The LIM-only proteins FHL2 and FHL3 interact with alpha- and beta-subunits of the muscle alpha7beta1 integrin receptor.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Biological Chemistry

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 15117962
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The LIM-only protein FHL2 is a serum-inducible transcriptional coactivator of AP-1

  2003cited by this paper
• Skeletal muscle LIM protein 1 (SLIM1/FHL1) induces alpha 5 beta 1-integrin-dependent myocyte elongation.

  2003cited by this paper
• FHL3 is an actin-binding protein that regulates alpha-actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly.

  2003cited by this paper
• Skeletal muscle LIM protein 1 regulates integrin-mediated myoblast adhesion, spreading, and migration.

  2003cited by this paper
• Defective integrin switch and matrix composition at alpha 7-deficient myotendinous junctions precede the onset of muscular dystrophy in mice.

  2003cited by this paper
• Insulin-like Growth Factor-binding Protein 5 (IGFBP-5) Interacts with a Four and a Half LIM Protein 2 (FHL2)*

  2002cited by this paper
• Alternative Splice Variants of α7β1Integrin Selectively Recognize Different Laminin Isoforms*

  2002cited by this paper
• The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus

  2002cited by this paper
• Integrin activation takes shape

  2002cited by this paper
• Integrins: bidirectional, allosteric signaling machines.

  2002cited by this paper
• Localization of α7 integrins and dystrophin suggests potential for both lateral and longitudinal transmission of tension in large mammalian muscles

  2002cited by this paper
• Expression of alpha7beta1 integrin splicing variants during skeletal muscle regeneration.

  2002cited by this paper
• Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2

  2002cited by this paper
• The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits.

  2002cited by this paper
• TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF‐κB activation

  2002cited by this paper
• The LIM-only Protein DRAL/FHL2 Interacts with and Is a Corepressor for the Promyelocytic Leukemia Zinc Finger Protein*

  2002cited by this paper
• The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation.

  2002cited by this paper
• The LIM-only protein FHL2 interacts with β-catenin and promotes differentiation of mouse myoblasts

  2002cited by this paper
• Cardiac-Specific LIM Protein FHL2 Modifies the Hypertrophic Response to &bgr;-Adrenergic Stimulation

  2001cited by this paper
• Protein–protein interaction of FHL3 with FHL2 and visualization of their interaction by green fluorescent proteins (GFP) two‐fusion fluorescence resonance energy transfer (FRET)

  2001cited by this paper
• The Integrin α7 Cytoplasmic Domain Regulates Cell Migration, Lamellipodia Formation, and p130CAS/Crk Coupling*

  2001cited by this paper
• Function and interactions of integrins

  2001cited by this paper
• Dral Is a P53-Responsive Gene Whose Four and a Half Lim Domain Protein Product Induces Apoptosis

  2000cited by this paper
• A Family of LIM-Only Transcriptional Coactivators: Tissue-Specific Expression and Selective Activation of CREB and CREM

  2000cited by this paper
• Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein.

  2000cited by this paper
• Integrin cytoplasmic domain-binding proteins.

  2000cited by this paper
• FHL2 (SLIM3) Is Not Essential for Cardiac Development and Function

  2000cited by this paper
• The LIM-only Protein DRAL/FHL2 Binds to the Cytoplasmic Domain of Several α and β Integrin Chains and Is Recruited to Adhesion Complexes*

  2000cited by this paper
• A structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunit.

  2000cited by this paper
• FHL2, a novel tissue‐specific coactivator of the androgen receptor

  2000cited by this paper
• Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains.

  1999cited by this paper
• The fourth member of the FHL family of LIM proteins is expressed exclusively in the testis.

  1999cited by this paper
• The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle.

  1999cited by this paper
• Characterization of Two Isoforms of the Skeletal Muscle LIM Protein 1, SLIM1

  1999cited by this paper
• CBP-independent activation of CREM and CREB by the LIM-only protein ACT

  1999cited by this paper
• The alpha7beta1 integrin in muscle development and disease.

  1999cited by this paper
• Structure, genetic localization, and identification of the cardiac and skeletal muscle transcripts of the human integrin alpha7 gene (ITGA7).

  1999cited by this paper
• Rack1, a Receptor for Activated Protein Kinase C, Interacts with Integrin β Subunit*

  1998cited by this paper
• Spatial and temporal expression of the beta1D integrin during mouse development.

  1997cited by this paper
• Molecular dissection of a LIM domain.

