Sexual Dysfunction and Fertility Problems in Men with Inflammatory Bowel Disease

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that is usually diagnosed in young individuals. Crohn's disease and ulcerative colitis are the 2 principal forms of IBD. Patients with IBD demonstrate varying degrees of disease activity and sometimes need to undergo bowel surgery such as proctocolectomy with ileal pouch-anal anastomosis that involves removal of the entire colon and rectum with consequent sexual dysfunction. Several studies have shown that sulfasalazine, affects male fertility. Additionally, many men with IBD are unable to control their smoking, drinking, and eating habits, which can cause worsening of disease activity and fertility. Therefore, infertility and sexual dysfunction are important issues in young patients diagnosed with IBD because they are related to optimal management of the disease and patients' quality of life. Only a few studies have reported sexual dysfunction and infertility in men with IBD. Therefore, this study reviewed the current literature describing male sexual dysfunction scales and evaluated the causes of sexual dysfunction and infertility in men with IBD.

• Publication year

  2019

• Venue

  The World Journal of Men's Health

• Publication date

  2019-03-22

• Fields of study

  Medicine

• Identifiers
  DOI 10.5534/wjmh.190007PMID 30929327PMCID 7308231
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Methotrexate Reduces DNA Integrity in Sperm From Men With Inflammatory Bowel Disease.

  2018cited by this paper
• Sexual Dysfunction in Men With Inflammatory Bowel Disease: A New IBD-Specific Scale.

  2018cited by this paper
• Inflammatory Bowel Diseases Can Adversely Impact Domains of Sexual Function Such as Satisfaction with Sex Life

  2018cited by this paper
• Sexual and reproductive issues and inflammatory bowel disease: a neglected topic in men

  2018cited by this paper
• Increased Use of Medications for Erectile Dysfunction in Men With Ulcerative Colitis and Crohn's Disease Compared to Men Without Inflammatory Bowel disease: A Nationwide cohort Study

  2018cited by this paper
• Psychologic and sexual dysfunction in primary and secondary infertile male patients.

  2017cited by this paper
• Vedolizumab exposure in pregnancy: outcomes from clinical studies in inflammatory bowel disease

  2017influential reference
• ESPEN guideline: Clinical nutrition in inflammatory bowel disease.

  2017cited by this paper
• Steroid therapy for inflammatory bowel disease.

  2017cited by this paper
• Ustekinumab therapy for Crohn's disease during pregnancy: a case report and review of the literature

  2017cited by this paper
• The toxicity of methotrexate in male fertility and paternal teratogenicity

  2017cited by this paper
• Aminosalicylates for induction of remission or response in Crohn's disease.

  2016cited by this paper
• Infertility in men with inflammatory bowel disease.

  2016cited by this paper
• Evaluation and treatment of infertility.

  2015cited by this paper
• Tu1993 Sexual Dysfunction in Women With Inflammatory Bowel Disease: A New IBD-Specific Scale

  2015cited by this paper
• Indications and Specific Surgical Techniques in Crohn's Disease

  2015cited by this paper
• Review article: the safety of therapeutic drugs in male inflammatory bowel disease patients wishing to conceive

  2015influential reference
• Sexual Dysfunctions in Men and Women with Inflammatory Bowel Disease: The Influence of IBD-Related Clinical Factors and Depression on Sexual Function.

  2015influential reference
• Assessment Of Sexual Function Among Inflammatory Bowel Disease Patients

  2015cited by this paper
• Development and Initial Validation of the PROMIS(®) Sexual Function and Satisfaction Measures Version 2.0.

  2015cited by this paper
• Pregnancy and fetal outcomes following natalizumab exposure in pregnancy. A prospective, controlled observational study

  2015cited by this paper
• Use of Thiopurines in Inflammatory Bowel Disease: A Consensus Statement by the Korean Association for the Study of Intestinal Diseases (KASID)

  2015cited by this paper
• Ustekinumab: targeting the IL-17 pathway to improve outcomes in psoriatic arthritis

  2014cited by this paper
• Mortality and causes of death in patients with inflammatory bowel disease: a nationwide register study in Finland.

