In vitro reactions of aflatoxin B1-adducted DNA.

No abstract is available for this paper.

• Publication year

  1981

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  1981-09-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1073/PNAS.78.9.5445PMID 6795633PMCID PMC348762
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Temporal patterns of covalent DNA adducts in rat liver after single and multiple doses of aflatoxin B1.

  1981cited by this paper
• Excretion of an aflatoxin-guanine adduct in the urine of aflatoxin B1-treated rats.

  1981cited by this paper
• A high pressure liquid chromatography study on the removal of DNA-bound aflatoxin B1 in rat liver and in vitro.

  1980cited by this paper
• Spontaneous reactions of aflatoxin B1 modified deoxyribonucleic acid in vitro.

  1980cited by this paper
• Nuclear distribution of aflatoxin B1 and its interaction with histones in rat liver in vivo.

  1980cited by this paper
• Formation and removal of aflatoxin B1-induced DNA lesions in epithelioid human lung cells.

  1979cited by this paper
• Comparison of aflatoxin B1 and aflatoxin G1 binding to cellular macromolecules in vitro, in vivo and after peracid oxidation; characterisation of the major nucleic acid adducts.

  1979cited by this paper
• Modification of DNA by aflatoxin B1 creates alkali-labile lesions in DNA at positions of guanine and adenine.

  1978cited by this paper
• Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro.

  1977cited by this paper
• 2,3-Dihydro-2-(guan-7-yl)-3-hydroxy-aflatoxin B1, a major acid hydrolysis product of aflatoxin B1-DNA or -ribosomal RNA adducts formed in hepatic microsome-mediated reactions and in rat liver in vivo.

  1977cited by this paper
• Possible Synthesis of Polyribonucleotides of Known Base-triplet Sequences

  1965cited by this paper
• A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

  1956cited by this paper

• Aflatoxin B1-induced DNA adduct formation in murine kidney and liver.

  2025cites this paper
• Transcription-Coupled Nucleotide Excision Repair: A Faster Solution or the Only Option?

  2025cites this paper
• Aflatoxin B1‐Induced Hepatic Mutagenesis in Mice Expressing Gene‐Edited Neil1

  2025cites this paper
• Structurally Similar Mycotoxins Aflatoxin B1 and Sterigmatocystin Trigger Different and Distinctive High-Resolution Mutational Spectra in Mammalian Cells

  2025cites this paper
• Role of NEIL1 in genome maintenance.

  2025cites this paper
• Tissue Organoid Cultures Metabolize Dietary Carcinogens Proficiently and Are Effective Models for DNA Adduct Formation

  2024cites this paper
• Nucleotide excision repair of aflatoxin-induced DNA damage within the 3D human genome organization

  2024cites this paper
• Frequencies and spectra of aflatoxin B1-induced mutations in liver genomes of NEIL1-deficient mice as revealed by duplex sequencing

  2024cites this paper
• Mass Spectrometry-Based Method to Measure Aflatoxin B1 DNA Adducts in Formalin-Fixed Paraffin-Embedded Tissues.

  2024cites this paper
• Synthesis and Characterization of 15N5-Labeled Aflatoxin B1–Formamidopyrimidines and Aflatoxin B1–N7-Guanine from a Partial Double-Stranded Oligodeoxynucleotide as Internal Standards for Mass Spectrometric Measurements

  2023cites this paper
• Diverse mycotoxin threats to safe food and feed cereals

  2023cites this paper
• A Narrative Review on Etiology and Mechanism of Aflatoxin B1 in the induction of Hepatocellular Carcinoma

  2022cites this paper
• Urinary metabolites as indicators of human exposure to chemical carcinogens

  2021cites this paper
• DNA adducts as biomarkers to predict, prevent, and diagnose disease - application of analytical chemistry to clinical investigations.

  2020cites this paper
• A Review: Sample Preparation and Chromatographic Technologies for Detection of Aflatoxins in Foods

  2020cites this paper
• Mode of action-based risk assessment of genotoxic carcinogens

  2020cites this paper
• Bridging Fe3O4@Au nanoflowers and Au@Ag nanospheres with aptamer for ultrasensitive SERS detection of aflatoxin B1.

  2020cites this paper
• Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods.

  2019cites this paper
• University of Groningen Aflatoxin, fumonisin, ochratoxin, zearalenone and deoxynivalenol biomarkers in human biological fluids

  2019cites this paper
• Aflatoxin, fumonisin, ochratoxin, zearalenone and deoxynivalenol biomarkers in human biological fluids: A systematic literature review, 2001-2018.

  2019cites this paper
• The role of bracken fern illudanes in bracken fern-induced toxicities.

  2019cites this paper
• A global view of hepatopancreas and intestinal reveals the potential influencing mechanism of aflatoxin B1 on nutrition and metabolism inLitopenaeus vannamei

  2019cites this paper
• Aflatoxin-Guanine DNA Adducts and Oxidatively Induced DNA Damage in Aflatoxin-Treated Mice in Vivo as Measured by Liquid Chromatography-Tandem Mass Spectrometry with Isotope Dilution.

