Lowering Plasma Cholesterol Levels Halts Progression of Aortic Valve Disease in Mice

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Circulation

• Publication date

  2009-05-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCULATIONAHA.108.834614PMID 19433756PMCID PMC2740986
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rapid regression of atherosclerosis: insights from the clinical and experimental literature

  2008cited by this paper
• Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans.

  2008cited by this paper
• Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells.

  2008cited by this paper
• Transglutaminase 2 Is Central to Induction of the Arterial Calcification Program by Smooth Muscle Cells

  2008cited by this paper
• Oxidative Stress Induces Vascular Calcification through Modulation of the Osteogenic Transcription Factor Runx2 by AKT Signaling*

  2008cited by this paper
• Transcription factors controlling osteoblastogenesis.

  2008cited by this paper
• Oxidant Generation Predominates Around Calcifying Foci and Enhances Progression of Aortic Valve Calcification

  2008cited by this paper
• The molecular mechanisms of the thrombotic complications of atherosclerosis

  2008cited by this paper
• Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis.

  2008cited by this paper
• Vascular Bmp–Msx2–Wnt Signaling and Oxidative Stress in Arterial Calcification

  2007cited by this paper
• Runx2 Represses Myocardin-Mediated Differentiation and Facilitates Osteogenic Conversion of Vascular Smooth Muscle Cells

  2007cited by this paper
• AP-1 stimulates the cathepsin K promoter in RAW 264.7 cells.

  2007cited by this paper
• Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis.

  2007cited by this paper
• Deficiency of Glutathione Peroxidase-1 Accelerates the Progression of Atherosclerosis in Apolipoprotein E-Deficient Mice

  2007cited by this paper
• Aortic Valve Calcification: Determinants and Progression in the Population

  2007cited by this paper
• Abstract 3707: A Novel Role of the Sympatho-Adrenergic System in Regulating Valve Calcification

  2006cited by this paper
• A high fat/high carbohydrate diet induces aortic valve disease in C57BL/6J mice.

  2006cited by this paper
• Coronary atherosclerosis can regress with very intensive statin therapy.

  2006cited by this paper
• Possible role for mast cell-derived cathepsin G in the adverse remodelling of stenotic aortic valves.

  2006cited by this paper
• The complex pattern of SMAD signaling in the cardiovascular system.

  2006cited by this paper
• Calcific Aortic Valve Stenosis in Old Hypercholesterolemic Mice

  2006cited by this paper
• Atorvastatin inhibits calcification and enhances nitric oxide synthase production in the hypercholesterolaemic aortic valve

  2005cited by this paper
• Age-associated aortic stenosis in apolipoprotein E-deficient mice.

  2005cited by this paper
• Reactive Oxygen Species Stimulates Receptor Activator of NF-κB Ligand Expression in Osteoblast*

  2005cited by this paper
• A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis.

  2005cited by this paper
• Non-lipid effects of statins: emerging new indications.

  2004cited by this paper
• The selective peroxisomal proliferator-activated receptor-gamma agonist has an additive effect on plaque regression in combination with simvastatin in experimental atherosclerosis: in vivo study by high-resolution magnetic resonance imaging.

  2004cited by this paper
• Expression and activity of matrix metalloproteinase-2 in calcific aortic stenosis

  2004cited by this paper
• Statins but Not Angiotensin-Converting Enzyme Inhibitors Delay Progression of Aortic Stenosis

  2004cited by this paper
• Multilineage Potential of Cells From the Artery Wall

  2003cited by this paper
• Human Aortic Valve Calcification Is Associated With an Osteoblast Phenotype

  2003cited by this paper
• Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis.

  2003cited by this paper
• Evidence for an altered balance between matrix metalloproteinase-9 and its inhibitors in calcific aortic stenosis.

  2003cited by this paper
• Eliminating Atherogenesis in Mice by Switching Off Hepatic Lipoprotein Secretion

  2003cited by this paper
• Microsomal triglyceride transfer protein and its role in apoB-lipoprotein assembly Published, JLR Papers in Press, September 16, 2002. DOI 10.1194/jlr.R200014-JLR200

  2003cited by this paper
• Simvastatin Reduces Neointimal Thickening in Low-Density Lipoprotein Receptor–Deficient Mice After Experimental Angioplasty Without Changing Plasma Lipids

  2002cited by this paper
• HMG CoA reductase inhibitor (statin) and aortic valve calcium.

