The Hippo Pathway Is Activated and Is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Circulation Research

• Publication date

  2014-01-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCRESAHA.114.302810PMID 24276085PMCID PMC3946717
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors.

  2013cited by this paper
• Beyond cell adhesion: the role of armadillo proteins in the heart.

  2013cited by this paper
• Desmosome assembly and dynamics.

  2013influential reference
• Hippo pathway effector Yap promotes cardiac regeneration

  2013cited by this paper
• Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy.

  2013cited by this paper
• Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos.

  2013cited by this paper
• Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2.

  2013cited by this paper
• Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity.

  2013cited by this paper
• SOX2 regulates YAP1 to maintain stemness and determine cell fate in the osteo-adipo lineage.

  2013cited by this paper
• The regulation of cell size.

  2013cited by this paper
• Molecular Insights into Arrhythmogenic Right Ventricular Cardiomyopathy Caused by Plakophilin-2 Missense Mutations

  2012cited by this paper
• Merlin: a tumour suppressor with functions at the cell cortex and in the nucleus

  2012influential reference
• Wnt/β-catenin signaling and disease.

  2012cited by this paper
• Merlin, a multi‐suppressor from cell membrane to the nucleus

  2012influential reference
• Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.

  2012cited by this paper
• Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

  2012cited by this paper
• Loss of Cadherin-Binding Proteins β-Catenin and Plakoglobin in the Heart Leads to Gap Junction Remodeling and Arrhythmogenesis

  2012influential reference
• Hippo signaling goes long range.

  2012cited by this paper
• Intercalated disc abnormalities, reduced Na(+) current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes.

  2012cited by this paper
• Abstract 18430: Human Molecular Genetic and Functional Studies Identify TRIM63, Encoding Muscle RING Finger Protein 1, as a Novel Gene for Human Hypertrophic Cardiomyopathy

  2012cited by this paper
• Hippo–YAP and mTOR pathways collaborate to regulate organ size

  2012cited by this paper
• YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy

  2012cited by this paper
• Usefulness of immunostaining for plakoglobin as a diagnostic marker of arrhythmogenic right ventricular cardiomyopathy.

  2012cited by this paper
• Merlin-deficient human tumors show loss of contact inhibition and activation of Wnt/β-catenin signaling linked to the PDGFR/Src and Rac/PAK pathways.

  2011cited by this paper
• Nuclear Plakoglobin Is Essential for Differentiation of Cardiac Progenitor Cells to Adipocytes in Arrhythmogenic Right Ventricular Cardiomyopathy

  2011cited by this paper
• Arrhythmogenic right ventricular cardiomyopathy

  2011cited by this paper
• Multistep phosphorylation by oncogenic kinases enhances the degradation of the NF2 tumor suppressor merlin.

  2011cited by this paper
• Cell-cell junctions: α-catenin and E-cadherin help fence in Yap1.

  2011cited by this paper
• Regulation of Insulin-Like Growth Factor Signaling by Yap Governs Cardiomyocyte Proliferation and Embryonic Heart Size

  2011cited by this paper
• The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster.

  2011cited by this paper
• E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components

  2011cited by this paper
• Molecular Genetics and Pathogenesis of Arrhythmogenic Right Ventricular Cardiomyopathy: A Disease of Cardiac Stem Cells

  2011cited by this paper
• The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

  2011cited by this paper
• Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

  2011cited by this paper
• The WW domain protein Kibra acts upstream of Hippo in Drosophila.

  2010cited by this paper
• Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations

  2010cited by this paper
• Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: Proposed Modification of the Task Force Criteria

  2010cited by this paper
• The Cardiac Desmosome and Arrhythmogenic Cardiomyopathies: From Gene to Disease

  2010cited by this paper
• Plakoglobin has both structural and signalling roles in zebrafish development.

  2009cited by this paper
• A study on the interactions between heparan sulfate proteoglycans and Wnt proteins

  2009cited by this paper
• Genetic Fate Mapping Identifies Second Heart Field Progenitor Cells As a Source of Adipocytes in Arrhythmogenic Right Ventricular Cardiomyopathy

  2009cited by this paper
• The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth

  2009cited by this paper
• Arrhythmogenic right ventricular cardiomyopathy

  2009cited by this paper
• Lats2 Is a Negative Regulator of Myocyte Size in the Heart

  2008cited by this paper
• A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy.

  2008cited by this paper
• Plakophilin 2: a critical scaffold for PKC (cid:2) that regulates intercellular junction assembly

  2008influential reference
• The area composita of adhering junctions connecting heart muscle cells of vertebrates. VI. Different precursor structures in non-mammalian species.

  2008cited by this paper
• Differential interactions of thin filament proteins in two cardiac troponin T mouse models of hypertrophic and dilated cardiomyopathies.