  2018cites this paper
• Editor’s Highlight: Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver

  2017influential citation
• Ultrasensitive detection of aflatoxin B1 by SERS aptasensor based on exonuclease-assisted recycling amplification.

  2017cites this paper
• Selectivity/Specificity Improvement Strategies in Surface-Enhanced Raman Spectroscopy Analysis

  2017cites this paper
• Genetic Single Nucleotide Polymorphisms (GSNPs) in the DNA Repair Genes and Hepatocellular Carcinoma Related to Aflatoxin B1 among Guangxiese Population

  2017cites this paper
• DNA Sequence Modulates Geometrical Isomerism of the trans-8,9-Dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxy Aflatoxin B1 Adduct

  2015cites this paper
• Sulforaphane-Mediated Reduction of Aflatoxin B-1-N7-Guanine in Rat Liver DNA : Impacts of Strain and Sex Citation

  2014cites this paper
• Error-prone Replication Bypass of the Primary Aflatoxin B1 DNA Adduct, AFB1-N7-Gua*

  2014cites this paper
• Research Proposal : Mycotoxin Detection in Dried Blood

  2014cites this paper
• An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride

  2014cites this paper
• Prenatal exposure of mice to the human liver carcinogen aflatoxin B1 reveals a critical window of susceptibility to genetic change

  2014cites this paper
• Genetic Polymorphisms of DNA Repair Genes and DNA Repair Capacity Related to Aflatoxin B1 (AFB1)-Induced DNA Damages

  2013cites this paper
• Determination of protective role of selenium against aflatoxin B1-induced DNA damage

  2013cites this paper
• Chemistry and Biology of Aflatoxin-DNA Adducts

  2012cites this paper
• DNA Repair Capacity-Related to Genetic Polymorphisms of DNA Repair Genes and Aflatoxin B1-Related Hepatocellular Carcinoma Among Chinese Population

  2012cites this paper
• Bypass of Aflatoxin B1 Adducts by the Sulfolobus solfataricus DNA Polymerase IV

  2011cites this paper
• Aflatoxin B1-DNA adduct formation and mutagenicity in livers of neonatal male and female B6C3F1 mice.

  2011cites this paper
• Aflatoxin B 1-DNA Adduct Formation and Mutagenicity in Livers of Neonatal Male and Female B 6 C 3 F 1 Mice

  2011influential citation
• DNA Repair Capacity-Related to Genetic Polymorphisms of DNA Repair Genes and Aflatoxin B1-Related Hepatocellular Carcinoma Among Chinese Population

  2011cites this paper
• Chemistry and Structural Biology of DNA Damage and Biological Consequences

  2011cites this paper
• 2'-Deoxyguanosine as a surrogate trapping agent for DNA reactive drug metabolites.

  2011cites this paper
• Sulforaphane-mediated reduction of aflatoxin B₁-N⁷-guanine in rat liver DNA: impacts of strain and sex.

  2011cites this paper
• Developing biomarkers of human exposure to mycotoxins

  2011cites this paper
• Aflatoxin B[subscript 1]-DNA adduct formation and mutagenicity in livers of neonatal female B6C3F1 mice

  2011cites this paper
• Differential mutagenicity of aflatoxin B1 in the liver of neonatal and adult mice

  2009cites this paper
• Structural Perturbations Induced by the α-Anomer of the Aflatoxin B1 Formamidopyrimidine Adduct in Duplex and Single-Strand DNA

  2009cites this paper
• Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens

  2009influential citation
• In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure.

  2009cites this paper
• The formation and biological significance of N7-guanine adducts.

  2009cites this paper
• Effect of some natural antioxidants on aflatoxin B1-induced hepatic toxicity

  2008cites this paper
• Original article: EFFECT OF SOME NATURAL ANTIOXIDANTS ON AFLA- TOXIN B1-INDUCED HEPATIC TOXICITY

  2008cites this paper
• The formamidopyrimidine derivative of 7-(2-oxoethyl)-2'-deoxyguanosine.

  2008cites this paper
• INVESTIGATION OF THE ROLE OF OXIDATIVE DNA DAMAGE IN AFLATOXIN B1-INDUCED PULMONARY CARCINOGENESIS

  2008cites this paper
• Analysis of DNA damage induced by aflatoxin B1 in Dunkin–Hartley guinea pigs

  2007cites this paper
• Champignons Mycotoxinogènes et Ochratoxine A (OTA) et Aflatoxine B1 (AFB1) dans les vignobles libanais : Occurrence et Origine

  2007cites this paper
• Extraction and Separation of the Bright-Greenish-Yellow Fluorescent Material from Aflatoxigenic Aspergillus spp. Infected Cotton Lint by HPLC-UV/FL

  2007cites this paper
• La exposición a la aflatoxina B1 en animales de laboratorio y su significado en la salud pública

  2007cites this paper
• Modulation of aflatoxin toxicity and biomarkers by lycopene in F344 rats.

  2007cites this paper
• Aflatoxin B 1 -induced DNA damage and its repair

  2006cites this paper
• Aflatoxin B1-induced DNA damage and its repair.

