Cyanidin reverses cisplatin-induced apoptosis in HK-2 proximal tubular cells through inhibition of ROS-mediated DNA damage and modulation of the ERK and AKT pathways.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Cancer Letters

• Publication date

  2013-06-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1016/j.canlet.2012.12.029PMID 23360684
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oxidative stress-based cytotoxicity of delphinidin and cyanidin in colon cancer cells.

  2010cited by this paper
• Selenocystine induces reactive oxygen species-mediated apoptosis in human cancer cells.

  2009cited by this paper
• Genistein protects the kidney from cisplatin-induced injury.

  2008cited by this paper
• Comparative evaluation of cytotoxicity and antioxidative activity of 20 flavonoids.

  2008cited by this paper
• Cisplatin nephrotoxicity: mechanisms and renoprotective strategies.

  2008cited by this paper
• Selenocystine induces apoptosis of A375 human melanoma cells by activating ROS-mediated mitochondrial pathway and p53 phosphorylation

  2008cited by this paper
• Mitochondrial membrane permeabilization in cell death.

  2007cited by this paper
• Bioavailability, antioxidant and biological properties of the natural free-radical scavengers cyanidin and related glycosides.

  2007cited by this paper
• Activation and involvement of p53 in cisplatin-induced nephrotoxicity.

  2007cited by this paper
• Cyanidin attenuates PGE2 production and cyclooxygenase-2 expression in LNCaP human prostate cancer cells.

  2006cited by this paper
• [Role of mitochondria in reactive oxygen species generation and removal; relevance to signaling and programmed cell death].

  2006cited by this paper
• Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis.

  2006cited by this paper
• Regulation of PUMA-α by p53 in cisplatin-induced renal cell apoptosis

  2006cited by this paper
• Poly(ADP-ribose): novel functions for an old molecule

  2006cited by this paper
• MEK inhibitor, U0126, attenuates cisplatin-induced renal injury by decreasing inflammation and apoptosis.

  2005cited by this paper
• Molecular mechanisms of caspase regulation during apoptosis

  2004cited by this paper
• Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells.

  2004cited by this paper
• ROS stress in cancer cells and therapeutic implications.

  2004cited by this paper
• p53: 25 years after its discovery.

  2004cited by this paper
• Mitochondrial intermembrane proteins in cell death.

  2003cited by this paper
• The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family

  2003cited by this paper
• Role of apoptosis in the pathogenesis of acute renal failure

  2002cited by this paper
• The Bcl2 family: regulators of the cellular life-or-death switch

  2002influential reference
• TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity.

  2002cited by this paper
• Antioxidant and antiproliferative activities of raspberries.

  2002cited by this paper
• The role of MAPK pathways in the action of chemotherapeutic drugs.

  2002cited by this paper
• TNF-α mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity

  2002cited by this paper
• Neurotensin- and EGF-Induced Metabolic Activation of Colon Carcinoma Cells Is Diminished by Dietary Flavonoid Cyanidin but Not by Its Glycosides

  2001cited by this paper
• Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

  2001cited by this paper
• Manganese superoxide dismutase attenuates Cisplatin-induced renal injury: importance of superoxide.

  2001cited by this paper
• Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells.

  2001cited by this paper
• The anthocyanidins cyanidin and delphinidin are potent inhibitors of the epidermal growth-factor receptor.

  2001cited by this paper
• PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

  2001cited by this paper
• DNA repair: spot(light)s on chromatin.

  2001cited by this paper
• Serine/threonine protein kinases and apoptosis.

  2000cited by this paper
• Involvement of H2O2 production in cisplatin-induced nephrotoxicity.

  1998cited by this paper
• Identification of gene family of caspases in rat kidney and altered expression in ischemia-reperfusion injury.

  1998cited by this paper
• Protective effects of vitamin E and C on cisplatin nephrotoxicity in developing rats

  1997cited by this paper
• Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.

  1997cited by this paper
• Generation of putative intrastrand cross-links and strand breaks in DNA by transition metal ion-mediated oxygen radical attack.

  1997cited by this paper
• Apoptosis by death factor.

  1997cited by this paper
• Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: apoptosis vs. necrosis.

