TGF-β Family Signaling in Connective Tissue and Skeletal Diseases.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Cold Spring Harbor Perspectives in Biology

• Publication date

  2017-02-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/cshperspect.a022269PMID 28246187PMCID PMC5666637
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1R206H Fibrodysplasia Ossificans Progressiva (FOP) Mutation

  2016cited by this paper
• Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins.

  2016cited by this paper
• BMP signalling in skeletal development, disease and repair

  2016cited by this paper
• TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease

  2016cited by this paper
• TGF-β Signaling from Receptors to Smads.

  2016cited by this paper
• Signaling Receptors for TGF-β Family Members.

  2016cited by this paper
• Mutations in a TGF-β Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections

  2015cited by this paper
• Neofunction of ACVR1 in fibrodysplasia ossificans progressiva

  2015cited by this paper
• Role of mechanotransduction in vascular biology: focus on thoracic aortic aneurysms and dissections.

  2015cited by this paper
• ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A

  2015cited by this paper
• AT1 receptor antagonism to reduce aortic expansion in Marfan syndrome: lost in translation or in need of different interpretation?

  2015cited by this paper
• Dysregulated TGF‐β signaling alters bone microstructure in a mouse model of Loeys‐Dietz syndrome

  2015cited by this paper
• Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice

  2015cited by this paper
• SMAD2 Mutations Are Associated with Arterial Aneurysms and Dissections

  2015cited by this paper
• The Type I BMP Receptor ACVR1/ALK2 is Required for Chondrogenesis During Development

  2015cited by this paper
• Latent TGF-β-binding proteins.

  2015cited by this paper
• Dimorphic Effects of Transforming Growth Factor-&bgr; Signaling During Aortic Aneurysm Progression in Mice Suggest a Combinatorial Therapy for Marfan Syndrome

  2015cited by this paper
• Activin/Nodal signalling in stem cells

  2015cited by this paper
• Alk2 Regulates Early Chondrogenic Fate in Fibrodysplasia Ossificans Progressiva Heterotopic Endochondral Ossification

  2014cited by this paper
• Osteogenesis imperfecta: Clinical diagnosis, nomenclature and severity assessment

  2014cited by this paper
• Excessive TGFβ signaling is a common mechanism in Osteogenesis Imperfecta

  2014cited by this paper
• Remodelling the extracellular matrix in development and disease

  2014cited by this paper
• Genesis and morphogenesis of limb synovial joints and articular cartilage.

  2014cited by this paper
• Extracellular matrix assembly: a multiscale deconstruction

  2014cited by this paper
• TGFβ signaling in cartilage development and maintenance.

  2014cited by this paper
• Cranial reconstruction for treatment of intracranial hypertension from sclerosteosis: case-based update.

  2014cited by this paper
• Atenolol versus losartan in children and young adults with Marfan's syndrome.

  2014cited by this paper
• Aortic aneurysms in Loeys-Dietz syndrome - a tale of two pathways?

  2014cited by this paper
• Anti-sclerostin antibodies: utility in treatment of osteoporosis.

  2014cited by this paper
• Vascular wall extracellular matrix proteins and vascular diseases.

  2014cited by this paper
• Osteoblast and osteocyte: games without frontiers.

  2014cited by this paper
• Osteogenic Gene Expression Correlates With Development of Heterotopic Ossification in War Wounds

  2014cited by this paper
• The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis

  2014cited by this paper
• Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.

  2014cited by this paper
• Structural determinants of integrin β-subunit specificity for latent TGF-β

  2014cited by this paper
• Serum Dickkopf 1 levels in sclerostin deficiency.

  2014cited by this paper
• Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.

  2014cited by this paper
• Loeys–Dietz syndrome: a primer for diagnosis and management

  2014cited by this paper
• TGFβ Receptor Mutations Impose a Strong Predisposition for Human Allergic Disease

  2013cited by this paper
• WNT signaling in bone homeostasis and disease: from human mutations to treatments

  2013cited by this paper
• BMP Receptor 1A Determines the Cell Fate of the Postnatal Growth Plate

  2013cited by this paper
• Wnt signaling in bone formation and its therapeutic potential for bone diseases

  2013cited by this paper
• Integrin Modulating Therapies Prevent Fibrosis and Autoimmunity in Genetic Mouse Models of Scleroderma

  2013cited by this paper
• From mysteries to medicines: drug development for fibrodysplasia ossificans progressiva

  2013cited by this paper
• Regulation of postnatal bone homeostasis by TGFβ.