  2006cites this paper
• Phytohormone levels in germinating seeds of Zea mays L. exposed to selenium and aflatoxines

  2006cites this paper
• Unraveling the aflatoxin-FAPY conundrum: structural basis for differential replicative processing of isomeric forms of the formamidopyrimidine-type DNA adduct of aflatoxin B1.

  2006cites this paper
• Genetics of hepatocellular tumors

  2006cites this paper
• Aflatoxin-induced Hepatic Tumorigenesis Transient Intervention with Oltipraz Protects against

  2006cites this paper
• Modulation of Aflatoxin Metabolism , Aflatoxin-7 V 7-guanineFormation , and Hepatic Tumorigenesis in Rats Fed Ethoxyquin : Role of Induction of Glutathione S-Transferases 1

  2006cites this paper
• Interstrand and intrastrand DNA-DNA cross-linking by 1,2,3,4-diepoxybutane: role of stereochemistry.

  2005cites this paper
• Biologically relevant chemical reactions of N7-alkylguanine residues in DNA.

  2004cites this paper
• S-(2-Chloroethyl)glutathione-generated p53 Mutation Spectra Are Influenced by Differential Repair Rates More than Sites of Initial DNA Damage*

  2004cites this paper
• Aflatoxin B1 formamidopyrimidine adducts are preferentially repaired by the nucleotide excision repair pathway in vivo.

  2004cites this paper
• The aflatoxin B(1) formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma.

  2002cites this paper
• Reactions of estradiol-2,3-quinone with deoxyribonucleosides: possible insights in the reactivity of estrogen quinones with DNA.

  2002cites this paper
• The aflatoxin B1 formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma

  2002cites this paper
• Thermal stabilization of the DNA duplex by adducts of aflatoxin B1

  2002cites this paper
• The chemistry and biology of aflatoxin B(1): from mutational spectrometry to carcinogenesis.

  2001cites this paper
• Effects of clarified neem oil on growth and aflatoxin B1 formation in submerged and plate cultures of aflatoxigenicAspergillus spp.

  2001cites this paper
• Development of Aflatoxin B1-Lysine Adduct Monoclonal Antibody for Human Exposure Studies

  2001cites this paper
• 1,3-butadiene: cancer, mutations, and adducts. Part I: Carcinogenicity of 1,2,3,4-diepoxybutane.

  2000cites this paper
• Identification and effects of maize silk volatiles on cultures of Aspergillus flavus.

  2000cites this paper
• Dose-response relationships for hepatic aflatoxin B1-DNA adduct formation in the rat in vivo and in vitro: the use of immunoslot blotting for adduct quantitation.

  1999cites this paper
• Persistence of N7-(2,3,4-trihydroxybutyl)guanine adducts in the livers of mice and rats exposed to 1,3-butadiene.

  1999cites this paper
• An intercalated and thermally stable FAPY adduct of aflatoxin B1 in a DNA duplex: structural refinement from 1H NMR.

  1998cites this paper
• DNA-glycation leads to depurination by the loss of N2-carboxyethylguanine in vitro.

  1998cites this paper
• Determination of aflatoxin B1-DNA adduct in rat liver by enzyme immunoassay.

  1997cites this paper
• Direct synthesis of aflatoxin B1-N7 guanine adduct: a reference standard for biological monitoring of dietary aflatoxin exposure in molecular epidemiological studies.

  1997cites this paper
• An intercalation inhibitor altering the target selectivity of DNA damaging agents: synthesis of site-specific aflatoxin B1 adducts in a p53 mutational hotspot.

  1997cites this paper
• Dissimilarity in aflatoxin dose-response relationships between DNA adduct formation and development of preneoplastic foci in rat liver.

  1997cites this paper
• Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines.

  1997cites this paper
• In vivo activation of aflatoxin B1 in C57BL/6N mice carrying a human fetus-specific CYP3A7 gene.

  1997cites this paper
• Identification and quantitation of DNA adducts from calf thymus DNA exposed to 3,4-epoxy-1-butene.

  1997cites this paper
• DNA Structure: Inherent Instability and Genotoxic Reactions

  1997cites this paper
• Synthesis, characterization, and in vitro quantitation of N-7-guanine adducts of diepoxybutane.

  1997cites this paper
• Mutational specificity of aflatoxin B1. Comparison of in vivo host-mediated assay with in vitro S9 metabolic activation.

  1996cites this paper
• Possible involvement of lipoxygenase in a defense response in aflatoxigenic Aspergillus - cotton plant interactions

  1996cites this paper
• Mutational properties of the primary aflatoxin B1-DNA adduct.

  1996cites this paper
• A viral genome containing an unstable aflatoxin B1-N7-guanine DNA adduct situated at a unique site.

  1996cites this paper
• Mutagenesis by the primary aflatoxin B₁ DNA adduct in Escherichia coli

  1996cites this paper
• Benzo[a]pyrene‐induced mutagenesis of p53 hot‐spot codons 248 and 249 in human hepatocytes

  1995cites this paper
• Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: the role of apurinic sites.

  1995cites this paper