Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  American Journal of Physiology - Gastrointestinal and Liver Physiology

• Publication date

  2003-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1152/AJPGI.00056.2003PMID 14561585
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Modification of cardiac sodium current by intracellular application of cAMP

  2004cited by this paper
• Intestinal transport during fasting and malnutrition.

  2003cited by this paper
• Epidermal growth factor and insulin short-term increase hPepT1-mediated glycylsarcosine uptake in Caco-2 cells.

  2003cited by this paper
• Intestinal peptide transporter PepT1 is over-expressed during acute cryptosporidiosis in suckling rats as a result of both malnutrition and experimental parasite infection

  2003influential reference
• H/dipeptide absorption across the human intestinal epithelium is controlled indirectly via a functional Na/H exchanger.

  2002cited by this paper
• Nutrition and Aging—Research Communication The Regionalization of PepT1, NBAT and EAAC1 Transporters in the Small Intestine of Rats Are Unchanged from Birth to Adulthood

  2002cited by this paper
• PepT1 mRNA Expression Is Induced by Starvation and Its Level Correlates with Absorptive Transport of Cefadroxil Longitudinally in the Rat Intestine

  2002cited by this paper
• PepT1-mediated fMLP transport induces intestinal inflammation in vivo.

  2002cited by this paper
• Thyroid hormone regulates the activity and expression of the peptide transporter PEPT1 in Caco-2 cells.

  2002influential reference
• Regulation of oligopeptide transporter (Pept-1) in experimental diabetes.

  2002influential reference
• Effect of Lipopolysaccharide on Peptide Transporter 1 Expression in Rat Small Intestine and Its Attenuation by Dexamethasone

  2002cited by this paper
• Distribution of the H+/peptide transporter PepT1 in human intestine: up-regulated expression in the colonic mucosa of patients with short-bowel syndrome.

  2002cited by this paper
• Diurnal rhythm of H+-peptide cotransporter in rat small intestine.

  2002cited by this paper
• PepT1-mediated epithelial transport of dipeptides and cephalexin is enhanced by luminal leptin in the small intestine.

  2001influential reference
• Developmental Expression of PEPT1 and PEPT2 in Rat Small Intestine, Colon, and Kidney

  2001influential reference
• Expression and cellular distribution during development of the peptide transporter (PepT1) in the small intestinal epithelium of the rat

  2001cited by this paper
• Growth factors regulation of rabbit sodium-dependent neutral amino acid transporter ATB0 and oligopeptide transporter 1 mRNAs expression after enteretomy.

  2001cited by this paper
• Colonic epithelial hPepT1 expression occurs in inflammatory bowel disease: transport of bacterial peptides influences expression of MHC class 1 molecules.

  2001cited by this paper
• Intestinal adaptation: structure, function, and regulation.

  2001cited by this paper
• Effects of Tacrolimus and Cyclosporin A on Peptide Transporter PEPT1 in Caco-2 Cells

  2001cited by this paper
• Epidermal growth factor inhibits glycylsarcosine transport and hPepT1 expression in a human intestinal cell line.

  2001cited by this paper
• Expression of peptide transporter following intestinal transplantation in the rat.

  2001cited by this paper
• Structure and function of eukaryotic peptide transporters

  2000cited by this paper
• Regulation of PepT1 Peptide Transporter Expression in the Rat Small Intestine under Malnourished Conditions

  2000cited by this paper
• cDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1.

  2000cited by this paper
• α2-Adrenergic Receptors Stimulate Oligopeptide Transport in a Human Intestinal Cell Line

  2000cited by this paper
• Hormonal regulation of oligopeptide transporter Pept-1 in a human intestinal cell line.

  1999influential reference
• Normal pregnancy is associated with enhanced endothelium-dependent flow-mediated vasodilation.

  1999cited by this paper
• Peptide Transporter in the Rat Small Intestine: Ultrastructural Localization and the Effect of Starvation and Administration of Amino Acids

  1999cited by this paper
• Functional and molecular expression of intestinal oligopeptide transporter (Pept-1) after a brief fast.