  1997cited by this paper
• Slim defines a novel family of LIM-proteins expressed in skeletal muscle.

  1996cited by this paper
• Distinct alpha 7A beta 1 and alpha 7B beta 1 integrin expression patterns during mouse development: alpha 7A is restricted to skeletal muscle but alpha 7B is expressed in striated muscle, vasculature, and nervous system.

  1996cited by this paper
• Specific Induction of Cell Motility on Laminin by 7 Integrin (*)

  1996cited by this paper
• Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains

  1995cited by this paper
• The LIM/double zinc-finger motif functions as a protein dimerization domain.

  1994cited by this paper
• Common metal ion coordination in LIM domain proteins.

  1994cited by this paper
• The LIM motif defines a specific zinc-binding protein domain.

  1993cited by this paper
• Expression of alpha 7 integrin cytoplasmic domains during skeletal muscle development: alternate forms, conformational change, and homologies with serine/threonine kinases and tyrosine phosphatases.

  1993cited by this paper
• Novel purification of vitronectin from human plasma by heparin affinity chromatography.

  1988cited by this paper
• Laminin-nidogen complex. Extraction with chelating agents and structural characterization.

  1987cited by this paper
• Purification of fibronectin from human plasma by affinity chromatography under non-denaturing conditions.

  1979cited by this paper
• [A chamber for determination of the rate of macrophage migration under different experimental conditions].

  1976cited by this paper

• FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis

  2025cites this paper
• Proteomic analysis of HeLa cells after stable transfection with the Chlamydia trachomatis CT143 gene.

  2024cites this paper
• FHL3 gene regulates bovine skeletal muscle cell growth through the PI3K/Akt/mTOR signaling pathway.

  2024cites this paper
• fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles

  2024cites this paper
• The roles of FHL2 as a mechanotransducer for cellular functions in the mechanical environment

  2024cites this paper
• FHL2 expression by cancer‐associated fibroblasts promotes metastasis and angiogenesis in lung adenocarcinoma

  2024cites this paper
• FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3

  2023cites this paper
• CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes

  2022cites this paper
• The Roles of FHL3 in Cancer

  2022cites this paper
• FHL5 controls vascular disease-associated gene programs in smooth muscle cells

  2022cites this paper
• The titin N2B and N2A regions: biomechanical and metabolic signaling hubs in cross-striated muscles

  2021cites this paper
• FHL1 Inhibits the Progression of Colorectal Cancer by Regulating the Wnt/β-Catenin Signaling Pathway

  2021cites this paper
• Striated muscle proteins are regulated both by mechanical deformation and by chemical post-translational modification

  2021cites this paper
• Plating human iPSC lines on micropatterned substrates reveals role for ITGB1 nsSNV in endoderm formation

  2021cites this paper
• Mechanosensing through direct binding of tensed F-actin by LIM domains

  2020cites this paper
• FHL2 Is Essential for Spleen T Cell–Dependent B Cell Activation and Antibody Response

  2020cites this paper
• The CDK inhibitor p57Kip2 enhances the activity of the transcriptional coactivator FHL2

  2020cites this paper
• Characterization of a novel interaction between four-and-a-half-LIM domains 2 and cardiomyopathy-associated protein 5 in cardiac myocytes

  2020cites this paper
• LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor 1 Expression

  2020cites this paper
• Deficiency of Fhl2 leads to delayed neuronal cell migration and premature astrocyte differentiation

  2019cites this paper
• Cell Adhesion by Integrins.

  2019cites this paper
• FHL3 negatively regulates the differentiation of skeletal muscle satellite cells in chicken

  2019cites this paper
• FHL2 mediates podocyte Rac1 activation and foot process effacement in hypertensive nephropathy

  2019cites this paper
• The role of FHL2 in wound healing and inflammation

  2019cites this paper
• Four and a half domain 2 (FHL2) scaffolding protein is a marker of connective tissues of developing digits and regulates fibrogenic differentiation of limb mesodermal progenitors

  2018cites this paper
• FHL2 Regulates Natural Killer Cell Development and Activation during Streptococcus pneumoniae Infection

  2017cites this paper
• Ankyrin Repeat Domain 1 Protein: A Functionally Pleiotropic Protein with Cardiac Biomarker Potential

  2017cites this paper
• LIM-Only Protein FHL2 Is a Negative Regulator of Transforming Growth Factor β1 Expression

  2017cites this paper
• Matrix mechanics controls FHL2 movement to the nucleus to activate p21 expression

  2016cites this paper
• FHL2 mediates tooth development and human dental pulp cell differentiation into odontoblasts, partially by interacting with Runx2

  2016cites this paper
• Protein-protein interactions of the LIM-only protein FHL2 and functional implication of the interactions relevant in cardiovascular disease.