  2008cited by this paper
• Plakophilin 2: a critical scaffold for PKCα that regulates intercellular junction assembly

  2008cited by this paper
• Clinical Features of Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Associated With Mutations in Plakophilin-2

  2006cited by this paper
• Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy.

  2006cited by this paper
• Phosphate-binding Tag, a New Tool to Visualize Phosphorylated Proteins*S

  2006cited by this paper
• The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins.

  2006cited by this paper
• Phosphorylation of neurofibromin by PKC is a possible molecular switch in EGF receptor signaling in neural cells

  2005cited by this paper
• Erbin Regulates Mitogen-activated Protein (MAP) Kinase Activation and MAP Kinase-dependent Interactions between Merlin and Adherens Junction Protein Complexes in Schwann Cells*

  2005cited by this paper
• The Phosphorylation status of merlin is important for regulating the Ras-ERK pathway.

  2005influential reference
• Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy

  2004cited by this paper
• What is known

  2003cited by this paper
• NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions.

  2003cited by this paper
• Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease).

  2000cited by this paper
• Arrhythmogenic right ventricular cardiomyopathy and fatty replacement of the right ventricular myocardium: are they different diseases?

  1998cited by this paper
• Spectrum of clinicopathologic manifestations of arrhythmogenic right ventricular cardiomyopathy/dysplasia: a multicenter study.

  1997cited by this paper
• Arrhythmogenic right ventricular cardiomyopathy. Dysplasia, dystrophy, or myocarditis?

  1996cited by this paper
• Overlapping positive and negative regulatory elements determine lens-specific activity of the delta 1-crystallin enhancer

  1993cited by this paper

• Molecular Pathology of Cardiomyopathies: Bridging Morphology, Genomics, and Clinical Phenotypes

  2026cites this paper
• Genetic Animal Models of Cardiovascular Pathologies

  2025cites this paper
• Advances in arrhythmogenic cardiomyopathy modeling using hiPSC-based models.

  2025cites this paper
• Genomic and molecular evidence that the lncRNA DSP-AS1 modulates Desmoplakin expression

  2025cites this paper
• Cardiomyocyte-specific plakophilin-2 loss is sufficient to induce aging and senescence of nonmyocytes. Relevance to arrhythmogenic cardiomyopathy

  2025cites this paper
• Alterations in the Hippo Signaling Pathway During Adenogenesis Impairment in Postnatal Mouse Uterus

  2025cites this paper
• Genomic and molecular evidence that the LncRNA DSP-AS1 modulates desmoplakin expression

  2025cites this paper
• p21‐Activated Kinase 1 (Pak1) as an Element in Functional and Dysfunctional Interplay Among the Myocardium, Adipose Tissue, and Pancreatic Beta Cells

  2025cites this paper
• Transmembrane Protein 43: Molecular and Pathogenetic Implications in Arrhythmogenic Cardiomyopathy and Various Other Diseases

  2025cites this paper
• Tailored therapeutics for cardiomyopathies

  2025cites this paper
• Genetic Implications of Fatty Tissue for the Development of Ventricular Arrhythmias

  2025cites this paper
• Cardiomyocyte cytosolic nuclear self-DNA contributes to the pathogenesis of desmoplakin cardiomyopathy

  2025cites this paper
• Naxos Disease and Related Cardio-Cutaneous Syndromes

  2025cites this paper
• Uncovering dendritic cell specific biomarkers for diagnosis and prognosis of cardiomyopathy using single cell RNA sequencing and comprehensive bioinformatics analysis

  2025cites this paper
• Desmoplakin loss leads to PKC-dependent insertion of series sarcomeres and contractile dysfunction in cardiomyocytes

  2025cites this paper
• Exercise in Inherited Cardiomyopathies: Optimizing the Dose-Response Curve.

  2025cites this paper
• Arrhythmogenic cardiomyopathy in children, on the link between injurious mutations and inflammation: Two case reports and review of the literature

  2025cites this paper
• Givinostat inhibits in vitro differentiation of cardiac fibroadipogenic precursors from a mouse model of arrhythmogenic cardiomyopathy.

  2025cites this paper
• Maintenance of Energy Metabolism Is an Integral Part of Plakophilin-2 and Desmosome Functions

  2025cites this paper
• The relationship between sperm secretion and the Hippo signaling pathway in the rat seminiferous tubules

  2025cites this paper
• Molecular Pathogenesis of Arrhythmogenic Cardiomyopathy: Mechanisms and Therapeutic Perspectives

  2025influential citation
• Fubylation as a Druggable Ubiquitin-Like Conjugation System Controlling Hippo Pathway Activity

  2025cites this paper
• In Vivo Approaches to Understand Arrhythmogenic Cardiomyopathy: Perspectives on Animal Models

  2024cites this paper
• Hippo pathway activation causes multiple lipid derangements in a murine model of cardiomyopathy.

