Neonatal seizures: an update on mechanisms and management.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Clinics of Perinatology

• Publication date

  2009-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.clp.2009.08.001PMID 19944840PMCID PMC2818833
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neurology of the newborn.

  2013cited by this paper
• Cooling for newborns with hypoxic ischaemic encephalopathy.

  2013cited by this paper
• Neurology of the Newborn, 5th Edition

  2010cited by this paper
• Clinical Neonatal Seizures are Independently Associated with Outcome in Infants at Risk for Hypoxic-Ischemic Brain Injury.

  2009cited by this paper
• Epileptogenesis in the immature brain: emerging mechanisms

  2009influential reference
• Different effects of two N-methyl-D-aspartate receptor antagonists on seizures, spontaneous behavior, and motor performance in immature rats.

  2009cited by this paper
• Neonatal seizures

  2009cited by this paper
• Talampanel suppresses the acute and chronic effects of seizures in a rodent neonatal seizure model

  2009cited by this paper
• A pilot study of continuous limited-channel aEEG in term infants with encephalopathy.

  2009cited by this paper
• Bumetanide enhances phenobarbital efficacy in a neonatal seizure model

  2008cited by this paper
• Long-term prognosis in children with neonatal seizures: A population-based study

  2008cited by this paper
• The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: A randomised controlled trial

  2008cited by this paper
• The age of plasticity: developmental regulation of synaptic plasticity in neocortical microcircuits.

  2008cited by this paper
• Delayed neural network degeneration after neonatal hypoxia‐ischemia

  2008cited by this paper
• The role of cytokines in the pathophysiology of epilepsy.

  2008cited by this paper
• Minocycline treatment following hypoxic/ischaemic injury attenuates white matter injury in a rodent model of periventricular leucomalacia

  2008cited by this paper
• Off-label use of antiepileptic drugs for the treatment of neonatal seizures.

  2008cited by this paper
• Early Alterations of AMPA Receptors Mediate Synaptic Potentiation Induced by Neonatal Seizures

  2008cited by this paper
• NMDA Receptor Blockade with Memantine Attenuates White Matter Injury in a Rat Model of Periventricular Leukomalacia

  2008cited by this paper
• Rapid astrocyte and microglial activation following pilocarpine‐induced seizures in rats

  2008cited by this paper
• Characterization of neonatal seizures by conventional EEG and single-channel EEG.

  2007cited by this paper
• Effects of a Single Dose of Erythropoietin on Subsequent Seizure Susceptibility in Rats Exposed to Acute Hypoxia at P10

  2007cited by this paper
• A single episode of neonatal seizures permanently alters glutamatergic synapses

  2007cited by this paper
• Neonatal seizures: multicenter variability in current treatment practices.

  2007cited by this paper
• The classical complement cascade mediates CNS synapse elimination.

  2007cited by this paper
• Sensitivity of Amplitude-Integrated Electroencephalography for Neonatal Seizure Detection

  2007cited by this paper
• Cooling for newborns with hypoxic ischaemic encephalopathy.

  2007cited by this paper
• Alterations of NR2B and PSD‐95 expression after early‐life epileptiform discharges in developing neurons

  2007cited by this paper
• Long-term prognosis in children with neonatal seizures

  2007cited by this paper
• A single episode of neonatal seizures permanently alters glutamatergic synapses

  2007cited by this paper
• Neonatal seizures

  2007cited by this paper
• Erythropoietin Enhances Long-Term Neuroprotection and Neurogenesis in Neonatal Stroke

  2007cited by this paper
• The Current Etiologic Profile and Neurodevelopmental Outcome of Seizures in Term Newborn Infants

  2006influential reference
• Summary proceedings from the neurology group on neonatal seizures.

  2006cited by this paper
• Prolonged electroencephalogram monitoring for seizures and their treatment.

  2006cited by this paper
• Minocycline inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after treatment with kainic acid in mice.