  2016cites this paper
• Mammalian Actin-binding Protein-1/Hip-55 Interacts with FHL2 and Negatively Regulates Cell Invasion*

  2016cites this paper
• Tumoral expression of nuclear cofactor FHL2 is associated with lymphatic metastasis in sporadic but not in HNPCC-associated colorectal cancer.

  2015cites this paper
• Inhibition of FHL1 inhibits cigarette smoke extract-induced proliferation in pulmonary arterial smooth muscle cells.

  2015cites this paper
• Absence of Four-and-a-Half LIM Domain Protein 2 Decreases Atherosclerosis in ApoE−/− Mice

  2015cites this paper
• Enhanced FHL2 and TGF-β1 Expression Is Associated With Invasive Growth and Poor Survival in Malignant Melanomas.

  2015cites this paper
• The FHL2 regulation in the transcriptional circuitry of human cancers.

  2015cites this paper
• Manipulation of pro-inflammatory cytokine production by the bacterial cell-penetrating effector protein YopM is independent of its interaction with host cell kinases RSK1 and PRK2

  2014cites this paper
• Proteomics of muscle chronological ageing in post-menopausal women

  2014cites this paper
• Global Transcriptome Analysis of Spermatogenically Regressed, Recrudescent and Active Testis of Seasonally Breeding Indian Wall Lizard Hemidactylus flaviviridis

  2014cites this paper
• The physiological role of cardiac cytoskeleton and its alterations in heart failure.

  2014cites this paper
• Inhibition of Four-and-a-Half LIM Domain Protein-2 Increases Survival, Migratory Capacity, and Paracrine Function of Human Early Outgrowth Cells Through Activation of the Sphingosine Kinase-1 Pathway: Implications for Endothelial Regeneration

  2014cites this paper
• Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer

  2013cites this paper
• Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes

  2013cites this paper
• Screening and identification of significant genes related to tumor metastasis and PSMA in prostate cancer using microarray analysis.

  2013cites this paper
• Associations between muscle gene expression pattern and technological and sensory meat traits highlight new biomarkers for pork quality assessment.

  2013cites this paper
• Characterization of the putative CALM/AF10 collaborator Meis1 in leukemia development

  2013cites this paper
• The Four and a Half LIM Family Members Are Novel Interactants of the Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein

  2013cites this paper
• Transcriptome Analysis of Spermatogenically Regressed, Recrudescent and Active Phase Testis of Seasonally Breeding Wall Lizards Hemidactylus flaviviridis

  2013cites this paper
• New insights into adhesion signaling in bone formation.

  2013cites this paper
• L’intégrine β1 et de son régulateur ICAP-1α dans l’ostéogenèse : rôle dans la prolifération, la différenciation et la fonction ostéoblastiques

  2013cites this paper
• A novel colon cancer gene therapy using rAAV‑mediated expression of human shRNA-FHL2.

  2013cites this paper
• The Four and a Half LIM-only Protein 2 (FHL2) Activates Transforming Growth Factor β (TGF-β) Signaling by Regulating Ubiquitination of the E3 Ligase Arkadia*

  2012cites this paper
• Changes in protein abundance between tender and tough meat from bovine longissimus thoracis muscle assessed by isobaric Tag for Relative and Absolute Quantitation (iTRAQ) and 2-dimensional gel electrophoresis analysis.

  2012cites this paper
• The LIM domain protein FHL2 interacts with the NR5A family of nuclear receptors and CREB to activate the inhibin-α subunit gene in ovarian granulosa cells.

  2012cites this paper
• Zasp regulates integrin activation

  2012cites this paper
• Three proteins regulating integrin function - filamin, 14-3-3 and RIAM

  2011cites this paper
• FHL2 interacts with CALM and is highly expressed in acute erythroid leukemia

  2011cites this paper
• FHL2 expression in peritumoural fibroblasts correlates with lymphatic metastasis in sporadic but not in HNPCC-associated colon cancer

  2011cites this paper
• Novel Players in the Integrin Signaling Orchestra: TCPTP and MDGI

  2011cites this paper
• Identification and characterisation of novel Mss4-binding Rab GTPases

  2011cites this paper
• CpG hypermethylation of human four-and-a-half LIM domains 1 contributes to migration and invasion activity of human bladder cancer.

