Regulatory Genotoxicity Testing: A Critical Appraisal

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Alternatives to Laboratory Animals

• Publication date

  1995-05-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1177/026119299502300312
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• The use of artificial intelligence systems for predicting toxicity

  1995cited by this paper
• Is polyploidy an important genotoxic lesion?

  1995cited by this paper
• Procedures for the detection of chemically induced aneuploidy: recommendations of a UK Environmental Mutagen Society working group.

  1995cited by this paper
• Using DEREK to predict the activity of some carcinogens/mutagens found in foods.

  1995cited by this paper
• The rodent dominant‐lethal assay

  1994cited by this paper
• Evaluation of the Genetic Toxicity of the Peroxisome Proliferator and Carcinogen Methyl Clofenapate, Including Assays Usin Muta TM Mouse and Big Blue™ Transgenic Mice

  1994cited by this paper
• Comparison between rodent carcinogenicity test results of 44 chemicals and a number of predictive systems.

  1994cited by this paper
• Activation of procarcinogens by human cytochrome P450 enzymes expressed in Escherichia coli. Simplified bacterial systems for genotoxicity assays.

  1994cited by this paper
• Series: 'Current issues in mutagenesis and carcinogenesis.' No. 41. Can a 'relatively simple' screening procedure for the detection of chemicals with aneugenic potential be recommended at the moment?

  1994cited by this paper
• Complementarity of genotoxic and nongenotoxic predictors of rodent carcinogenicity.

  1994cited by this paper
• The application of the restriction site mutation assay to the study of the induction of mutations in the tissues of rodents.

  1994cited by this paper
• Propositions in genetic toxicology and their erasure.

  1994cited by this paper
• A preliminary evaluation of the performance of the Muta Mouse (lacZ) and Big Blue (lacI) transgenic mouse mutation assays.

  1994cited by this paper
• FISH "painting" patterns resulting from complex exchanges.

  1994cited by this paper
• Recommendations for the performance of UDS tests in vitro and in vivo.

  1994cited by this paper
• Molecular modeling of enzymes and receptors involved in carcinogenesis: QSARs and compact-3D.

  1994cited by this paper
• Report of in vivo subgroup

  1994cited by this paper
• International Commission for Protection Against Environmental Mutagens and Carcinogens. Approaches to SAR in carcinogenesis and mutagenesis. Prediction of carcinogenicity/mutagenicity using MULTI-CASE.

  1994cited by this paper
• Similarity in the molecular profile of mutations induced by UV light in shuttle vector plasmids propagated in mouse and human cells.

  1994cited by this paper
• Use of transgenic mouse lacI/Z mutation assays in genetic toxicology.

  1994cited by this paper
• Use of SAR in computer-assited prediction of carcinogenicity and mutagenicity of chemicals by the TOPKAT program

  1994cited by this paper
• First European Commission Report on Statistics of Animal Use

  1994cited by this paper
• Regulatory requirement for three dose levels and proof of tissue localisation in rodent genetic toxicity assays--a call for supporting data.

  1994cited by this paper
• On the need for confirmation of negative genotoxicity results in vitro and on the usefulness of mammalian cell mutation tests in a core battery: experiences of a contract research laboratory.

  1994cited by this paper
• The micronucleus assay in human lymphocytes: screening for inter-individual variability and application to biomonitoring.

  1994cited by this paper
• Series: 'Current issues in mutagenesis and carcinogenesis.' No. 42. Strategies and philosophies of genotoxicity testing: what is the question?

  1994cited by this paper
• Detecting and predicting the activity of rodent carcinogens.

  1994cited by this paper
• Gene manipulation and genetic toxicology.

  1994cited by this paper
• Strategies and philosophies of genotoxicity testing: highly sophisticated versus pragmatic regulatory approaches (reply to Zeiger (1994), strategies and philosophies of genotoxicity testing: what is the question?)

  1994cited by this paper
• Extended-term culture of human T lymphocytes: Material potentially useful in genotoxicity testing.

  1994cited by this paper
• Series: current issues in mutagenesis and carcinogenesis, No. 51. Dose-level selection for in vivo genetic toxicity assays.

  1994cited by this paper
• Evaluation of a three‐exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals

  1993influential reference
• Introduction. Updated worldwide regulatory guidelines for genotoxicity testing. Workshop proceedings from the 1992 environmental mutagen scoiety meeting

  1993cited by this paper
• Expression of human cytochrome P450 enzymes in yeast and bacteria and relevance to studies on catalytic specificity.

  1993cited by this paper
• The single cell gel electrophoresis assay (comet assay): a European review.