  2014cited by this paper
• Review article: the psychosexual impact of inflammatory bowel disease in male patients

  2014cited by this paper
• Methotrexate induces germ cell apoptosis and impairs spermatogenesis in a rat

  2013cited by this paper
• Lifestyle factors and reproductive health: taking control of your fertility

  2013cited by this paper
• A clinical review of recent findings in the epidemiology of inflammatory bowel disease

  2013cited by this paper
• Systematic Review and Meta-analysis on the Effects of Thiopurines on Birth Outcomes from Female and Male Patients with Inflammatory Bowel Disease

  2013cited by this paper
• Long-term Results After Restorative Proctocolectomy With Ileal Pouch-Anal Anastomosis at a Young Age

  2012cited by this paper
• A Comparison of the Quality of Life of Ulcerative Colitis Patients after IPAA vs Ileostomy

  2012cited by this paper
• Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis.

  2012cited by this paper
• Impact of TNF-blocking agents on male sperm characteristics and pregnancy outcomes in fathers exposed to TNF-blocking agents at time of conception.

  2012influential reference
• Guidelines for the management of inflammatory bowel disease in adults

  2011cited by this paper
• Impact of inflammation on male fertility.

  2011cited by this paper
• Association between socio-psycho-behavioral factors and male semen quality: systematic review and meta-analyses.

  2011cited by this paper
• [Fertility and inflammatory bowel diseases].

  2010cited by this paper
• Semen quality in fertile men in relation to psychosocial stress.

  2010cited by this paper
• Outcomes of Pregnancies Fathered by Inflammatory Bowel Disease Patients Exposed to Thiopurines

  2010cited by this paper
• Characteristics and Trends in the Incidence of Inflammatory Bowel Disease in Korean Children: A Single-Center Experience

  2010influential reference
• Aminosalicylates for induction of remission or response in Crohn's disease.

  2010cited by this paper
• Cigarette smoke extract immobilizes human spermatozoa and induces sperm apoptosis.

  2009cited by this paper
• Sulfasalazine induced oxidative stress: a possible mechanism of male infertility.

  2009cited by this paper
• Sexual and Reproductive Issues for Men With Inflammatory Bowel Disease

  2009influential reference
• Sexual problems and associated help‐seeking behavior patterns: Results of a population‐based survey in France

  2009cited by this paper
• Depression and anxiety in inflammatory bowel disease: A review of comorbidity and management

  2009cited by this paper
• Surgery for inflammatory bowel disease.

  2008cited by this paper
• Female sexual dysfunction, sexual distress, and compatibility with partner.

  2008cited by this paper
• Determinants of male sexual function in inflammatory bowel disease: A survey‐based cross‐sectional analysis in 280 men

  2007influential reference
• Elective and emergent operative management of ulcerative colitis.

  2007influential reference
• Risk of Fecal Diversion in Complicated Perianal Crohn’s Disease

  2007cited by this paper
• Sexual function in persons with inflammatory bowel disease: a survey with matched controls.

  2007influential reference
• Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis.

  2007cited by this paper
• Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression.

  2006cited by this paper
• A randomised dose finding study of oral tacrolimus (FK506) therapy in refractory ulcerative colitis

  2006cited by this paper
• Effects of 6-mercaptopurine treatment on sperm production and reproductive performance: A study in male mice

  2005cited by this paper
• Male sexual function improves after ileal pouch anal anastomosis

  2005influential reference
• Practice Parameters for the Surgical Treatment of Ulcerative Colitis

  2005cited by this paper
• Practice Parameters Practice Parameters for the Surgical Treatment of Ulcerative Colitis

  2005cited by this paper
• Fertility and pregnancy in the patient with inflammatory bowel disease

  2005influential reference
• Symptomatic eosinophilic gastritis cured with Helicobacter pylori eradication

  2005cited by this paper
• Levels of plasma ACTH in men from infertile couples.

  2005cited by this paper
• Perianal Crohn Disease: Predictors of Need for Permanent Diversion

  2005cited by this paper
• Sulfasalazine-induced abnormal sperm penetration assay reversed on changing to 5-aminosalicylic acid enemas

  2005cited by this paper
• Infliximab and Semen Quality in Men With Inflammatory Bowel Disease

  2005influential reference
• The transport of chemicals in semen.

