The chondrocyte, architect of cartilage. Biomechanics, structure, function and molecular biology of cartilage matrix macromolecules

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Bioessays

• Publication date

  1995-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/bies.950171208PMID 8634065
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Is Essential for Skeletal Morphogenesis

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• Expression of cartilage-specific molecules is retained on long-term culture of human articular chondrocytes.

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• The link proteins.

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• Characterization of type II and type XI collagen synthesis by an immortalized rat chondrocyte cell line (IRC) having a low level of type II collagen mRNA expression.

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• Of mice and men: heritable skeletal disorders.

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• Alternative splice form of type II procollagen mRNA (IIA) is predominant in skeletal precursors and non‐cartilaginous tissues during early mouse development

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• Link protein is ubiquitously expressed in non-cartilaginous tissues where it enhances and stabilizes the interaction of proteoglycans with hyaluronic acid.

  1994cited by this paper
• Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia.

  1994cited by this paper
• Mouse cartilage matrix deficiency (cmd) caused by a 7 bp deletion in the aggrecan gene

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• Self-assembly into fibrils of collagen II by enzymic cleavage of recombinant procollagen II. Lag period, critical concentration, and morphology of fibrils differ from collagen I.

  1994cited by this paper
• Normal long bone growth and development in type X collagen-null mice

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• The chondrocyte: a cell under pressure.

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• Phenotypic stability of bovine articular chondrocytes after long-term culture in alginate beads.

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• Human link protein gene: structure and transcription pattern in chondrocytes.

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• cDNA cloning of chick cartilage chondroitin sulfate (aggrecan) core protein and identification of a stop codon in the aggrecan gene associated with the chondrodystrophy, nanomelia.

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• Deletion of a large domain in recombinant human procollagen II does not alter the thermal stability of the triple helix.

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• Assembly of cartilage collagen fibrils is disrupted by overexpression of normal type II collagen in transgenic mice.

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• Mutation in type II procollagen (COL2A1) that substitutes aspartate for glycine alpha 1-67 and that causes cataracts and retinal detachment: evidence for molecular heterogeneity in the Wagner syndrome and the Stickler syndrome (arthro-ophthalmopathy)

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• Nanomelic chondrocytes synthesize, but fail to translocate, a truncated aggrecan precursor.

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• Regulation of matrix synthesis rates by the ionic and osmotic environment of articular chondrocytes

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• Expression and role of c-myc in chondrocytes undergoing endochondral ossification.

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• A fourth example suggests that premature termination codons in the COL2A1 gene are a common cause of the Stickler syndrome: analysis of the COL2A1 gene by denaturing gradient gel electrophoresis.

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• Osteoarthritis associated with mild chondrodysplasia in transgenic mice expressing alpha 1(IX) collagen chains with a central deletion.

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• Osteoarthritis associated with mild chondrodysplasia in transgenic mice expressing α1 (IX) collagen chains with a central deletion

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• Ultrastructural organization of type XI collagen in fetal bovine epiphyseal cartilage

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• Intermediary metabolism in the Swarm rat chondrosarcoma chondrocyte.

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• Acquisition of hyaluronate-binding affinity in vivo by newly synthesized cartilage proteoglycans.

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• Cartilage contains mixed fibrils of collagen types II, IX, and XI

  1989cited by this paper
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  1988cited by this paper
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  1987cited by this paper
• Chondrocytes from the cartilage proteoglycan-deficient mutant, nanomelia, synthesize greatly reduced levels of the proteoglycan core protein transcript.

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• Contact pressures in the human hip joint.

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• Nonexpression of cartilage type II collagen in a case of Langer-Saldino achondrogenesis.

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• Ultrastructural changes in articular cartilage after experimental section of the anterior cruciate ligament of the dog knee.

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  1979cited by this paper
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