Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Cancer Research

• Publication date

  2010-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/0008-5472.CAN-09-3537PMID 20103647
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• trans-Resveratrol inhibits H2O2-induced adenocarcinoma gastric cells proliferation via inactivation of MEK1/2-ERK1/2-c-Jun signalling axis.

  2009cited by this paper
• c-Jun NH2-terminal kinase activation is essential for DRAM-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-treated Ewing sarcoma cells.

  2009cited by this paper
• The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells

  2009cited by this paper
• Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death.

  2009cited by this paper
• Control of autophagy by oncogenes and tumor suppressor genes

  2009cited by this paper
• Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells

  2009cited by this paper
• Gene expression profiling of imatinib and PD166326-resistant CML cell lines identifies Fyn as a gene associated with resistance to BCR-ABL inhibitors

  2009cited by this paper
• Autophagy is an important event for megakaryocytic differentiation of the chronic myelogenous leukemia K562 cell line

  2009cited by this paper
• Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells.

  2009cited by this paper
• Apoptosis and autophagy: Targeting autophagy signalling in cancer cells –‘trick or treats’?

  2009cited by this paper
• Autophagy suppresses tumorigenesis through elimination of p62.

  2009cited by this paper
• Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells

  2008cited by this paper
• Essential Role of Sequestosome 1/p62 in Regulating Accumulation of Lys63-ubiquitinated Proteins*

  2008cited by this paper
• Imatinib mesylate‐resistant human chronic myelogenous leukemia cell lines exhibit high sensitivity to the phytoalexin resveratrol

  2008influential reference
• The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

  2008cited by this paper
• The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis.

  2008cited by this paper
• Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

  2008influential reference
• Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives.

  2008cited by this paper
• Identifying the estrogen receptor coactivator PELP1 in autophagosomes.

  2007cited by this paper
• Self-eating and self-killing: crosstalk between autophagy and apoptosis

  2007cited by this paper
• Apoptosis and erythroid differentiation triggered by Bcr-Abl inhibitors in CML cell lines are fully distinguishable processes that exhibit different sensitivity to caspase inhibition

  2007cited by this paper
• Resveratrol stimulates AMP kinase activity in neurons

  2007cited by this paper
• Resveratrol: a review of preclinical studies for human cancer prevention.

  2007cited by this paper
• Self-eating and self-killing: crosstalk between autophagy and apoptosis.

  2007cited by this paper
• Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress

  2006cited by this paper
• A survey of the signaling pathways involved in megakaryocytic differentiation of the human K562 leukemia cell line by molecular and c-DNA array analysis

  2006cited by this paper
• Resveratrol improves health and survival of mice on a high-calorie diet

  2006cited by this paper
• Induction of quinone reductase NQO1 by resveratrol in human K562 cells involves the antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2.

  2006cited by this paper
• Cardioprotective effect of resvaratrol pretreatment on myocardial ischemia-reperfusion induced injury in rats.

  2006cited by this paper
• NF‐kB inhibition as a strategy to enhance etoposide‐induced apoptosis in K562 cell line

  2006cited by this paper
• Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D.

  2006cited by this paper
• Lysosomes and autophagy in cell death control

  2005cited by this paper
• Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells.

  2004cited by this paper
• Autophagy: molecular mechanisms, physiological functions and relevance in human pathology

  2004cited by this paper
• Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC δ signal transduction

  2004cited by this paper
• Differential sensitivity to resveratrol-induced apoptosis of human chronic myeloid (K562) and acute lymphoblastic (HSB-2) leukemia cells.

  2004cited by this paper
• JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis

  2004cited by this paper
• Imatinib induces mitochondria‐dependent apoptosis of the Bcr‐Abl‐positive K562 cell line and its differentiation toward the erythroid lineage 1

  2003cited by this paper
• The molecular mechanism of chronic myelogenous leukemia and its therapeutic implications: studies in a murine model

  2002influential reference
• Involvement of c‐jun NH2‐terminal kinases in resveratrol‐induced activation of p53 and apoptosis

  2002cited by this paper
• Structure and functional properties of the ubiquitin binding protein p62

  2002cited by this paper
• Disparate in vitro and in vivo antileukemic effects of resveratrol, a natural polyphenolic compound found in grapes.

  2002cited by this paper
• The molecular biology of chronic myeloid leukemia.

  2000cited by this paper
• Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance.

  2000cited by this paper
• Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity.

  1999cited by this paper
• Immediate early response of the p62 gene encoding a non‐proteasomal multiubiquitin chain binding protein

  1998cited by this paper
• Linkage of proliferative and maturational abnormalities in chronic myelogenous leukemia and relevance to treatment.