  2013cited by this paper
• Skeletal Morphogenesis and Embryonic Development

  2013cited by this paper
• Augmentation of smad‐dependent BMP signaling in neural crest cells causes craniosynostosis in mice

  2013cited by this paper
• Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms.

  2013cited by this paper
• Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial.

  2013cited by this paper
• Van Buchem disease: Clinical, biochemical, and densitometric features of patients and disease carriers

  2013cited by this paper
• Expression and Functional Study of Extracellular BMP Antagonists during the Morphogenesis of the Digits and Their Associated Connective Tissues

  2013cited by this paper
• Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification

  2013cited by this paper
• Fibrodysplasia ossificans progressiva: diagnosis, management, and therapeutic horizons.

  2013cited by this paper
• Increased fracture risk and low bone mineral density in patients with loeys–dietz syndrome

  2013cited by this paper
• A GDF5 Point Mutation Strikes Twice - Causing BDA1 and SYNS2

  2013cited by this paper
• Mutations in the TGF-β Repressor SKI Cause Shprintzen-Goldberg Syndrome with Aortic Aneurysm

  2012cited by this paper
• TGFβ signalling in context

  2012cited by this paper
• Palatogenesis: morphogenetic and molecular mechanisms of secondary palate development

  2012cited by this paper
• Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva

  2012cited by this paper
• Roles of BMP signaling pathway in lip and palate development.

  2012cited by this paper
• New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): Mutation within the GDF5 knuckle epitope causes noggin‐resistance

  2012cited by this paper
• GARP regulates the bioavailability and activation of TGFβ

  2012cited by this paper
• Modulation of noncanonical TGF-β signaling prevents cleft palate in Tgfbr2 mutant mice.

  2012cited by this paper
• Different Roles of GNAS and cAMP Signaling During Early and Late Stages of Osteogenic Differentiation

  2012cited by this paper
• TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation

  2012cited by this paper
• Angiotensin receptor blockade attenuates cigarette smoke-induced lung injury and rescues lung architecture in mice.

  2012cited by this paper
• In-frame mutations in exon 1 of SKI cause dominant Shprintzen-Goldberg syndrome.

  2012cited by this paper
• LTBPs, more than just an escort service

  2012cited by this paper
• TGFB2 loss of function mutations cause familial thoracic aortic aneurysms and acute aortic dissections associated with mild systemic features of the Marfan syndrome

  2012cited by this paper
• A Large Bioactive BMP Ligand with Distinct Signaling Properties Is Produced by Alternative Proconvertase Processing

  2012cited by this paper
• The role of extracellular signal-related kinase during abdominal aortic aneurysm formation.

  2012cited by this paper
• Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm

  2012cited by this paper
• Interaction of TGFβ and BMP Signaling Pathways during Chondrogenesis

  2011cited by this paper
• Latent TGF-β structure and activation

  2011cited by this paper
• Cardiovascular biology

  2011cited by this paper
• Angiotensin II Type 2 Receptor Signaling Attenuates Aortic Aneurysm in Mice Through ERK Antagonism

  2011cited by this paper
• Molecular control of cell differentiation and programmed cell death during digit development

  2011cited by this paper
• Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix.

  2011cited by this paper
• Mechanisms of digit formation: Human malformation syndromes tell the story

  2011cited by this paper
• Expression of dominant negative TGF-β receptors inhibits cartilage formation in conditional transgenic mice

  2011cited by this paper
• Emerging drugs for osteoarthritis

  2011cited by this paper
• New insights on the roles of BMP signaling in bone-A review of recent mouse genetic studies.

  2011cited by this paper
• Patients with sclerosteosis and disease carriers: Human models of the effect of sclerostin on bone turnover

  2011cited by this paper
• Signaling mechanisms that regulate smooth muscle cell differentiation.

  2011cited by this paper
• Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation.

  2011cited by this paper
• Age-dependent alteration of TGF-β signalling in osteoarthritis

  2011cited by this paper
• Signaling through Toll‐like receptor 4 and mast cell‐dependent innate immunity responses

  2011cited by this paper
• Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

  2011cited by this paper
• Potent Inhibition of Heterotopic Ossification by Nuclear Retinoic Acid Receptor γ Agonists

  2011cited by this paper
• Integrin structure, activation, and interactions.

  2011cited by this paper
• Glucocorticoids are not always deleterious for bone

  2010cited by this paper
• Germline TGF‐β receptor mutations and skeletal fragility: A report on two patients with Loeys–Dietz syndrome

  2010cited by this paper
• Bone morphogenetic proteins and articular cartilage: To serve and protect or a wolf in sheep clothing's?