  2006cited by this paper
• Enhancing GABAA Receptor α1 Subunit Levels in Hippocampal Dentate Gyrus Inhibits Epilepsy Development in an Animal Model of Temporal Lobe Epilepsy

  2006cited by this paper
• Selective impairment of GABAergic synaptic transmission in the flurothyl model of neonatal seizures

  2006cited by this paper
• Development of microglia in the cerebral white matter of the human fetus and infant

  2006cited by this paper
• Models of Seizures and Epilepsy

  2006cited by this paper
• Whole-Body Hypothermia for Neonates With Hypoxic–Ischemic Encephalopathy

  2006cited by this paper
• Effects of seizures on developmental processes in the immature brain.

  2006cited by this paper
• Development of an optimal lidocaine infusion strategy for neonatal seizures

  2006cited by this paper
• Seizure detection algorithm for neonates based on wave-sequence analysis.

  2006cited by this paper
• CHAPTER 25 – Modeling Hypoxia-Induced Seizures and Hypoxic Encephalopathy in the Neonatal Period

  2006cited by this paper
• Antiepileptic drugs trials: neonates and infants.

  2006cited by this paper
• Models of Pediatric Epilepsies: Strategies and Opportunities

  2006cited by this paper
• Developmental regulation of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. I. Rodent cerebral white matter and cortex

  2006cited by this paper
• Risk Factors for Seizures in Very Low Birthweight Infants With Periventricular Leukomalacia

  2006cited by this paper
• Acute injury to the immature brain with hypoxia with or without hypoperfusion.

  2006cited by this paper
• Developmental regulation of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole‐propionic acid receptor subunit expression in forebrain and relationship to regional susceptibility to hypoxic/ischemic injury. II. Human cerebral white matter and cortex

  2006cited by this paper
• Mutational scanning of potassium, sodium and chloride ion channels in malignant migrating partial seizures in infancy.

  2006cited by this paper
• Amplitude integrated electroencephalography in the full-term newborn.

  2006cited by this paper
• Acute injury to the immature brain with hypoxia with or without hypoperfusion.

  2006cited by this paper
• Levetiracetam in a neonate with malignant migrating partial seizures.

  2006cited by this paper
• Erythropoietin Improves Functional and Histological Outcome in Neonatal Stroke

  2005cited by this paper
• AMPA/Kainate Receptor-Mediated Downregulation of GABAergic Synaptic Transmission by Calcineurin after Seizures in the Developing Rat Brain

  2005cited by this paper
• Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain.

  2005cited by this paper
• Synchronized network activity in developing rat hippocampus involves regional hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channel function

  2005cited by this paper
• Electroencephalography in neonatal seizures: comparison of a reduced and a full 10/20 montage.

  2005cited by this paper
• Patterns of brain injury in term neonatal encephalopathy.

  2005cited by this paper
• Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial.

  2005cited by this paper
• Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.

  2005cited by this paper
• Drug treatment of neonatal seizures by neonatologists and paediatric neurologists

  2005cited by this paper
• Axonal development in the cerebral white matter of the human fetus and infant

  2005cited by this paper
• NKCC1 transporter facilitates seizures in the developing brain

  2005cited by this paper
• Doxycycline Reduces Cleaved Caspase-3 and Microglial Activation in An Animal Model of Neonatal Hypoxia-Ischemia

  2005cited by this paper
• Neonatal seizures

  2005cited by this paper
• Models of Seizures and Epilepsy

  2005cited by this paper
• Topiramate Extends the Therapeutic Window for Hypothermia-Mediated Neuroprotection After Stroke in Neonatal Rats

  2004cited by this paper
• Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus

  2004cited by this paper
• Risk Factors for Neonatal Seizures in Very Low Birthweight Infants

  2004cited by this paper
• KCNQ/M Channels Control Spike Afterdepolarization and Burst Generation in Hippocampal Neurons

  2004cited by this paper
• NBQX or Topiramate Treatment after Perinatal Hypoxia‐induced Seizures Prevents Later Increases in Seizure‐induced Neuronal Injury

  2004cited by this paper
• Anticonvulsants for neonates with seizures.

  2004cited by this paper
• Seizures in the Developing Brain Cause Adverse Long‐term Effects on Spatial Learning and Anxiety

  2004cited by this paper
• Therapeutic doses of topiramate are not toxic to the developing rat brain.