  1993cited by this paper
• Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22.

  1984cited by this paper

• Jolkinolide B Activates Mitophagy to Exhibit Antipancreatic Cancer Activity and Alleviate Cognitive Deficits in Alzheimer's Disease

  2025cites this paper
• Autophagy in disease management: Exploring the potential of natural products as targeted therapies.

  2025cites this paper
• The Potential of Resveratrol as an Anticancer Agent: Updated Overview of Mechanisms, Applications, and Perspectives

  2025cites this paper
• Autophagy mediated immune response regulation and drug resistance in cancer

  2025cites this paper
• Novel treatment strategies for lymphangioleiomyomatosis: a narrative review

  2025cites this paper
• Autophagy in brain tumors: molecular mechanisms, challenges, and therapeutic opportunities

  2025cites this paper
• XMU-MP-1, Inhibitor of STE20-like MST1/2 Kinases of the Hippo Signaling Pathway, Suppresses the Cell Cycle, Activates Apoptosis and Autophagy, and Induces Death of Hematopoietic Tumor Cells

  2025cites this paper
• Resveratrol-rich extract from Vitis vinifera canes exhibits enhanced anticancer activity in A549 cells and 3D lung cancer co-culture model

  2025cites this paper
• Crosstalk Between Autophagy and Oxidative Stress in Hematological Malignancies: Mechanisms, Implications, and Therapeutic Potential

  2025cites this paper
• EMT-ciliary signaling in quasi-mesenchymal-stem-like cells drives therapeutic resistance and is a druggable vulnerability in triple-negative breast cancer

  2025cites this paper
• The Interplay Between Autophagy and Apoptosis in the Mechanisms of Action of Stilbenes in Cancer Cells

  2025cites this paper
• Natural compounds combined with imatinib as promising antileukemic therapy: An updated review.

  2024cites this paper
• Phytochemicals regulate cancer metabolism through modulation of the AMPK/PGC-1α signaling pathway

  2024cites this paper
• Zosterabisphenone B, a new diarylheptanoid heterodimer from the seagrass Zostera marina, induces apoptosis cell death in colon cancer cells and reduces tumour growth in mice

  2024cites this paper
• The Role of Artificial Intelligence in the Development of Anticancer Therapeutics from Natural Polyphenols: Current Advances and Future Prospects.

  2024cites this paper
• Anti-Leukemic Attributes of Natural Compounds Targeting Autophagy: A Closer Look into the Molecular Mechanisms

  2024cites this paper
• (-)-Epicatechin and colonic metabolite 2,3-dihydroxybenzoic acid, alone or in combination with metformin, protect cardiomyocytes from high glucose/high palmitic acid-induced damage by regulating redox status, apoptosis and autophagy.

  2024cites this paper
• Resveratrol inhibited colorectal cancer progression by reducing oxidative DNA damage by targeting the JNK signaling pathway

  2024cites this paper
• Advances in Diet and Physical Activity in Breast Cancer Prevention and Treatment

  2024cites this paper
• Phytochemistry of Genus Buxus and Pharmacology of Cyclovirobuxine D

  2024cites this paper
• Resveratrol and Its Role in the Management of B-Cell Malignancies—A Recent Update

  2023cites this paper
• Cuproptosis: p53-regulated metabolic cell death?

  2023cites this paper
• Safety and efficacy of combined resveratrol and sirolimus in lymphangioleiomyomatosis.

  2023cites this paper
• Enhancing Anti-Cancer Therapy with Selective Autophagy Inhibitors by Targeting Protective Autophagy

  2023cites this paper
• The role and implication of autophagy in cholangiocarcinoma

  2023cites this paper
• Improving the Antitumor Effect of Chemotherapy with Ocoxin as a Novel Adjuvant Agent to Treat Prostate Cancer

  2023cites this paper
• Leflunomide alleviates obesity via activation of the TAK1‐AMPK pathway and induction of lipophagy

  2023cites this paper
• Natural compounds modulating mitophagy: Implications for cancer therapy.

  2023cites this paper
• Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6P

  2023cites this paper
• Antitumor Effects of β-Elemene Through Inducing Autophagy-Mediated Apoptosis in Ewing Sarcoma Family Tumor Cells

  2023cites this paper
• Autophagy: A challengeable paradox in cancer treatment

  2023cites this paper
• Resveratrol against Echinococcus sp.: Discrepancies between In Vitro and In Vivo Responses

  2023cites this paper
• Evaluation of novel pyrazol-4-yl pyridine derivatives possessing arylsulfonamide tethers as c-Jun N-terminal kinase (JNK) inhibitors in leukemia cells.

