hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Nature Structural &Molecular Biology

• Publication date

  2010-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nsmb.1815PMID 20473314PMCID PMC2908492
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene

  2009cited by this paper
• Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs.

  2009cited by this paper
• Cells lacking the fragile X mental retardation protein (FMRP) have normal RISC activity but exhibit altered stress granule assembly.

  2009cited by this paper
• MicroRNA regulation of Alzheimer's Amyloid precursor protein expression.

  2009cited by this paper
• CLIP: crosslinking and immunoprecipitation of in vivo RNA targets of RNA-binding proteins.

  2008cited by this paper
• miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels

  2008cited by this paper
• MKP-1 mRNA Stabilization and Translational Control by RNA-Binding Proteins HuR and NF90

  2008cited by this paper
• MicroRNAs can regulate human APP levels

  2008cited by this paper
• Promoter polymorphisms which modulate APP expression may increase susceptibility to Alzheimer's disease.

  2008cited by this paper
• Regulating amyloid precursor protein synthesis through an internal ribosomal entry site

  2008cited by this paper
• P bodies: at the crossroads of post-transcriptional pathways

  2007cited by this paper
• Phosphorylation of HuR by Chk2 regulates SIRT1 expression.

  2007cited by this paper
• FMRP Mediates mGluR5-Dependent Translation of Amyloid Precursor Protein

  2007cited by this paper
• P bodies and the control of mRNA translation and degradation.

  2007cited by this paper
• A role for hnRNP C1/C2 and Unr in internal initiation of translation during mitosis

  2007cited by this paper
• mRNPs, polysomes or granules: FMRP in neuronal protein synthesis.

  2006cited by this paper
• Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.

  2006cited by this paper
• Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54

  2006cited by this paper
• Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies.

  2006cited by this paper
• From Birth to Death: The Complex Lives of Eukaryotic mRNAs

  2005cited by this paper
• Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2.

  2005cited by this paper
• A 57-Nucleotide Upstream Early Polyadenylation Element in Human Papillomavirus Type 16 Interacts with hFip1, CstF-64, hnRNP C1/C2, and Polypyrimidine Tract Binding Protein

  2005cited by this paper
• Cytoplasmic foci are sites of mRNA decay in human cells

  2004cited by this paper
• Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway

  2004cited by this paper
• RNA and microRNAs in fragile X mental retardation

  2004cited by this paper
• Phosphorylation influences the translation state of FMRP-associated polyribosomes.

  2003cited by this paper
• Single mRNA molecules demonstrate probabilistic movement in living mammalian cells.

  2003cited by this paper
• The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses.

  2003cited by this paper
• The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95

  2003cited by this paper
• The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

  2002cited by this paper
• Fragile X-related protein and VIG associate with the RNA interference machinery.

  2002cited by this paper
• A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins.

  2002cited by this paper
• An Iron-responsive Element Type II in the 5′-Untranslated Region of the Alzheimer's Amyloid Precursor Protein Transcript*

  2002cited by this paper
• Review a Unified Theory of Gene Expression of Metabolic Enzymes Are Often Regulated Directly by Metabolites. Once Activated, Transcription Factors Bind Syngenta Central Toxicology Laboratory to Gene Regulatory Elements And, through Interactions Alderley Park with Other Components of the Transcriptio

  2002cited by this paper
• The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.

  2002cited by this paper
• Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures

  2002cited by this paper
• Extracellular-regulated kinase controls β-amyloid precursor protein mRNA decay

  2001cited by this paper
• Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome.

  2001cited by this paper
• Evidence that fragile X mental retardation protein is a negative regulator of translation.

  2001cited by this paper
• Extracellular-regulated kinase controls beta-amyloid precursor protein mRNA decay.

  2001cited by this paper
• Growth Factor‐Mediated Stabilization of Amyloid Precursor Protein mRNA Is Mediated by a Conserved 29‐Nucleotide Sequence in the 3′‐Untranslated Region

  2000cited by this paper
• The Drosophila β-Amyloid Precursor Protein Homolog Promotes Synapse Differentiation at the Neuromuscular Junction

  1999cited by this paper
• hnRNP C increases amyloid precursor protein (APP) production by stabilizing APP mRNA.

