Mx Proteins: Antiviral Gatekeepers That Restrain the Uninvited

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Microbiology and Molecular Reviews

• Publication date

  2013-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MMBR.00024-13PMID 24296571PMCID PMC3973384
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• An evolutionary perspective on the broad antiviral specificity of MxA.

  2013cited by this paper
• Pandemic Influenza A Viruses Escape from Restriction by Human MxA through Adaptive Mutations in the Nucleoprotein

  2013influential reference
• Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA.

  2012influential reference
• MxA inhibits hepatitis B virus replication by interaction with hepatitis B core antigen

  2012cited by this paper
• The Structure of Native Influenza Virion Ribonucleoproteins

  2012cited by this paper
• Partial antiviral activities of the Asn631 chicken Mx against newcastle disease virus and vesicular stomatitis virus

  2012cited by this paper
• Development of an in vitro system to measure the sensitivity to the antiviral Mx protein of fish viruses.

  2012cited by this paper
• In Vivo Modulation of the Innate Response to Pneumovirus by Type-I and -III Interferon-Induced Bos taurus Mx1

  2012cited by this paper
• Interferon-Inducible Protein Mx1 Inhibits Influenza Virus by Interfering with Functional Viral Ribonucleoprotein Complex Assembly

  2012cited by this paper
• Human MxA protein inhibits the replication of classical swine fever virus.

  2011cited by this paper
• The Viral Nucleoprotein Determines Mx Sensitivity of Influenza A Viruses

  2011cited by this paper
• Tanglegrams for rooted phylogenetic trees and networks

  2011cited by this paper
• Stalk Domain of the Dynamin-like MxA GTPase Protein Mediates Membrane Binding and Liposome Tubulation via the Unstructured L4 Loop*

  2011cited by this paper
• Crystal structure of nucleotide-free dynamin

  2011cited by this paper
• The Cellular RNA Helicase UAP56 Is Required for Prevention of Double-Stranded RNA Formation during Influenza A Virus Infection

  2011cited by this paper
• Three Mx genes with differential response to VNNV infection have been identified in Gilthead seabream (Sparus aurata).

  2011cited by this paper
• Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function.

  2011cited by this paper
• Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication

  2010cited by this paper
• Anti-viral mechanism of barramundi Mx against betanodavirus involves the inhibition of viral RNA synthesis through the interference of RdRp.

  2010cited by this paper
• Structural basis of oligomerization in the stalk region of dynamin-like MxA

  2010influential reference
• Dynamin-like MxA GTPase: Structural Insights into Oligomerization and Implications for Antiviral Activity*

  2010cited by this paper
• Cyclin T1/CDK9 Interacts with Influenza A Virus Polymerase and Facilitates Its Association with Cellular RNA Polymerase II

  2010cited by this paper
• Structure of the MxA stalk elucidates the assembly of ring-like units of an antiviral module

  2010cited by this paper
• Interferon-induced Sus scrofa Mx1 blocks endocytic traffic of incoming influenza A virus particles

  2010cited by this paper
• rtracklayer: an R package for interfacing with genome browsers

  2009cited by this paper
• Enhanced grass carp reovirus resistance of Mx-transgenic rare minnow (Gobiocypris rarus).

  2009cited by this paper
• Modulating mouse innate immunity to RNA viruses by expressing the Bos taurus Mx system

  2009cited by this paper
• Jalview Version 2—a multiple sequence alignment editor and analysis workbench

  2009cited by this paper
• Efficient production of Rift Valley fever virus-like particles: The antiviral protein MxA can inhibit primary transcription of bunyaviruses.

  2009cited by this paper
• GTPase activity is not essential for the interferon-inducible MxA protein to inhibit the replication of hepatitis B virus

  2008influential reference
• Inhibition of a Large Double-Stranded DNA Virus by MxA Protein

  2008cited by this paper
• In vitro inhibition of sole aquabirnavirus by Senegalese sole Mx.

  2008cited by this paper
• Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design

  2008cited by this paper
• Asparagine 631 Variants of the Chicken Mx Protein Do Not Inhibit Influenza Virus Replication in Primary Chicken Embryo Fibroblasts or In Vitro Surrogate Assays

  2008cited by this paper
• Grouper Mx confers resistance to nodavirus and interacts with coat protein.

