Current perspectives on acid-sensing ion channels: new advances and therapeutic implications

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Expert Review of Clinical Pharmacology

• Publication date

  2010-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1586/ecp.10.13PMID 22111614
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The Aminoglycosides Modulate the Acid-Sensing Ionic Channel Currents in Dorsal Root Ganglion Neurons from the Rat

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• Psalmotoxin-1 Docking to Human Acid-sensing Ion Channel-1*

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• An acid-sensing channel sows fear and panic.

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• Identification of Protein Domains That Control Proton and Calcium Sensitivity of ASIC1a*

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• Native and recombinant ASIC1a receptors conduct negligible Ca2+ entry.

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• ASIC2 Subunits Target Acid-Sensing Ion Channels to the Synapse via an Association with PSD-95

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• Conformational sampling on acid-sensing ion channel 1 (ASIC1): implication for a symmetric conformation

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• Acid-Sensing Ion Channel-1a in the Amygdala, a Novel Therapeutic Target in Depression-Related Behavior

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• The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior.

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• Asic3−/− Female Mice with Hearing Deficit Affects Social Development of Pups

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• Structural Elements for the Generation of Sustained Currents by the Acid Pain Sensor ASIC3*

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• Acid-sensing ion channel 3 expression in mouse knee joint afferents and effects of carrageenan-induced arthritis.

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• Acid-sensing ion channel 3 in retinal function and survival.

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• Sour Ageusia in Two Individuals Implicates Ion Channels of the ASIC and PKD Families in Human Sour Taste Perception at the Anterior Tongue

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• Dynorphin Opioid Peptides Enhance Acid-Sensing Ion Channel 1a Activity and Acidosis-Induced Neuronal Death

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• Pore architecture and ion sites in acid sensing ion channels and P2X receptors

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• The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation.

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• Interaction of the Aromatics Tyr-72/Trp-288 in the Interface of the Extracellular and Transmembrane Domains Is Essential for Proton Gating of Acid-sensing Ion Channels

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• Acid increases inflammatory pain in rats: effect of local peripheral ASICs inhibitors.

  2009cited by this paper
• Functional TRP and ASIC-like channels in cultured urothelial cells from the rat.

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• Inherent Dynamics of the Acid-Sensing Ion Channel 1 Correlates with the Gating Mechanism

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• The Cytoskeletal Protein α-Actinin Regulates Acid-sensing Ion Channel 1a through a C-terminal Interaction

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• Hsc70 regulates cell surface ASIC2 expression and vascular smooth muscle cell migration.

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• Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism.

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• σ-1 Receptor Modulation of Acid-Sensing Ion Channel a (ASIC1a) and ASIC1a-Induced Ca2+ Influx in Rat Cortical Neurons

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• Differential effects of ASIC3 and TRPV1 deletion on gastroesophageal sensation in mice.

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• Seizure termination by acidosis depends on ASIC1a.

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• Increase of insulin sensitivity and reversal of age-dependent glucose intolerance with inhibition of ASIC3.

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• Enhanced muscle fatigue occurs in male but not female ASIC3-/- mice.

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• ASIC3, a sensor of acidic and primary inflammatory pain

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• ASIC proteins regulate smooth muscle cell migration.

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• Restoring Acid-Sensing Ion Channel-1a in the Amygdala of Knock-Out Mice Rescues Fear Memory But Not Unconditioned Fear Responses

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• Functional characterization of acid-sensing ion channels in cultured neurons of rat inferior colliculus.

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• Endogenous Arginine-Phenylalanine-Amide-related Peptides Alter Steady-state Desensitization of ASIC1a*

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• A new trick for an old dogma: ENaC proteins as mechanotransducers in vascular smooth muscle.

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• Acid Sensing Ion Channels in Dorsal Spinal Cord Neurons

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  2007cited by this paper
• Modulation of Acid-Sensing Ion Channel Activity by Nitric Oxide

  2007cited by this paper
• Subunit‐dependent cadmium and nickel inhibition of acid‐sensing ion channels

  2007cited by this paper
• A Kinase-anchoring Protein 150 and Calcineurin Are Involved in Regulation of Acid-sensing Ion Channels ASIC1a and ASIC2a*

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• Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH.

  2007cited by this paper
• A tarantula peptide against pain via ASIC1a channels and opioid mechanisms

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• High density SNP association study of a major autism linkage region on chromosome 17.

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• Targeting ASIC1a reduces innate fear and alters neuronal activity in the fear circuit.

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• Arachidonic acid potentiates acid-sensing ion channels in rat sensory neurons by a direct action.

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• ODULATION OF ACID-SENSING ION CHANNELS BY Cu 2 IN ULTURED HYPOTHALAMIC NEURONS OF THE RAT

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• Nafamostat mesilate reversibly blocks acid-sensing ion channel currents.

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  2018cites this paper
• Up-regulation of ASIC3 expression by β-estradiol.

  2018cites this paper
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• Pharmacology of acid-sensing ion channels - Physiological and therapeutical perspectives.

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• ION CHANNELS

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• CATALYTIC RECEPTORS

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• Guide to Receptors and Channels (GRAC), 5th edition

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• ENZYMES

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• TRANSPORTERS

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• Consultants

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