Recognition of Lyso-Phospholipids by Human Natural Killer T Lymphocytes

Lisa M. Fox,D. Cox,Jennifer L. Lockridge,Xiaohuan Wang,Xiuxu Chen,L. Scharf,D. L. Trott,Rachel M. Ndonye,N. Veerapen,G. Besra,A. Howell,M. Cook,E. Adams,W. Hildebrand,J. Gumperz

Published 2009 in PLoS Biology

ABSTRACT

By identifying the lipid LPC as an endogenous antigen, recognized by the invariant subset of human NKT cells, this study establishes a novel link between these immunoregulatory cells and an inflammatory lipid mediator.

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