Plasma biomarkers of acute GVHD and nonrelapse mortality: predictive value of measurements before GVHD onset and treatment.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Blood

• Publication date

  2015-07-02

• Fields of study

  Medicine

• Identifiers
  DOI 10.1182/blood-2015-03-636753PMID 25987657PMCID PMC4492194
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A refined risk score for acute graft-versus-host disease that predicts response to initial therapy, survival, and transplant-related mortality.

  2015cited by this paper
• High day 28 ST2 levels predict for acute graft-versus-host disease and transplant-related mortality after cord blood transplantation.

  2015cited by this paper
• Composite end point of graft-versus-host disease-free, relapse-free survival after allogeneic hematopoietic cell transplantation.

  2015cited by this paper
• Circulating angiogenic factors associated with response and survival in patients with acute graft-versus-host disease: results from Blood and Marrow Transplant Clinical Trials Network 0302 and 0802.

  2015cited by this paper
• A prognostic score for acute graft-versus-host disease based on biomarkers: a multicentre study.

  2015cited by this paper
• Prognostic factors and outcomes of severe gastrointestinal graft-vs.-host disease after allogeneic hematopoietic cell transplantation

  2014cited by this paper
• Cytokine and chemokine patterns across 100 days after hematopoietic stem cell transplantation in children.

  2014cited by this paper
• Low Paneth cell numbers at onset of gastrointestinal graft-versus-host disease identify patients at high risk for nonrelapse mortality.

  2013influential reference
• Clinical Severity Scores in Gastrointestinal Graft-Versus-Host Disease

  2013cited by this paper
• A novel soluble form of Tim-3 associated with severe graft-versus-host disease.

  2013cited by this paper
• ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death.

  2013cited by this paper
• Steroid-refractory acute GVHD: lack of long-term improved survival using new generation anticytokine treatment.

  2012cited by this paper
• Evaluation of oral beclomethasone dipropionate for prevention of acute graft-versus-host disease.

  2012cited by this paper
• Fecal calprotectin and alpha-1 antitrypsin predict severity and response to corticosteroids in gastrointestinal graft-versus-host disease.

  2012cited by this paper
• Decreased serum albumin as a biomarker for severe acute graft-versus-host disease after reduced-intensity allogeneic hematopoietic cell transplantation.

  2011cited by this paper
• Discovery and validation of graft-versus-host disease biomarkers.

  2011cited by this paper
• Regenerating islet-derived 3-alpha is a biomarker of gastrointestinal graft-versus-host disease.

  2011cited by this paper
• Reduced mortality after allogeneic hematopoietic-cell transplantation.

  2010cited by this paper
• Initial therapy of acute graft-versus-host disease with low-dose prednisone does not compromise patient outcomes.

  2009cited by this paper
• Press Review

  2009cited by this paper
• Prolonged anorexia and elevated plasma cytokine levels following myeloablative allogeneic hematopoietic cell transplant

  2007cited by this paper
• Treatment of acute graft-versus-host disease with prednisolone: significant survival advantage for day +5 responders and no advantage for nonresponders receiving anti-thymocyte globulin.

  2006cited by this paper
• An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens.

  2006cited by this paper
• Prognostic value of apoptotic cells and infiltrating neutrophils in graft-versus-host disease of the gastrointestinal tract in humans: TNF and Fas expression.

  2004cited by this paper
• Graft-versus-host disease after nonmyeloablative versus conventional hematopoietic stem cell transplantation.

  2003cited by this paper
• 1994 Consensus Conference on Acute GVHD Grading.

  1995cited by this paper
• The diagnostic accuracy of the rectal biopsy in acute graft-versus-host disease: a prospective study of thirteen patients.

  1980influential reference

• Assessing the Clinical Performance of a Presymptomatic Acute Graft-Versus-Host Disease Biomarker Test in Hematopoietic Stem Cell Transplant Recipients.

  2026cites this paper
• Monitoring plasma regenerating islet‐derived 3α and citrulline levels during pediatric allogeneic hematopoietic stem cell transplantation to predict acute gastrointestinal graft‐versus‐host disease

  2025cites this paper
• Age-enhanced MAGIC algorithm predicts mortality in pediatric aGVHD: a multicenter study

  2025cites this paper
• Relevant biomarkers in acute graft-versus-host disease secondary to transplantation of hematopoietic stem cells.

  2025cites this paper
• A higher ratio of IL-2/IL-4 may be an early predictor of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

  2025cites this paper
• Predictive strategies for poor outcomes after allotransplantation in patients with acute myeloid leukemia: what are the options and when should clinicians use them?

