Estudo da genotoxicidade e citotoxicidade da indometacina nanoencapsulada in vitro

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Unknown venue

• Publication date

  2016-02-16

• Fields of study

  Medicine, Materials Science, Chemistry, Environmental Science

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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• Delivery of Cancer Therapeutics Using Nanotechnology

  2013influential reference
• Nanoparticles for oral delivery: targeted nanoparticles with peptidic ligands for oral protein delivery.

  2013cited by this paper
• Lung toxicities of core–shell nanoparticles composed of carbon, cobalt, and silica

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  2013influential reference
• DNA repair mechanisms in dividing and non-dividing cells.

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  2013influential reference
• Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond

  2013cited by this paper
• Design of indomethacin-loaded nanoparticles: effect of polymer matrix and surfactant

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  2012cited by this paper
• Clinical pharmacology of non-steroidal anti-inflammatory drugs: a review.

  2012influential reference
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  2010cited by this paper
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  2010cited by this paper
• Cellular uptake, cytotoxicity, and innate immune response of silica-titania hollow nanoparticles based on size and surface functionality.

  2010cited by this paper
• Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats

  2009cited by this paper
• Effects of indomethacin‐loaded nanocapsules in experimental models of inflammation in rats

  2009influential reference
• Design of bio-mimetic particles with enhanced vascular interaction.

  2009cited by this paper
• Nanovehicular intracellular delivery systems.

  2008cited by this paper
• ANTI-ADHESION evolves to a promising therapeutic concept in oncology.

  2008cited by this paper
• Antigenotoxicity and antimutagenicity of lycopene in HepG2 cell line evaluated by the comet assay and micronucleus test.

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• Drug penetration in solid tumours

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  2001cited by this paper
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  2001cited by this paper
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• Nonsteroidal anti-inflammatory drug prescribing: past, present, and future.

  2001cited by this paper
• Association between nonsteroidal anti-inflammatory drugs and upper gastrointestinal tract bleeding/perforation: an overview of epidemiologic studies published in the 1990s.

  2000cited by this paper
• Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing

  2000cited by this paper
• Cyclooxygenases: structural, cellular, and molecular biology.

  2000cited by this paper
• Strategies and testing methods for identifying mutagenic risks.

  2000cited by this paper
• Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice.

  2000influential reference
• The in vitro micronucleus technique.

  2000influential reference
• Cyclooxygenases 1 and 2.

  1998cited by this paper
• The contribution of cytotoxicity to DNA-effects in the single cell gel test (comet assay).

  1997cited by this paper
• Association of upper gastrointestinal toxicity of non-steroidal anti-inflammatory drugs with continued exposure: cohort study

  1997cited by this paper
• Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis

  1996cited by this paper
• Prevention of benzene-induced myelotoxicity by nonsteroidal anti-inflammatory drugs.

  1989cited by this paper
• Viability measurements in mammalian cell systems.

  1989cited by this paper
• The prevention of benzene-induced genotoxicity in mice by indomethacin.

  1989cited by this paper
• 1989

  1989cited by this paper
• A simple technique for quantitation of low levels of DNA damage in individual cells.

  1988cited by this paper
• Mammalian in vivo cytogenetic assays. Analysis of chromosome aberrations in bone marrow cells.

  1987cited by this paper
• Evaluation of the anti-inflammatory drug indomethacin, for its genotoxicity in mice.

  1987influential reference
• Preparation

  1986cited by this paper
• Solutions to the kinetic problem in the micronucleus assay.

  1985cited by this paper
• Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells.

  1984cited by this paper
• Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

  1983influential reference
• Indomethacin in rheumatoid arthritis: comparison of oral and rectal dosing.

  1980cited by this paper

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