Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2

No abstract is available for this paper.

• Publication year

  2006

• Venue

  EMBO Journal

• Publication date

  2006-05-03

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.emboj.7601079PMID 16601676PMCID PMC1456944
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 1 Origins and Principles of Translational Control

  2007cited by this paper
• Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms.

  2005cited by this paper
• Interaction of anti‐proliferative protein Tob with poly(A)‐binding protein and inducible poly(A)‐binding protein: implication of Tob in translational control

  2005cited by this paper
• A Family of Mammalian E3 Ubiquitin Ligases That Contain the UBR Box Motif and Recognize N-Degrons

  2005cited by this paper
• Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis.

  2005cited by this paper
• Somatic Mutations and Altered Expression of the Candidate Tumor Suppressors CSNK1ε, DLG1, and EDD/hHYD in Mammary Ductal Carcinoma

  2004cited by this paper
• N-terminal polyubiquitination and degradation of the Arf tumor suppressor.

  2004cited by this paper
• Bortezomib rapidly suppresses ubiquitin thiolesterification to ubiquitin-conjugating enzymes and inhibits ubiquitination of histones and type I inositol 1,4,5-trisphosphate receptor.

  2004cited by this paper
• The Drosophila Poly(A) Binding Protein-Interacting Protein, dPaip2, Is a Novel Effector of Cell Growth

  2004cited by this paper
• Edd, the Murine Hyperplastic Disc Gene, Is Essential for Yolk Sac Vascularization and Chorioallantoic Fusion

  2004cited by this paper
• A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay

  2004cited by this paper
• N-Terminal Ubiquitination of Extracellular Signal-Regulated Kinase 3 and p21 Directs Their Degradation by the Proteasome

  2004cited by this paper
• La Autoantigen Is Necessary for Optimal Function of the Poliovirus and Hepatitis C Virus Internal Ribosome Entry Site In Vivo and In Vitro

  2004cited by this paper
• N-terminal ubiquitination: more protein substrates join in.

  2004influential reference
• Molecular mechanisms of translational control

  2004cited by this paper
• Structural basis of ligand recognition by PABC, a highly specific peptide‐binding domain found in poly(A)‐binding protein and a HECT ubiquitin ligase

  2004influential reference
• EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer

  2003cited by this paper
• Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression

  2003cited by this paper
• EDD, the Human Hyperplastic Discs Protein, Has a Role in Progesterone Receptor Coactivation and Potential Involvement in DNA Damage Response*

  2002cited by this paper
• The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms

  2002cited by this paper
• Analysis of gene function in somatic mammalian cells using small interfering RNAs.

  2002cited by this paper
• Characterization of rat100, a 300-kilodalton ubiquitin-protein ligase induced in germ cells of the rat testis and similar to the Drosophila hyperplastic discs gene.

  2002cited by this paper
• Cooperation of HECT-domain Ubiquitin Ligase hHYD and DNA Topoisomerase II-binding Protein for DNA Damage Response*

  2002cited by this paper
• A Novel Role of the Mammalian GSPT/eRF3 Associating with Poly(A)-binding Protein in Cap/Poly(A)-dependent Translation*

  2002cited by this paper
• Paip1 Interacts with Poly(A) Binding Protein through Two Independent Binding Motifs

  2002cited by this paper
• The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.

  2002cited by this paper
• The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure.

  2001cited by this paper
• Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

  2001cited by this paper
• Ubiquitin and proteasomes: Themes and variations on ubiquitylation

  2001cited by this paper
• Translational repression by a novel partner of human poly(A) binding protein, Paip2.

  2001influential reference
• Structure and function of the C-terminal PABC domain of human poly(A)-binding protein

  2001influential reference
• Dual Interactions of the Translational Repressor Paip2 with Poly(A) Binding Protein

  2001influential reference
• Mechanisms underlying ubiquitination.

  2001cited by this paper
• Proteasome inhibition in cancer: development of PS-341.

  2001cited by this paper
• Poly(A)-binding protein interaction with elF4G stimulates picornavirus IRES-dependent translation.

  2001cited by this paper
• Genetic imbalances in preleukemic thymuses.

  2001cited by this paper
• X-ray structure of the human hyperplastic discs protein: An ortholog of the C-terminal domain of poly(A)-binding protein

  2001influential reference
• The mRNA closed-loop model: the function of PABP and PABP-interacting proteins in mRNA translation.

  2001cited by this paper
• Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions

  2000cited by this paper
• 2 The Pathway and Mechanism of Initiation of Protein Synthesis

  2000cited by this paper
• 10 Physical and Functional Interactions between the mRNA Cap Structure and the Poly(A) Tail

  2000cited by this paper
• eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.

  1999cited by this paper
• Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E

  1999cited by this paper
• The Eukaryotic Polypeptide Chain Releasing Factor (eRF3/GSPT) Carrying the Translation Termination Signal to the 3′-Poly(A) Tail of mRNA

  1999influential reference
• Degradation signal masking by heterodimerization of MATalpha2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway.

