Intermittent high glucose enhances apoptosis in human umbilical vein endothelial cells in culture.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  American Journal of Physiology. Endocrinology and Metabolism

• Publication date

  2001-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPENDO.2001.281.5.E924PMID 11595647
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes

  2002cited by this paper
• Glucose tolerance and mortality: comparison of WHO and American Diabetes Association diagnostic criteria

  1999cited by this paper
• Intermittent high glucose enhances cell growth and collagen synthesis in cultured human tubulointerstitial cells

  1999cited by this paper
• Glucose tolerance and mortality: comparison of WHO and American Diabetes Association diagnostic criteria. The DECODE study group. European Diabetes Epidemiology Group. Diabetes Epidemiology: Collaborative analysis Of Diagnostic criteria in Europe.

  1999cited by this paper
• The Role of Antiapoptotic Bcl-2 Family Members in Endothelial Apoptosis Elucidated with Antisense Oligonucleotides*

  1999cited by this paper
• The Bcl-2 protein family: arbiters of cell survival.

  1998influential reference
• High Blood Glucose Concentration Is a Risk Factor for Mortality in Middle-Aged Nondiabetic Men: 20-year follow-up in the Whitehall Study, the Paris Prospective Study, and the Helsinki Policemen Study

  1998cited by this paper
• Introduction of apoptosis by high proinsulin and glucose in cultured human umbilical vein endothelial cells is mediated by reactive oxygen species.

  1998cited by this paper
• The emerging role of post‐prandial hyperglycaemic spikes in the pathogenesis of diabetic complications

  1998cited by this paper
• Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

  1998cited by this paper
• Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.

  1998cited by this paper
• Death receptors: signaling and modulation.

  1998cited by this paper
• Induction of apoptosis by high proinsulin and glucose in cultured human umbilical vein endothelial cells is mediated by reactive oxygen species

  1998cited by this paper
• Long-term instability of fasting plasma glucose, a novel predictor of cardiovascular mortality in elderly patients with non-insulin-dependent diabetes mellitus: the Verona Diabetes Study.

  1997cited by this paper
• Expression of Apoptosis-Regulatory Genes in Renal Proximal Tubular Epithelial Cells Exposed to High Ambient Glucose and in Diabetic Kidneys

  1997cited by this paper
• Induction of human endothelial cell apoptosis requires both heat shock and oxidative stress responses.

  1997cited by this paper
• High Glucose Induces Antioxidant Enzymes in Human Endothelial Cells in Culture: Evidence Linking Hyperglycemia and Oxidative Stress

  1996cited by this paper
• Diverse molecular provocation of programmed cell death.

  1996cited by this paper
• Cultured retinal capillary pericytes die by apoptosis after an abrupt fluctuation from high to low glucose levels: a comparative study with retinal capillary endothelial cells

  1996cited by this paper
• High-Glucose–Triggered Apoptosis in Cultured Endothelial Cells

  1995cited by this paper
• Periodic high extracellular glucose enhances production of collagens III and IV by mesangial cells.

  1995cited by this paper
• Age-dependent injury in human umbilical vein endothelial cells: relationship to apoptosis and correlation with a lack of A20 expression.

  1995cited by this paper
• The Relationship of Glycemic Exposure (HbA1c) to the Risk of Development and Progression of Retinopathy in the Diabetes Control and Complications Trial

  1995cited by this paper
• Consensus review of the clinical utility of DNA flow cytometry in neoplastic hematopathology.

  1993cited by this paper
• Eicosanoids in the pathogenesis of the functional and structural alterations of the kidney in diabetes.

  1993cited by this paper
• Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

  1993cited by this paper
• A role for glycosphingolipid accumulation in the renal hypertrophy of streptozotocin-induced diabetes mellitus.

  1993cited by this paper
• DISFUNCTION OF VASCULAR ENDOTHELIUM IN DIABETES MELLITUS

  1993cited by this paper
• Glucose and diabetic vascular disease 1

  1992cited by this paper
• High glucose increases diacylglycerol mass and activates protein kinase C in mesangial cell cultures.

  1991cited by this paper
• Pathobiology of Endothelial and Other Vascular Cells in Diabetes Mellitus: Call for Data

  1991cited by this paper
• Glucose inhibits myo-inositol uptake and reduces myo-inositol content in cultured rat glomerular mesangial cells.

  1990cited by this paper
• Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic β -cells

  1989cited by this paper
• Glucose Toxicity for Human Endothelial Cells in Culture: Delayed Replication, Disturbed Cell Cycle, and Accelerated Death

  1985cited by this paper
• The study group.

  1980cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.

  1973cited by this paper
• Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics

  1972cited by this paper

• The endothelial plasma membrane lipidome and its remodeling under hyperglycemia: an exploratory study.