  1996cited by this paper
• The relative antioxidant activities of plant-derived polyphenolic flavonoids.

  1995cited by this paper
• Role of vascular congestion in cisplatin-induced acute renal failure in the rat.

  1992cited by this paper
• Long-term effects of chemotherapy in patients with testicular cancer.

  1992cited by this paper
• Reduced renal blood flow in early cisplatin-induced acute renal failure in the rat.

  1985cited by this paper
• Amelioration of cis-platinum nephrotoxicity by orgotein (superoxide dismutase).

  1978cited by this paper

• Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual-Action Therapeutic Strategy.

  2026cites this paper
• Hellebrigenin Induces Apoptosis and Inhibits PI3K/AKT-Mediated Inflammation and Metastasis in Human Osteosarcoma Cells

  2025cites this paper
• Cyanidin and Cyanidin-3-Glucoside Alleviate Peptic Ulcer Disease: Insights from in vitro, and in vivo Studies

  2025cites this paper
• Tamarix honey phenolics attenuate cisplatin-induced kidney toxicity by inhibition of inflammation mediated IL-6/STAT3/TNF-α and oxidative stress-dependent Nrf2/caspase-3 apoptotic signaling pathways

  2025cites this paper
• The Effects of Anthocyanins Added to Semen Diluent on Semen Quality, Semen Antioxidant Capacity, and Sperm Apoptosis in Zi Geese

  2025cites this paper
• The Antioxidant Ergothioneine Alleviates Cisplatin-Induced Hearing Loss Through the Nrf2 Pathway

  2024cites this paper
• Inhibition of CISD1 attenuates cisplatin-induced hearing loss in mice via the PI3K and MAPK pathways.

  2024cites this paper
• Doxepin as OCT2 inhibitor ameliorates inflammatory response and modulates PI3K/Akt signaling associated with cisplatin-induced nephrotoxicity in rats

  2024cites this paper
• Regulation of Optimized New Shengmai Powder on cardiomyocyte apoptosis and ferroptosis in ischemic heart failure rats: the mediating role of phosphatidylinositol-3-kinase/protein kinase B/tumor protein 53 signaling pathway.

  2024cites this paper
• Protective effect of spore oil-functionalized nano-selenium system on cisplatin-induced nephrotoxicity by regulating oxidative stress-mediated pathways and activating immune response

  2023cites this paper
• Influence of spontaneous and inoculated fermentation of açai on simulated digestion, antioxidant capacity and cytotoxic activity.

  2023cites this paper
• MicroRNAs Involved in Intrinsic Apoptotic Pathway during Cisplatin-Induced Nephrotoxicity: Potential Use of Natural Products against DDP-Induced Apoptosis

  2022cites this paper
• Cyanidin attenuates the apoptosis of rat nucleus pulposus cells and the degeneration of intervertebral disc via the JAK2/STAT3 signal pathway in vitro and in vivo

  2022cites this paper
• Protective effect of food derived nutrients on cisplatin nephrotoxicity and its mechanism.

  2022cites this paper
• Icariin exhibits protective effects on cisplatin-induced cardiotoxicity via ROS-mediated oxidative stress injury in vivo and in vitro.

  2022cites this paper
• Anthocyanins, effects in mitochondria and metabolism

  2021cites this paper
• Protective effects of natural products against drug-induced nephrotoxicity: a review in recent years.

  2021cites this paper
• Carbon Monoxide in Renal Physiology, Pathogenesis and Treatment of Renal Disease.

  2021cites this paper
• The effect of repeated passaging on the susceptibility of human proximal tubular HK-2 cells to toxic compounds.

  2020cites this paper
• GANT61 plays antitumor effects by inducing oxidative stress through the miRNA‐1286/RAB31 axis in osteosarcoma

  2020cites this paper
• Platycodin D suppresses cisplatin‐induced cytotoxicity by suppressing ROS‐mediated oxidative damage, apoptosis, and inflammation in HEK‐293 cells

  2020cites this paper
• Protective effect of Gallic acid and Gallic acid-loaded Eudragit-RS 100 nanoparticles on cisplatin-induced mitochondrial dysfunction and inflammation in rat kidney.

