IL-19 is a component of the pathogenetic IL-23/IL-17 cascade in psoriasis.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Investigative Dermatology

• Publication date

  2014-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/jid.2014.308PMID 25046339
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses.

  2013cited by this paper
• Therapeutic opportunities of the IL-22–IL-22R1 system

  2013cited by this paper
• Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice.

  2013influential reference
• IL-29 Is Produced by TH17 Cells and Mediates the Cutaneous Antiviral Competence in Psoriasis

  2013influential reference
• Psoriasis and metabolic syndrome: a systematic review and meta-analysis of observational studies.

  2013cited by this paper
• Genome‐wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway

  2012cited by this paper
• IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+ Th17 cells

  2012cited by this paper
• The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury.

  2012cited by this paper
• Psoriasis-associated variant Act1 D10N with impaired regulation by Hsp90

  2012cited by this paper
• Targeting IL-17 and TH17 cells in chronic inflammation

  2012cited by this paper
• Deficiency of IL-22 Contributes to a Chronic Inflammatory Disease: Pathogenetic Mechanisms in Acne Inversa

  2011cited by this paper
• The Anti-Inflammatory Cytokine Interleukin 19 Is Expressed By and Angiogenic for Human Endothelial Cells

  2011cited by this paper
• Protective role of interleukin-19 gene polymorphisms in patients with ulcerative colitis.

  2011cited by this paper
• Interleukin-19 (IL-19) Induces Heme Oxygenase-1 (HO-1) Expression and Decreases Reactive Oxygen Species in Human Vascular Smooth Muscle Cells*

  2011cited by this paper
• Anti-inflammatory cytokine interleukin-19 inhibits smooth muscle cell migration and activation of cytoskeletal regulators of VSMC motility.

  2011cited by this paper
• IL-10 family of cytokines.

  2010influential reference
• Interleukin-26: an IL-10-related cytokine produced by Th17 cells.

  2010cited by this paper
• IL-24 Transgenic Mice: In Vivo Evidence of Overlapping Functions for IL-20, IL-22, and IL-24 in the Epidermis

  2010cited by this paper
• Further association analysis of chr 6q22-24 suggests a role of IL-20RA polymorphisms in psoriasis.

  2010cited by this paper
• Interleukin‐20 plays a critical role in maintenance and development of psoriasis in the human xenograft transplantation model

  2009cited by this paper
• Genome-wide association study and meta-analysis finds over 40 loci affect risk of type 1 diabetes

  2009cited by this paper
• Inhibition of ERK MAPK Suppresses IL-23- and IL-1-Driven IL-17 Production and Attenuates Autoimmune Disease1

  2009cited by this paper
• IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not

  2009cited by this paper
• The Th17 cytokine IL‐22 induces IL‐20 production in keratinocytes: A novel immunological cascade with potential relevance in psoriasis

  2009cited by this paper
• Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: important implications in asthma.

  2008cited by this paper
• The biological functions of T helper 17 cell effector cytokines in inflammation.

  2008cited by this paper
• Gene Expression Profiling in Autoimmune Noninfectious Uveitis Disease1

  2008cited by this paper
• IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation.

  2008cited by this paper
• Expression of IL-19 and its receptors in RA: potential role for synovial hyperplasia formation.

  2008cited by this paper
• Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia.

  2008cited by this paper
• Chemotactic Activity of S100A7 (Psoriasin) Is Mediated by the Receptor for Advanced Glycation End Products and Potentiates Inflammation with Highly Homologous but Functionally Distinct S100A151

  2008cited by this paper
• Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2).

  2008cited by this paper
• Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1).

  2008cited by this paper
• Th17 cytokines interleukin (IL)‐17 and IL‐22 modulate distinct inflammatory and keratinocyte‐response pathways

  2008cited by this paper
• Genomewide Scan Reveals Association of Psoriasis with IL-23 and NF-κB Pathways

  2008cited by this paper
• Pathogenesis and clinical features of psoriasis.

  2007cited by this paper
• The murine liver is a potential target organ for IL-19, IL-20 and IL-24: Type I Interferons and LPS regulate the expression of IL-20R2.