  2026cites this paper
• Glucose metabolic dysregulation of diabetes and Its role in atrial fibrillation pathogenesis.

  2026cites this paper
• The effect of sodium‐glucose cotransporter 2 inhibitors on HbA1c variability and cardiovascular and renal adverse outcome in patients with T2DM

  2025cites this paper
• The association of dysglycaemia metrics over the first 7 days of ICU stay with ICU mortality among patients with and without diabetes

  2025cites this paper
• Luseogliflozin Suppresses Late-Night Basal Glycemic Variability in Type 2 Diabetes: A Retrospective Observational Study

  2025cites this paper
• The Impact of Glycaemic Variability on Vascular Dysfunction in Diabetes

  2025influential citation
• Comprehensive treatment of diabetic endothelial dysfunction based on pathophysiological mechanism

  2025cites this paper
• Tropisetron attenuates high-glucose-induced vascular endothelial dysfunction via inhibition of calcineurin/NFAT signalling.

  2025cites this paper
• Association between urinary albumin-to-creatinine ratio within the normal range and continuous glucose monitoring-derived metrics in children and adolescents with type 1 diabetes

  2025cites this paper
• The Impact of Liraglutide, a GLP-1 Receptor Agonist, on High Glucose-Induced Inflammation, Apoptosis, Oxidative Stress, and NLRP3 Signaling

  2025cites this paper
• Impact of Glycemic Variability on Prognosis in Sepsis Patients

  2025cites this paper
• Comprehensive evaluation of S-nitrosoglutathionine and S-nitroso-N-acetylpenicillamine stability in biomedical contexts.

  2025cites this paper
• Identifying early blood glucose trajectories in sepsis linked to distinct long-term outcomes: a K-means clustering study with external validation

  2025cites this paper
• Correlation between time in range and mild cognitive impairment in older adults with type 2 diabetes mellitus

  2025cites this paper
• Glycemic Variability and Its Association with Traditional Glycemic Control Biomarkers in Patients with Type 1 Diabetes: A Cross-Sectional, Multicenter Study

  2025cites this paper
• Immortalized Schwann cell lines as useful tools for pathogenesis-based therapeutic approaches to diabetic peripheral neuropathy

  2025cites this paper
• Association of glycemic variability with short and long-term mortality among critically ill patients with heart failure: Analysis of the MIMIC-IV database.

  2025cites this paper
• Glycemic Variability and Systemic Immune-Inflammation Index: A Synergistic Predictive Model for Atrial Fibrillation in Type 2 Diabetes.

  2025cites this paper
• Modeling blood vessel dynamics: Effects of glucose variations on HUVECs in a hollow fiber bioreactor under laminar shear stress

  2024cites this paper
• Short-term glycemic variability in non-diabetic, non-obese dogs assessed by common glycemic variability indices.

  2024cites this paper
• How to Use Continuous Glucose Monitoring Efficiently in Diabetes Management: Opinions and Recommendations by German Experts on the Status and Open Questions

  2024cites this paper
• Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial apoptosis in diabetic wound healing

  2024cites this paper
• Associations of variability in blood glucose and systolic blood pressure with mortality in patients with coronary artery disease: A retrospective cohort study from the MIMIC-IV database.

  2024cites this paper
• Association of glycemic variability and prognosis in patients with traumatic brain injury: A retrospective study from the MIMIC-IV database.

  2024cites this paper
• Diabetes and high-glucose could upregulate the expression of receptor for activated C kinase 1 in retina

  2024cites this paper
• The role of low glycemic index and load diets in medical nutrition therapy for type 2 diabetes: an update

  2024cites this paper
• Hyperglycemia and Other Glycemic Measures Throughout Therapy for Pediatric Acute Lymphoblastic Leukemia and Lymphoma

  2023cites this paper
• Visit-to-visit HbA1c variability is associated with aortic stiffness progression in participants with type 2 diabetes

  2023cites this paper
• Effects of a 5-week intake of erythritol and xylitol on vascular function, abdominal fat and glucose tolerance in humans with obesity: a pilot trial

  2023cites this paper
• JunB condensation attenuates vascular endothelial damage under hyperglycemic condition

  2023cites this paper
• Glycemic variability: Measurement, target, impact on complications of diabetes and does it really matter?

  2023cites this paper
• Association of fasting blood glucose variability with all‐cause mortality in heart transplant recipients

  2023cites this paper
• Pre-stroke glycemic variability estimated by glycated albumin predicts hematoma expansion and poor outcomes in patients with spontaneous intracerebral hemorrhage

  2023cites this paper
• Glycaemic control in people with diabetes following acute myocardial infarction.