  1998cited by this paper
• Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation

  1998influential reference
• The ubiquitin system.

  1998cited by this paper
• Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs

  1998cited by this paper
• A newly identified N‐terminal amino acid sequence of human eIF4G binds poly(A)‐binding protein and functions in poly(A)‐dependent translation

  1998influential reference
• Translation Initiation Factors eIF-iso4G and eIF-4B Interact with the Poly(A)-binding Protein and Increase Its RNA Binding Activity*

  1997cited by this paper
• Gene expression profiles in normal and cancer cells.

  1997cited by this paper
• Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor suppressor protein.

  1997cited by this paper
• Ubiquitin-dependent protein degradation.

  1996cited by this paper
• Association of the yeast poly(A) tail binding protein with translation initiation factor eIF‐4G.

  1996cited by this paper
• A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.

  1995cited by this paper
• The mRNA poly(A)-binding protein: localization, abundance, and RNA-binding specificity.

  1994cited by this paper
• Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain.

  1994cited by this paper
• Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains.

  1990cited by this paper
• A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein.

  1989cited by this paper
• A single domain of yeast poly(A)-binding protein is necessary and sufficient for RNA binding and cell viability

  1987cited by this paper

• mRNA poly(A)-tail length is a battleground for coronavirus–host competition

  2025cites this paper
• Deep mutational scanning of an engineered high-affinity ligand of the polyA binding protein MLLE domain.

  2025cites this paper
• Latitudinal–environmental variations driving the local adaptation of Pampus argenteus stocks along the Chinese coast

  2025cites this paper
• Inhibition of K63 ubiquitination by G-Protein pathway suppressor 2 (GPS2) regulates mitochondria-associated translation

  2024cites this paper
• Structure of the human UBR5 E3 ubiquitin ligase.

  2023cites this paper
• Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes

  2022cites this paper
• Translation initiation and dysregulation of initiation factors in rare diseases

  2022cites this paper
• PAIP2 is a potential diagnostic and prognostic biomarker of breast cancer and is associated with immune infiltration

  2022cites this paper
• Structure of the human UBR5 E3 ubiquitin ligase

  2022cites this paper
• Structured and disordered regions of Ataxin-2 contribute differently to the specificity and efficiency of mRNP granule formation

  2022cites this paper
• PABP prevents the untimely decay of select mRNA populations in human cells

  2022cites this paper
• A small stem-loop-forming region within the 3′-UTR of a nonpolyadenylated LCMV mRNA promotes translation

  2022cites this paper
• Exploring the "other" subfamily of HECT E3-ligases for therapeutic intervention.

  2021cites this paper
• Paip2 associates with PABPC1 on mRNA, and may facilitate PABPC1 dissociation from mRNA upon deadenylation

  2021cites this paper
• Poly(A) binding protein is required for mRNP remodeling to form P-bodies in mammalian cells

  2021cites this paper
• Inhibition of Mul1-mediated ubiquitination promotes mitochondria-associated translation

  2021cites this paper
• Activated Wnt/β-Catenin signaling contributes to E3 ubiquitin ligase EDD-conferred docetaxel resistance in prostate cancer.

  2020cites this paper
• The necdin interactome: evaluating the effects of amino acid substitutions and cell stress using proximity-dependent biotinylation (BioID) and mass spectrometry

  2020cites this paper
• Murine cytomegaloviruses m139 targets DDX3 to curtail interferon production and promote viral replication

  2020cites this paper
• The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells

  2019cites this paper
• E3 ubiquitin ligases in B-cell malignancies.

  2019cites this paper
• Septin-2 is overexpressed in epithelial ovarian cancer and mediates proliferation via regulation of cellular metabolic proteins

  2019cites this paper
• CELF1 is an EIF4E binding protein that promotes translation of epithelial-mesenchymal transition effector mRNAs

  2019cites this paper
• UBR5 is a Novel E3 Ubiquitin Ligase involved in Skeletal Muscle Hypertrophy and Recovery from Atrophy

  2019cites this paper
• Characterization of interaction and ubiquitination of phosphoenolpyruvate carboxykinase by E3 ligase UBR5

  2018influential citation
• Dynamic interaction of poly(A)-binding protein with the ribosome

  2018cites this paper
• The Biological Function of Human Epididymis Protein 4 in Epithelial Ovarian Cancer

  2018cites this paper
• USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1

  2017cites this paper
• Control of nerve cord formation by Engrailed and Gooseberry-Neuro: A multi-step, coordinated process.