  2002cited by this paper
• Regression of Atherosclerosis in Monkeys Reduces Vascular Superoxide Levels

  2002cited by this paper
• Monocyte/Macrophage Regulation of Vascular Calcification In Vitro

  2002cited by this paper
• Atorvastatin Inhibits Hypercholesterolemia-Induced Cellular Proliferation and Bone Matrix Production in the Rabbit Aortic Valve

  2002cited by this paper
• Matrix metalloproteinase-2 is associated with tenascin-C in calcific aortic stenosis.

  2001cited by this paper
• The development of calcium deposits in atherosclerotic lesions and their persistence after lipid regression.

  2001cited by this paper
• Effect of Hydroxymethylglutaryl Coenzyme A Reductase Inhibitors on the Progression of Calcific Aortic Stenosis

  2001cited by this paper
• p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice.

  2001cited by this paper
• Oxidative stress modulates osteoblastic differentiation of vascular and bone cells.

  2001cited by this paper
• ACC/AHA Guidelines for the Management of Patients With Valvular Heart Disease. Executive Summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Valvular Heart Disease).

  1998cited by this paper
• Functional improvement precedes structural regression of atherosclerosis.

  1994cited by this paper
• Characterization of the Early Lesion of ‘Degenerative’ Valvular Aortic Stenosis: Histological and Immunohistochemical Studies

  1994cited by this paper
• Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis.

  1987cited by this paper

• Preclinical Mouse Models in Calcific Aortic Valve Disease: Bridging Pathophysiology and Therapeutic Innovation

  2026cites this paper
• Anti‐Malondialdehyde Low‐Density Lipoprotein Antibodies and Valvular Calcification: A Substudy of the SCOT‐HEART Trial

  2025cites this paper
• Unraveling the Link Between Aortic Stenosis and Atherosclerosis: What Have We Learned?

  2025cites this paper
• Insights into preclinical models of calcific aortic valve disease and their translational potential

  2025cites this paper
• Deciphering the Enigma of Calcific Aortic Valve Disease: The Pivotal Role of Animal Models in Unraveling Pathogenesis and Advancing Therapeutic Strategies

  2025cites this paper
• Combined Raman Microscopy and Transmission Electron Microscopy shows the co-existence of whitlockite crystals and carbonated hydroxyapatite-mineralized collagen fibrils in human calcified aortic valves

  2025cites this paper
• Mechanistic Insights into Bioprosthetic Heart Valve Calcification and Anti-Calcification Strategies

  2025cites this paper
• Targeted proteomics reveals immune protein patterns in serum from patients with calcific aortic stenosis

  2025cites this paper
• Large-Scale Proteomics Identifies Novel Biomarkers and Circulating Risk Factors for Aortic Stenosis.

  2024cites this paper
• Large vessel occlusion mediated fluid attenuated inversion recovery signal intensity ratio is associated with stroke within 4.5 h

  2024cites this paper
• Statin treatment after surgical aortic valve replacement for aortic stenosis is associated with better long-term outcome

  2024cites this paper
• AVCAPIR: A Novel Procalcific PIWI-Interacting RNA in Calcific Aortic Valve Disease

  2024cites this paper
• 3D histopathology of stenotic aortic valve cusps using ex vivo microfocus computed tomography

  2023cites this paper
• X-ray-Based 3D Histology of Murine Hearts Using Contrast-Enhanced Microfocus Computed Tomography (CECT) and Cryo-CECT

  2023cites this paper
• Myofibroblasts: A New Factor Affecting the Hyperlipidemia-Induced Elastic Abnormality of Corpus Cavernosum in Rabbits Detected by 2-D Shear Wave Elastography.

  2023cites this paper
• Reduced Proteolytic Cleavage of von Willebrand Factor Leads to Aortic Valve Stenosis and Load-Dependent Ventricular Remodeling

  2022cites this paper
• Innate immune cells in the pathophysiology of calcific aortic valve disease: lessons to be learned from atherosclerotic cardiovascular disease?

  2022cites this paper
• Multiparametric MRI identifies subtle adaptations for demarcation of disease transition in murine aortic valve stenosis

  2022cites this paper
• Models and Techniques to Study Aortic Valve Calcification in Vitro, ex Vivo and in Vivo. An Overview

  2022cites this paper
• Development and validation of a new prediction model for calcific aortic valve stenosis

  2022cites this paper
• Contribution of Oxidative Stress (OS) in Calcific Aortic Valve Disease (CAVD): From Pathophysiology to Therapeutic Targets

  2022cites this paper
• Role of oxidative stress in calcific aortic valve disease and its therapeutic implications

  2021cites this paper
• Calcific Aortic Stenosis—A Review on Acquired Mechanisms of the Disease and Treatments

  2021cites this paper
• Genetic and Developmental Contributors to Aortic Stenosis

  2021cites this paper
• Optical coherence tomography and multiphoton microscopy offer new options for the quantification of fibrotic aortic valve disease in ApoE−/− mice

  2021cites this paper
• Drugs for prevention and treatment of aortic stenosis: how close are we?

