A Staphylococcal GGDEF Domain Protein Regulates Biofilm Formation Independently of Cyclic Dimeric GMP

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Bacteriology

• Publication date

  2008-05-23

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1128/JB.00375-08PMID 18502872PMCID PMC2493275
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Roles of cyclic diguanylate in the regulation of bacterial pathogenesis.

  2007influential reference
• A cyclic-di-GMP receptor required for bacterial exopolysaccharide production

  2007cited by this paper
• Spontaneous switch to PIA-independent biofilm formation in an ica-positive Staphylococcus epidermidis isolate.

  2007cited by this paper
• PilZ Domain Proteins Bind Cyclic Diguanylate and Regulate Diverse Processes in Vibrio cholerae*

  2007cited by this paper
• The second messenger bis‐(3′‐5′)‐cyclic‐GMP and its PilZ domain‐containing receptor Alg44 are required for alginate biosynthesis in Pseudomonas aeruginosa

  2007cited by this paper
• Structure of BeF3- -modified response regulator PleD: implications for diguanylate cyclase activation, catalysis, and feedback inhibition.

  2007cited by this paper
• ica and beyond: biofilm mechanisms and regulation in Staphylococcus epidermidis and Staphylococcus aureus.

  2007cited by this paper
• DgrA is a member of a new family of cyclic diguanosine monophosphate receptors and controls flagellar motor function in Caulobacter crescentus

  2007cited by this paper
• Identification of a novel regulatory protein (CsrD) that targets the global regulatory RNAs CsrB and CsrC for degradation by RNase E.

  2006cited by this paper
• Spx Is a Global Effector Impacting Stress Tolerance and Biofilm Formation in Staphylococcus aureus

  2006cited by this paper
• Isolation and Characterization of Biofilm Formation-Defective Mutants of Staphylococcus aureus

  2006cited by this paper
• The PilZ Domain Is a Receptor for the Second Messenger c-di-GMP

  2006cited by this paper
• PilZ domain is part of the bacterial c-di-GMP binding protein

  2006cited by this paper
• NMR structure and binding studies confirm that PA4608 from Pseudomonas aeruginosa is a PilZ domain and a c‐di‐GMP binding protein

  2006cited by this paper
• Cell-cell signaling in Xanthomonas campestris involves an HD-GYP domain protein that functions in cyclic di-GMP turnover.

  2006cited by this paper
• Role of the luxS Quorum-Sensing System in Biofilm Formation and Virulence of Staphylococcus epidermidis

  2006cited by this paper
• c-di-GMP (3′-5′-Cyclic Diguanylic Acid) Inhibits Staphylococcus aureus Cell-Cell Interactions and Biofilm Formation

  2005cited by this paper
• SarA Is an Essential Positive Regulator of Staphylococcus epidermidis Biofilm Development

  2005cited by this paper
• Cyclic Diguanylate Is a Ubiquitous Signaling Molecule in Bacteria: Insights into Biochemistry of the GGDEF Protein Domain

  2005cited by this paper
• 3′,5′-Cyclic Diguanylic Acid Reduces the Virulence of Biofilm-Forming Staphylococcus aureus Strains in a Mouse Model of Mastitis Infection

  2005cited by this paper
• Identification and Characterization of a Cyclic di-GMP-specific Phosphodiesterase and Its Allosteric Control by GTP*

  2005cited by this paper
• C‐di‐GMP: the dawning of a novel bacterial signalling system

  2005cited by this paper
• The Ubiquitous Protein Domain EAL Is a Cyclic Diguanylate-Specific Phosphodiesterase: Enzymatically Active and Inactive EAL Domains

  2005cited by this paper
• Pfam: clans, web tools and services

  2005cited by this paper
• Cell cycle-dependent dynamic localization of a bacterial response regulator with a novel di-guanylate cyclase output domain.

  2004cited by this paper
• GGDEF and EAL domains inversely regulate cyclic di‐GMP levels and transition from sessility to motility

  2004cited by this paper
• RsbU-Dependent Regulation of Staphylococcus epidermidis Biofilm Formation Is Mediated via the Alternative Sigma Factor σB by Repression of the Negative Regulator Gene icaR

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  2004cited by this paper
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  2004cited by this paper
• Control of Glucose- and NaCl-Induced Biofilm Formation by rbf in Staphylococcus aureus

  2004cited by this paper
• Bacterial signal transduction network in a genomic perspective.

  2004cited by this paper
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  2004influential reference
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  2004cited by this paper
• Inactivations of rsbU and sarA by IS256 Represent Novel Mechanisms of Biofilm Phenotypic Variation in Staphylococcus epidermidis

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• Mutation of sarA in Staphylococcus aureus Limits Biofilm Formation

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  2003cited by this paper
• Application of comparative genomics in the identification and analysis of novel families of membrane-associated receptors in bacteria

  2003cited by this paper
• Regulation of icaR gene expression in Staphylococcus epidermidis.

  2002cited by this paper
• icaR Encodes a Transcriptional Repressor Involved in Environmental Regulation of ica Operon Expression and Biofilm Formation in Staphylococcus epidermidis

  2002influential reference
• Biofilm Formation by Staphylococcus epidermidis Depends on Functional RsbU, an Activator of thesigB Operon: Differential Activation Mechanisms Due to Ethanol and Salt Stress

  2001cited by this paper
• Regulation of sigmaB-dependent transcription of sigB and asp23 in two different Staphylococcus aureus strains.

  1999cited by this paper
• The Intercellular Adhesion (ica) Locus Is Present in Staphylococcus aureus and Is Required for Biofilm Formation

  1999cited by this paper
• Three cdg Operons Control Cellular Turnover of Cyclic Di-GMP in Acetobacter xylinum: Genetic Organization and Occurrence of Conserved Domains in Isoenzymes

  1998cited by this paper
• Gene replacement in Staphylococcus carnosus and Staphylococcus xylosus.

  1997cited by this paper
• c‐di‐GMP‐binding protein, a new factor regulating cellulose synthesis in Acetobacter xylinum

  1997cited by this paper
• Molecular basis of intercellular adhesion in the biofilm‐forming Staphylococcus epidermidis

  1996cited by this paper
• Regulation of cellulose synthesis in Acetobacter xylinum by cyclic diguanylic acid

  1987cited by this paper
• The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage

  1983cited by this paper

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  2025cites this paper
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  2025cites this paper
• Surfaces modified with small molecules that interfere with nucleotide signaling reduce Staphylococcus epidermidis biofilm and increase the efficacy of ciprofloxacin.

  2023cites this paper
• Nucleotides as Bacterial Second Messengers

  2023cites this paper
• Evolution of cyclic di-GMP signalling on a short and long term time scale

  2023influential citation
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• Biofilms by bacterial human pathogens: Clinical relevance - development, composition and regulation - therapeutical strategies

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  2020cites this paper
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• A systematic pipeline for classifying bacterial operons reveals the evolutionary landscape of biofilm machineries

  2019cites this paper
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  2019cites this paper
• σB Inhibits Poly-N-Acetylglucosamine Exopolysaccharide Synthesis and Biofilm Formation in Staphylococcus aureus

  2019influential citation
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• Comparative Tn-Seq reveals common daptomycin resistance determinants in Staphylococcus aureus despite strain-dependent differences in essentiality of shared cell envelope genes

  2019cites this paper
• Cyclic di-AMP in host-pathogen interactions.

  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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