  2010cites this paper
• The Integrin Tail: A Tale of Cell Motility and Division

  2010cites this paper
• Deficiency of the LIM-Only Protein FHL2 Reduces Intestinal Tumorigenesis in Apc Mutant Mice

  2010cites this paper
• Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway.

  2009cites this paper
• A LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.

  2009cites this paper
• Oncogene Functions of FHL2 Are Independent from NF-κBIα in Gastrointestinal Cancer

  2009cites this paper
• The cell migration protein Grb7 associates with transcriptional regulator FHL2 in a Grb7 phosphorylation‐dependent manner

  2009cites this paper
• Mechanisms that regulate adaptor binding to β-integrin cytoplasmic tails

  2009cites this paper
• Deficiency in the LIM‐only protein FHL2 impairs assembly of extracellular matrix proteins

  2008influential citation
• Deletion of the FHL2 gene attenuating neovascularization after corneal injury.

  2008cites this paper
• The four‐and‐a‐half‐LIM protein 2 (FHL2) is overexpressed in gliomas and associated with oncogenic activities

  2008cites this paper
• A broken heart: a stretch too far: an overview of mouse models with mutations in stretch-sensor components.

  2008cites this paper
• Increasing α7β1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression

  2008cites this paper
• Increasing alpha 7 beta 1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression.

  2008cites this paper
• Genetically Determined Proteolytic Cleavage Modulates α7β1 Integrin Function*

  2008cites this paper
• The sarcomere and the nucleus: functional links to hypertrophy, atrophy and sarcopenia.

  2008cites this paper
• FHL3 binds MyoD and negatively regulates myotube formation

  2007cites this paper
• Def-6, a Guanine Nucleotide Exchange Factor for Rac1, Interacts with the Skeletal Muscle Integrin Chain α7A and Influences Myoblast Differentiation*

  2007cites this paper
• Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle.

  2007cites this paper
• Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction

  2007cites this paper
• FHL2 Regulates Cell Cycle-Dependent and Doxorubicin-Induced p21Cip1/Waf1 Expression in Breast Cancer Cells

  2007cites this paper
• Comparison of sarcoplasmic proteomes between two groups of pig muscles selected for shear force of cooked meat.

  2007cites this paper
• (cid:1) 7 (cid:2) 1 Integrin Putting the Brakes on Smooth Muscle Cell Proliferation

  2007cites this paper
• Effects of streptozotocin-induced diabetes and physical training on gene expression of titin-based stretch-sensing complexes in mouse striated muscle.

  2007cites this paper
• The diverse biofunctions of LIM domain proteins: determined by subcellular localization and protein—protein interaction

  2007cites this paper
• The binding of Mss4 to α‐integrin subunits regulates matrix metalloproteinase activation and fibronectin remodeling

  2007cites this paper
• Deficiency in the LIM-only protein Fhl2 impairs skin wound healing

  2007influential citation
• The binding of Mss4 to (cid:1) -integrin subunits regulates matrix metalloproteinase activation and fibronectin remodeling

  2007cites this paper
• Interaction of TACC proteins with the FHL family: implications for ERK signaling

  2007cites this paper
• The biological relevance of FHL2 in tumour cells and its role as a putative cancer target.

  2007cites this paper
• Alpha 7 beta 1 integrin: putting the brakes on smooth muscle cell proliferation.

  2007cites this paper
• FHL2 interacts with both ADAM‐17 and the cytoskeleton and regulates ADAM‐17 localization and activity

  2006influential citation
• Four and a Half LIM Protein 1 Binds Myosin-binding Protein C and Regulates Myosin Filament Formation and Sarcomere Assembly*

  2006cites this paper
• Mechanical stress-strain sensors embedded in cardiac cytoskeleton: Z disk, titin, and associated structures.

  2006cites this paper
• The sarcomeric Z-disc: a nodal point in signalling and disease

  2006cites this paper
• Structural organization of the perimysium in bovine skeletal muscle: Junctional plates and associated intracellular subdomains.

  2006cites this paper
• The multifunctional roles of the four-and-a-half-LIM only protein FHL2

  2006cites this paper
• Roles of LIM proteins in cardiac hypertrophy.

  2005cites this paper
• Assembly and signaling of adhesion complexes.

  2005cites this paper