  2025cites this paper
• Immune Monitoring after Cell Therapy and Hematopoietic Cell Transplantation: Guidelines by the ISCT Stem Cell Engineering Committee

  2025cites this paper
• Deep insight into cytokine storm: from pathogenesis to treatment

  2025cites this paper
• Clinical and molecular landscapes of steroid-refractory graft-versus-host disease following hematopoietic stem cell transplantation: a narrative review

  2025cites this paper
• Prediction and Prognostication of Acute Graft‐Versus‐Host Disease by MAGIC Biomarkers

  2025cites this paper
• Utilization of Clinical Data and Evaluation of Biomarkers in the Investigation of Graft-Versus-Host Disease Outcomes.

  2025cites this paper
• Bronchial structural changes analyzed with three-dimensional computed tomography correlate with severe acute graft-versus-host disease after allogenic hematopoietic stem cell transplantation

  2025cites this paper
• Soluble ST2 as a Predictive Biomarker for Acute Graft‐Versus‐Host Disease Post ‐Allogeneic Stem Cell Transplantation

  2025cites this paper
• Early inflammatory markers as prognostic indicators following allogeneic stem cell transplantation

  2024cites this paper
• Practical considerations of promising zone design for interim sample size Re-estimation: An application to GRAPHITE for graft vs host disease.

  2024cites this paper
• Two machine learning-derived nomogram for predicting the occurrence and severity of acute graft-versus-host disease: a retrospective study based on serum biomarkers

  2024cites this paper
• Serum 5-S-cysteinyldopa as a predictive biomarker for stem cell transplantation-related complications in children and young adults

  2024cites this paper
• ST2 and Reg3α: Can they predict aGvHD, steroid refractoriness and transplant-related mortality in pediatric patients after HSCT?

  2024cites this paper
• Unlocking protein-based biomarker potential for graft-versus-host disease following allogenic hematopoietic stem cell transplants

  2024cites this paper
• Altered lipid metabolism in patients with acute graft-versus-host disease after allogeneic hematopoietic cell transplantation.

  2024cites this paper
• Prognostic value of blood biomarkers in steroid-refractory or steroid-dependent acute graft-versus-host disease: a REACH2 analysis

  2023cites this paper
• The level of Tim-3+CD8+ T cells can serve as a potential marker for evaluating the severity of acute graft-versus-host disease after haplo-PBSCT

  2023cites this paper
• Galectin-3 predicts acute GvHD and overall mortality post reduced intensity allo-HCT: a BMT-CTN biorepository study

  2023cites this paper
• Immunological dynamic characteristics in AML predict the long-term outcomes and GVHD occurrences post-transplantation.

  2023cites this paper
• Acute GVHD classification based on the dynamics of GVHD skin involvement from its appearance to the start of systemic treatment

  2023cites this paper
• A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury

  2023cites this paper
• Hepatic graft-versus-host disease: What we know, when to biopsy, and how to diagnose.

  2023cites this paper
• Biomarkers for early complications post hematopoietic cell transplantation: Insights and challenges

  2023cites this paper
• EASIX score predicts inferior survival after allogeneic hematopoietic cell transplantation

  2023cites this paper
• Extracellular Vesicles as Biomarkers of Acute Graft-vs.-Host Disease After Haploidentical Stem Cell Transplantation and Post-Transplant Cyclophosphamide

  2022cites this paper
• Toxic epidermal necrolysis‐like acute graft‐versus‐host disease in pediatric bone marrow transplant patients: Case series and review of the literature

  2022cites this paper
• Cell‐free DNA levels are increased in acute graft‐versus‐host disease

  2022cites this paper
• Soluble T Cell Immunoglobulin and Mucin Domain-3 (sTIM-3) Predict Graft-Versus-Host Disease (GVHD) in Iranian Allogeneic Hematopoietic Stem Cell Transplantation

  2022cites this paper
• Assessment of systemic and gastrointestinal tissue damage biomarkers for GVHD risk stratification

  2022cites this paper
• Increased risk of nonrelapse mortality post T‐cell‐replete haploidentical stem cell transplantation in patients with recurrence of acute graft‐versus‐host disease

  2022cites this paper
• General Rehabilitation Program after Knee or Hip Replacement Significantly Influences Erythrocytes Oxidative Stress Markers and Serum ST2 Levels

  2022cites this paper
• Noncoding RNAs in diagnosis and prognosis of graft‐versus‐host disease (GVHD)

  2022cites this paper
• Dynamic forecasting of severe acute graft-versus-host disease after transplantation

  2021cites this paper
• Efficiency and Toxicity of Ruxolitinib as a Salvage Treatment for Steroid-Refractory Chronic Graft-Versus-Host Disease

  2021cites this paper
• National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIb. The 2020 Preemptive Therapy Working Group Report.