  2020cites this paper
• Nephrotoxicity: Topical issue.

  2019cites this paper
• Induced cross-resistance of BRAFV600E melanoma cells to standard chemotherapeutic dacarbazine after chronic PLX4032 treatment

  2019cites this paper
• Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway.

  2019cites this paper
• Iron (II) Polypyridyl Complexes as Antiglioblastoma Agents to Overcome the Blood-Brain Barrier and Inhibit Cell Proliferation by Regulating p53 and 4E-BP1 Pathways

  2019cites this paper
• Thermosensitive hydrogels for sustained-release of sorafenib and selenium nanoparticles for localized synergistic chemoradiotherapy.

  2019cites this paper
• Self‐Assembly of Copper Polypyridyl Supramolecular Metallopolymers to Achieve Enhanced Anticancer Efficacy

  2019cites this paper
• S-Sulfhydration of SIRT3 by Hydrogen Sulfide Attenuates Mitochondrial Dysfunction in Cisplatin-Induced Acute Kidney Injury

  2019cites this paper
• Glaucocalyxin A-induced oxidative stress inhibits the activation of STAT3 signaling pathway and suppresses osteosarcoma progression in vitro and in vivo.

  2019cites this paper
• Polyphenol-rich blue honeysuckle extract alleviates silica-induced lung fibrosis by modulating Th immune response and NRF2/HO-1 MAPK signaling

  2019cites this paper
• Chiral ruthenium(ii) complex as potent radiosensitizer of 125I through DNA-damage-mediated apoptosis

  2018cites this paper
• Down-regulation of GADD45A enhances chemosensitivity in melanoma

  2018cites this paper
• Role of Daucosterol Linoleate on Breast Cancer: Studies on Apoptosis and Metastasis.

  2018cites this paper
• Renoprotective Effects of Hypoxylonol C and F Isolated from Hypoxylon truncatum against Cisplatin-Induced Cytotoxicity in LLC-PK1 Cells

  2018cites this paper
• Cytoprotective effects of the medicinal herb Astragalus membranaceus on lipopolysaccharide-exposed cells

  2018cites this paper
• Tongmai Yangxin pills anti-oxidative stress alleviates cisplatin-induced cardiotoxicity: Network pharmacology analysis and experimental evidence.

  2018cites this paper
• Caesalpinia sappan L. heartwood ethanolic extract exerts genotoxic inhibitory and cytotoxic effects

  2018cites this paper
• Investigation of the effect of cornelian cherry (Cornus mas L.) fruit extract against cisplatin-induced renal cell injury in vitro

  2017cites this paper
• Target/signalling pathways of natural plant-derived radioprotective agents from treatment to potential candidates: A reverse thought on anti-tumour drugs.

  2017cites this paper
• Netrin-1 Prevents Rat Primary Cortical Neurons from Apoptosis via the DCC/ERK Pathway

  2017cites this paper
• Activation of Sirtuin 3 by Silybin Attenuates Mitochondrial Dysfunction in Cisplatin-induced Acute Kidney Injury

  2017cites this paper
• Stevia and stevioside protect against cisplatin nephrotoxicity through inhibition of ERK1/2, STAT3, and NF-κB activation.

  2017cites this paper
• Cyanidin ameliorates cisplatin-induced cardiotoxicity via inhibition of ROS-mediated apoptosis

  2017cites this paper
• Coptisine-induced apoptosis in human colon cancer cells (HCT-116) is mediated by PI3K/Akt and mitochondrial-associated apoptotic pathway.

  2017cites this paper
• Research progress on cardiotoxicity induced by cisplatin

  2017cites this paper
• Neutrophil gelatinase-associated lipocalin production negatively correlates with HK-2 cell impairment: Evaluation of NGAL as a marker of toxicity in HK-2 cells.

  2017cites this paper
• Antimutagenic evaluation of traditional medicinal plants from South America Peumus boldus and Cryptocarya alba using Drosophila melanogaster

  2017cites this paper
• Molecular mechanisms underlying attenuation of cisplatin-induced acute kidney injury by epicatechin gallate

  2016cites this paper
• Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling.