  2024cites this paper
• Coupling of β-adrenergic and Hippo pathway signaling: Implications for heart failure pathophysiology and metabolic therapy.

  2024cites this paper
• Role of miRNA–mRNA Interactome in Pathophysiology of Arrhythmogenic Cardiomyopathy

  2024cites this paper
• Molecular Pathways and Animal Models of Arrhythmias.

  2024cites this paper
• AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy

  2024cites this paper
• The role of fibrosis in cardiomyopathies: an opportunity to develop novel biomarkers of disease activity.

  2024cites this paper
• The Hippo-YAP Signaling Pathway in Osteoarthritis and Rheumatoid Arthritis

  2024cites this paper
• Interleukin-1β Drives Disease Progression in Arrhythmogenic Cardiomyopathy

  2024cites this paper
• The Multifaceted Roles of Hippo-YAP in Cardiovascular Diseases

  2024cites this paper
• Animal Models and Molecular Pathogenesis of Arrhythmogenic Cardiomyopathy Associated with Pathogenic Variants in Intercalated Disc Genes

  2024influential citation
• cAMP: A master regulator of cadherin‐mediated binding in endothelium, epithelium and myocardium

  2023cites this paper
• Arrhythmogenic Cardiomyopathy: from Preclinical Models to Genotype–phenotype Correlation and Pathophysiology

  2023cites this paper
• Role of MicroRNAs in Arrhythmogenic Cardiomyopathy: translation as biomarkers into clinical practice.

  2023cites this paper
• Desmosomes in Cell Fate Determination: From Cardiogenesis to Cardiomyopathy

  2023cites this paper
• Emerging Signaling Regulation of Sinoatrial Node Dysfunction

  2023cites this paper
• Genetic inactivation of β-catenin is salubrious whereas its activation is deleterious in desmoplakin cardiomyopathy.

  2023cites this paper
• A novel DSP zebrafish model reveals training- and drug-induced modulation of arrhythmogenic cardiomyopathy phenotypes

  2023cites this paper
• Evaluation of Coenzyme Q10 (CoQ10) Deficiency and Therapy in Mouse Models of Cardiomyopathy

  2023cites this paper
• Yes-Associated Protein and Transcriptional Coactivator with PDZ-Binding Motif in Cardiovascular Diseases

  2023cites this paper
• Using Zebrafish Animal Model to Study the Genetic Underpinning and Mechanism of Arrhythmogenic Cardiomyopathy

  2023cites this paper
• Arrhythmogenic cardiomyopathy as a myogenic disease: highlights from cardiomyocytes derived from human induced pluripotent stem cells

  2023influential citation
• Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization

  2023cites this paper
• PITX2 induction leads to impaired cardiomyocyte function in arrhythmogenic cardiomyopathy

  2023cites this paper
• Genetic Inactivation of β-Catenin Attenuates and Its Activation Aggravates Desmoplakin Cardiomyopathy

  2023cites this paper
• Desmosomal protein degradation as an underlying cause of arrhythmogenic cardiomyopathy

  2023influential citation
• Leucocyte-derived micro-RNAs as candidate biomarkers in Brugada syndrome

  2023cites this paper
• Mitochondrial damage in a Takotsubo syndrome-like mouse model mediated by activation of b-adrenoceptor-Hippo signaling pathway.

  2023cites this paper
• Omics Analyses of Stromal Cells from ACM Patients Reveal Alterations in Chromatin Organization and Mitochondrial Homeostasis

  2023cites this paper
• Alterations in Calcium Handling Are a Common Feature in an Arrhythmogenic Cardiomyopathy Cell Model Triggered by Desmosome Genes Loss

  2023influential citation
• The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes.

  2023cites this paper
• The role of β-catenin in cardiac diseases

  2023cites this paper
• The hippo kinases MST1/2 in cardiovascular and metabolic diseases: A promising therapeutic target option for pharmacotherapy

  2023cites this paper
• Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence

  2023cites this paper
• The Hippo signalling pathway and its implications in human health and diseases

  2022cites this paper
• The Regulation of the Hippo Pathway by Intercellular Junction Proteins

  2022cites this paper
• Hippo-Yap Signaling Maintains Sinoatrial Node Homeostasis

  2022cites this paper
• Non Coding RNAs as Regulators of Wnt/β-Catenin and Hippo Pathways in Arrhythmogenic Cardiomyopathy

  2022influential citation
• The role of YAP in the control of the metastatic potential of oral cancer

  2022cites this paper
• Humanized Dsp ACM Mouse Model Displays Stress-Induced Cardiac Electrical and Structural Phenotypes