  2007cited by this paper
• β‐Defensins chemoattract macrophages and mast cells but not lymphocytes and dendritic cells: CCR6 is not involved

  2007cited by this paper
• Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis

  2007cited by this paper
• Immunopathogenesis of psoriasis

  2007cited by this paper
• IL-19 IS INVOLVED IN THE PATHOGENESIS OF ENDOTOXIC SHOCK

  2007cited by this paper
• The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis

  2007cited by this paper
• Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis

  2007cited by this paper
• Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides

  2006cited by this paper
• Interleukin (IL)‐19, IL‐20 and IL‐24 are produced by and act on keratinocytes and are distinct from classical ILs

  2006cited by this paper
• IL‐22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

  2006cited by this paper
• Possible relations between the polymorphisms of the cytokines IL-19, IL-20 and IL-24 and plaque-type psoriasis

  2005cited by this paper
• IL-22 increases the innate immunity of tissues.

  2004cited by this paper
• Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol.

  2003influential reference
• Endogenous antimicrobial peptides and skin infections in atopic dermatitis.

  2002cited by this paper
• Interleukins 19, 20, and 24 Signal through Two Distinct Receptor Complexes

  2002cited by this paper
• Cutting Edge: Immune Cells as Sources and Targets of the IL-10 Family Members?

  2002cited by this paper
• Interleukin 20: discovery, receptor identification, and role in epidermal function.

  2001cited by this paper
• Cutting Edge: STAT Activation By IL-19, IL-20 and mda-7 Through IL-20 Receptor Complexes of Two Types1

  2001cited by this paper
• Cloning, expression and initial characterisation of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)

  2000cited by this paper
• Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor-alpha and epidermal growth factor.

  1987cited by this paper

• Inhibition of the JAK/STAT Signaling Pathway Suggests a Protective Effect against Acantholysis in Pemphigus

  2026cites this paper
• Clinical proof of concept for small molecule mediated inhibition of IL-17 in psoriasis

  2026cites this paper
• Interventions in cytokine signaling: novel horizons for psoriasis treatment

  2025cites this paper
• T cells promote distinct transcriptional programs of cutaneous inflammatory disease in keratinocytes and dermal fibroblasts.

  2025cites this paper
• Alloferon and IL-22 receptor expression regulation on the pathogenesis of imiquimod-induced psoriasis

  2025cites this paper
• Psoriasis and diabetes: a review of the pathophysiological and therapeutic interconnections.

  2025cites this paper
• Unveiling the molecular mechanisms of Haitang-Xiaoyin Mixture in psoriasis treatment based on bioinformatics, network pharmacology, machine learning, and molecular docking verification

  2025cites this paper
• Molecular, Histological, and Clinical Effects of Selective TYK2 Inhibition with Zasocitinib (TAK-279) in Patients with Moderate-to-Severe Plaque Psoriasis.

  2025cites this paper
• Radon exposure delays the development of skin lesions in a mouse model of psoriasis

  2025cites this paper
• Targeting psoriatic inflammation with natural compounds: mechanistic insights and therapeutic promise

  2025cites this paper
• Skin immunity and inflammation: cellular interactions and communication

  2025cites this paper
• Cooling Blood and Detoxicating Formula Treats Psoriasis Through RHCG-Related Mechanisms

  2025cites this paper
• Cytokines in psoriasis: From pathogenesis to targeted therapy.

  2024cites this paper
• Extracellular release of damaged mitochondria induced by prehematopoietic stem cell transplant conditioning exacerbates GVHD

  2024cites this paper
• The Immunology of Psoriasis—Current Concepts in Pathogenesis

  2024cites this paper
• Decreased HMGCS1 inhibits proliferation and inflammatory response of keratinocytes and ameliorates imiquimod-induced psoriasis via the STAT3/IL-23 axis.

  2024cites this paper
• Skin barrier-inflammatory pathway is a driver of the psoriasis-atopic dermatitis transition

  2024influential citation
• Topical application of berberine ameliorates imiquimod-induced psoriasis-like dermatitis in BALB/c mice via suppressing JAK1/STAT1 signaling pathway

  2024cites this paper
• Interleukins and Psoriasis

  2024cites this paper
• T cells promote distinct transcriptional programs of cutaneous inflammatory disease in keratinocytes and dermal fibroblasts

  2024cites this paper
• Unveiling the Role of Resident Memory T Cells in Psoriasis.

  2024cites this paper
• NETosis in autoimmune diseases with focus on psoriasis

  2024cites this paper
• Circulating CD31 and resistin levels reflect different stages of coronary atherosclerosis in patients with psoriasis

  2024cites this paper
• Efficacy and safety of guselkumab in European patients with palmoplantar pustulosis: A multi-center, single-arm clinical trial (GAP study)

  2024cites this paper
• Immunological Advancements In Hand Eczema Treatment: Progress With Small Molecules and Biologics

  2024cites this paper
• Pharmacodynamic Response to Deucravacitinib, an Oral, Selective, Allosteric TYK2 Inhibitor, in a Global, Phase 2, Randomized, Double-Blind, Placebo-Controlled Psoriasis Trial

  2024influential citation
• Clinical characteristic, laboratory biomarkers, treatment regimen and psychiatry problems predictors of outcomes of alopecia areata: a prospective study

  2024cites this paper
• STATs, promising targets for the treatment of autoimmune and inflammatory diseases.