  2008cited by this paper
• Interferon-inducible antiviral effectors

  2008cited by this paper
• Influenza A Virus Strains Differ in Sensitivity to the Antiviral Action of Mx-GTPase

  2008cited by this paper
• Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus

  2008cited by this paper
• Cloning and analysis of antiviral activity of a barramundi (Lates calcarifer) Mx gene.

  2007cited by this paper
• Identification of cellular interaction partners of the influenza virus ribonucleoprotein complex and polymerase complex using proteomic-based approaches.

  2007cited by this paper
• Mx1 Gene Protects Mice Against the Highly Lethal Human H5N1 Influenza Virus

  2007cited by this paper
• Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene

  2007cited by this paper
• The Mx1 Gene Protects Mice against the Pandemic 1918 and Highly Lethal Human H5N1 Influenza Viruses

  2007cited by this paper
• Clustal W and Clustal X version 2.0

  2007cited by this paper
• Human MxA protein confers resistance to double-stranded RNA viruses of two virus families.

  2007cited by this paper
• Induction of MxA Gene Expression by Influenza A Virus Requires Type I or Type III Interferon Signaling

  2007cited by this paper
• Involvement of Hsp90 in Assembly and Nuclear Import of Influenza Virus RNA Polymerase Subunits

  2006cited by this paper
• Bovine and water buffalo Mx2 genes: polymorphism and antiviral activity

  2006cited by this paper
• Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium

  2006cited by this paper
• Interferon-Induced, Antiviral Human MxA Protein Localizes to a Distinct Subcompartment of the Smooth Endoplasmic Reticulum

  2006cited by this paper
• Inhibition of nervous necrosis virus propagation by fish Mx proteins.

  2006cited by this paper
• Functional characterisation of the Japanese flounder, Paralichthys olivaceus, Mx promoter.

  2006cited by this paper
• Expression of the interferon-alpha/beta-inducible bovine Mx1 dynamin interferes with replication of rabies virus.

  2006cited by this paper
• Intracellular Localization and Antiviral Property of Canine Mx Proteins

  2005cited by this paper
• Constitutive expression of Atlantic salmon Mx1 protein in CHSE-214 cells confers resistance to Infectious Salmon Anaemia virus

  2005cited by this paper
• Conditional Expression of Type I Interferon-Induced Bovine Mx1 GTPase in a Stable Transgenic Vero Cell Line Interferes with Replication of Vesicular Stomatitis Virus

  2004cited by this paper
• Thogoto Virus Lacking Interferon-Antagonistic Protein ML Is Strongly Attenuated in Newborn Mx1-Positive but Not Mx1-Negative Mice

  2004cited by this paper
• The dynamin superfamily: universal membrane tubulation and fission molecules?

  2004cited by this paper
• Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome.

  2004cited by this paper
• Missorting of LaCrosse Virus Nucleocapsid Protein by the Interferon‐Induced MxA GTPase Involves Smooth ER Membranes

  2004influential reference
• Inhibition of Infectious Pancreatic Necrosis Virus Replication by Atlantic Salmon Mx1 Protein

  2004cited by this paper
• Inhibition of nuclear import and cell-cycle progression by mutated forms of the dynamin-like GTPase MxB

  2004cited by this paper
• Dynamin GTPase Domain Mutants That Differentially Affect GTP Binding, GTP Hydrolysis, and Clathrin-mediated Endocytosis*

  2004cited by this paper
• Genomic structure, organisation, and promoter analysis of the bovine (Bos taurus) Mx1 gene.

  2004cited by this paper
• Human MxA Protein Inhibits the Replication of Crimean-Congo Hemorrhagic Fever Virus

  2004cited by this paper
• Native antiviral specificity of chicken Mx protein depends on amino acid variation at position 631.

  2004cited by this paper
• Inhibition of Dugbe nairovirus replication by human MxA protein.

  2004cited by this paper
• In vitro inhibition of fish rhabdoviruses by Japanese flounder, Paralichthys olivaceus Mx.