  2004cited by this paper
• De novo KCNQ2 mutations in patients with benign neonatal seizures

  2004cited by this paper
• Selective Vulnerability of Subplate Neurons after Early Neonatal Hypoxia-Ischemia

  2003cited by this paper
• Association between genetic variation of CACNA1H and childhood absence epilepsy

  2003cited by this paper
• KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum.

  2003cited by this paper
• A novel KCNQ2 K+channel mutation in benign neonatal convulsions and centrotemporal spikes

  2003cited by this paper
• Dynamics of microglia in the developing rat brain

  2003cited by this paper
• The biology of epilepsy genes.

  2003cited by this paper
• M-channels: neurological diseases, neuromodulation, and drug development.

  2003cited by this paper
• Antiepileptic Drugs and Apoptosis in the Developing Brain

  2003cited by this paper
• Role of Subplate Neurons in Functional Maturation of Visual Cortical Columns

  2003cited by this paper
• Excitatory Actions of Endogenously Released GABA Contribute to Initiation of Ictal Epileptiform Activity in the Developing Hippocampus

  2003cited by this paper
• Patterns of cerebral inflammatory response in a rabbit model of intrauterine infection-mediated brain lesion.

  2003cited by this paper
• Early microglial activation following neonatal excitotoxic brain damage in mice: a potential target for neuroprotection.

  2003cited by this paper
• Increased activity of cyclooxygenase-2 signals early neurodegenerative events in the rat retina following transient ischemia.

  2003cited by this paper
• A Developmental Switch of AMPA Receptor Subunits in Neocortical Pyramidal Neurons

  2002cited by this paper
• Seizure-induced neuronal death in the immature brain.

  2002cited by this paper
• Temporal and regional expression of NMDA receptor subunit NR3A in the mammalian brain

  2002cited by this paper
• Antiepileptic drugs and apoptotic neurodegeneration in the developing brain

  2002cited by this paper
• Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress

  2001cited by this paper
• Maturational Aspects of Epilepsy Mechanisms and Consequences for the Immature Brain

  2001influential reference
• Corticotropin (ACTH) acts directly on amygdala neurons to down‐regulate corticotropin‐releasing hormone gene expression

  2001cited by this paper
• Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia

  2001cited by this paper
• Pyridoxine‐dependent and pyridoxine‐responsive seizures

  2001cited by this paper

• Neonatal seizure detection: a review of current methods, challenges and future directions

  2026cites this paper
• Methods of induction of labour: a network meta-analysis.

  2026cites this paper
• Detection of pre-ictal epileptic events using a self-attention based neural network from raw Neonatal EEG data

  2025cites this paper
• Cardiovascular changes: a biomarker for seizures after hypoxia-ischaemia in preterm fetal sheep.

  2025cites this paper
• Arterial switch and neurological outcomes: a retrospective study of medical records

  2025cites this paper
• Cannabidiol potentiates phenobarbital effects in the control of pentylenetetrazole (PTZ)-induced epileptic seizures in neonate rats

  2025cites this paper
• Treatment considerations for the management of neonatal onset seizures.

  2025cites this paper
• Efficacy of phenobarbital is maintained after exposure to mild‐to‐moderate seizures in neonates

  2025cites this paper
• Seizures may worsen outcomes of neonatal hypoxic ischemic encephalopathy: a longitudinal serum biomarkers study

  2024cites this paper
• Cerebrospinal Fluid Composition of Infants with Ischemic Stroke

  2024cites this paper
• Assessment of Outcome and Prognosis among Neonatal Seizure Patients

  2024influential citation
• Case Report of Hyponatremic Seizures in a Term Neonate Attributed to Excessive Maternal Coconut Water Ingestion During Labor.

  2024cites this paper
• Determinants of neonatal seizure among neonates admitted to neonatal intensive care units in the Awi Zone hospitals, 2023: A multi-center unmatched case control study

  2024cites this paper
• Neonatal Seizures.