  2024cites this paper
• The Role of Collagens in Atopic Dermatitis

  2024cites this paper
• Phase 2 Trial of Deucravacitinib in Psoriatic Arthritis: Biomarkers Associated With Disease Activity, Pharmacodynamics, and Clinical Responses

  2024cites this paper
• Management of Infections in Psoriatic Patients Treated with Systemic Therapies: A Lesson from the Immunopathogenesis of Psoriasis

  2023cites this paper
• Biology of Interleukin-17 and Novel Therapies for Hidradenitis Suppurativa

  2023cites this paper
• “Input/output cytokines” in epidermal keratinocytes and the involvement in inflammatory skin diseases

  2023cites this paper
• Research progress on the neutrophil components and their interactions with immune cells in the development of psoriasis

  2023cites this paper
• Human NCF190H Variant Promotes IL-23/IL-17—Dependent Mannan-Induced Psoriasis and Psoriatic Arthritis

  2023cites this paper
• Single‐cell RNA‐seq reveals abnormal differentiation of keratinocytes and increased inflammatory differentiated keratinocytes in atopic dermatitis

  2023cites this paper
• TYK2 as a novel therapeutic target in psoriasis

  2023cites this paper
• Recent advancements in novel formulations of anti-psoriatic agents for effective delivery: clinical importance and patent survey.

  2023cites this paper
• The neglected twin: nummular eczema is a variant of atopic dermatitis with co-dominant Th2/Th17 immune response.

  2023cites this paper
• Evaluation of Interleukin 19 level in acne vulgaris patients

  2023cites this paper
• Commentary: Transcriptome analysis of host inflammatory responses to the ectoparasitic mite Sarcoptes scabiei var. hominis

  2023cites this paper
• Interleukin-19 Levels Are Increased in Palmoplantar Pustulosis and Reduced following Apremilast Treatment

  2023cites this paper
• Gut Microbiota in Psoriasis

  2022cites this paper
• Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation

  2022cites this paper
• Psoriasis between Autoimmunity and Oxidative Stress: Changes Induced by Different Therapeutic Approaches

  2022cites this paper
• Multiple Roles for Cytokines in Atopic Dermatitis: From Pathogenic Mediators to Endotype-Specific Biomarkers to Therapeutic Targets

  2022cites this paper
• Non-immune functions of inflammatory cytokines targeted by anti-psoriatic biologics: a review

  2022cites this paper
• Upregulation of interleukin-19 in saliva of patients with COVID-19

  2022cites this paper
• Phytotherapeuthics Affecting the IL-1/IL-17/G-CSF Axis: A Complementary Treatment Option for Hidradenitis Suppurativa?

  2022cites this paper
• Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity

  2021cites this paper
• Thrombosis in Psoriasis: Cutaneous Cytokine Production as a Potential Driving Force of Haemostatic Dysregulation and Subsequent Cardiovascular Risk

  2021cites this paper
• Combination of FLG mutations and SNPs of IL-17A and IL-19 influence on atopic dermatitis occurrence

  2021cites this paper
• Topical hypochlorous acid (HOCl) blocks inflammatory gene expression and tumorigenic progression in UV-exposed SKH-1 high risk mouse skin

  2021cites this paper
• High inflammation in HS extends to perilesional skin, and can be subdivided by LCN2 expression.

  2021cites this paper
• Cytokines and apoptosis in atopic dermatitis

  2021cites this paper
• Pathophysiology of psoriasis: A review

  2021cites this paper
• Immune responses and therapeutic options in psoriasis

  2021cites this paper
• Immunotherapy in psoriasis.

  2021cites this paper
• Insights into interplay of immunopathophysiological events and molecular mechanistic cascades in psoriasis and its associated comorbidities.

  2021cites this paper
• Assessment of serum interleukin‐19 in acne vulgaris patients of different clinical severities

  2021cites this paper
• Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis.