  2010cited by this paper
• TGF-beta in the pathogenesis and prevention of disease: a matter of aneurysmic proportions.

  2010cited by this paper
• Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis

  2010cited by this paper
• Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways*

  2010cited by this paper
• Inherited human diseases of heterotopic bone formation

  2010cited by this paper
• Cellular context‐dependent “colors” of transforming growth factor‐β signaling

  2010cited by this paper
• Accumulation of plasmacytoid DC: Roles in disease pathogenesis and targets for immunotherapy

  2010cited by this paper
• Conditional inactivation of TGF-β type II receptor in smooth muscle cells and epicardium causes lethal aortic and cardiac defects

  2010cited by this paper

• TGF-β-induced fibrotic scar formation limits recovery of spinal cord injury

  2026cites this paper
• Novel Biallelic TGFBR3 Mutation in Brothers Presenting With Craniosynostosis

  2025cites this paper
• Transforming growth factor-beta (TGF-β) in the pathogenesis of hereditary thoracic aneurysm disorders.

  2025cites this paper
• Latent-Transforming growth factor − β Binding protein 1 (LTBP1) in corneal stroma

  2025cites this paper
• Smooth Muscle Cell-Specific TGFβ2 Protects Against Thoracic Aortic Aneurysm and Dissection in Mice

  2025cites this paper
• trans-Resveratrol and Hesperidin Supplementation with Treadmill Exercise Alleviates Methylglyoxal-Induced Skeletal Muscle Dysfunction

  2025cites this paper
• Sex-specific longitudinal reversal of aging in old frail mice

  2025cites this paper
• BMP9 attenuates microgravity-related disuse osteoporosis by modulating TGFβ and BMP signaling

  2025cites this paper
• The Genetic and Biological Basis of Pseudoarthrosis in Fractures: Current Understanding and Future Directions

  2025cites this paper
• Unraveling the Role of RSPRY1 in TGF-β Pathway Dysregulation: Insights into the Pathogenesis of Spondyloepimetaphyseal Dysplasia

  2025cites this paper
• Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion

  2025cites this paper
• Pollutants to pathogens: The role of heavy metals in modulating TGF-β signaling and lung cancer risk.

  2024cites this paper
• Tissue Engineering 3D‐Printed Scaffold Using Allograft/Alginate/Gelatin Hydrogels Coated With Platelet‐Rich Fibrin or Adipose Stromal Vascular Fraction Induces Osteogenesis In Vitro

  2024cites this paper
• Bioactive peptides and proteins for tissue repair: microenvironment modulation, rational delivery, and clinical potential

  2024cites this paper
• The Acetylated 2,3,5,4′-Tetrahydroxystilbene-2-O-β-d-Glucoside Improved Pharmacokinetics and Enhanced Anti-Osteoporosis Effects

  2024cites this paper
• Investigating the potential effect of Holothuria scabra extract on osteogenic differentiation in preosteoblast MC3T3-E1 cells

  2024cites this paper
• Integrating spatial transcriptomics and single-nucleus RNA-seq revealed the specific inhibitory effects of TGF-β on intramuscular fat deposition

  2024cites this paper
• A nomoscore of four genes for predicting the rupture risk in abdominal aortic aneurysm patients with osteoarthritis.

  2024cites this paper
• Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion

  2024cites this paper
• Pelvic Floor Dysfunction Among Persons With Marfan and Loeys-Dietz Syndrome

  2024cites this paper
• Emerging Landscape of Osteogenesis Imperfecta Pathogenesis and Therapeutic Approaches.

  2024cites this paper
• Follistatin forms a stable complex with Inhibin A that does not interfere with Activin A antagonism.

  2023cites this paper
• Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz(Wwtr1) Activation in Male LDLR-/- Mice.

  2023cites this paper
• Changes of miR-139-5p, TGFB1, and COL1A1 in the placental tissue of cases with gestational diabetes mellitus.

  2023cites this paper
• Risk Factors for Aortic Dissection

  2023cites this paper
• In-silico prediction of TGF-β1 non-synonymous variants and their impact on binding affinity to Fresolimumab

  2023cites this paper
• The osteogenic and angiogenic potential of microRNA-26a delivered via a non-viral delivery peptide for bone repair.

  2023cites this paper
• TGF-β and BMP Signaling Pathways in Skeletal Dysplasia with Short and Tall Stature.

