Interleukin-21 promotes osteoclastogenesis in humans with rheumatoid arthritis and in mice with collagen-induced arthritis.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Arthritis & Rheumatism

• Publication date

  2012-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/art.33390PMID 21968544
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses

  2010cited by this paper
• A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice

  2009cited by this paper
• A Positive Feedback Loop of IL-21 Signaling Provoked by Homeostatic CD4+CD25− T Cell Expansion Is Essential for the Development of Arthritis in Autoimmune K/BxN Mice 1

  2009cited by this paper
• Th17 cells in human disease

  2008cited by this paper
• Osteoimmunology: interactions of the bone and immune system.

  2008cited by this paper
• IL-23 Induces Receptor Activator of NF-κB Ligand Expression on CD4+ T Cells and Promotes Osteoclastogenesis in an Autoimmune Arthritis Model1

  2008cited by this paper
• Interleukin-21: basic biology and implications for cancer and autoimmunity.

  2008cited by this paper
• Osteoimmunology: cytokines and the skeletal system.

  2008cited by this paper
• Interleukin-6 inhibits receptor activator of nuclear factor kappaB ligand-induced osteoclastogenesis by diverting cells into the macrophage lineage: key role of Serine727 phosphorylation of signal transducer and activator of transcription 3.

  2008cited by this paper
• Interleukin 21 as a target of intervention in autoimmune disease

  2008cited by this paper
• [Serum IL-21 level in patients with primary Sjogren's syndrome and clinical significance of IL-21].

  2007cited by this paper
• Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation.

  2007cited by this paper
• Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

  2007cited by this paper
• Treatment of BXSB‐Yaa Mice with IL‐21R‐Fc Fusion Protein Minimally Attenuates Systemic Lupus Erythematosus

  2007cited by this paper
• IL-21 Is Produced by Th17 Cells and Drives IL-17 Production in a STAT3-dependent Manner*

  2007cited by this paper
• Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis.

  2007cited by this paper
• Cells of the synovium in rheumatoid arthritis. T lymphocytes

  2007cited by this paper
• IL-21 Has a Pathogenic Role in a Lupus-Prone Mouse Model and Its Blockade with IL-21R.Fc Reduces Disease Progression

  2007cited by this paper
• Interleukin‐21 Induces T‐cell Activation and Proinflammatory Cytokine Secretion in Rheumatoid Arthritis

  2006cited by this paper
• Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

  2006cited by this paper
• The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment.

  2006cited by this paper
• Joint erosion in rheumatoid arthritis: interactions between tumour necrosis factor alpha, interleukin 1, and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclasts.

  2004cited by this paper
• Progression of radiologic damage in patients with rheumatoid arthritis in clinical remission.

  2004cited by this paper
• Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial.

  2004cited by this paper
• Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis.

  2004cited by this paper
• Joint erosion in rheumatoid arthritis: interactions between tumour necrosis factor α, interleukin 1, and receptor activator of nuclear factor κB ligand (RANKL) regulate osteoclasts

  2004cited by this paper
• Course of radiographic damage over 10 years in a cohort with early rheumatoid arthritis

  2003cited by this paper
• Angiogenesis as a target in rheumatoid arthritis

  2003cited by this paper
• A Critical Role for IL-21 in Regulating Immunoglobulin Production

  2002cited by this paper
• Bone destruction in arthritis

  2002cited by this paper
• Cyclosporine differentially regulates interleukin-10, interleukin-15, and tumor necrosis factor a production by rheumatoid synoviocytes.

  2002cited by this paper
• Ten year outcome in a cohort of patients with early rheumatoid arthritis: health status, disease process, and damage

  2002cited by this paper
• Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients.

  2001cited by this paper
• The course of radiologic damage during the first six years of rheumatoid arthritis.

  2000cited by this paper
• Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group.

  2000cited by this paper
• Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis.

  2000cited by this paper
• Distinct vascular patterns of early synovitis in psoriatic, reactive, and rheumatoid arthritis.

  1999cited by this paper
• OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

  1999cited by this paper
• Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors?

