Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea

No abstract is available for this paper.

• Publication year

  2010

• Venue

  British Journal of Dermatology

• Publication date

  2010-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1365-2133.2010.09633.xPMID 20105169
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Transforming growth factor-beta in systemic sclerosis (scleroderma).

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• Low number of regulatory T cells in skin lesions of patients with cutaneous lupus erythematosus.

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• Glucocorticoid amplifies IL‐2‐dependent expansion of functional FoxP3+CD4+CD25+ T regulatory cells in vivo and enhances their capacity to suppress EAE

  2006cited by this paper
• Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease

  2006cited by this paper
• Systemic and localized scleroderma.

  2006cited by this paper
• Regulatory T cells in human autoimmune diseases

  2006cited by this paper
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• Induction of Oral Tolerance

  2006cited by this paper
• Characterisation of the immune response to type I collagen in scleroderma

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  2000cited by this paper
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  1996cited by this paper
• Peripheral blood mononuclear cells of patients with systemic sclerosis produce increased amounts of interleukin 6, but not transforming growth factor beta 1.

  1996cited by this paper
• Interleukin-10 modulates type I collagen and matrix metalloprotease gene expression in cultured human skin fibroblasts.

  1994cited by this paper
• Immunocytochemical localization and serologic detection of transforming growth factor beta 1. Association with type I procollagen and inflammatory cell markers in diffuse and limited systemic sclerosis, morphea, and Raynaud's phenomenon.

  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1990cited by this paper
• Scleroderma (systemic sclerosis): classification, subsets and pathogenesis.

  1988cited by this paper

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