  1998cited by this paper
• Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives.

  1997cited by this paper
• Amyloid precursor protein mRNA levels in the mononuclear blood cells of Alzheimer's and Down's patients.

  1993cited by this paper
• Altered levels of amyloid protein precursor transcripts in the basal forebrain of behaviorally impaired aged rats.

  1990cited by this paper
• Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease.

  1989cited by this paper
• In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.

  1988cited by this paper
• Frontiers in Neural Circuits Neural Circuits Review Article Synaptic Plasticity General Features of Mrna Translation

  year unknowncited by this paper

• RNA Granules at the Crossroads of Synaptic Dysfunction and Neurodegeneration

  2025influential citation
• Molecular interactome of HNRNPU reveals regulatory networks in neuronal differentiation and DNA methylation

  2025cites this paper
• RNA methylation modifications in neurodegenerative diseases: Focus on their enzyme system

  2025cites this paper
• DJ-1-mediated repression of the RNA-binding protein FMRP is predicted to impact known Alzheimer's disease-related protein networks

  2024cites this paper
• FMRP cooperates with miRISC components to repress translation and regulate neurite morphogenesis in Drosophila

  2024cites this paper
• hnRNPs: roles in neurodevelopment and implication for brain disorders

  2024cites this paper
• TFAIP6 facilitates hepatocellular carcinoma cell glycolysis through upregulating c-myc/PKM2 axis

  2024cites this paper
• Cancer-derived exosomal lncRNA SNHG3 promotes the metastasis of colorectal cancer through hnRNPC-mediating RNA stability of β-catenin

  2024cites this paper
• RNA m6A Methylation and Alzheimer's Disease: Current Evidence and Future Perspectives

  2024influential citation
• HNRNPC promotes estrogen receptor‐positive breast cancer cell cycle by stabilizing WDR77 mRNA in an m6A‐dependent manner

  2024cites this paper
• Age-Dependent Dysregulation of APP in Neuronal and Skin Cells from Fragile X Individuals

  2023cites this paper
• Role of N6-methyladenosine modification in central nervous system diseases and related therapeutic agents.

  2023cites this paper
• Identification and prediction of molecular subtypes of atherosclerosis based on m6A immune cell infiltration.

  2023cites this paper
• IGF2 is upregulated by its antisense RNA to potentiate pancreatic cancer progression

  2023cites this paper
• The Roles of hnRNP Family in the Brain and Brain-Related Disorders

  2023cites this paper
• Toward an understanding of the role of the exposome on fragile X phenotypes.

  2023cites this paper
• Insulin Receptor Isoforms and Insulin Growth Factor-like Receptors: Implications in Cell Signaling, Carcinogenesis, and Chemoresistance

  2023cites this paper
• Therapeutic Candidates for Alzheimer’s Disease: Saponins

  2023cites this paper
• RNA Binding Proteins in Senescence: A Potential Common Linker for Age-related Diseases?

  2023cites this paper
• Drosophila FMRP recruits the miRISC to target mRNAs to repress translation

  2023influential citation
• Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers

  2023cites this paper
• HNRNPC downregulation inhibits IL‐6/STAT3‐mediated HCC metastasis by decreasing HIF1A expression

  2022cites this paper
• Mechanisms of RNA and Protein Quality Control and Their Roles in Cellular Senescence and Age-Related Diseases

  2022cites this paper
• Blockade of Type 2A Protein Phosphatase Signaling Attenuates Complement C1q-Mediated Microglial Phagocytosis of Glutamatergic Synapses Induced by Amyloid Fibrils

  2022cites this paper
• Intracellular and intercellular transport of RNA organelles in CXG repeat disorders: The strength of weak ties

  2022cites this paper
• LncRNA CEBPA-DT promotes liver cancer metastasis through DDR2/β-catenin activation via interacting with hnRNPC

  2022cites this paper
• Research progress of live-cell RNA imaging techniques.

