Chapter 4 – GTP-binding Proteins and Signal Transduction

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• Publication year

  2009

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  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/B978-0-12-369441-6.00004-0
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  Open on Semantic Scholar

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  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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• RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins.

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• The G Protein Gα13 Is Required for Growth Factor-Induced Cell Migration

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• Stable association of G proteins with beta 2AR is independent of the state of receptor activation.

  1999cited by this paper
• Divergence of RGS proteins: evidence for the existence of six mammalian RGS subfamilies.

  1999cited by this paper
• RGS proteins: more than just GAPs for heterotrimeric G proteins.

  1999cited by this paper
• Phospholipase C-β1 Directly Accelerates GTP Hydrolysis by Gαq and Acceleration Is Inhibited by Gβγ Subunits*

  1999cited by this paper
• The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit.

  1999cited by this paper
• Modulation of Rap Activity by Direct Interaction of Gαo with Rap1 GTPase-activating Protein*

  1999cited by this paper
• Interdomain interactions regulate GDP release from heterotrimeric G proteins.

  1999cited by this paper
• Inhibition of oxytocin receptor function by direct binding of progesterone

  1998cited by this paper
• The G protein Gα12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain

  1998cited by this paper
• The helical domain of a G protein alpha subunit is a regulator of its effector.

  1998cited by this paper
• RGS9, a GTPase accelerator for phototransduction.

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• GTPase-activating proteins: helping hands to complement an active site.

  1998cited by this paper
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• Sites Important for PLCβ2 Activation by the G Protein βγ Subunit Map to the Sides of the β Propeller Structure*

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• p115 RhoGEF, a GTPase activating protein for Gα12 and Gα13

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• Differential Activity of the G Protein β5γ2 Subunit at Receptors and Effectors*

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• A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gβ5 subunits

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• Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13.

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• Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D.

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• Direct stimulation of Bruton's tyrosine kinase by Gq-protein α-subunit

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• Regulation of Phosphoinositide-specific Phospholipase C Isozymes*

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• Functional interactions of phosphatidylinositol 3-kinase with GTPase-activating protein in 3T3-L1 adipocytes

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• Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.

  1996cited by this paper
• Regulation of phospholipase C-beta1 by Gq and m1 muscarinic cholinergic receptor. Steady-state balance of receptor-mediated activation and GTPase-activating protein-promoted deactivation.

  1996cited by this paper
• Complexity and diversity of mammalian adenylyl cyclases.

  1996cited by this paper
• Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit.

  1996cited by this paper
• Insulin action impaired by deficiency of the G-protein subunit Giα2

  1996cited by this paper
• β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor

  1996cited by this paper
• Signal transduction: evolution of an idea.

  1995cited by this paper
• Activation of the cloned muscarinic potassium channel by G protein βγ subunits

  1994cited by this paper
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  1994cited by this paper
• Structural determinants for activation of the α-subunit of a heterotrimeric G protein

  1994cited by this paper
• Differential regulation of cellular activities by GTPase-activating protein and NF1

  1993cited by this paper
• Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

  1993cited by this paper
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  1993cited by this paper
• Function and regulation of ras.

  1993cited by this paper
• The PH domain: a common piece in the structural patchwork of signalling proteins.

  1993cited by this paper
• Separate GTP binding and GTPase activating domains of a G alpha subunit.

  1993cited by this paper
• Antigen-induced B lymphocyte activation involves the p21ras and ras.GAP signaling pathway

  1993cited by this paper
• Residues crucial for Ras interaction with GDP-GTP exchangers.

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  1992cited by this paper
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  1992cited by this paper
• Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins.

  1992cited by this paper
• The GppNHp‐activated adenylyl cyclase complex from turkey erythrocyte membranes can be isolated with its βγ subunits

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• Analysis of the fibroblast transformation potential of GTPase-deficient gip2 oncogenes

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• Identification of effector-activating residues of Gsα

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• Stimulation of p21ras upon T-cell activation

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• Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2.

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• ras GTPase activating protein: signal transmitter and signal terminator.

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• The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

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• Reversal of transformed phenotype by monoclonal antibodies against Ha-ras p21 proteins.

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• Functional homology of mammalian and yeast RAS genes.

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• GTP-binding proteins couple cardiac muscarinic receptors to a K channel

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• Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells

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