  1996cited by this paper

• Mesenchymal stem cells attenuate systemic sclerosis related lung fibrosis by inhibiting T follicular helper cells in tertiary lymphoid structure

  2026cites this paper
• Assessment of Interleukin-21 Gene Polymorphisms and Protein Level in Rheumatoid Arthritis among Egyptians

  2025cites this paper
• Deciphering the role of ERK and PI3K/Akt as crosstalk pathways between fibroblast-like synoviocytes and osteoclasts; novel therapeutic approach for rheumatoid arthritis

  2025cites this paper
• Impact of interaction between IL-21 gene variants and smoking status on susceptibility to rheumatoid arthritis

  2025cites this paper
• Helper T cells: A potential target for sex hormones to ameliorate rheumatoid arthritis? (Review)

  2024cites this paper
• Comprehensive Co-Inhibitory Receptor (Co-IR) Expression on T Cells and Soluble Proteins in Rheumatoid Arthritis

  2024cites this paper
• Osteoporosis and inflammation: Cause to effect or comorbidity?

  2024cites this paper
• Signaling pathways in rheumatoid arthritis: implications for targeted therapy

  2023cites this paper
• CXCR3 antagonist NBI-74330 mitigates joint inflammation in Collagen-Induced arthritis model in DBA/1J mice.

  2023cites this paper
• Mechanistic insight of interleukin-9 induced osteoclastogenesis

  2023cites this paper
• T cells in health and disease

  2023cites this paper
• T Follicular Helper Cells in Tertiary Lymphoid Structure Contribute to Renal Fibrosis by IL-21

  2023cites this paper
• In vitro osteoclastogenesis in autoimmune diseases – Strengths and pitfalls of a tool for studying pathological bone resorption and other disease characteristics

  2023cites this paper
• The role of Interleukin-21 in autoimmune Diseases: Mechanisms, therapeutic Implications, and future directions.

  2023cites this paper
• An Update on the Emerging Role of Wnt/β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis.

  2023cites this paper
• Piperine suppresses inflammatory fibroblast-like synoviocytes derived from rheumatoid arthritis patients Via NF-κB inhibition.

  2023cites this paper
• Sjögren Syndrome: New Insights in the Pathogenesis and Role of Nuclear Medicine

  2022cites this paper
• Two Main Cellular Components in Rheumatoid Arthritis: Communication Between T Cells and Fibroblast-Like Synoviocytes in the Joint Synovium

  2022cites this paper
• The role of secreted osteoclastogenic factor of activated T cells in bone remodeling

  2022cites this paper
• miR-10 and Its Negative Correlation with Serum IL-35 Concentration and Positive Correlation with STAT5a Expression in Patients with Rheumatoid Arthritis

  2022cites this paper
• Prospects of JAK Inhibition in the Framework of Bone Loss

  2021influential citation
• IL-21 impairs pro-inflammatory activity of M1-like macrophages exerting anti-inflammatory effects on rheumatoid arthritis

  2021cites this paper
• The role of Th17 cells in viral infections.

  2021cites this paper
• New developments implicating IL-21 in autoimmune disease.

  2021cites this paper
• Expression and Correlation of IgG4 and IL-21 in Collagen-Induced Arthritis Rats

  2021cites this paper
• The Germinal Center Milieu in Rheumatoid Arthritis: The Immunological Drummer or Dancer?

  2021cites this paper
• Tertiary Lymphoid Organs in Rheumatoid Arthritis.

  2020cites this paper
• miR‐506‐3p alleviates uncontrolled osteoclastogenesis via repression of RANKL/NFATc1 signaling pathway

  2020cites this paper
• Plasma interleukin-21 levels and genetic variants are associated with susceptibility to rheumatoid arthritis

  2020cites this paper
• Role of Interleukins on Physiological and Pathological Bone Resorption and Bone Formation: Effects by Cytokines in The IL-1 and IL-2 Families

  2020cites this paper
• The Role of Inflammation in the Pathogenesis of Osteoarthritis

  2020cites this paper
• Mendelian Randomization Identifies CpG Methylation Sites With Mediation Effects for Genetic Influences on BMD in Peripheral Blood Monocytes

  2020cites this paper
• A bispecific soluble receptor fusion protein that targets TNF‐α and IL‐21 for synergistic therapy in inflammatory arthritis

  2020cites this paper
• Pentraxin 3 inhibits fibroblast growth factor 2 induced osteoclastogenesis in rheumatoid arthritis.