  2022cites this paper
• The RNA-Binding Landscape of HAX1 Protein Indicates Its Involvement in Translation and Ribosome Assembly

  2022cites this paper
• lncRNA CYTOR promotes aberrant glycolysis and mitochondrial respiration via HNRNPC-mediated ZEB1 stabilization in oral squamous cell carcinoma

  2022cites this paper
• 1-L Transcription in Alzheimer’s Disease

  2022cites this paper
• Manuscript title : The RNA-binding landscape of HAX1 protein indicates its involvement in ribosome biogenesis and translation.

  2022cites this paper
• Analysis of Serum miRNAs in Alzheimer’s Disease

  2021cites this paper
• A landscape of the genetic and cellular heterogeneity in Alzheimer disease

  2021cites this paper
• FMRP and MOV10 regulate Dicer1 expression and dendrite development

  2021cites this paper
• Symptomatic, Genetic, and Mechanistic Overlaps between Autism and Alzheimer’s Disease

  2021cites this paper
• Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation

  2021influential citation
• FMRP-Driven Neuropathology in Autistic Spectrum Disorder and Alzheimer's disease: A Losing Game

  2021cites this paper
• Testing Fmr1KO Phenotypes in Response to GSK3 Inhibitors: SB216763 versus AFC03127

  2021cites this paper
• Tau Modulates mRNA Transcription, Alternative Polyadenylation Profiles of hnRNPs, Chromatin Remodeling and Spliceosome Complexes

  2021cites this paper
• HNRNPC impedes m6A-dependent anti-metastatic alternative splicing events in pancreatic ductal adenocarcinoma.

  2021cites this paper
• N6-Methyladenosine RNA Methylation Regulator-Related Alternative Splicing (AS) Gene Signature Predicts Non–Small Cell Lung Cancer Prognosis

  2021cites this paper
• An “Omic” Overview of Fragile X Syndrome

  2021cites this paper
• An ‘’Omic’’ Overview of Fragile X Syndrome

  2021cites this paper
• Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders

  2021cites this paper
• G-Quadruplexes as pathogenic drivers in neurodegenerative disorders

  2021cites this paper
• ncRNA BC1 influences translation in the oocyte

  2021cites this paper
• Elevated Heterogeneous Nuclear Ribonucleoprotein C Expression Correlates With Poor Prognosis in Patients With Surgically Resected Lung Adenocarcinoma

  2021cites this paper
• Cataloguing and Selection of mRNAs Localized to Dendrites in Neurons and Regulated by RNA-Binding Proteins in RNA Granules

  2020cites this paper
• Astrocytes deliver CK1 to neurons via extracellular vesicles in response to inflammation promoting the translation and amyloidogenic processing of APP

  2020cites this paper
• How autism and Alzheimer’s disease are TrAPPed

  2020cites this paper
• Identification of RNA-Binding Proteins as Targetable Putative Oncogenes in Neuroblastoma

  2020cites this paper
• Heterogeneous Nuclear Ribonucleoproteins: Implications in Neurological Diseases

  2020cites this paper
• Prognostic values of m6A RNA methylation regulators in differentiated Thyroid Carcinoma

  2020cites this paper
• The Cancer Genome Atlas (TCGA) based m6A methylation-related genes predict prognosis in hepatocellular carcinoma

  2020cites this paper
• FMRP Regulates the Nuclear Export of Adam9 and Psen1 mRNAs: Secondary Analysis of an N6-Methyladenosine Dataset

  2020cites this paper
• Mining the Prognostic Value of HNRNPAB and Its Function in Breast Carcinoma

  2020cites this paper
• Regulation of RNA granules by FMRP and implications for neurological diseases

  2020cites this paper
• Unraveling a new player in multiple sclerosis pathogenesis: The RNA-binding protein HuR.

  2020cites this paper
• Transient upregulation of translational efficiency in prodromal and early symptomatic Tg2576 mice contributes to Aβ pathology.

  2020cites this paper
• Transient upregulation of translational efficiency in prodromal Tg2576 mice precipitates AD symptoms

  2019cites this paper
• HNRNP Q suppresses polyglutamine huntingtin aggregation by post‐transcriptional regulation of vaccinia‐related kinase 2

  2019cites this paper
• The FMRP–MOV10 complex: a translational regulatory switch modulated by G-Quadruplexes

  2019cites this paper
• RNA binding protein HuD and microRNA-203a cooperatively regulate insulinoma-associated 1 mRNA.

