A human serum mannose-binding protein inhibits in vitro infection by the human immunodeficiency virus

In vitro infection by the human immunodeficiency virus (HIV) of CD4+ H9 lymphoblasts is inhibited by a mannose-binding protein (MBP) purified from human serum. In addition, MBP is able to selectively bind to HIV- infected H9 cells and HIV-infected cells from the monocyte cell line U937. These results indicate MBP most likely recognizes high mannose glycans known to be present on gp120 in the domain that is recognized by CD4 and thereby inhibits viral entry to susceptible cells. In support of this contention, recombinant gp120 binds directly to MBP; the binding is saturable, mannan inhibitable, removed by N-glycanase treatment, and dependent on divalent cations.

• Publication year

  1989

• Venue

  Journal of Experimental Medicine

• Publication date

  1989-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/JEM.169.1.185PMID 2909656PMCID 2189190
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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