Resveratrol protects against arsenic trioxide‐induced cardiotoxicity in vitro and in vivo

No abstract is available for this paper.

• Publication year

  2008

• Venue

  British Journal of Pharmacology

• Publication date

  2008-05-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/bjp.2008.81PMID 18332854PMCID PMC2438979
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Arsenic trioxide-induced apoptosis in H9c2 cardiomyocytes: implications in cardiotoxicity.

  2008influential reference
• Resveratrol Increases Vascular Oxidative Stress Resistance

  2007cited by this paper
• Arsenic patent keeps drug for rare cancer out of reach of many

  2007cited by this paper
• Resveratrol, a natural ingredient of grape skin: antiarrhythmic efficacy and ionic mechanisms.

  2006cited by this paper
• Use of resveratrol to improve the effectiveness of cisplatin and doxorubicin: study in human gynecologic cancer cell lines and in rodent heart.

  2006cited by this paper
• Proteomic profiling and identification of cofilin responding to oxidative stress in vascular smooth muscle

  2006cited by this paper
• Resveratrol in cardioprotection: a therapeutic promise of alternative medicine.

  2006cited by this paper
• Choline-modulated arsenic trioxide-induced prolongation of cardiac repolarization in Guinea pig.

  2006cited by this paper
• Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo.

  2006cited by this paper
• Resveratrol glucoside (Piceid) synthesis in seeds of transgenic oilseed rape (Brassica napus L.)

  2005influential reference
• Arsenite causes DNA damage in keratinocytes via generation of hydroxyl radicals.

  2004cited by this paper
• HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS

  2004influential reference
• Calcium, ATP, and ROS: a mitochondrial love-hate triangle.

  2004cited by this paper
• Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.

  2004cited by this paper
• Resveratrol Inhibits Drug-Induced Apoptosis in Human Leukemia Cells by Creating an Intracellular Milieu Nonpermissive for Death Execution

  2004cited by this paper
• Calcium: Regulation of cell death: the calcium–apoptosis link

  2003cited by this paper
• Signaling by carcinogenic metals and metal-induced reactive oxygen species.

  2003cited by this paper
• The effect of arsenic trioxide on QT interval prolongation during APL therapy.

  2003cited by this paper
• Pro‐oxidant Activity of Low Doses of Resveratrol Inhibits Hydrogen Peroxide—Induced Apoptosis

  2003cited by this paper
• Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses.

  2003cited by this paper
• Mechanisms of action of arsenic trioxide.

  2002cited by this paper
• Pharmacological preconditioning with resveratrol: an insight with iNOS knockout mice.

  2002influential reference
• Prolongation of cardiac repolarization by arsenic trioxide.

  2002cited by this paper
• Mitochondria, calcium and nitric oxide in the apoptotic pathway of esophageal carcinoma cells induced by As2O3.

  2002cited by this paper
• Oxidized low-density lipoprotein-induced apoptosis.

  2002cited by this paper
• Calcium and oxidative stress: from cell signaling to cell death.

  2002cited by this paper
• Sudden death among patients with acute promyelocytic leukemia treated with arsenic trioxide.

  2001cited by this paper
• Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia.

  2001cited by this paper
• Prolongation of the QT Interval and Ventricular Tachycardia in Patients Treated with Arsenic Trioxide for Acute Promyelocytic Leukemia

  2000influential reference
• Apoptosis. Basic concepts and implications in coronary artery disease.

  1999cited by this paper
• Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells.

  1998cited by this paper
• Measurement of heart rate and Q-T interval in the conscious mouse.

  1998influential reference
• Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients.

  1997influential reference
• Long Reflections on the QT Interval:

  1996cited by this paper
• Reactive oxygen species and programmed cell death.

  1996cited by this paper
• Oxygen free radicals and cardiac reperfusion abnormalities.

  1992cited by this paper
• Torsade de Pointes and T‐U Wave Alternans Associated with Arsenic Poisoning

  1990cited by this paper

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• Potential of natural products in combination with arsenic trioxide: Investigating cardioprotective effects and mechanisms.

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• Plant-derived natural compounds in the treatment of arsenic-induced toxicity

  2023cites this paper
• Arsenic trioxide: applications, mechanisms of action, toxicity and rescue strategies to date

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• IL-33 regulates M1/M2 chemokine expression via mitochondrial redox-related mitophagy in human monocytes.

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• Phytochemicals in the Management of Arsenic Toxicity.

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• Assessing Drug-Induced Mitochondrial Toxicity in Cardiomyocytes: Implications for Preclinical Cardiac Safety Evaluation

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• Natural Dietary Compounds in the Treatment of Arsenic Toxicity

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• Resveratrol alleviated 5-FU-induced cardiotoxicity by attenuating GPX4 dependent ferroptosis.

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• Arsenic trioxide-induced cardiotoxicity triggers ferroptosis in cardiomyoblast cells

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• In silico mechanisms of arsenic trioxide-induced cardiotoxicity

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• Flavonoids and stilbenoids as a promising arsenal for the management of chronic arsenic toxicity.

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• Disruption of Leydig cell steroidogenic function by sodium arsenite and/or sodium fluoride.

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  2021cites this paper
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• Mitigation of arsenic induced developmental cardiotoxicity by ferulic acid in zebrafish.

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• Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management.

  2021cites this paper
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  2020cites this paper
• [The role of resveratrol on heavy metal-induced oxidative stress].

  2020cites this paper
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  2020cites this paper
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• Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes

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  2017cites this paper
• Antioxidants Protect against Arsenic Induced Mitochondrial Cardio-Toxicity

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• Omega-3 Fatty Acid Protects Against Arsenic Trioxide-Induced Cardiotoxicity In Vitro and In Vivo

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• Medicinal plants and natural products in amelioration of arsenic toxicity: a short review

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  2016cites this paper
• Resveratrol protects against arsenic trioxide‐induced oxidative damage through maintenance of glutathione homeostasis and inhibition of apoptotic progression

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• Arsenic cardiotoxicity: An overview.

  2015cites this paper
• Combined 1,25-Dihydroxy-vitamin D and Resveratrol: A Novel Therapeutic Approach to Ameliorate Ischemia Reperfusion-Induced Myocardial Injury.

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• Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases.

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• The rescuable function and mechanism of resveratrol on As2O3-induced hERG K+ channel deficiency

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  2014cites this paper
• Tetrandrine enhances the anticancer effects of arsenic trioxide in vitro.

  2014cites this paper
• Arsenic Induced Myocardial Toxicity in Rats: Alleviative Effect of Trichosanthes dioica Fruit

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• Potential of resveratrol in the treatment of heart failure.

  2014cites this paper
• Chemistry and pharmacological properties of some natural and synthetic antioxidants for heavy metal toxicity.

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013influential citation
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  2013cites this paper
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