  2005cited by this paper
• Results and Complications after Ileal Pouch Anal Anastomosis: A Meta-Analysis of 43 Observational Studies Comprising 9,317 Patients

  2005cited by this paper
• Association of stress, hostility and plasma testosterone levels.

  2005cited by this paper
• Mesalazine-induced reversible infertility in a young male.

  2004influential reference
• Guidelines for the management of inflammatory bowel disease in adults

  2004influential reference
• Faculty Opinions recommendation of Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization.

  2004cited by this paper
• Outcome of Pregnancy in Women Receiving Infliximab for the Treatment of Crohn's Disease and Rheumatoid Arthritis

  2004cited by this paper
• Optimizing anti-TNF treatment in inflammatory bowel disease.

  2004cited by this paper
• Sexuality in patients with ulcerative colitis before and after restorative proctocolectomy: a prospective study

  2004cited by this paper
• EFFECT OF CHRONIC LOW DOSE OF METHOTREXATE ON CELLULAR PROLIFERATION DURING SPERMATOGENESIS IN RATS

  2004cited by this paper
• Multiple Apoptotic Caspase Cascades Are Required in Nonapoptotic Roles for Drosophila Spermatid Individualization

  2003cited by this paper
• Epidemiology of inflammatory bowel disease in the Songpa‐Kangdong district, Seoul, Korea, 1986–2005: A KASID study

  2003influential reference
• The safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: a retrospective cohort study.

  2003cited by this paper
• Zinc deficiency in men with Crohn's disease may contribute to poor sperm function and male infertility

  2003cited by this paper
• Randomized, Double-Blind, Placebo-Controlled Trial of Sildenafil (Viagra®) for Erectile Dysfunction After Rectal Excision for Cancer and Inflammatory Bowel Disease

  2002cited by this paper
• GI distension in severe ulcerative colitis

  2002cited by this paper
• Impotence after mesorectal and close rectal dissection for inflammatory bowel disease

  2001cited by this paper
• Sulphasalazine and 5-aminosalicylic acid in long-term treatment of ulcerative colitis: report on tolerance and side-effects.

  2001cited by this paper
• Azathioprine treatment and male fertility in inflammatory bowel disease.

  2001influential reference
• Pregnancy outcome after cyclosporine therapy during pregnancy: a meta-analysis.

  2001cited by this paper
• Sexual and bladder dysfunction after total mesorectal excision for benign diseases.

  2000cited by this paper
• Sexual and bladder dysfunction after total mesorectal excision for benign diseases.

  2000cited by this paper
• Analysis of 100 pregnancy outcomes in women treated systemically with tacrolimus

  2000cited by this paper
• Functional outcomes after ileal pouch-anal anastomosis for chronic ulcerative colitis.

  2000cited by this paper
• The construction and testing of the EORTC colorectal cancer-specific quality of life questionnaire module (QLQ-CR38). European Organization for Research and Treatment of Cancer Study Group on Quality of Life.

  1999cited by this paper
• Outcome of pregnancies when fathers are treated with 6-mercaptopurine for inflammatory bowel disease

  1998cited by this paper
• The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction.

  1997influential reference
• Pregnancy after liver transplantation under tacrolimus.

  1997cited by this paper
• Effects of corticosterone on reproduction in male Sprague-Dawley rats.

  1997cited by this paper
• A new measure of health status for clinical trials in inflammatory bowel disease.

  1989cited by this paper
• Influence of salazosulphapyridine and 5-aminosalicylic acid on seminal qualities and male sex hormones.

  1988cited by this paper
• Sulphasalazine induced seminal abnormalities in ulcerative colitis: results of mesalazine substitution.

  1987cited by this paper
• Male fertility in Crohn's disease.

  1986cited by this paper
• Reversible male infertility due to sulphasalazine: studies in man and rat.

  1984cited by this paper
• Sulphasalazine and male infertility: reversibility and possible mechanism.

  1981cited by this paper

• The potential link between inflammatory bowel disease and male erectile dysfunction: mechanistic insights and novel therapeutic perspectives

  2026cites this paper
• Impact of moderate-to-severe ulcerative colitis and Crohn’s disease on sexual activity: United States and European patient perspectives from the communicating needs and features of IBD experiences (CONFIDE) survey

  2025cites this paper
• When inflammatory bowel disease meets pregnancy.

