Cytokines and Chemokines in Cerebral Malaria Pathogenesis

Cerebral malaria is among the major causes of malaria-associated mortality and effective adjunctive therapeutic strategies are currently lacking. Central pathophysiological processes involved in the development of cerebral malaria include an imbalance of pro- and anti-inflammatory responses to Plasmodium infection, endothelial cell activation, and loss of blood-brain barrier integrity. However, the sequence of events, which initiates these pathophysiological processes as well as the contribution of their complex interplay to the development of cerebral malaria remain incompletely understood. Several cytokines and chemokines have repeatedly been associated with cerebral malaria severity. Increased levels of these inflammatory mediators could account for the sequestration of leukocytes in the cerebral microvasculature present during cerebral malaria, thereby contributing to an amplification of local inflammation and promoting cerebral malaria pathogenesis. Herein, we highlight the current knowledge on the contribution of cytokines and chemokines to the pathogenesis of cerebral malaria with particular emphasis on their roles in endothelial activation and leukocyte recruitment, as well as their implication in the progression to blood-brain barrier permeability and neuroinflammation, in both human cerebral malaria and in the murine experimental cerebral malaria model. A better molecular understanding of these processes could provide the basis for evidence-based development of adjunct therapies and the definition of diagnostic markers of disease progression.

• Publication year

  2017

• Venue

  Frontiers in Cellular and Infection Microbiology

• Publication date

  2017-07-20

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3389/fcimb.2017.00324PMID 28775960PMCID 5517394
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• [Plasmodium falciparum].

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• miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria

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• Uptake of parasite‐derived vesicles by astrocytes and microglial phagocytosis of infected erythrocytes may drive neuroinflammation in cerebral malaria

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• Severe malaria: what's new on the pathogenesis front?

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• Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria

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• Synergistic induction of CXCL10 by interferon-gamma and lymphotoxin-alpha in astrocytes: Possible role in cerebral malaria.

  2016cited by this paper
• Transcriptomic profiling of microglia reveals signatures of cell activation and immune response, during experimental cerebral malaria

  2016influential reference
• Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria

  2016cited by this paper
• Malaria‐derived hemozoin exerts early modulatory effects on the phenotype and maturation of human dendritic cells

  2016influential reference
• Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria

  2016cited by this paper
• Exploring experimental cerebral malaria pathogenesis through the characterisation of host-derived plasma microparticle protein content

  2016cited by this paper
• Seven-Year Efficacy of RTS,S/AS01 Malaria Vaccine among Young African Children.

  2016cited by this paper
• Monocyte- and Neutrophil-Derived CXCL10 Impairs Efficient Control of Blood-Stage Malaria Infection and Promotes Severe Disease

  2016influential reference
• Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass

  2016influential reference
• Quantitative Assessment of Multiorgan Sequestration of Parasites in Fatal Pediatric Cerebral Malaria.

  2015cited by this paper
• Fever and the thermal regulation of immunity: the immune system feels the heat

  2015cited by this paper
• Pathogenesis of cerebral malaria: new diagnostic tools, biomarkers, and therapeutic approaches

  2015cited by this paper
• Activated Brain Endothelial Cells Cross-Present Malaria Antigen

  2015influential reference
• The Role of Chemokines in Shaping the Balance Between CD4+ T Cell Subsets and Its Therapeutic Implications in Autoimmune and Cancer Diseases

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• Pathogenic CD8+ T cells in experimental cerebral malaria

  2015influential reference
• Phagosomal Acidification Prevents Macrophage Inflammatory Cytokine Production to Malaria, and Dendritic Cells Are the Major Source at the Early Stages of Infection

  2015influential reference
• Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network

  2015cited by this paper
• Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial

  2015cited by this paper
• Chemokines and chemokine receptors: positioning cells for host defense and immunity.

  2014cited by this paper
• The systemic pathology of cerebral malaria in African children

  2014cited by this paper
• Interferon-mediated innate immune responses against malaria parasite liver stages.

  2014influential reference
• Pathogenesis of cerebral malaria—inflammation and cytoadherence

  2014influential reference
• MicroRNA‐155 negatively affects blood–brain barrier function during neuroinflammation

  2014cited by this paper
• The peculiarities and paradoxes of Plasmodium heme metabolism.