  2023cites this paper
• Effects of Dichlorvos on cardiac cells: Toxicity and molecular mechanism of action.

  2023cites this paper
• Resveratrol downregulates ENaCs through the activation of AMPK in human colon cancer cells.

  2023cites this paper
• Hydroquinone destabilizes BIM mRNA through upregulation of p62 in chronic myeloid leukemia cells.

  2022cites this paper
• The Cooperative Anti-Neoplastic Activity of Polyphenolic Phytochemicals on Human T-Cell Acute Lymphoblastic Leukemia Cell Line MOLT-4 In Vitro

  2022cites this paper
• Identification of Key Pathways Involved in White Strain of Hypsizygus marmoreus Extracts-Induced Cell Death of Human Hepatoma Hep3B Cells by Next Generation Sequencing

  2022cites this paper
• Resveratrol as a modulatory of apoptosis and autophagy in cancer therapy

  2022influential citation
• PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40

  2022cites this paper
• Mechanism of Resveratrol-Induced Programmed Cell Death and New Drug Discovery against Cancer: A Review

  2022cites this paper
• Hydroxycitric Acid Inhibits Chronic Myelogenous Leukemia Growth through Activation of AMPK and mTOR Pathway

  2022cites this paper
• Molecular Basis of Resveratrol-Induced Resensitization of Acquired Drug-Resistant Cancer Cells

  2022influential citation
• Trans‐gnetin H isolated from the seeds of Paeonia species induces autophagy via inhibiting mTORC1 signalling through AMPK activation

  2022cites this paper
• New Visions on Natural Products and Cancer Therapy: Autophagy and Related Regulatory Pathways

  2022influential citation
• Nrf2 and Parkin-Hsc70 regulate the expression and protein stability of p62/SQSTM1 under hypoxia

  2022cites this paper
• Epibrassinolide impaired colon tumor progression and induced autophagy in SCID mouse xenograft model via acting on cell cycle progression without affecting endoplasmic reticulum stress observed in vitro.

  2022cites this paper
• 6‐Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF‐7 cells by accumulating ROS to suppress the PI3K/AKT/mTOR signaling pathway

  2022cites this paper
• Porcine epidemic diarrhoea virus (PEDV) infection activates AMPK and JNK through TAK1 to induce autophagy and enhance virus replication

  2022cites this paper
• Colon cancer and colorectal cancer: Prevention and treatment by potential natural products.

  2022cites this paper
• The mRNA Expression of PTEN, LEF1, JAK3, LC3 and p62/SQSTM1 Genes in Patients with Chronic Myeloid Leukemia.

  2022cites this paper
• Neuroprotection of resveratrol against cadmium-poisoning acts through dual inhibition of mTORC1/2 signaling.

  2022cites this paper
• Synthesis and anti-melanoma effect of 3-O-prenyl glycyrrhetinic acid against B16F10 cells via induction of endoplasmic reticulum stress-mediated autophagy through ERK/AKT signaling pathway

  2022cites this paper
• Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies

  2022cites this paper
• PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40

  2022cites this paper
• A Renewed Concept on the MAPK Signaling Pathway in Cancers: Polyphenols as a Choice of Therapeutics.

  2022cites this paper
• Modulation of Autophagy in Cancer Cells by Dietary Polyphenols

  2021cites this paper
• Targeting Abnormal Hematopoietic Stem Cells in Chronic Myeloid Leukemia and Philadelphia Chromosome-Negative Classical Myeloproliferative Neoplasms

  2021cites this paper
• Regulation of autophagy by controlling Erk1/2 and mTOR for platelet-derived growth factor-BB-mediated vascular smooth muscle cell phenotype shift.

  2021cites this paper
• Artemisia annua L. Polyphenol-Induced Cell Death Is ROS-Independently Enhanced by Inhibition of JNK in HCT116 Colorectal Cancer Cells

  2021cites this paper
• Eupatilin Suppresses Pancreatic Cancer Cells via Glucose Uptake Inhibition, AMPK Activation, and Cell Cycle Arrest

  2021cites this paper
• The unique Akt inhibitor SC66 suppressed AMPK activity and abolished autophagy through the EGFR‐p62 pathway

  2021cites this paper
• p62 works as a hub modulation in the ageing process.

  2021cites this paper
• A Notch inhibitor plus Resveratrol induced blockade of autophagy drives glioblastoma cell death by promoting a switch to apoptosis.

  2021cites this paper
• Molecular Action of Polyphenols in Leukaemia and Their Therapeutic Potential

  2021cites this paper
• Targeting AMPK Signaling by Dietary Polyphenols in Cancer Prevention.