  2022cites this paper
• PANoptosis is a prominent feature of desmoplakin cardiomyopathy

  2022cites this paper
• YAP Inhibition by Verteporfin Causes Downregulation of Desmosomal Genes and Proteins Leading to the Disintegration of Intercellular Junctions

  2022cites this paper
• Spatial transcriptomics unveils ZBTB11 as a regulator of cardiomyocyte degeneration in arrhythmogenic cardiomyopathy

  2022cites this paper
• Transcriptomic Analysis of Dysregulated Genes of the nDNA-mtDNA Axis in a Mouse Model of Dilated Cardiomyopathy

  2022cites this paper
• Fibro-fatty remodelling in arrhythmogenic cardiomyopathy

  2022cites this paper
• Arrhythmogenic Right Ventricular Cardiomyopathy.

  2022cites this paper
• Activation of PDGFRA signaling contributes to filamin C–related arrhythmogenic cardiomyopathy

  2022influential citation
• Dominant Myocardial Fibrosis and Complex Immune Microenvironment Jointly Shape the Pathogenesis of Arrhythmogenic Right Ventricular Cardiomyopathy

  2022cites this paper
• The WNT/β-catenin pathway regulates expression of the genes involved in cell cycle progression and mitochondrial oxidative phosphorylation in the postmitotic cardiac myocytes

  2022cites this paper
• Structure and regulation of desmosomes in intercalated discs: Lessons from epithelia

  2022cites this paper
• Hippo signaling in cardiac fibroblasts during development, tissue repair, and fibrosis.

  2022cites this paper
• The Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response

  2022cites this paper
• The role of the Hippo pathway in autophagy in the heart.

  2022cites this paper
• Some Insights into the Regulation of Cardiac Physiology and Pathology by the Hippo Pathway

  2022cites this paper
• Depletion of VGLL4 Causes Perinatal Lethality without Affecting Myocardial Development

  2022cites this paper
• Focusing on Mechanoregulation Axis in Fibrosis: Sensing, Transduction and Effecting

  2022cites this paper
• Analysis of buccal mucosa as a prognostic tool in children with arrhythmogenic cardiomyopathy

  2021cites this paper
• Sympatho-adrenergic mechanisms in heart failure: new insights into pathophysiology

  2021cites this paper
• Circulating miR-185-5p as a Potential Biomarker for Arrhythmogenic Right Ventricular Cardiomyopathy

  2021cites this paper
• Continuous live imaging reveals a subtle pathological alteration with cell behaviors in congenital heart malformation

  2021cites this paper
• Arrhythmogenic Cardiomyopathy.

  2021influential citation
• Transcriptomic Coupling of PKP2 With Inflammatory and Immune Pathways Endogenous to Adult Cardiac Myocytes

  2021cites this paper
• Desmosomes as Signaling Hubs in the Regulation of Cell Behavior

  2021cites this paper
• Facts and Gaps in Exercise Influence on Arrhythmogenic Cardiomyopathy: New Insights From a Meta-Analysis Approach

  2021cites this paper
• Inflammation in the Pathogenesis of Arrhythmogenic Cardiomyopathy: Secondary Event or Active Driver?

  2021cites this paper
• Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization

  2021cites this paper
• Insights Into Genetics and Pathophysiology of Arrhythmogenic Cardiomyopathy

  2021cites this paper
• Activation of Hippo signaling pathway mediates mitochondria dysfunction and dilated cardiomyopathy in mice

  2021cites this paper
• Epicardial differentiation drives fibro-fatty remodeling in arrhythmogenic cardiomyopathy

  2021cites this paper
• Oxidized LDL‐dependent pathway as new pathogenic trigger in arrhythmogenic cardiomyopathy

  2021cites this paper
• Desmoplakin and clinical manifestations of desmoplakin cardiomyopathy

  2021cites this paper
• Pharmacological suppression of the WNT signaling pathway attenuates age-dependent expression of the phenotype in a mouse model of arrhythmogenic cardiomyopathy

  2021cites this paper
• The Emerging Role of Epigenetics in Therapeutic Targeting of Cardiomyopathies

  2021cites this paper
• Vinclozolin-induced mouse penile malformation and "small testis" via miR132, miR195a together with the Hippo signaling pathway.

  2021cites this paper
• Oxidative Stress-Mediated YAP Dysregulation Contributes to the Pathogenesis of Pemphigus Vulgaris

  2021cites this paper
• The Role of Galectin-3 in the Pathogenesis of Arrhythmogenic Cardiomyopathy - It's Complicated.

  2021cites this paper
• The genetic architecture of Plakophilin 2 cardiomyopathy

  2021cites this paper
• Arrhythmogenic Cardiomyopathy: Mechanisms, Genetics, and Their Clinical Implications

  2021cites this paper