Continuous synthesis of artemisinin-derived medicines.

K. Gilmore,Daniel Kopetzki,Ju Weon Lee,Z. Horváth,D. McQuade,A. Seidel‐Morgenstern,A. Seidel‐Morgenstern,Peter H. Seeberger,Peter H. Seeberger

Published 2014 in Chemical Communications

ABSTRACT

Described is a continuous, divergent synthesis system which is coupled to continuous purification and is capable of producing four anti-malarial APIs. The system is comprised of three linked reaction modules for photooxidation/cyclization, reduction, and derivatization. A fourth module couples the crude reaction stream with continuous purification to yield pure API.

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