  2014cited by this paper
• Innate sensing of malaria parasites

  2014cited by this paper
• Malarial Pigment Hemozoin and the Innate Inflammatory Response

  2014cited by this paper
• Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.

  2014cited by this paper
• Toll-Like Receptors and Malaria - Sensing and Susceptibility

  2014cited by this paper
• Type I interferons contribute to experimental cerebral malaria development in response to sporozoite or blood‐stage Plasmodium berghei ANKA

  2013cited by this paper
• Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system.

  2013cited by this paper
• Development, maintenance and disruption of the blood-brain barrier

  2013cited by this paper
• The role of chemokines in severe malaria: more than meets the eye

  2013cited by this paper
• Severe malaria is associated with parasite binding to endothelial protein C receptor

  2013cited by this paper
• Rosetting Plasmodium falciparum-Infected Erythrocytes Bind to Human Brain Microvascular Endothelial Cells In Vitro, Demonstrating a Dual Adhesion Phenotype Mediated by Distinct P. falciparum Erythrocyte Membrane Protein 1 Domains

  2013cited by this paper
• Association of TNF level with production of circulating cellular microparticles during clinical manifestation of human cerebral malaria.

  2013cited by this paper
• An evolving new paradigm: endothelial cells – conditional innate immune cells

  2013cited by this paper
• Malaria's deadly grip: cytoadhesion of Plasmodium falciparum‐infected erythrocytes

  2013influential reference
• Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection

  2013influential reference
• Sequestration and microvascular congestion are associated with coma in human cerebral malaria.

  2012cited by this paper
• IFN-γ–Producing CD4+ T Cells Promote Experimental Cerebral Malaria by Modulating CD8+ T Cell Accumulation within the Brain

  2012cited by this paper
• The chemokine superfamily revisited.

  2012cited by this paper
• The Role of Animal Models for Research on Severe Malaria

  2012cited by this paper
• Cerebral malaria

  2012influential reference
• Diagnosis, prognosis and treatment of severe falciparum malaria in African children

  2012cited by this paper
• Innate recognition of malarial parasites by mammalian hosts.

  2012cited by this paper
• Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood–brain barrier disruption

  2011cited by this paper
• CXCL4 and CXCL10 Predict Risk of Fatal Cerebral Malaria

  2011cited by this paper
• Granzyme B Expression by CD8+ T Cells Is Required for the Development of Experimental Cerebral Malaria

  2011cited by this paper
• Cell biology and immunology of malaria

  2011cited by this paper
• Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.

  2011cited by this paper
• Circulating red cell-derived microparticles in human malaria.

  2011cited by this paper
• Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF

  2011cited by this paper
• Distinct clinical and immunologic profiles in severe malarial anemia and cerebral malaria in Zambia.

  2011influential reference
• Proinflammatory responses by glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum are mainly mediated through the recognition of TLR2/TLR1.

  2011influential reference
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• Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation

  2010cited by this paper
• Neuropathogenesis of human and murine malaria.

  2010cited by this paper
• The murine IL‐8 homologues KC, MIP‐2, and LIX are found in endothelial cytoplasmic granules but not in Weibel‐Palade bodies

  2010cited by this paper
• Cerebral malaria: mechanisms of brain injury and strategies for improved neurocognitive outcome.

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• Augmented plasma microparticles during acute Plasmodium vivax infection

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• Cerebral Malaria: Mechanisms of Brain Injury and Strategies for Improved Neurocognitive Outcome

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  2010cited by this paper
• Microvesiculation and cell interactions at the brain-endothelial interface in cerebral malaria pathogenesis.

  2010influential reference
• Pattern recognition receptors and inflammation.

  2010influential reference
• Perfusion abnormalities in children with cerebral malaria and malarial retinopathy.

  2009cited by this paper
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• Plasmodium falciparum-infected erythrocytes induce NF-kappaB regulated inflammatory pathways in human cerebral endothelium.

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  2008influential reference
• Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malaria.

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• Cerebral Malaria in Children Is Associated With Long-term Cognitive Impairment

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• Malaria: mechanisms of erythrocytic infection and pathological correlates of severe disease.

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• Plasmodium falciparum and the blood-brain barrier--contacts and consequences.

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