  2021cites this paper
• Biomarkers for Early Complications of Endothelial Origin After Allogeneic Hematopoietic Stem Cell Transplantation: Do They Have a Potential Clinical Role?

  2021cites this paper
• Acute GVHD, BK virus hemorrhagic cystitis and age are risk factors for transplant-associated thrombotic microangiopathy in adults

  2021cites this paper
• Antigen-specific T cell responses correlate with decreased occurrence of acute GVHD in a multicenter contemporary cohort

  2021cites this paper
• New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD)

  2021cites this paper
• Association of Pre-Transplant Angiopoietin-2 Index with the Risk of Acute Graft-Versus-Host Disease after Hematopoietic Stem Cell Transplantation

  2021cites this paper
• Biomarkers of graft-vs-host disease: Understanding and applications for the future

  2021cites this paper
• Circulating miR-455-3p, miR-5787, and miR-548a-3p as potential noninvasive biomarkers in the diagnosis of acute graft-versus-host disease: a validation study

  2021cites this paper
• Pre-transplant sTIM-3 levels may have a predictive impact on transplant outcome in acute leukemia patients

  2020cites this paper
• Inflammatory Cytokine Profile in Individuals with Inherited Chromosomally Integrated Human Herpesvirus 6.

  2020cites this paper
• Assessment of ST2 for risk of death following graft-versus-host disease in the pediatric and adult age groups.

  2020cites this paper
• Extracorporeal Photopheresis (ECP) and the Potential of Novel Biomarkers in Optimizing Management of Acute and Chronic Graft vs. Host Disease (GvHD)

  2020cites this paper
• Preliminary Results of a Combined Score Based on sIL2-Rα and TIM-3 Levels Assayed Early After Hematopoietic Transplantation

  2020cites this paper
• Post‐haematopoietic cell transplantation outcomes: why ST2 became a ‘golden nugget’ biomarker

  2020influential citation
• Defibrotide modulates pulmonary endothelial cell activation and protects against lung inflammation in pre-clinical models of LPS-induced lung injury and idiopathic pneumonia syndrome

  2020cites this paper
• Serum albumin and C-reactive protein as significant predictors of non-relapse mortality in lower gastrointestinal graft-versus-host disease

  2020cites this paper
• Biomarkers for Allogeneic HCT Outcomes

  2020cites this paper
• Comparative Analyses of the Conformational Dynamics Between the Soluble and Membrane-Bound Cytokine Receptors

  2020cites this paper
• Predicting Immuno-Metabolic Complications After Allogeneic Hematopoietic Cell Transplant with the Cytokine Interleukin-33 (IL-33) and its Receptor Serum-Stimulation 2 (ST2)

  2020cites this paper
• Age-related modifications of macrophages influenced by “inflammageing” in graft vs. host disease

  2020cites this paper
• Novel Biomarkers for Outcome After Allogeneic Hematopoietic Stem Cell Transplantation

  2020cites this paper
• Prognostic plasma biomarkers of early complications and graft‐versus‐host disease in patients undergoing allogeneic hematopoietic stem cell transplantation

  2020cites this paper
• ICOSL+ plasmacytoid dendritic cells as inducer of graft-versus-host disease, responsive to a dual ICOS/CD28 antagonist

  2020cites this paper
• Nidogen 1‐Enriched Extracellular Vesicles Facilitate Extrahepatic Metastasis of Liver Cancer by Activating Pulmonary Fibroblasts to Secrete Tumor Necrosis Factor Receptor 1

  2020cites this paper
• Decline of serum albumin precedes severe acute GVHD after haploidentical HSCT

  2020cites this paper
• Biomarkers for acute and chronic graft versus host disease: state of the art

  2020cites this paper
• ST2/MyD88 Deficiency Protects Mice against Acute Graft-versus-Host Disease and Spares Regulatory T Cells

  2019cites this paper
• Biomarkers for Early Complications After Hematopoietic Stem Cell Transplantation.