  2003cited by this paper
• Polymorphisms and the differential antiviral activity of the chicken Mx gene.

  2002cited by this paper
• Polymorphisms and the antiviral property of porcine Mx1 protein.

  2002cited by this paper
• Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes

  2002cited by this paper
• Cloning, expression, and initial characterization of a novel cytokine-like gene family.

  2002cited by this paper
• Effect of double-stranded RNA and interferon on the antiviral activity of Atlantic salmon cells against infectious salmon anemia virus and infectious pancreatic necrosis virus.

  2002cited by this paper
• The Antiviral Dynamin Family Member, MxA, Tubulates Lipids and Localizes to the Smooth Endoplasmic Reticulum*

  2002cited by this paper
• Self-assembly of Human MxA GTPase into Highly Ordered Dynamin-like Oligomers*

  2002cited by this paper
• Interferon‐Induced Mx Proteins: Dynamin‐Like GTPases with Antiviral Activity

  2002cited by this paper
• Identification of Hsp90 as a Stimulatory Host Factor Involved in Influenza Virus RNA Synthesis*

  2002cited by this paper
• Inhibition of Hepatitis B Virus Replication by the Interferon-Inducible MxA Protein

  2001cited by this paper
• Mouse Mx2 protein inhibits hantavirus but not influenza virus replication

  2001cited by this paper
• The rainbow trout (Oncorhynchus mykiss) Mx1 promoter

  2001cited by this paper
• Expression of the antiviral protein Mx in peripheral blood mononuclear cells of pregnant and bred, non-pregnant ewes.

  2001cited by this paper
• The rainbow trout (Oncorhynchus mykiss) Mx1 promoter. Structural and functional characterization.

  2001cited by this paper
• Interferon-Induced Rat Mx Proteins Confer Resistance to Rift Valley Fever Virus and Other Arthropod-Borne Viruses

  2001cited by this paper
• A Monomeric GTPase-Negative MxA Mutant with Antiviral Activity

  2000cited by this paper
• MxA GTPase Blocks Reporter Gene Expression of Reconstituted Thogoto Virus Ribonucleoprotein Complexes

  2000cited by this paper
• Identification of the Murine Mx2 Gene: Interferon-Induced Expression of the Mx2 Protein from the Feral Mouse Gene Confers Resistance to Vesicular Stomatitis Virus

  1999cited by this paper
• Respiratory syncytial virus strain A2 is resistant to the antiviral effects of type I interferons and human MxA.

  1999cited by this paper
• GTP-bound Human MxA Protein Interacts with the Nucleocapsids of Thogoto Virus (Orthomyxoviridae)*

  1999influential reference
• The central interactive region of human MxA GTPase is involved in GTPase activation and interaction with viral target structures

  1999cited by this paper
• Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids.

  1999influential reference
• Intramolecular Backfolding of the Carboxyl-terminal End of MxA Protein Is a Prerequisite for Its Oligomerization*

  1999cited by this paper
• Human MxA Protein Protects Mice Lacking a Functional Alpha/Beta Interferon System against La Crosse Virus and Other Lethal Viral Infections

  1999cited by this paper
• Interferon‐inducible Mx proteins in fish

  1998cited by this paper
• Human MxA Protein Confers Resistance to Semliki Forest Virus and Inhibits the Amplification of a Semliki Forest Virus-Based Replicon in the Absence of Viral Structural Proteins

  1998cited by this paper
• Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity

  1997cited by this paper
• Mx1 sensitivity: Batken virus is an orthomyxovirus closely related to Dhori virus.

  1997cited by this paper
• Antiviral determinants of rat Mx GTPases map to the carboxy-terminal half

  1997cited by this paper
• Inhibition of puumala and tula hantaviruses in Vero cells by MxA protein.

  1996cited by this paper
• Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein

  1996cited by this paper
• Human MxB Protein, an Interferon-α-inducible GTPase, Contains a Nuclear Targeting Signal and Is Localized in the Heterochromatin Region beneath the Nuclear Envelope*

  1996cited by this paper

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