Proposal of the reverse flow model for the origin of the eukaryotic cell based on comparative analyses of Asgard archaeal metabolism

No abstract is available for this paper.

• Publication year

  2019

• Venue

  Nature Microbiology

• Publication date

  2019-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/s41564-019-0406-9PMID 30936488
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Structure of an Ancient Respiratory System.

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  2017cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2010cited by this paper
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  1976cited by this paper
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  1968cited by this paper
• [Neurovirulence of ECHO and Coxsackie viruses].

  1965cited by this paper

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