  2024cites this paper
• A STUDY OF CLINICAL AND BIOCHEMICAL PROFILE IN NEONATAL SEIZURES IN A TERTIARY CARE CENTRE

  2023cites this paper
• Methods of induction of labour: a network meta-analysis 

  2023cites this paper
• The P2X7 receptor contributes to seizures and inflammation‐driven long‐lasting brain hyperexcitability following hypoxia in neonatal mice

  2023cites this paper
• Pain and neurodevelopmental outcomes of infants born very preterm

  2023cites this paper
• Variable Association of Physiologic Changes with Electrographic Seizure-Like Events in Infants Born Preterm.

  2023cites this paper
• Tolerability and Safety of Lacosamide in Neonatal Population

  2023cites this paper
• Maternal hyperhomocysteinemia increases seizures susceptibility of neonatal rats.

  2023cites this paper
• Comparing the effect of different loading doses of phenobarbitone on serum phenobarbitone levels in babies with neonatal seizures and effect of therapeutic hypothermia on phenobarbitone levels.

  2022cites this paper
• Incidence of Neonatal Convulsion/Seizures Associated with Primary Disturbance of Calcium, Phosphorus, and Magnesium in University of Port Harcourt Teaching Hospital (UPTH)

  2022cites this paper
• Anti-seizure medications for neonates with seizures.

  2022cites this paper
• Efficacy of Levetiracetam and Phenobarbital as First-Line Treatment for Neonatal Seizures

  2022cites this paper
• Quercetin Administration Following Hypoxia-Induced Neonatal Brain Damage Attenuates Later-Life Seizure Susceptibility and Anxiety-Related Behavior: Modulating Inflammatory Response

  2022cites this paper
• Levetiracetam

  2022cites this paper
• Neonatal Seizures

  2022cites this paper
• Neurological conditions – a permanent challenge from pregnancy to childhood

  2022cites this paper
• Rapid Genome Sequencing: Consent for New Technologies in the Neonatal Intensive Care Context.

  2022cites this paper
• The duration of successive epileptic seizures is monotonically correlated in neonates.

  2022cites this paper
• Can hyperoxic stress cause susceptibility to acute seizure in the neonatal period?: a rat study

  2022influential citation
• Preclinical efficacy of cannabidiol for the treatment of early-life seizures

  2022influential citation
• Lissencephaly causing refractory neonatal seizures in a term neonate

  2022cites this paper
• Neonatal seizures treatment based on conventional multichannel EEG monitoring: an overview of therapeutic options

  2022cites this paper
• SARS-CoV-2 Infection and Possible Neonatal Neurological Outcomes: A Literature Review

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• Clinical and biochemical profile of neonatal seizures admitted in neonatal intensive care unit of a tertiary care hospital

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• Cannabinoids: A New Perspective on Epileptogenesis and Seizure Treatment in Early Life in Basic and Clinical Studies

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• Neonatal Seizure Management: Is the Timing of Treatment Critical?

  2021influential citation
• Treating Seizures after Hypoxic-Ischemic Encephalopathy—Current Controversies and Future Directions

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• A Decision-Tree Approach to Assist in Forecasting the Outcomes of the Neonatal Brain Injury

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• Utility of Rapid Sequence Magnetic Resonance Imaging in Guiding Management of Patients With Neonatal Seizures.

  2020cites this paper
• Neonatal Seizures and Purinergic Signalling

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• Seizure classification, etiology, and management.

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  2018cites this paper
• Aberrant plasticity in the hippocampus after neonatal seizures

  2018cites this paper
• Long-term outcome in children with neonatal seizures: A tertiary center experience in cohort of 168 patients.

  2018cites this paper
• Regulation of seizure-induced MeCP2 Ser421 phosphorylation in the developing brain.

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• Neonatal Seizure Models to Study Epileptogenesis

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• Outcomes after Neonatal Seizures in Infants Less Than 29 Weeks' Gestation: A Population-Based Cohort Study

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  2017cites this paper
• Effects of P2X7 receptor antagonists on hypoxia‐induced neonatal seizures in mice

  2017cites this paper
• A Review on Pharmacokinetics of Levetiracetam in Neonates.

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• ETIOLOGICAL, CLINICAL AND EEG PROFILE OF NEONATAL SEIZURES- AN INSTITUTIONAL STUDY

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• Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives

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