  2020cites this paper
• Inducible Lymphoid Organs

  2020cites this paper
• Berberine coated mannosylated liposomes curtail RANKL stimulated osteoclastogenesis through the modulation of GSK3β pathway via upregulating miR-23a.

  2019cites this paper
• Clinical significance and immunobiology of IL-21 in autoimmunity.

  2019cites this paper
• IL-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility

  2019cites this paper
• IL-21/type I interferon interplay regulates neutrophil-dependent innate immune responses to Staphylococcus aureus

  2019cites this paper
• Association between interleukin-21 gene rs6822844 polymorphism and rheumatoid arthritis susceptibility

  2019cites this paper
• Paradoxical role of Breg-inducing cytokines in autoimmune diseases

  2019cites this paper
• Rheumatoid arthritis: ‘melting pot’ of T helper subsets

  2019cites this paper
• Glycogen synthase kinase-3 inhibitor as a multi-targeting anti-rheumatoid drug.

  2019cites this paper
• This information is current as Direct Targeting of IL-17 A miR-340 Alleviates Psoriasis in Mice through

  2018cites this paper
• IL-21 Enhances the Degradation of Cartilage Through the JAK-STAT Signaling Pathway During Osteonecrosis of Femoral Head Cartilage

  2018cites this paper
• Multifaceted role of IL‐21 in rheumatoid arthritis: Current understanding and future perspectives

  2018influential citation
• miR-340 Alleviates Psoriasis in Mice through Direct Targeting of IL-17A

  2018cites this paper
• Berberine inhibits IL‐21/IL‐21R mediated inflammatory proliferation of fibroblast‐like synoviocytes through the attenuation of PI3K/Akt signaling pathway and ameliorates IL‐21 mediated osteoclastogenesis

  2018cites this paper
• A critical epitope in CD147 facilitates memory CD4+ T-cell hyper-activation in rheumatoid arthritis

  2018cites this paper
• Chapter 69 – Etiology and Pathogenesis of Rheumatoid Arthritis

  2017cites this paper
• Autoantibodies against interleukin-21 correlate with disease activity in patients with rheumatoid arthritis

  2017cites this paper
• Increased frequency of peripheral blood follicular helper T cells and elevated serum IL-21 levels in patients with knee osteoarthritis

  2017cites this paper
• Synovial IL‐21/TNF‐producing CD4+ T cells induce joint destruction in rheumatoid arthritis by inducing matrix metalloproteinase production by fibroblast‐like synoviocytes

  2017influential citation
• IL-21 Is Positively Associated with Intervertebral Disc Degeneration by Interaction with TNF-α Through the JAK-STAT Signaling Pathway

  2017cites this paper
• The role of T helper 17 cells in the pathogenesis of hepatitis B virus-related liver cirrhosis

  2017cites this paper
• The role of stromal cells in inflammatory bone loss

  2017cites this paper
• A review on interleukins: The key manipulators in rheumatoid arthritis

  2017cites this paper
• Increased frequency of peripheral blood IL-21 + follicular helper T cells and increased serum IL-21 levels in patients with non-traumatic osteonecrosis of the femoral head

  2017cites this paper
• Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis

  2017cites this paper
• Ectopic lymphoid neogenesis in rheumatic autoimmune diseases

  2017cites this paper
• IL21R expressing CD14+CD16+ monocytes expand in multiple myeloma patients leading to increased osteoclasts

  2017cites this paper
• STA-21, a STAT-3 inhibitor, attenuates the development and progression of inflammation in collagen antibody-induced arthritis.

  2017cites this paper
• Interleukin-21 gene polymorphism rs2221903 is associated with disease activity in patients with rheumatoid arthritis

  2017cites this paper
• Interleukin‐21 induces migration and invasion of fibroblast‐like synoviocytes from patients with rheumatoid arthritis

  2016cites this paper
• Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis

  2016cites this paper
• Recombinant human endostatin inhibits TNF‐alpha‐induced receptor activator of NF‐κB ligand expression in fibroblast‐like synoviocytes in mice with adjuvant arthritis

  2016cites this paper
• Safety, PK, and PD of recombinant anti-interleukin-21 monoclonal antibody in a first-in-human trial.

  2016cites this paper
• Novel Immunotherapeutic Avenues for Rheumatoid Arthritis.

  2016cites this paper
• Biological effects of IL-21 on different immune cells and its role in autoimmune diseases.

