The role of melanocortin pathways in the mesocorticolimbic system in the regulation of energy homeostasis

K. Banks

Published 2015 in Unknown venue

ABSTRACT

...................................................................................................................................... 2 Declaration of originality .............................................................................................................. 3 Copyright declaration ............................................................................................................... 3 Declaration of contributors .......................................................................................................... 4 Acknowledgements...................................................................................................................... 5 Abbreviations .............................................................................................................................. 6 Table of contents ....................................................................................................................... 12 List of figures ............................................................................................................................. 20 List of tables..................................................................................................................................................24 Chapter 1: General introduction ................................................................................................. 25 1.1 Obesity ....................................................................................................................... 26 1.2 Homeostatic and hedonic control of food intake .......................................................... 27 1.3 Hypothalamic control of food intake ............................................................................ 29 1.3.1 The adipostat mechanism ............................................................................................. 29 1.3.2 The arcuate nucleus ...................................................................................................... 30 1.3.3 The paraventricular nucleus ......................................................................................... 33 1.3.4 The ventromedial nucleus and dorsomedial nucleus ................................................... 34 1.3.5 The lateral hypothalamus ............................................................................................. 35 1.4 Extra-hypothalamic control of food intake ................................................................... 36 1.5 The mesocorticolimbic system ..................................................................................... 37 1.5.1 Dopamine ...................................................................................................................... 38 1.5.2 Dopamine receptors ..................................................................................................... 38 1.5.3 Dopaminergic pathways ............................................................................................... 39 1.5.4 The nucleus accumbens ................................................................................................ 40 1.5.5 The amygdala ................................................................................................................ 43 1.5.6 The ventral pallidum ..................................................................................................... 43

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