  1993cited by this paper
• Report of the BTS/UKEMS Working Group on Dose Setting in In-Vivo Mutagenicity Assays

  1993cited by this paper
• An overview of the results of testing of known or suspected aneugens using mammalian cells in vitro.

  1993cited by this paper
• A perspective on nonmutagenic mechanisms in carcinogenesis.

  1993cited by this paper
• Mutation, cancer and transgenic models: relevance to the toxicology industry.

  1993cited by this paper
• Precedents or possibilities: which should guide the harmonization of mutagenicity test protocols and carcinogen prediction strategies?

  1993cited by this paper
• Gambling and the conduct of genetic toxicology tests.

  1993cited by this paper
• Validation and use of cloned, expressed human drug-metabolizing enzymes in heterologous cells for analysis of drug metabolism and drug-drug interactions.

  1993cited by this paper
• An assessment of the in vitro hepatocyte micronucleus assay.

  1993cited by this paper
• Micronucleus assays using cytochalasin-blocked MCL-5 cells, a proprietary human cell line expressing five human cytochromes P-450 and microsomal epoxide hydrolase.

  1993cited by this paper
• Development of screening tests for aneuploidy induction by environmental pollutants.

  1993cited by this paper
• Cell-cycle dependent micronucleus formation and mitotic disturbances induced by 5-azacytidine in mammalian cells.

  1993cited by this paper
• Predicting rodent carcinogenicity of Ames test false positives by in vivo biochemical parameters.

  1993cited by this paper
• Problem of the harmonization of philosophies for genotoxicity testing.

  1993cited by this paper
• Mutant rodent cell lines sensitive to ultraviolet light, ionizing radiation and cross-linking agents: a comprehensive survey of genetic and biochemical characteristics.

  1993cited by this paper
• Structural relationships between mutagenicity, maximum tolerated dose, and carcinogenicity in rodents

  1993cited by this paper
• Testing of known carcinogens and noncarcinogens in the Syrian hamster embryo (SHE) micronucleus test in vitro; correlations with in vivo micronucleus formation and cell transformation.

  1993cited by this paper
• The influence of chemical structure on the extent and sites of carcinogenesis for 522 rodent carcinogens and 55 different human carcinogen exposures.

  1993cited by this paper
• Micronucleus test with mouse peripheral blood erythrocytes by acridine orange supravital staining: the summary report of the 5th collaborative study by CSGMT/JEMS.MMS. The Collaborative Study Group for the Micronucleus Test.

  1992cited by this paper
• Prediction of non-genotoxic carcinogenesis.

  1992cited by this paper
• International Commission for Protection Against Environmental Mutagens and Carcinogens. A method for comparing and combining short-term genotoxicity test data: results and interpretation.

  1992cited by this paper
• Nongenotoxic carcinogens: an extension of the perspective provided by Perera.

  1992cited by this paper
• Dose-ranging and dose-setting for in vivo genetic toxicology studies.

  1992cited by this paper
• Non-genotoxic factors in the carcinogenetic process: problems of detection and hazard evaluation.

  1992cited by this paper
• Predictive assay for rodent carcinogenicity using in vivo biochemical parameters: operational characteristics and complementarity.

  1992cited by this paper
• Alternatives to Aroclor 1254-induced S9 in in vitro genotoxicity assays.

  1992cited by this paper
• Simultaneous visualization of seven different DNA probes by in situ hybridization using combinatorial fluorescence and digital imaging microscopy.

  1992cited by this paper
• Transgenic mouse mutation assays: Potential for confusion of genotoxic an non‐genotoxic carcinogenesis: A proposed Solution

  1992cited by this paper
• HazardExpert: An Expert System for Predicting Chemical Toxicity

  1992cited by this paper
• The in vivo relevance of in vitro genotoxicity assays incorporating enzyme activation systems

  1992cited by this paper
• Considerations in the U.S. Environmental Protection Agency's testing approach for mutagenicity.

  1991cited by this paper
• Data selection and treatment of chemicals tested for genotoxicity and carcinogenicity.

  1991cited by this paper
• Micronuclei as an index of cytogenetic damage: Past, present, and future

  1991cited by this paper
• A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing.

  1991cited by this paper
• Computer Prediction of Possible Toxic Action from Chemical Structure; The DEREK System

  1991cited by this paper
• Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the U.S. NTP.

  1991cited by this paper
• Micronuclei induction by dichlorvos in the mouse skin.

  1991cited by this paper
• Genotoxicity and cell proliferative activity of omeprazole in rat stomach mucosa.

  1991cited by this paper
• The use of genetically engineered V79 Chinese hamster cultures expressing rat liver CYP1A1, 1A2 and 2B1 cDNAs in micronucleus assays.