  2021cites this paper
• Preventing Aortic Stenosis by Changing the Way We Think About an Old Disease.

  2020cites this paper
• Platelet Membrane-Coated Nanoparticles Target Sclerotic Aortic Valves in ApoE−/− Mice by Multiple Binding Mechanisms Under Pathological Shear Stress

  2020cites this paper
• NFκB (Nuclear Factor κ-Light-Chain Enhancer of Activated B Cells) Activity Regulates Cell-Type–Specific and Context-Specific Susceptibility to Calcification in the Aortic Valve

  2020cites this paper
• Prevalence and risk factors of aortic stenosis and aortic sclerosis: a 21-year follow-up of middle-aged men

  2020cites this paper
• Nuclear and Molecular Imaging Modalities for Predicting Calcific Aortic Valve Disease Progression in Animal Models

  2020cites this paper
• Cholesterol (Blood lipid) lowering potential of Rosuvastatin chitosan nanoparticles for atherosclerosis: Preclinical study in rabbit model.

  2020cites this paper
• Omega-3 Polyunsaturated Fatty Acids Decrease Aortic Valve Disease Through the Resolvin E1 and ChemR23 Axis

  2020cites this paper
• Characterizing valve dynamics in mice by high‐resolution cine‐MRI

  2019influential citation
• I-κB kinase-ε knockout protects against angiotensin II induced aortic valve thickening in apolipoprotein E deficient mice.

  2019cites this paper
• Adaptive Immune Cells in Calcific Aortic Valve Disease.

  2019cites this paper
• Short‐term LPS induces aortic valve thickening in ApoE*3Leiden mice

  2019cites this paper
• [Galectin-3 as a novel biotarget in cardiovascular alterations associated to development of severe aortic stenosis].

  2019cites this paper
• Celastrol Alleviates Aortic Valve Calcification Via Inhibition of NADPH Oxidase 2 in Valvular Interstitial Cells

  2019cites this paper
• Characterization of sex differences in aortic valve disease in mice

  2019influential citation
• Interactive and Multifactorial Mechanisms of Calcific Vascular and Valvular Disease.

  2019cites this paper
• MG53 Protein Protects Aortic Valve Interstitial Cells From Membrane Injury and Fibrocalcific Remodeling

  2019cites this paper
• Novel pharmacological targets for calcific aortic valve disease: Prevention and treatments

  2018cites this paper
• Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges

  2018cites this paper
• The Genetic Regulation of Aortic Valve Development and Calcific Disease

  2018cites this paper
• Discovery of an Experimental Model of Unicuspid Aortic Valve

  2018cites this paper
• Valvular Heart Disease

  2018cites this paper
• Increased Calcific Aortic Valve Disease in response to a diabetogenic, procalcific diet in the LDLr-/-ApoB100/100 mouse model.

  2018cites this paper
• MICRO-/NANOTECHNOLOGIES TO ENGINEER MICROENVIRONMENTAL CUES FOR REGENERATIVE HEART VALVE THERAPIES

  2018cites this paper
• Osteocardiology: Calcific Aortic Valve Disease

  2018cites this paper
• Nouveaux marqueurs pronostiques dans la sténose aortique à bas débit

  2017cites this paper
• Pathophysiology of Aortic Stenosis and Mitral Regurgitation.

  2017cites this paper
• Effect Modifications of Lipid-Lowering Therapy on Progression of Aortic Stenosis (from the Simvastatin and Ezetimibe in Aortic Stenosis [SEAS] Study).

  2017cites this paper
• Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice

  2017cites this paper
• Epidemiological aspects of aortic stenosis

  2017cites this paper
• Histopathological assessment of calcification and inflammation of calcific aortic valves from patients with and without diabetes mellitus.

  2017cites this paper
• Shape-Specific Nanoceria Mitigate Oxidative Stress-Induced Calcification in Primary Human Valvular Interstitial Cell Culture

  2017cites this paper
• Rheumatic Mineralization of Aortic Valve and Anterior Mitral Leaflet—A Case Report

  2017cites this paper
• 7 Calcific Aortic Valve Disease

  2017cites this paper
• Oxidative Stress in Cardiac Valve Development

  2017cites this paper
• Estenosis aórtica severa en la vida real. Determinantes del manejo y pronóstico

  2017cites this paper
• Association Between Cardiovascular Risk Factors and Aortic Stenosis: The CANHEART Aortic Stenosis Study.