  1999cited by this paper
• sigma Receptor ligand-induced up-regulation of the H(+)/peptide transporter PEPT1 in the human intestinal cell line Caco-2.

  1999cited by this paper
• Neural Modulation of Cephalexin Intestinal Absorption Through the Di-and Tripeptide Brush Border Transporter of Rat Jejunum In Vivo 1

  1999cited by this paper
• Cellular and molecular mechanisms of dietary regulation on rat intestinal H+/Peptide transporter PepT1.

  1999cited by this paper
• Hormonal regulation of oligopeptide transporter pept-1 in a human intestinal cell line.

  1999cited by this paper
• ς Receptor Ligand-Induced Up-Regulation of the H+/Peptide Transporter PEPT1 in the Human Intestinal Cell Line Caco-2

  1999cited by this paper
• Substrate upregulation of the human small intestinal peptide transporter, hPepT1

  1998influential reference
• Regulation of the PepT1 peptide transporter in the rat small intestine in response to 5-fluorouracil-induced injury.

  1998influential reference
• hPepT1-mediated epithelial transport of bacteria-derived chemotactic peptides enhances neutrophil-epithelial interactions.

  1998cited by this paper
• Molecular and structural features of the proton-coupled oligopeptide transporter superfamily.

  1998cited by this paper
• Mechanism of dipeptide stimulation of its own transport in a human intestinal cell line.

  1998influential reference
• The oligopeptide transporter (Pept-1) in human intestine: biology and function.

  1997cited by this paper
• Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter.

  1996cited by this paper
• Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney.

  1995cited by this paper
• Human Intestinal H+/Peptide Cotransporter

  1995cited by this paper
• Regional expression and dietary regulation of rat small intestinal peptide and amino acid transporter mRNAs.

  1995cited by this paper
• Expression cloning of a cDNA from rabbit small intestine related to proton-coupled transport of peptides, ßlactam antibiotics and ACE-inhibitors

  1994cited by this paper
• Expression cloning of a mammalian proton-coupled oligopeptide transporter

  1994cited by this paper
• Insulin and IGE-1 receptors in a human intestinal adenocarcinoma cell line (CACO-2): regulation of Na+ glucose transport across the brush border.

  1993cited by this paper
• Inhibition of sucrose-isomaltase expression by EGF in the human colon adenocarcinoma cells Caco-2.

  1991cited by this paper
• Water, electrolyte, glucose, and glycine absorption in rat small intestinal transplants.

  1988cited by this paper
• Dietary regulation of intestinal transport of the dipeptide carnosine.

  1988cited by this paper
• Effect of starvation on amino acid and peptide transport and peptide hydrolysis in humans.

  1985cited by this paper
• Development of Dipeptide Transport in the Intestinal Mucosa of Rabbits

  1982cited by this paper
• Age-Dependent Change in Intestinal Absorption of Dipeptides and Their Constituent Amino Acids in the Guinea Pig

  1980cited by this paper
• Amino acid and peptide absorption after proximal small intestinal resection in the rat.

  1979cited by this paper
• Kinetics of uptake of an amino acid and a dipeptide into hamster jejunum and ileum: the effect of semistarvation and starvation.

  1979cited by this paper
• Peptide absorption.

  1976cited by this paper
• Evidence for two different modes of tripeptide disappearance in human intestine. Uptake by peptide carrier systems and hydrolysis by peptide hydrolases.

  1975cited by this paper
• Functional characterization of dipeptide transport system in human jejunum.

  1974cited by this paper
• Protein digestion in human intestine as reflected in luminal, mucosal, and plasma amino acid concentrations after meals.

  1973cited by this paper
• Intestinal transport of dipeptides in man: relative importance of hydrolysis and intact absorption.

  1971cited by this paper
• Intestinal transport of dipeptides in man: relative importance of hydrolysis and intact absorption

  1971cited by this paper

• Revitalizing health with Lactobacillus isolates: Mitigating Aflatoxin B1 toxicity in HT-29 cell line and Balb/c mice.