  1991cited by this paper
• Ability of short-term tests to predict carcinogenesis in rodents.

  1990cited by this paper
• The induction of micronucleated polychromatic erythrocytes in mice using single and multiple treatments.

  1990cited by this paper
• Carcinogenicity results for 114 laboratory animal studies used to assess the predictivity of four in vitro genetic toxicity assays for rodent carcinogenicity

  1990cited by this paper
• Biology of mammalian germ cell mutagenesis

  1990cited by this paper
• Evaluation of four in vitro genetic toxicity tests for predicting rodent carcinogenicity: Confirmation of earlier results with 41 additional chemicals

  1990cited by this paper
• The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides.

  1990cited by this paper
• Effect of treatment protocol and sample time on the frequencies of micronucleated polychromatic erythrocytes in mouse bone marrow and peripheral blood.

  1990cited by this paper
• Genetic and epigenetic losses of heterozygosity in cancer predisposition and progression.

  1990cited by this paper
• The international validation of a fixed-dose procedure as an alternative to the classical LD50 test.

  1990cited by this paper
• The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the U.S. Environmental Protection Agency Gene-Tox Program.

  1990cited by this paper
• Origins of current uncertainties in carcinogen/mutagen screening

  1989influential reference
• Development of a transgenic mouse system for the analysis of stages in liver carcinogenesis using tissue-specific expression of SV40 large T-antigen controlled by regulatory elements of the human alpha-1-antitrypsin gene.

  1989cited by this paper
• Early years of the salmonella mutagen tester strains: Lessons from hycanthone

  1989cited by this paper
• Statistical evaluation of mutagenicity test data

  1989cited by this paper
• Development of a human cell line by selection and drug-metabolizing gene transfection with increased capacity to activate promutagens.

  1989cited by this paper
• Stable expression of rat cytochrome P-450IIB1 cDNA in Chinese hamster cells (V79) and metabolic activation of aflatoxin B1.

  1988cited by this paper
• Predicting carcinogenicity with short-term tests: biological models and operational approaches.

  1988cited by this paper
• International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC working paper No. 5. Genotoxicity tests as predictors of carcinogens: an analysis.

  1988cited by this paper
• Mutagenicity Screening/in Vitro Testing–the End of an Era; Animal and Human Studies–the Direction for the Future

  1988cited by this paper
• Genetic toxicology at the crossroads--a personal view on the deployment of short-term tests for predicting carcinogenicity.

  1988cited by this paper
• Species-specific response to the rodent carcinogens 1,2-dimethylhydrazine and 1,2-dibromo-3-chloropropane in rodent bone-marrow micronucleus assays.

  1988cited by this paper
• Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP.

  1988cited by this paper
• A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures.

  1988cited by this paper
• Implications of treatment-condition-induced genotoxicity for chemical screening and data interpretation.

  1987cited by this paper
• Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays.

  1987cited by this paper
• Genotoxicity produced in cultured mammalian cell assays by treatment conditions. A symposium. June 9, 1986, Amsterdam. Proceedings.

  1987cited by this paper
• Genetic risk assessment.

  1987cited by this paper

• Cell Transformation Assays: Are we Barking up the Wrong Tree?

  2012cites this paper
• High-content micronucleus assay in genotoxicity profiling: initial-stage development and some applications in the investigative/lead-finding studies in drug discovery.

  2010cites this paper
• Integrated Decision-tree Testing Strategies for Mutagenicity and Carcinogenicity with Respect to the Requirements of the EU REACH Legislation

  2008cites this paper
• Proposed Integrated Decision-tree Testing Strategies for Mutagenicity and Carcinogenicity in Relation to the EU REACH Legislation

  2007cites this paper
• A Scientific and Animal Welfare Assessment of the OECD Health Effects Test Guidelines for the Safety Testing of Chemicals under the European Union REACH System

  2004cites this paper
• The Mouse Bioassay for Diarrhetic Shellfish Poisoning: A Gross Misuse of Laboratory Animals and of Scientific Methodology

  2003cites this paper
• Alternative (non-animal) methods for chemicals testing: Current status and future prospects - Overview

  2002cites this paper
• An Assessment of Progress in the Use of Alternatives in Toxicity Testing since the Publication of the Report of the Second FRAME Toxicity Committee (1991)

  2002cites this paper
• A Critical Analysis of the Testing of Potentially Carcinogenic Food Contaminants

  1997cites this paper
• Risk assessment: alternatives to animal testing

  1997cites this paper
• 14 – In Vitro Genotoxicity and Cell Transformation Assessment

  1996cites this paper