  2023cites this paper
• Transcriptomics reveals the molecular regulation of Chinese medicine formula on improving bone quality in broiler

  2023cites this paper
• Functional Characterization of Lysophospholipids by Proteomic and Lipidomic Analysis of Fibroblast-like Synoviocytes

  2023cites this paper
• The Multifaceted Effects of Osteocytic TGFβ Signaling on the Skeletal and Extraskeletal Functions of Bone

  2023cites this paper
• Medication-Related Osteonecrosis of the Jaw: Successful Medical Management of Complex Maxillary Alveolus with Sinus Involvement

  2023cites this paper
• TGFβ−2 haploinsufficiency causes early death in mice with Marfan syndrome

  2023cites this paper
• Potential Targets and Mechanisms of Jiedu Quyu Ziyin Decoction for Treating SLE-GIOP: Based on Network Pharmacology and Molecular Docking

  2023cites this paper
• RAB23 regulates musculoskeletal development and patterning

  2023cites this paper
• Characterization of Histone Modifications in Late-Stage Rotator Cuff Tendinopathy

  2023cites this paper
• The role of TGF-beta3 in cartilage development and osteoarthritis

  2023cites this paper
• TGF-beta signal transduction: biology, function and therapy for diseases

  2022cites this paper
• Role of Indoleamine 2,3-dioxygenase 1 (IDO1) and Kynurenine pathway in the regulation of the aging process.

  2022cites this paper
• Targeted IL-4Rα blockade ameliorates refractory allergic eosinophilic inflammation in a patient with dysregulated TGF-β signalling due to ERBIN deficiency.

  2022cites this paper
• Unraveling the Genetics of Congenital Diaphragmatic Hernia: An Ongoing Challenge

  2022cites this paper
• Circulating TGF-β Pathway in Osteogenesis Imperfecta Pediatric Patients Subjected to MSCs-Based Cell Therapy

  2022cites this paper
• 3D Printed Scaffold Based on Type I Collagen/PLGA_TGF-β1 Nanoparticles Mimicking the Growth Factor Footprint of Human Bone Tissue

  2022cites this paper
• Association of TGF-β Canonical Signaling-Related Core Genes With Aortic Aneurysms and Aortic Dissections

  2022influential citation
• Blockade of TGF-β (Transforming Growth Factor Beta) Signaling by Deletion of Tgfbr2 in Smooth Muscle Cells of 11-Month-Old Mice Alters Aortic Structure and Causes Vasomotor Dysfunction—Brief Report

  2022cites this paper
• Adenosine/adenosine type 1 receptor signaling pathway did not play dominant roles on the influence of sodium–glucose cotransporter 2 inhibitor in the kidney of bovine serum albumin‐overloaded streptozotocin‐induced diabetic mice

  2022cites this paper
• LncRNA RAD51-AS1 Regulates Human Bone Marrow Mesenchymal Stem Cells via Interaction with YBX1 to Ameliorate Osteoporosis

  2022cites this paper
• MicroRNA global profiling in cystic fibrosis cell lines reveals dysregulated pathways related with inflammation, cancer, growth, glucose and lipid metabolism, and fertility: an exploratory study

  2022cites this paper
• Myostatin: a multifunctional role in human female reproduction and fertility – a short review

  2022cites this paper
• Signaling new therapeutic opportunities: cytokines in prostate cancer

  2022cites this paper
• Enhancing autophagy and energy metabolism in the meniscus can delay the occurrence of PTOA in ACLT rat

  2022cites this paper
• 12-Epi-Napelline regulated TGF-β/BMP signaling pathway mediated by BMSCs paracrine acceleration against osteoarthritis.

  2022cites this paper
• Molecular and Genetic Mechanisms of Spinal Stenosis Formation: Systematic Review

  2022cites this paper
• miR-17-92 cluster in osteoarthritis: Regulatory roles and clinical utility

  2022cites this paper
• Targeting TGF-β signaling in the multiple myeloma microenvironment: Steering CARs and T cells in the right direction

  2022cites this paper
• Congenital Defects in a Patient Carrying a Novel Homozygous AEBP1 Variant: Further Expansion of the Phenotypic Spectrum of Ehlers–Danlos Syndrome Classical-like Type 2?

  2022cites this paper
• Connective tissue disease in the practice of a cosmetologist and dermatologist. Features of diagnosis and management of patients

  2021cites this paper
• Reciprocal interactions between transforming growth factor beta signaling and collagens: Insights from Caenorhabditis elegans

  2021cites this paper
• Recombinant human bone morphogenetic protein 2 and 7 inhibit the degeneration of intervertebral discs by blocking the Puma-dependent apoptotic signaling

  2021cites this paper
• Genetic and Epigenetic Fine‐Tuning of TGFB1 Expression Within the Human Osteoarthritic Joint

  2021cites this paper
• [Cervical artery dissection in women: relationships with pregnancy and postpartum period].