  2019cites this paper
• Evolutions in the Clinical Management of GVHD

  2019cites this paper
• T-Cell Costimulation and Coinhibition in Graft-Versus-Host Disease and Graft-Versus-Leukemia Effect

  2019cites this paper
• Randomized Multicenter Trial of Sirolimus vs. Prednisone as Initial Therapy for Standard Risk Acute GVHD: BMT CTN 1501.

  2019cites this paper
• Serum level of soluble interleukin‐2 receptor is positively correlated with metabolic tumor volume on 18F‐FDG PET/CT in newly diagnosed patients with diffuse large B‐cell lymphoma

  2019cites this paper
• Systemic biomarkers of allogeneic haematopoietic stem cell transplantation outcome—Brief introduction

  2019influential citation
• Biomarkers in acute graft-versus-host disease: new insights

  2019cites this paper
• Follistatin and Soluble Endoglin Predict 1-year Non-Relapse Mortality after Allogeneic Hematopoietic Cell Transplant.

  2019cites this paper
• Advance of Biomarkers for Predicting Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

  2019influential citation
• Interleukin-6 as Biomarker for Acute GvHD and Survival After Allogeneic Transplant With Post-transplant Cyclophosphamide

  2019cites this paper
• Pulmonary Impairment after Respiratory Viral Infections Is Associated with High Mortality in Allogeneic Hematopoietic Cell Transplant Recipients.

  2019cites this paper
• Acute GVHD Diagnosis and Adjudication in a Multicenter Trial: A Report From the BMT CTN 1202 Biorepository Study

  2019cites this paper
• Predictive Values of Early Suppression of Tumorigenicity 2 for Acute GVHD and Transplant-related Complications after Allogeneic Stem Cell Transplantation: Prospective Observational Study

  2019influential citation
• Multiple functional variants in the IL1RL1 region are pretransplant markers for risk of GVHD and infection deaths.

  2019cites this paper
• A panel of 4 biomarkers for the early diagnosis and therapeutic efficacy of aGVHD.

  2019cites this paper
• MicroRNAs as Potential Diagnostic, Prognostic and Predictive Biomarkers for Acute Graft Versus Host Disease.

  2019cites this paper
• Review of Graft-Versus-Host Disease.

  2019cites this paper
• Intestinal microbiota can predict aGVHD following allogeneic hematopoietic stem cell transplantation.

  2019cites this paper
• Cytokines in GVHD and GVL

  2019cites this paper
• Prediction of acute GVHD and relapse by metabolic biomarkers after allogeneic hematopoietic stem cell transplantation.

  2018cites this paper
• Tocilizumab, tacrolimus and methotrexate for the prevention of acute graft-versus-host disease: low incidence of lower gastrointestinal tract disease

  2018cites this paper
• Biomarkers in Graft-Versus-Host Disease: from Prediction and Diagnosis to Insights into Complex Graft/Host Interactions

  2018cites this paper
• Immunomonitoring of MSC-Treated GvHD Patients Reveals Only Moderate Potential for Response Prediction but Indicates Treatment Safety

  2018cites this paper
• Peripheral tissues reprogram CD8+ T cells for pathogenicity during graft-versus-host disease

  2018cites this paper
• ST2/MYD88 signaling is a therapeutic target alleviating murine acute graft-versus-host disease sparing T regulatory cell function

  2018cites this paper
• Complement-mediated thrombotic microangiopathy as a link between endothelial damage and steroid-refractory GVHD.

  2018cites this paper
• Clinical Proteomics for Post‐Hematopoeitic Stem Cell Transplantation Outcomes

  2018cites this paper
• Exosomal miRNA Signatures for Late-Onset Acute Graft-Versus-Host Disease in Allogenic Hematopoietic Stem Cell Transplantation

  2018cites this paper
• From proteomics to discovery of first-in-class ST2 inhibitors active in vivo.

  2018cites this paper
• Plasma vascular non-inflammatory molecule 3 is associated with gastrointestinal acute graft-versus-host disease in mice

  2018cites this paper
• Biomarkers for posttransplantation outcomes.

  2018cites this paper
• Associations between levels of insulin-like growth factor 1 and sinusoidal obstruction syndrome after allogeneic haematopoietic stem cell transplantation

  2017cites this paper
• Citrulline and Monocyte-Derived Macrophage Reactivity before Conditioning Predict Acute Graft-versus-Host Disease.

  2017cites this paper
• PREDICTIVE VALUE OF CLINICAL FINDINGS AND PLASMA BIOMARKERS AFTER 14 DAYS OF PREDNISONE TREATMENT FOR ACUTE GRAFT-VERSUS-HOST DISEASE

  2017cites this paper