induced apoptosis in glioma cells: evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress.

  2006cites this paper
• Anticancer effects of fenretinide in human medulloblastoma.

  2006cites this paper
• Apoptotic and anti-proliferative effects of all-trans retinoic acid. Adenine nucleotide translocase sensitizes HeLa cells to all-trans retinoic acid.

  2006cites this paper
• Mechanisms of fenretinide-induced apoptosis

  2006cites this paper
• BMS-345541 Targets Inhibitor of κB Kinase and Induces Apoptosis in Melanoma: Involvement of Nuclear Factor κB and Mitochondria Pathways

  2006cites this paper
• Involvement of mitochondrial and Akt signaling pathways in augmented apoptosis induced by a combination of low doses of celecoxib and N-(4-hydroxyphenyl) retinamide in premalignant human bronchial epithelial cells.

  2006cites this paper
• FENRETINIDE (4-HYDROXYPHENYLRETINAMIDE) INCREASES DIHYDROCERAMIDE AND DIHYDROSPHINGOLIPIDS DUE TO INHIBITION OF DIHYDROCERAMIDE DESATURASE

  2006cites this paper
• Apoptosis effector mechanisms: A requiem performed in different keys

  2006cites this paper
• N-(4-Hydroxyphenyl)retinamide-induced apoptosis triggered by reactive oxygen species is mediated by activation of MAPKs in head and neck squamous carcinoma cells

  2006influential citation
• The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death

  2005influential citation
• Mitochondria: A novel target for the chemoprevention of cancer

  2005cites this paper
• Retinamide-Induced Apoptosis in Glioblastomas is Associated with Down-Regulation of Bcl-xL and Bcl-2 Proteins

  2005cites this paper
• N-(4-Hydroxyphenyl)Retinamide Inhibits Invasion, Suppresses Osteoclastogenesis, and Potentiates Apoptosis through Down-regulation of IκBα Kinase and Nuclear Factor-κB–Regulated Gene Products

  2005cites this paper
• Intracellular glutathione levels determine cell sensitivity to apoptosis induced by the antineoplasic agent N-(4-hydroxyphenyl) retinamide.

  2005cites this paper
• Mitochondrial Cell Death Suppressors Carried by Human and Murine Cytomegalovirus Confer Resistance to Proteasome Inhibitor-Induced Apoptosis

  2005cites this paper
• Modulation of mitochondrial transition pore components by thyroid hormone.

  2005cites this paper
• Fenretinide: a p53-independent way to kill cancer cells.

  2005cites this paper
• Inhibition of Macroautophagy Triggers Apoptosis

  2005cites this paper
• Proteasome Inhibitor-Induced Apoptosis Cytomegalovirus Confer Resistance to Carried by Human and Murine Mitochondrial Cell Death Suppressors

  2005cites this paper
• The NF-kappaB pathway mediates fenretinide-induced apoptosis in SH-SY5Y neuroblastoma cells.

  2005cites this paper
• p38MAPK-Dependent Sensitivity of Ewing's Sarcoma Family of Tumors to Fenretinide-Induced Cell Death

  2005cites this paper
• p 38 MAPK-Dependent Sensitivity of Ewing ’ s Sarcoma Family of Tumors to Fenretinide-Induced Cell Death

  2005cites this paper
• N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products.

  2005cites this paper
• The NF-κB pathway mediates fenretinide-induced apoptosis in SH-SY5Y neuroblastoma cells

  2005cites this paper
• Different ways to induce apoptosis by fenretinide and all-trans-retinoic acid in human B lymphoma cells.

  2005cites this paper
• Viral proteins targeting mitochondria: controlling cell death.

  2004cites this paper
• Retinoid related molecules an emerging class of apoptotic agents with promising therapeutic potential in oncology: pharmacological activity and mechanisms of action.

  2004cites this paper
• ROS stress in cancer cells and therapeutic implications.

  2004cites this paper
• Inhibition of N-(4-hydroxyphenyl)retinamide-Induced Apoptosis in Breast Cancer Cells by Galectin-3

  2004cites this paper
• Role of mitochondrial membrane permeabilization in apoptosis and cancer

  2004influential citation
• Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-{kappa}B and Mat1A genes in the early stages of rat liver carcinogenesis.

  2004cites this paper
• Apoptosis of human T-cell acute lymphoblastic leukemia cells by diphenhydramine, an H1 histamine receptor antagonist.

  2004cites this paper