  2025cites this paper
• Exploring microbiota as a diagnostic tool for paediatric Ulcerative colitis and Crohn's disease: a bioinformatics approach

  2025influential citation
• Validation of dietary whey protein substrate challenge absorption test as an indicator of proteolysis

  2025cites this paper
• Gastrointestinal changes in paediatric malnutrition that may impact on nutrition choice

  2025cites this paper
• Absorption of food-derived peptides: Mechanisms, influencing factors, and enhancement strategies.

  2024cites this paper
• Molecular Variability in Levodopa Absorption and Clinical Implications for the Management of Parkinson’s Disease

  2024cites this paper
• Oral glutamine supplementation relieves muscle loss in immobilized rats, altering p38MAPK and FOXO3a signaling pathways.

  2023cites this paper
• The Contribution of Phytate-Degrading Enzymes to Chicken-Meat Production

  2023cites this paper
• A 90‐day toxicity study of tripeptide, arginine‐alanine‐lysine

  2023cites this paper
• The effect of reducing dietary energy on performance, intestinal morphology and intestinal peptide and amino acid transporters in broiler chicks

  2022cites this paper
• Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers

  2022cites this paper
• The Effect of Reduced CP, Synthetic Amino Acid Supplemented Diets on Growth Performance and Nutrient Excretion in Wean to Finish Swine.

  2022cites this paper
• Peptides or Amino Acids?—‘The Smaller, the Better?’

  2022cites this paper
• Can spike fragments of SARS-CoV-2 induce genomic instability and DNA damage in the guppy, Poecilia reticulate? An unexpected effect of the COVID-19 pandemic

  2022cites this paper
• Protein digestion and bioavailability

  2021cites this paper
• Drug Related Complications After Bariatric Surgery

  2021cites this paper
• Regulation of drug transporters by microRNA and implications in disease treatment

  2021cites this paper
• Expression, Regulation, and Role of an Oligopeptide Transporter: PEPT1 in Tumors.

  2021cites this paper
• Protective Effects of Collagen Tripeptides in Human Aortic Endothelial Cells by Restoring ROS-Induced Transcriptional Repression

  2021influential citation
• Regulation of drug transporters by microRNA and implications in disease treatment

  2021cites this paper
• Feeding Protocol Modulates the Digestive Process in Senegalese Sole (Solea senegalensis) Juveniles

  2021cites this paper
• A Review of the Literature Relating to Collagen Hydrolysate and Its Potential Clinical Applications

  2021cites this paper
• Comparison of Digestive Enzyme Activities and Expression of Small Intestinal Transporter Genes in Jinhua and Landrace Pigs

  2021cites this paper
• Glutamine supplementation: hope, hype, or stay tuned?

  2021cites this paper
• The digestive function of gilthead seabream juveniles in relation to feeding frequency

  2021cites this paper
• Caco-2/HT29-MTX co-cultured cells as a model for studying physiological properties and toxin-induced effects on intestinal cells

  2021cites this paper
• L-glutamine for sickle cell disease: Knight or pawn?

  2020cites this paper
• An Amino Acid-Based Oral Rehydration Solution Regulates Radiation-Induced Intestinal Barrier Disruption in Mice.

  2020cites this paper
• Physiologie des Verdauungstraktes im Kindesalter

  2019cites this paper
• Association of SLC15A1 polymorphisms with susceptibility to dyslipidaemia in a Chinese Han population

  2019cites this paper
• Intestinal oligopeptide transporter PepT1-targeted polymeric micelles for further enhancing the oral absorption of water-insoluble agents.

  2019cites this paper
• Dysregulation of Mucosal Membrane Transporters and Drug-Metabolizing Enzymes in Ulcerative Colitis.

  2019cites this paper
• Acquisition of alanyl-alanine in an Agnathan: Characteristics of dipeptide transport across the hindgut of the Pacific hagfish Eptatretus stoutii.

  2019cites this paper
• The Emerging Role of l-Glutamine in Cardiovascular Health and Disease

  2019cites this paper
• Oral glutamine supplementation attenuate inflammation and oxidative stress-mediated skeletal muscle protein content degradation in immobilized rats: Role of 70 kDa heat shock protein.