  2025cites this paper
• Systemic Consequences of Inflammatory Bowel Disease Beyond Immune-Mediated Manifestations

  2025cites this paper
• 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Alleviate TNBS-Induced Colitis and Exhibit No Significant Testicular Toxicity

  2025cites this paper
• Influence of biological sex in inflammatory bowel diseases

  2025influential citation
• Position statement of the Spanish Working Group on Crohn’s Disease and Ulcerative Colitis on sexuality and inflammatory bowel disease

  2024cites this paper
• Association between severe headache or migraine and erectile dysfunction in American adults: a cross-sectional of data study from the NHANES

  2024cites this paper
• Gut‐Derived Exosomes Mediate the Microbiota Dysbiosis‐Induced Spermatogenesis Impairment by Targeting Meioc in Mice

  2024cites this paper
• A Mendelian randomization study on causal effects of inflammatory bowel disease on the risk of erectile dysfunction

  2024cites this paper
• Position Statement of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis on Sexuality and Inflammatory Bowel Disease.

  2024cites this paper
• Protective roles of vitamin C and 5-aminosalicylic acid on reproduction in acrylamide intoxicated male mice

  2023cites this paper
• New pattern of individualized management of chronic diseases: focusing on inflammatory bowel diseases and looking to the future

  2023cites this paper
• Prospective Evaluation of Sexual Dysfunction in Men With Chronic Pancreatitis

  2023cites this paper
• Sexual functions in individuals with inflammatory bowel diseases

  2023influential citation
• The Benefits and Drawbacks of Staging Pelvic Pouches

  2022cites this paper
• Minor impact on fertility in men with inflammatory bowel disease: A National Cohort Study from Sweden

  2022cites this paper
• Paternal Medications in Inflammatory Bowel Disease and Male Fertility and Reproductive Outcomes: A Systematic Review and Meta-Analysis.

  2022cites this paper
• Effect of ozone versus naringin on testicular injury in experimentally induced ulcerative colitis in adult male albino rats

  2022cites this paper
• Long-Term Proton Pump Inhibitor Therapy and its Effect on Endocrine Hormones in Selected Patient Population

  2022cites this paper
• Migraine Is Associated With High Risk of Erectile Dysfunction: A Systematic Review and Cumulative Analysis.

  2022cites this paper
• Chronic Inflammation Impairs Male Fertility—A Case-Control Study in Ulcerative Colitis Patients

  2021cites this paper
• Prevalence, predictors and age‐related sexual and erectile dysfunction in patients with inflammatory bowel disease: A tertiary centre experience

  2021cites this paper
• Mitochondrial nicotinamide adenine dinucleotide hydride dehydrogenase (NADH) subunit 4 (MTND4) polymorphisms and their association with male infertility

  2021cites this paper
• Timing and Holistic Measure of Sexual Function in Patients with IBD After Proctectomy.

  2021cites this paper
• Chronic Inflammation Impairs Male Fertility—A Case-Control Study in Ulcerative Colitis Patients

  2021cites this paper
• Quality of life in patients with moderate to severe ulcerative colitis and the impact of treatment: A narrative review.

  2021cites this paper
• Reproductive Health in IBD Patients

  2021cites this paper
• Using the PCR and Blood Agar in Diagnosis of Semen Bacterial Contamination of Fertile and Infertile Men.

  2021cites this paper
• Men With Inflammatory Bowel Disease: Sexual Function, Fertility, Medication Safety, and Prostate Cancer.

  2020cites this paper
• Sexual Dysfunction in Patients with Inflammatory Bowel Disease

  2020cites this paper
• Ulcerative Colitis (General Pediatric Surgery of Abdomen)

  2020cites this paper
• Mobile health applications for improving the sexual health outcomes among adults with chronic diseases: A systematic review

  2020cites this paper
• Increased Use of Medications for Erectile Dysfunction in Men With Ulcerative Colitis and Crohn's Disease Compared to Men Without Inflammatory Bowel disease: A Nationwide cohort Study

  2018cites this paper
• Inflammatory Bowel Diseases Can Adversely Impact Domains of Sexual Function Such as Satisfaction with Sex Life

  2018cites this paper