  2016cites this paper
• Interleukin-21 promotes osteoclastogenesis in RAW264.7 cells through the PI3K/AKT signaling pathway independently of RANKL

  2016influential citation
• Ectopic Lymphoid Structures: Powerhouse of Autoimmunity

  2016cites this paper
• Interleukin‐21 Induces Proliferation and Proinflammatory Cytokine Profile of Fibroblast‐like Synoviocytes of Patients with Rheumatoid Arthritis

  2016cites this paper
• Cytokines in the Germinal Center Niche

  2016cites this paper
• Inhibition of GSK-3β Alleviates Collagen II-Induced Rheumatoid Arthritis in Rats

  2016cites this paper
• Correction: Cytokines in the Germinal Center Niche Antibodies 2016, 5(1), 5

  2016cites this paper
• Constitutive STAT3 Phosphorylation in Circulating CD4+ T Lymphocytes Associates with Disease Activity and Treatment Response in Recent-Onset Rheumatoid Arthritis

  2015cites this paper
• Th17 cytokines regulate osteoclastogenesis in rheumatoid arthritis.

  2015cites this paper
• (5R)-5-Hydroxytriptolide (LLDT-8) inhibits osteoclastogenesis via RANKL/RANK/OPG signaling pathway

  2015cites this paper
• Potential role of Th17 cells in the pathogenesis of type 2 autoimmune pancreatitis

  2015cites this paper
• [The role of medicaments, exosomes and miRNA molecules in modulation of macrophage immune activity].

  2015cites this paper
• Circulating monocytes: an appropriate model for bone-related study

  2015cites this paper
• [Immunoexpression and clinical significance of interleukin-21 and receptor activator of nuclear factor κB ligand in human periapical granulomas and radicular cysts].

  2015cites this paper
• Constitutive STAT 3 Phosphorylation in Circulating CD 4 + T Lymphocytes Associates with Disease Activity and Treatment Response in Recent-Onset Rheumatoid Arthritis

  2015cites this paper
• Osteoimmunology in the Oral Cavity (Periodontal Disease, Lesions of Endodontic Origin, and Orthodontic Tooth Movement)

  2015cites this paper
• A Longitudinal Evaluation of Bone Erosive Damage in the Metacarpophalangeal Joints of Patients with Rheumatoid Arthritis Using Early Erosions in Rheumatoid Arthritis (EERA) Software

  2015cites this paper
• In vitro evaluation of the biological effect of SOFAT on osteoblasts.

  2015cites this paper
• Evaluation of the effects of collagen-induced arthritis and metal hypersensitivity on osteolysis and the inflammatory response to wear debris in the murine air pouch

  2014cites this paper
• The roles of TL1A and Pno1 in the pathogenesis of rheumatoid arthritis

  2014influential citation
• Entzündung und Knochenabbau

  2014cites this paper
• Oestrogen up‐regulates interleukin‐21 production by CD4+ T lymphocytes in patients with systemic lupus erythematosus

  2014cites this paper
• IL-21 as a therapeutic target in inflammatory disorders

  2014cites this paper
• Domain I: the hidden face of antiphospholipid syndrome

  2014cites this paper
• Th17 and regulatory T cell balance in autoimmune and inflammatory diseases.

  2014cites this paper
• Interleukin‐21 Receptor Deficiency Increases the Initial Toll‐like Receptor 2 Response but Protects Against Joint Pathology by Reducing Th1 and Th17 Cells During Streptococcal Cell Wall Arthritis

  2014cites this paper
• Interleukin-21: a double-edged sword with therapeutic potential

  2014cites this paper
• CARD11 blockade suppresses murine collagen‐induced arthritis via inhibiting CARD11/Bcl10 assembly and T helper type 17 response

  2014cites this paper
• New Tests to Detect Antiphospholipid Antibodies: Anti-Domain I Beta-2-Glycoprotein-I Antibodies

  2014cites this paper
• Role of interleukin-21 in HBV infection: friend or foe?

  2014cites this paper
• Simultaneous analysis of T helper subsets (Th1, Th2, Th9, Th17, Th22, Tfh, Tr1 and Tregs) markers expression in periapical lesions reveals multiple cytokine clusters accountable for lesions activity and inactivity status

  2014cites this paper
• Emerging cell and cytokine targets in rheumatoid arthritis

  2014cites this paper