  2019cites this paper
• Morphological bases for intestinal paracellular absorption in bats and rodents

  2019cites this paper
• Oral administration of alanyl-glutamine and glutamine improve random pattern dorsal skin flap survival in rats

  2018cites this paper
• Impact of mash and crumble diets on intestinal amino acids transporters, intestinal morphology and pancreatic enzyme activity of broilers

  2018cites this paper
• Immunomodulatory Protein Hydrolysates and Their Application

  2018cites this paper
• Gossypol reduced the intestinal amino acid absorption capacity of young grass carp (Ctenopharyngodon idella)

  2018cites this paper
• Transport of ACE Inhibitory Peptides Ile-Gln-Pro and Val-Glu-Pro Derived from Spirulina platensis Across Caco-2 Monolayers.

  2018cites this paper
• Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation

  2018cites this paper
• Gut health and serum growth hormone levels of broiler chickens fed dietary chitin and chitosan from cricket and shrimp

  2018cites this paper
• Solubility, Permeability, and Their Interplay

  2018cites this paper
• Spatial transcriptional profile of PepT1 mRNA in the yolk sac and small intestine in broiler chickens

  2017cites this paper
• Oral Contraceptives after Bariatric Surgery

  2017cites this paper
• Comment on: "Influence of an ω3-fatty acid-enriched enteral diet with and without added glutamine on the metabolic response to injury in a rat model of prolonged acute catabolism".

  2017cites this paper
• Impact of dietary energy density on the liver health of broilers exposed to heat stress and their performance during finisher period.

  2017cites this paper
• Effect of Energy Sources and Levels on Caecal Microbial Population , Jejunal Morphology , Gene Expression of Jejunal Transporters ( SGLT 1 , FABP ) and Performance of Broilers Under Heat Stress

  2017cites this paper
• Expression and regulation of the neutral amino acid transporter B0AT1 in rat small intestine

  2017cites this paper
• Influence of an ω3-fatty acid-enriched enteral diet with and without added glutamine on the metabolic response to injury in a rat model of prolonged acute catabolism.

  2017cites this paper
• The interaction between lysyl-lysine and arginine in the neonatal Yucatan miniature pig small intestine

  2017cites this paper
• Regulation profile of the intestinal peptide transporter 1 (PepT1)

  2017influential citation
• Effect of Aging on the Absorption of Small Peptides in Spontaneously Hypertensive Rats.

  2017cites this paper
• Current knowledge of intestinal absorption of bioactive peptides.

  2017cites this paper
• Fermented goat milk consumption during anaemia recovery: ergogenic effect and improvement of skeletal muscle homeostasis

  2017cites this paper
• Effects of dietary NaCl on the in vivo apparent absorption of dietary nutrients determined in rainbow trout (Oncorhynchus mykiss)

  2016cites this paper
• PepT1 Expression Helps Maintain Intestinal Homeostasis by Mediating the Differential Expression of miRNAs along the Crypt-Villus Axis

  2016cites this paper
• Analysis of the Role of Satiety of the Parents during Irradiation in the Assimilation of Substrates of the Protein Origin in two Generations of their Posterity

  2016cites this paper
• Bioactive Peptides from Milk

  2016cites this paper
• Energy sources and levels influenced on performance parameters, thyroid hormones, and HSP70 gene expression of broiler chickens under heat stress

  2016cites this paper
• Critical Role of PepT1 in Promoting Colitis-Associated Cancer and Therapeutic Benefits of the Anti-inflammatory PepT1-Mediated Tripeptide KPV in a Murine Model

  2016cites this paper
• Study of PepT1 and SPAK on Intestinal Homeostasis and Intestinal Inflammation

  2016cites this paper
• Drug transporter gene expression in human colorectal tissue and cell lines: modulation with antiretrovirals for microbicide optimization.

  2016cites this paper
• Di- and tripeptide transport in vertebrates: the contribution of teleost fish models

  2016cites this paper
• Postnatal ontogeny of small intestinal histomorphology, crypt cell proliferation and peptide transporter 1 gene expression in piglets

  2016cites this paper
• Peptide transport in the neonatal Yucatan miniature pig

  2015cites this paper
• Contrary seasonal changes of rates of nutrient uptake, organ mass, and voluntary food intake in red deer (Cervus elaphus).