  2023cites this paper
• Ex Vivo treatment of coronary artery endothelial cells with serum post-exercise training offers limited protection against in vitro exposure to FEC-T chemotherapy

  2023cites this paper
• Glycated hemoglobin variability and the risk of cardiovascular events in patients with prediabetes and type 2 diabetes mellitus: A post‐hoc analysis of a prospective and multicenter study

  2023cites this paper
• Long-Term Experimental Hyperglycemia Does Not Impair Macrovascular Endothelial Barrier Integrity and Function in vitro

  2023cites this paper
• Acute Coronary Syndrome Due to Intraplaque Hemorrhage in a Post-gastrectomy Patient with a Latent Severe Glycemic Disorder

  2023cites this paper
• Evaluating glucose variability through OGTT in early pregnancy and its association with hypertensive disorders of pregnancy in non-diabetic pregnancies: a large-scale multi-center retrospective study

  2023cites this paper
• Therapeutic potential of paeoniflorin in atherosclerosis: A cellular action and mechanism-based perspective

  2022cites this paper
• Short-term Glycemic Variability and Its Association With Macrovascular and Microvascular Complications in Patients With Diabetes

  2022cites this paper
• In Vitro Modeling of Diabetes Impact on Vascular Endothelium: Are Essentials Engaged to Tune Metabolism?

  2022cites this paper
• Association between visit-to-visit fasting glycemic variability and depression: a retrospective cohort study in a representative Korean population without diabetes

  2022cites this paper
• Effect of Influenza Vaccination on the Reduction of the Incidence of Chronic Kidney Disease and Dialysis in Patients with Type 2 Diabetes Mellitus

  2022cites this paper
• Long-Term Risk of Cardiovascular Disease Among Type 2 Diabetes Patients According to Average and Visit-to-Visit Variations of HbA1c Levels During the First 3 Years of Diabetes Diagnosis

  2022cites this paper
• Endothelial Dysfunction and Platelet Hyperactivation in Diabetic Complications Induced by Glycemic Variability

  2022cites this paper
• Glycaemia dynamics in gestational diabetes mellitus.

  2022cites this paper
• The Effect of High and Variable Glucose on the Viability of Endothelial Cells Co-Cultured with Smooth Muscle Cells

  2022cites this paper
• Intermittent exposure of cultured endothelial cells to physiologically relevant fructose concentrations has a profound impact on nitric oxide production and bioenergetics

  2022cites this paper
• High glycemic variability: An underestimated determinant of stroke functional outcome following large vessel occlusion.

  2022cites this paper
• Expertenaustausch zum Einsatz von kontinuierlichem Glukosemonitoring (CGM) im Diabetesmanagement: Eine aktuelle Bestandsaufnahme und Blick in die Zukunft

  2022influential citation
• High-Intensity Interval Training Improves Cardiac Function by miR-206 Dependent HSP60 Induction in Diabetic Rats

  2022cites this paper
• Anagliptin twice‐daily regimen improves glycaemic variability in subjects with type 2 diabetes: A double‐blind, randomized controlled trial

  2022cites this paper
• The Association of Postprandial Triglyceride Variability with Renal Dysfunction and Microalbuminuria in Patients with Type 2 Diabetic Mellitus: A Retrospective and Observational Study

  2022cites this paper
• Long-term glycemic variability and the risk of mortality in diabetic patients receiving peritoneal dialysis

  2022cites this paper
• Effect of angiotensin-converting enzyme inhibitor on DNA damage and inflammatory molecules expression in rabbit aortic endothelial cells cultured in vitro in hypercholesterolemic and hyperglycemic conditions

  2021cites this paper
• Does HbA1c Remain the Most Important Therapeutic Target in Outpatient Management of Diabetes?

  2021cites this paper
• The Association of Postprandial Triglyceride Variability with Renal Dysfunction and Microalbuminuria in Patients with Type 2 Diabetic Mellitus A Retrospective and Observational Study.

  2021cites this paper
• The Role of Glycemic Variability in Cardiovascular Disorders

  2021cites this paper
• Glycemic Variability Impacted by SGLT2 Inhibitors and GLP 1 Agonists in Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis

  2021cites this paper
• Hyperglycemia and Thrombocytopenia　― Combinatorially Increase the Risk of Mortality in Patients With Acute Myocardial Infarction Undergoing Veno-Arterial Extracorporeal Membrane Oxygenation ―

  2021cites this paper
• Association of Chinese Visceral Adiposity Index and Its Dynamic Change With Risk of Carotid Plaque in a Large Cohort in China

  2021cites this paper
• Association Between Fasting Hyperglycemia and New-Onset Atrial Fibrillation in Patients With Acute Myocardial Infarction and the Impact on Short- and Long-Term Prognosis

  2021cites this paper
• An Oat β-Glucan Beverage Reduces LDL Cholesterol and Cardiovascular Disease Risk in Men and Women with Borderline High Cholesterol: A Double-Blind, Randomized, Controlled Clinical Trial.