  2021cites this paper
• LTBP3 Frameshift Variant in British Shorthair Cats with Complex Skeletal Dysplasia

  2021cites this paper
• The Effect of Moderate-Intensity Treadmill Exercise on Bone Mass and the Transcription of Peripheral Blood Mononuclear Cells in Ovariectomized Rats

  2021cites this paper
• A biallelic SNIP1 Amish founder variant causes a recognizable neurodevelopmental disorder

  2021cites this paper
• An Overview of Investigational and Experimental Drug Treatment Strategies for Marfan Syndrome

  2021cites this paper
• Genetic Variations in the Transforming Growth Factor-β1 Pathway May Improve Predictive Power for Overall Survival in Non-small Cell Lung Cancer

  2021cites this paper
• Bi-allelic variants in IPO8 cause a connective tissue disorder associated with cardiovascular defects, skeletal abnormalities, and immune dysregulation

  2021cites this paper
• Audiologic and Otologic Clinical Manifestations of Loeys-Dietz Syndrome: A Heritable Connective Tissue Disorder

  2021cites this paper
• Molecular signatures of labor and nonlabor myometrium with parsimonious classification from 2 calcium transporter genes

  2021cites this paper
• Ongoing controversies and recent insights of the ARMS2-HTRA1 locus in age-related macular degeneration.

  2021cites this paper
• Transforming growth factor beta signaling: The master sculptor of fingers

  2021cites this paper
• Therapeutic Advances in Diabetes, Autoimmune, and Neurological Diseases

  2021cites this paper
• Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family.

  2021cites this paper
• Genetic and epigenetic factors fine-tune TGFB1 expression within the osteoarthritic articular joint

  2021cites this paper
• Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva

  2021cites this paper
• Chondrodysplasias and Aneurysmal Thoracic Aortopathy: An Emerging Tale of Molecular Intersection.

  2020cites this paper
• Subchronic toxicity evaluation of glucosamine and glucosamine in combination with chondroitin sulfate in obese Zucker rats.

  2020cites this paper
• Molecular events in the clinicopathological diagnosis of alveolar osteitis.

  2020cites this paper
• Transforming Growth Factor-β and the Renin-Angiotensin System in Syndromic Thoracic Aortic Aneurysms: Implications for Treatment

  2020cites this paper
• Aortic Dissection: A Review of the Pathophysiology, Management and Prospective Advances

  2020cites this paper
• Yarrow oil ameliorates ulcerative colitis in mice model via regulating the NF‐κB and PPAR-γ pathways

  2020cites this paper
• Spatiotemporal changes in mechanical matrisome components of the human ovary from prepuberty to menopause.

  2020cites this paper
• Network and pathway-based analyses of genes associated with osteoporosis

  2020cites this paper
• Long noncoding RNA TUG1 inhibits osteogenesis of bone marrow mesenchymal stem cells via Smad5 after irradiation

  2019cites this paper
• Cellular signaling in pseudoxanthoma elasticum: an update.

  2019cites this paper
• Identification of novel FBN1 variations implicated in congenital scoliosis

  2019cites this paper
• Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways

  2019cites this paper
• Chronic mucocutaneous candidiasis and connective tissue disorder in humans with impaired JNK1-dependent responses to IL-17A/F and TGF-β

  2019cites this paper
• Nanomaterials for bone tissue regeneration: updates and future perspectives.

  2019cites this paper
• High Salt Intake Worsens Aortic Dissection in Mice

  2019cites this paper
• Genetics of Aortic Diseases

  2019cites this paper
• Smad7 Binds Differently to Individual and Tandem WW3 and WW4 Domains of WWP2 Ubiquitin Ligase Isoforms

  2019cites this paper
• Bench-to-bedside strategies for osteoporotic fracture: From osteoimmunology to mechanosensation

  2019cites this paper
• Chemotropic signaling by BMP7 requires selective interaction at a key residue in ActRIIA

  2019cites this paper
• Specificity, versatility, and control of TGF-β family signaling

  2019cites this paper
• Cutis laxa and excessive bone growth due to de novo mutations in PTDSS1

  2018cites this paper
• Characterization of SMAD2 Activation in Human Thoracic Aortic Aneurysm

  2018cites this paper
• Increased kielin/chordin-like protein levels are associated with the severity of heart failure.

  2018cites this paper
• Tgfbr2 is required in Acan‐expressing cells for maintenance of the intervertebral and sternocostal joints

  2018cites this paper
• Computing at the Front-End by Receptor Networks.

  2017cites this paper