  2021cites this paper
• Targeting regulated cell death (RCD) with small-molecule compounds in cancer therapy: a revisited review of apoptosis, autophagy-dependent cell death and necroptosis.

  2021cites this paper
• Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma

  2021cites this paper
• [6]-Gingerol Suppresses Oral Cancer Cell Growth by Inducing the Activation of AMPK and Suppressing the AKT/mTOR Signaling Pathway

  2021cites this paper
• Targeting Drug Chemo-Resistance in Cancer Using Natural Products

  2021cites this paper
• Targeting Autophagy with Natural Compounds in Cancer: A Renewed Perspective from Molecular Mechanisms to Targeted Therapy

  2021cites this paper
• Myricetin Induces Autophagy and Cell Cycle Arrest of HCC by Inhibiting MARCH1-Regulated Stat3 and p38 MAPK Signaling Pathways

  2021cites this paper
• Autophagy based cellular physiological strategies target oncogenic progression

  2021cites this paper
• Autophagy is induced and modulated by cholesterol depletion through transcription of autophagy-related genes and attenuation of flux

  2021cites this paper
• Inhibition of the sonic hedgehog pathway activates TGF-β-activated kinase (TAK1) to induce autophagy and suppress apoptosis in thyroid tumor cells

  2021cites this paper
• Autophagy and aging

  2021cites this paper
• Effects of Copper Nanoparticles on mRNA and Small RNA Expression in Human Hepatocellular Carcinoma (HepG2) Cells.

  2021cites this paper
• Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics

  2021cites this paper
• ERK5 Inhibition Induces Autophagy-Mediated Cancer Cell Death by Activating ER Stress

  2021cites this paper
• Jaridon 6, a new diterpene from Rabdosia rubescens (Hemsl.) Hara, can display anti‐gastric cancer resistance by inhibiting SIRT1 and inducing autophagy

  2021cites this paper
• Activators of SIRT1 in the kidney and protective effects of SIRT1 during acute kidney injury (AKI) (effect of SIRT1 activators on acute kidney injury)

  2021cites this paper
• Targeting autophagy to overcome drug resistance: further developments

  2020cites this paper
• Resveratrol attenuates TLR-4 mediated inflammation and elicits therapeutic potential in models of sepsis

  2020cites this paper
• Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics.

  2020cites this paper
• Regulatory Roles of Autophagy in Cancer

  2020cites this paper
• Sirt1 attenuates diabetic keratopathy by regulating the endoplasmic reticulum stress pathway.

  2020cites this paper
• High Levels of miR-7-5p Potentiate Crizotinib-Induced Cytokilling and Autophagic Flux by Targeting RAF1 in NPM-ALK Positive Lymphoma Cells

  2020cites this paper
• Autophagy induction can regulate skin pigmentation by causing melanosome degradation in keratinocytes and melanocytes

  2020cites this paper
• Flavokawain B and Doxorubicin Work Synergistically to Impede the Propagation of Gastric Cancer Cells via ROS-Mediated Apoptosis and Autophagy Pathways

  2020cites this paper
• Resveratrol modulates the apoptosis and autophagic death of human lung adenocarcinoma A549 cells via a p53-dependent pathway: Integrated bioinformatics analysis and experimental validation

  2020cites this paper
• Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies

  2020cites this paper
• Apigetrin induces extrinsic apoptosis, autophagy and G2/M phase cell cycle arrest through PI3K/AKT/mTOR pathway in AGS human gastric cancer cell.

  2020cites this paper
• The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells

  2020cites this paper
• Forced expression of miR-143 and -145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift

  2020cites this paper
• L-Ascorbic Acid Inhibits Breast Cancer Growth by Inducing IRE/JNK/CHOP-Related Endoplasmic Reticulum Stress-Mediated p62/SQSTM1 Accumulation in the Nucleus

  2020cites this paper
• Drug Targets in Cellular Processes of Cancer: From Nonclinical to Preclinical Models

  2020cites this paper
• Gut microbiome: A possible common therapeutic target for treatment of atherosclerosis and cancer.

  2020cites this paper
• Compression stress induces nucleus pulposus cell autophagy by inhibition of the PI3K/AKT/mTOR pathway and activation of the JNK pathway

  2020cites this paper
• Oxidative resistance of leukemic stem cells and oxidative damage to hematopoietic stem cells under pro-oxidative therapy

  2020cites this paper
• Glycyrrhiza glabra-Enhanced Extract and Adriamycin Antiproliferative Effect on PC-3 Prostate Cancer Cells

  2020cites this paper