  2015influential citation
• 1.7 Gastrointestinal development, nutrient digestion and absorption.

  2015cites this paper
• Digestive adaptations of aerial lifestyles.

  2015cites this paper
• MicroRNA-193a-3p Reduces Intestinal Inflammation in Response to Microbiota via Down-regulation of Colonic PepT1*

  2015cites this paper
• Effects of glucocorticoid-induced stress on absorption of glycylsarcosine in jejunum of broilers.

  2015cites this paper
• Nod2–Rip2 Signaling Contributes to Intestinal Injury Induced by Muramyl Dipeptide Via Oligopeptide Transporter in Rats

  2015cites this paper
• Biological Membranes and Barriers

  2015cites this paper
• Glucose-dependent insulinotropic polypeptide-mediated signaling pathways enhance apical PepT1 expression in intestinal epithelial cells.

  2015cites this paper
• The Modulation of Non-steroidal Anti-inflammatory Toxicity as a Function of the Interplay between Uptake and Efflux Transporters

  2015cites this paper
• Systems biology of inborn errors of metabolism

  2014cites this paper
• A high-protein formula increases colonic peptide transporter 1 activity during neonatal life in low-birth-weight piglets and disturbs barrier function later in life

  2014cites this paper
• Paracellular nutrient absorption is higher in bats than rodents: integrating from intact animals to the molecular level

  2014cites this paper
• Meeting Digestive Demand With Smaller Intestines

  2014cites this paper
• Oral supplementations with free and dipeptide forms of L-glutamine in endotoxemic mice: effects on muscle glutamine-glutathione axis and heat shock proteins.

  2014cites this paper
• Prospects for the replenishment of a feed protein deficit in aquaculture

  2014cites this paper
• Oral free and dipeptide forms of glutamine supplementation attenuate oxidative stress and inflammation induced by endotoxemia.

  2014cites this paper
• Identification of Peptides in Sediments Derived from an Acidic Enzymatic Soy Protein Hydrolysate Solution

  2014cites this paper
• Segmental-Dependent Drug Absorption and Delivery: The Intestinal Tract

  2014influential citation
• Alanyl-glutamine and glutamine plus alanine supplements improve skeletal redox status in trained rats: involvement of heat shock protein pathways.

  2014cites this paper
• Are intact peptides absorbed from the healthy gut in the adult human?

  2014influential citation
• Essential amino acid supplementation for the prevention and treatment of obesity

  2014cites this paper
• Membrane transporters in a human genome-scale metabolic knowledgebase and their implications for disease

  2014cites this paper
• Theaflavins, dimeric catechins, inhibit peptide transport across Caco-2 cell monolayers via down-regulation of AMP-activated protein kinase-mediated peptide transporter PEPT1.

  2013cites this paper
• Selection for high muscle fat in rainbow trout induces potentially higher chylomicron synthesis and PUFA biosynthesis in the intestine.

  2013cites this paper
• Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications.

  2013cites this paper
• Benzotropolone moiety in theaflavins is responsible for inhibiting peptide-transport and activating AMP-activated protein kinase in Caco-2 cells

  2013cites this paper
• PepT1 mRNA expression levels in sea bream (Sparus aurata) fed different plant protein sources

  2013cites this paper
• Dipeptide transport in Yucatan miniature piglet intestine

  2013cites this paper
• PepT1 expressed in immune cells has an important role in promoting the immune response during experimentally induced colitis

  2013cites this paper
• PEPT (SLC15A) Family

  2013cites this paper
• IL-16 Induces Intestinal Inflammation via PepT1 Upregulation in a Pufferfish Model: New Insights into the Molecular Mechanism of Inflammatory Bowel Disease

  2013cites this paper
• SUPLEMENTAÇõES NUTRICIONAIS E ESTRESSE OXIDATIVO: IMPLICAÇõES NA ATIVIDADE FÍSICA E NO ESPORTE

  2013cites this paper
• Digestive physiology of the pig symposium: gut chemosensing and the regulation of nutrient absorption and energy supply.

  2013cites this paper