  2017cites this paper
• Pathophysiology of Aortic Valve Stenosis: Is It Both Fibrocalcific and Sex Specific?

  2017cites this paper
• Wnt signaling pathway in cardiac fibrosis: New insights and directions.

  2016cites this paper
• Valve Endothelial Cell–Derived Tgf&bgr;1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification

  2016cites this paper
• Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice

  2016cites this paper
• Experimental Animal Models Evaluating the Causal Role of Lipoprotein(a) in Atherosclerosis and Aortic Stenosis

  2016cites this paper
• Role for Galectin‐3 in Calcific Aortic Valve Stenosis

  2016cites this paper
• Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts

  2016cites this paper
• Lipoprotein(a) and oxidized phospholipids in calcific aortic valve stenosis

  2016cites this paper
• Influence of aortic valve leaflet calcification on dynamic aortic valve motion assessed by cardiac computed tomography.

  2016cites this paper
• Microarray analyses to quantify advantages of 2D and 3D hydrogel culture systems in maintaining the native valvular interstitial cell phenotype.

  2016cites this paper
• Calcific Aortic Valve Disease: Part 1—Molecular Pathogenetic Aspects, Hemodynamics, and Adaptive Feedbacks

  2016cites this paper
• Medical Treatment of Aortic Stenosis

  2016cites this paper
• Sélection in vivo par phage display dans un modèle de sténose valvulaire aortique chez la souris pour la découverte de nouveaux peptides ciblant la valve aortique

  2016influential citation
• Válvula aórtica bicúspide y aortopatía familiar

  2016cites this paper
• [Dystrophic Mineralization of Soft Tissues: Parallels in Formation of Dysfunctions of Cardiac Valves, Calcified Aortic Stenosis, and Atherosclerosis].

  2015cites this paper
• The role of Sox9 in heart valve maintenance and disease

  2015cites this paper
• Spontaneous Aortic Regurgitation and Valvular Cardiomyopathy in Mice

  2015cites this paper
• Mechanical and Matrix Regulation of Valvular Fibrosis

  2015cites this paper
• Role of serum high density lipoprotein levels and functions in calcific aortic valve stenosis progression.

  2015cites this paper
• Wave mice: a new tool in the quest to characterize aortic valvular disease etiologies.

  2015cites this paper
• BMP-2 and TGF-β1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells

  2015influential citation
• The lipid theory in the pathogenesis of calcific aortic stenosis.

  2015cites this paper
• Platelet activation and arterial peripheral serotonin turnover in cardiac remodeling associated to aortic stenosis

  2015cites this paper
• Calcific aortic valve disease: is it another face of atherosclerosis?

  2015cites this paper
• Carbonic anhydrase XII in valve interstitial cells promotes the regression of calcific aortic valve stenosis.

  2015cites this paper
• Early Development of Calcific Aortic Valve Disease and Left Ventricular Hypertrophy in a Mouse Model of Combined Dyslipidemia and Type 2 Diabetes Mellitus

  2014cites this paper
• Calcific and Degenerative Heart Valve Disease

  2014cites this paper
• Association Between Shear Stress and Platelet-Derived Transforming Growth Factor-&bgr;1 Release and Activation in Animal Models of Aortic Valve Stenosis

  2014cites this paper
• The platelet: sensing shear and the endocrine regulation of cardiovascular sclerosis.

  2014cites this paper
• Aortic valve sclerosis in mice deficient in endothelial nitric oxide synthase.

  2014cites this paper
• Mouse Models of Calcifi c Aortic Valve Disease

  2014cites this paper
• Carotid Plaque, Intima-Media Thickness, and Incident Aortic Stenosis: A Prospective Cohort Study

  2014cites this paper
• Mouse Models of Calcific Aortic Valve Disease

  2014cites this paper
• New therapeutic targets for calcific aortic valve stenosis: the lipoprotein(a)-lipoprotein-associated phospholipase A2-oxidized phospholipid axis.

  2014cites this paper
• Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis.

  2014cites this paper
• Valvular interstitial cell transformation : implications for aortic valve calcification

  2014cites this paper
• Decorin and biglycan retain LDL in disease-prone valvular and aortic subendothelial intimal matrix.

  2014cites this paper
• Pioglitazone Attenuates Valvular Calcification Induced by Hypercholesterolemia

  2013cites this paper