  2016cites this paper
• Induction of Autophagy and Apoptosis in Melanoma Treated With Palladacycle Complexes

  2016cites this paper
• Carvacrol attenuates acute kidney injury induced by cisplatin through suppression of ERK and PI3K/Akt activation.

  2016cites this paper
• Fenofibrate reduces cisplatin-induced apoptosis of renal proximal tubular cells via inhibition of JNK and p38 pathways.

  2016cites this paper
• Indole-3-carbinol protects against cisplatin-induced acute nephrotoxicity: role of calcitonin gene-related peptide and insulin-like growth factor-1

  2016cites this paper
• Plant-Derived Agents for Counteracting Cisplatin-Induced Nephrotoxicity

  2016cites this paper
• The Journal of Toxicological Sciences

  2016cites this paper
• The antigenotoxic potential of dietary flavonoids

  2016cites this paper
• Cyanidin suppresses amyloid beta-induced neurotoxicity by inhibiting reactive oxygen species-mediated DNA damage and apoptosis in PC12 cells

  2016cites this paper
• Intracellular prostaglandin E2 mediates cisplatin-induced proximal tubular cell death.

  2016cites this paper
• Dichloroacetate enhances the cytotoxic effect of Cisplatin via decreasing the level of FOXM 1 in prostate cancer

  2016cites this paper
• Furazolidone induces apoptosis through activating reactive oxygen species-dependent mitochondrial signaling pathway and suppressing PI3K/Akt signaling pathway in HepG2 cells.

  2015cites this paper
• Antioxidant's cytoprotective effects on rotator cuff tenofibroblasts exposed to aminoamide local anesthetics

  2015cites this paper
• Saikosaponin-D reduces cisplatin-induced nephrotoxicity by repressing ROS-mediated activation of MAPK and NF-κB signalling pathways.

  2015cites this paper
• Cisplatin-induced apoptosis in auditory, renal, and neuronal cells is associated with nitration and downregulation of LMO4

  2015cites this paper
• An Oxidative Stress Mechanism of Shikonin in Human Glioma Cells

  2014cites this paper
• Epidermal Growth Factor Receptor Inhibition with Erlotinib Partially Prevents Cisplatin-Induced Nephrotoxicity in Rats

  2014influential citation
• Effects of Zizyphi Spinosae Extract on Cisplatin and t-Butylhydroperoxide Induced Acute Renal Failure in Rabbits

  2014cites this paper
• Photodynamic effect of functionalized single-walled carbon nanotubes: a potential sensitizer for photodynamic therapy.

  2014cites this paper
• Pre-treatment with cardamonin protects against cisplatin-induced nephrotoxicity in rats: impact on NOX-1, inflammation and apoptosis.

  2014cites this paper
• Combination of Cl-IB-MECA with paclitaxel is a highly effective cytotoxic therapy causing mTOR-dependent autophagy and mitotic catastrophe on human melanoma cells

  2014cites this paper
• The effects of bioactive compounds from plant foods on mitochondrial function: a focus on apoptotic mechanisms.

  2014cites this paper
• Low Concentration of Quercetin Antagonizes the Cytotoxic Effects of Anti-Neoplastic Drugs in Ovarian Cancer

  2014cites this paper
• Strategy to enhance the anticancer efficacy of X-ray radiotherapy in melanoma cells by platinum complexes, the role of ROS-mediated signaling pathways.

  2014cites this paper
• Effects of Zizyphi Spinosae Extract on Cisplatin and t-Butylhydroperoxide Induced Acute Renal Failure in Rabbits

  2014cites this paper
• miR-381, a novel intrinsic WEE1 inhibitor, sensitizes renal cancer cells to 5-FU by up-regulation of Cdc2 activities in 786-O

  2013cites this paper
• Molecular Characterization of Alkaline Phosphatase and PLAP in the Germinal Epithelium of Pb and Se+Zn Treated Adult Sprague Dawley Rats

  2013cites this paper
• A novel binuclear palladacycle complex inhibits melanoma growth in vitro and in vivo through apoptosis and autophagy.

  2013cites this paper