  2019cites this paper
• Roles of Topoisomerases in Heterochromatin, Aging, and Diseases

  2019cites this paper
• The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data

  2019cites this paper
• Activation of mGluR1 Mediates C1q-Dependent Microglial Phagocytosis of Glutamatergic Synapses in Alzheimer’s Rodent Models

  2019cites this paper
• Fragile X and APP: a Decade in Review, a Vision for the Future

  2018cites this paper
• The m6A‐epitranscriptomic signature in neurobiology: from neurodevelopment to brain plasticity

  2018cites this paper
• Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer’s Disease

  2018cites this paper
• Function of HNRNPC in breast cancer cells by controlling the dsRNA‐induced interferon response

  2018cites this paper
• E2F1 and E2F7 differentially regulate KPNA2 to promote the development of gallbladder cancer

  2018cites this paper
• Insulin Receptor Isoforms in Cancer

  2018cites this paper
• Characterization of the hnRNP RALY in RNA transcription and metabolism

  2017cites this paper
• Long Noncoding RNAs and RNA-Binding Proteins in Oxidative Stress, Cellular Senescence, and Age-Related Diseases

  2017cites this paper
• Commentary: Depletion of the Fragile X Mental Retardation Protein in Embryonic Stem Cells Alters the Kinetics of Neurogenesis

  2017cites this paper
• Proteomic analysis of polyribosomes identifies splicing factors as potential regulators of translation during mitosis

  2017cites this paper
• Nuclear poly(A) binding protein 1 (PABPN1) and Matrin3 interact in muscle cells and regulate RNA processing

  2017cites this paper
• Protein Translation and Signaling in Human Eosinophils

  2017cites this paper
• CUGBP1 and HuR regulate E-cadherin translation by altering recruitment of E-cadherin mRNA to processing bodies and modulate epithelial barrier function.

  2016cites this paper
• RNA-binding protein HuD reduces triglyceride production in pancreatic β cells by enhancing the expression of insulin-induced gene 1.

  2016cites this paper
• T-cell-restricted intracellular antigen 1 facilitates mitochondrial fragmentation by enhancing the expression of mitochondrial fission factor

  2016cites this paper
• Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss

  2016cites this paper
• Novel Roles of Amyloid-Beta Protein Precursor Metabolites in Fragile X Syndrome and Autism

  2016cites this paper
• Long non-coding RNA GAS5 inhibited hepatitis C virus replication by binding viral NS3 protein.

  2016cites this paper
• FMRP Associates with Cytoplasmic Granules at the Onset of Meiosis in the Human Oocyte

  2016cites this paper
• Drugs development and fragile X syndrome translational success story

  2016cites this paper
• An investigation into the RNA-binding protein UNR and its interactors

  2016cites this paper
• HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP

  2016influential citation
• RNA Secondary Structure Modulates FMRP’s Bi-Functional Role in the MicroRNA Pathway

  2016cites this paper
• The hnRNP family: insights into their role in health and disease

  2016cites this paper
• Neurobehavioral features and targeted treatments in fragile X syndrome: Current insights and future directions

  2015cites this paper
• Branched-chain amino acids supplementation protects streptozotocin-induced insulin secretion and the correlated mechanism.

  2015cites this paper
• Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells

  2015cites this paper
• High‐Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient‐Derived Induced Pluripotent Stem Cells

  2015cites this paper
• Evaluating the role of hnRNP-C and FMRP in the cAMP-induced APP metabolism.

  2015cites this paper
• Opposite Dysregulation of Fragile-X Mental Retardation Protein and Heteronuclear Ribonucleoprotein C Protein Associates with Enhanced APP Translation in Alzheimer Disease

  2015cites this paper
• RNA Binding Protein Nanos2 Organizes Post-transcriptional Buffering System to Retain Primitive State of Mouse Spermatogonial Stem Cells.

  2015cites this paper
• Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome.

  2015influential citation
• Fragile X mental retardation protein: from autism to neurodegenerative disease

  2015cites this paper
• Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity

  2015cites this paper