  2021cites this paper
• Transcriptome Analysis of Host Inflammatory Responses to the Ectoparasitic Mite Sarcoptes scabiei var. hominis

  2021cites this paper
• Fast Maturation of Splenic Dendritic Cells Upon TBI Is Associated With FLT3/FLT3L Signaling

  2021cites this paper
• Molecular and clinical effects of selective TYK2 inhibition with deucravacitinib in psoriasis.

  2021cites this paper
• Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis

  2021cites this paper
• Interleukin-17A Drives IL-19 and IL-24 Expression in Skin Stromal Cells Regulating Keratinocyte Proliferation

  2021cites this paper
• Diacerein Alone and in Combination with Infliximab Suppresses the Combined Proinflammatory Effects of IL-17A, IL-22, Oncostatin M, IL-1A, and TNF-alpha in Keratinocytes: A Potential Therapeutic Option in Psoriasis

  2021cites this paper
• Early immune suppression leads to uncontrolled mite proliferation and potent host inflammatory responses in a porcine model of crusted versus ordinary scabies

  2020influential citation
• IL-20-receptor signaling delimits IL-17 production in psoriatic inflammation.

  2020cites this paper
• Biological depletion of neutrophils attenuates pro-inflammatory markers and the development of the psoriatic phenotype in a murine model of psoriasis.

  2020cites this paper
• Immunopathogenesis of Progressive Scarring Trachoma: Results of a 4-Year Longitudinal Study in Tanzanian Children

  2020influential citation
• Interleukin-17A and Keratinocytes in Psoriasis

  2020influential citation
• IL-19 as a Biomarker for the Seveity of Acute Myocardial Infarction.

  2020cites this paper
• Skin - a vast organ with immunological function (Review).

  2020cites this paper
• IL-10 and its related superfamily members IL-19 and IL-24 provide parallel/redundant immune-modulation in Loa loa infection.

  2020cites this paper
• Resolution of inflammation in immune and non-immune cells by Interleukin-19.

  2020cites this paper
• Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis

  2020cites this paper
• Effective inhibition of Th17/Th22 pathway in 2D and 3D human models of psoriasis by Celastrol enriched plant cell culture extract.

  2020cites this paper
• A Systematic Review of Promising Therapeutic Targets in Hidradenitis Suppurativa: A Critical Evaluation of Mechanistic and Clinical Relevance.

  2020cites this paper
• Aetiology and pathogenesis of hidradenitis suppurativa

  2020cites this paper
• Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis.

  2020cites this paper
• Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin

  2020influential citation
• Immunophenotyping in pemphigus reveals a Th17/Tfh17-dominated immune response promoting desmoglein1/3-specific autoantibody production.

  2020cites this paper
• Antimicrobial peptides: bridging innate and adaptive immunity in the pathogenesis of psoriasis

  2020cites this paper
• Serum Interleukin 19 in Patients with Alopecia Areata

  2020cites this paper
• Profiles of Innate Immune Cell Infiltration and Related Core Genes in Psoriasis

  2020cites this paper
• Emerging role of immune cell network in autoimmune skin disorders: An update on pemphigus, vitiligo and psoriasis.

  2019cites this paper
• Expression of interleukin (IL)‐10 family cytokines in aqueous humour of patients with specific endogenous uveitic entities: elevated levels of IL‐19 in human leucocyte antigen‐B27‐associated uveitis

  2019cites this paper
• Increased interleukin-26 expression promotes Th17 and Th2-associated cytokine production by keratinocytes in atopic dermatitis.

  2019cites this paper
• JAK/STAT Signaling Pathway and Inhibitors in Inflammatory and Neoplasmatic Skin Diseases

  2019cites this paper
• [Recent progress in the pathophysiological role of interleukin-19].

  2019cites this paper
• Effect of white mange mixture in a murine model of psoriasis

  2019cites this paper
• The IL-1 Pathway Is Hyperactive in Hidradenitis Suppurativa and Contributes to Skin Infiltration and Destruction.

  2019cites this paper
• Atopic dermatitis endotypes and implications for targeted therapeutics.

  2019cites this paper
• Effect of white mange mixture in a murine model of psoriasis.

  2019cites this paper
• Personalized medicine—concepts, technologies, and applications in inflammatory skin diseases

  2019cites this paper
• Combining Understanding of Immunological Mechanisms and Genetic Variants Toward Development of Personalized Medicine for Psoriasis Patients

  2019cites this paper
• T cell pathology in skin inflammation

  2019cites this paper
• Targeted therapies and precision medicine for inflammatory skin diseases

  2019cites this paper
• Interleukin-10 Family Cytokines Immunobiology and Structure.

  2019cites this paper