  2021cites this paper
• Time in range correlates glycated albumin measured immediately after 2 weeks of continuous glucose monitoring.

  2021cites this paper
• Effect of glucose concentration and culture substrate on HUVECs viability in in vitro cultures: A literature review and own results

  2021cites this paper
• Early Worsening of Retinopathy in Type 1 and Type 2 Diabetes After Rapid Improvement in Glycaemic Control: A Systematic Review

  2021cites this paper
• Current concepts and clinical importance of glycemic variability.

  2021cites this paper
• Critical illness myopathy precedes hyperglycaemia and high glucose variability.

  2021cites this paper
• Evidence of Early Diabetic Nephropathy in Pediatric Type 1 Diabetes

  2021cites this paper
• Physicochemical Properties and Effects of Honeys on Key Biomarkers of Oxidative Stress and Cholesterol Homeostasis in HepG2 Cells

  2021cites this paper
• DNA damage in leukocytes and serum nitrite concentration are negatively associated in type 1 diabetes.

  2021cites this paper
• Pathophysiological Association between Diabetes Mellitus and Endothelial Dysfunction

  2021cites this paper
• Visceral Fat-Reducing Effect and Safety of Continuous Consumption of Beverage Containing Resistant Maltodextrin: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial.

  2020cites this paper
• Coronary Flow Reserve and Glycemic Variability in Patients with Coronary Artery Disease

  2020cites this paper
• Update on postprandial hyperglycaemia: the pathophysiology, prevalence, consequences and implications of treating diabetes.

  2020cites this paper
• Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications

  2020cites this paper
• The relationship between glycemic variability and blood pressure variability in normoglycemic normotensive individuals.

  2020cites this paper
• A human retinal microvascular endothelial-pericyte co-culture model to study diabetic retinopathy in vitro.

  2020cites this paper
• Selective synthesis of new sugars based on 8-hydroxyquinoline as corrosion inhibitors for mild steel in HCl solution-effect of the saturated hydrocarbon chain: Theoretical and experimental studies

  2020cites this paper
• Digitalisierung im Therapiealltag: Softwarelösungen für das kontinuierliche Glukosemonitoring

  2020cites this paper
• Effect of Prestroke Glycemic Variability Estimated Glycated Albumin on Stroke Severity and Infarct Volume in Diabetic Patients Presenting With Acute Ischemic Stroke

  2020cites this paper
• Ganoderma lucidum Polysaccharide Enzymatic Hydrolysate Suppresses the Growth of Human Colon Cancer Cells via Inducing Apoptosis

  2020cites this paper
• SGLT1 knockdown prevents glucose fluctuation-induced apoptosis of cardiomyocytes through attenuating oxidative stress and mitochondrial dysfunction.

  2020cites this paper
• Glycemic Variability in Diabetes Increases the Severity of Influenza

  2020cites this paper
• Effect of Dapagliflozin as an Add-on Therapy to Insulin on the Glycemic Variability in Subjects with Type 2 Diabetes Mellitus (DIVE): A Multicenter, Placebo-Controlled, Double-Blind, Randomized Study

  2020cites this paper
• Update on postprandial hyperglycemia: The pathophysiology, prevalence, consequences and implications of treating diabetes

  2020cites this paper
• The variability of glycated hemoglobin is associated with renal function decline in patients with type 2 diabetes

  2020cites this paper
• Assessment of Glucose Control Metrics by Discriminant Ratio

  2020cites this paper
• High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier

  2020cites this paper
• Glucose Fluctuations Are Linked to Disrupted Brain Functional Architecture and Cognitive Impairment

  2020cites this paper
• Predictive value of random blood glucose versus fasting blood glucose on in-hospital adverse events in patients with ST-segment elevation acute myocardial infarction

  2020cites this paper
• Glycemic variability is associated with poor outcomes in pediatric hematopoietic stem cell transplant patients

  2020cites this paper
• Glycemic Variability and CNS Inflammation: Reviewing the Connection

  2020cites this paper
• Glycaemic variability: The under‐recognized therapeutic target in type 1 diabetes care

  2019cites this paper
• Antitumor activity of enzymatically hydrolyzed Ganoderma lucidum polysaccharide on U14 cervical carcinoma–bearing mice

  2019cites this paper
• The Effects of a Low GI Diet on Cardiometabolic and Inflammatory Parameters in Patients with Type 2 and Gestational Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

  2019cites this paper
• Recurrent short-term hypoglycemia and hyperglycemia induce apoptosis and oxidative stress via the ER stress response in immortalized adult mouse Schwann (IMS32) cells.

  2019cites this paper
• CGM-Parameter für das Diabetesmanagement – ein Update

  2019cites this paper
• Diabetes and Vascular Disease: is it all about Glycemia?

  2019cites this paper