  2017cites this paper
• The p90 ribosomal S6 kinase-UBR5 pathway controls toll-like receptor signaling via miRNA-induced translational inhibition of TNF receptor–associated factor 3

  2017cites this paper
• Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5

  2017influential citation
• Investigating the role of UBR5, a ubiquitin-protein ligase of the N-end rule pathway, in skeletal tissue homeostasis

  2017cites this paper
• The p90 ribosomal S6 kinase–UBR5 pathway controls Toll-like receptor signaling via miRNA-induced translational inhibition of tumor necrosis factor receptor–associated factor 3

  2017cites this paper
• Control of the negative IRES trans-acting factor KHSRP by ubiquitination

  2016cites this paper
• An Investigation of the Non-Redundant Functions of PABP4 via Protein-Protein Interactions and PABP-Depletion Studies

  2016influential citation
• Translational control of nicotine-evoked synaptic potentiation in mice and neuronal responses in human smokers by eIF2α

  2016cites this paper
• Systematic approaches to identify E3 ligase substrates

  2016cites this paper
• Functional Roles of the E3 Ubiquitin Ligase UBR5 in Cancer

  2015cites this paper
• The MLLE Domain of the Ubiquitin Ligase UBR5 Binds to Its Catalytic Domain to Regulate Substrate Binding*

  2015cites this paper
• Functional Roles of the E 3 Ubiquitin Ligase UBR 5 in Cancer

  2015cites this paper
• Title 1 Poly ( A ) binding protein is required for mRNP remodeling to form P-bodies in mammalian 2 cells 3 4 Running title 5 Poly ( A ) binding protein and P-body formation 6 7

  2015cites this paper
• Drosophila E3 ubiquitin ligase Hyperplastic Discs interacts with Shaggy and regulates morphogen signalling in the developing eye

  2015cites this paper
• ROCK inhibition enhances microRNA function by promoting deadenylation of targeted mRNAs via increasing PAIP2 expression

  2015cites this paper
• Weighing up the possibilities: Controlling translation by ubiquitylation and sumoylation

  2014influential citation
• The "tale" of poly(A) binding protein: the MLLE domain and PAM2-containing proteins.

  2014cites this paper
• Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects.

  2014cites this paper
• Proteasome Modulates Positive and Negative Translational Regulators in Long-Term Synaptic Plasticity

  2014influential citation
• Poly(A) Binding Protein 1 Enhances Cap-Independent Translation Initiation of Neurovirulence Factor from Avian Herpesvirus

  2014cites this paper
• A new role for the cellular PABP repressor Paip2 as an innate restriction factor capable of limiting productive cytomegalovirus replication

  2013influential citation
• Control of synaptic plasticity and memory via suppression of poly(A)-binding protein.

  2013cites this paper
• The E 3 ubiquitin ligase UBR 5 is recurrently mutated in mantle cell lymphoma

  2013cites this paper
• eIF4GI Facilitates the MicroRNA-Mediated Gene Silencing

  2013cites this paper
• Poly(A)-binding proteins: Structure, domain organization, and activity regulation

  2013cites this paper
• Poly(A) RNA and Paip2 act as allosteric regulators of poly(A)-binding protein

  2013cites this paper
• A functional genomic approach reveals the transcriptional role of EDD in the expression and function of angiogenesis regulator ACVRL1.

  2013cites this paper
• The novel interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression.

  2013cites this paper
• Evaluation of Selected Binding Domains for the Analysis of Ubiquitinated Proteomes

  2013cites this paper
• Structural and Functional Relationships between Ubiquitin Conjugating Enzymes (E2s) and Ubiquitin Ligases (E3s)

  2013influential citation
• The E3 ubiquitin ligase UBR5 is recurrently mutated in mantle cell lymphoma.

  2013cites this paper
• EDD induces cell cycle arrest by increasing p53 levels

  2012cites this paper
• Translational homeostasis via the mRNA cap-binding protein, eIF4E.

  2012cites this paper
• Structure of the HECT C-lobe of the UBR5 E3 ubiquitin ligase.

  2012cites this paper
• Translational homeostasis via eIF4E and 4E-BP1.

  2012cites this paper
• A novel role for RIP1 kinase in mediating TNFα production

  2012cites this paper
• The N-end rule pathway.

  2012cites this paper
• Poly(A) Binding Protein C1 Is Essential for Efficient L1 Retrotransposition and Affects L1 RNP Formation

  2012cites this paper
• F-Box Proteins Elongate Translation During Stress Recovery

  2012cites this paper
• Spermatids do it differently! Paip2a-the essential regulator of spermiogenesis?

  2011cites this paper
• Characterization of the Interaction of Alpha4 Phosphoprotein with Novel Binding Partners: EDD E3 Ubiquitin Ligase and Poly(A)-Binding Protein

  2011cites this paper
• EDD Inhibits ATM-mediated Phosphorylation of p53*

  2011cites this paper
• Mammalian hyperplastic discs homolog EDD regulates miRNA-mediated gene silencing.

  2011cites this paper
• Functions of the ubiquitin system in mammalian spermatogenesis and skeletal muscle

  2011cites this paper
• Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPs

  2011cites this paper
• In the absence of cellular poly (A) binding protein, the glycolytic enzyme GAPDH translocated to the cell nucleus and activated the GAPDH mediated apoptotic pathway by enhancing acetylation and serine 46 phosphorylation of p53.

  2011cites this paper
• Depletion of cellular poly (A) binding protein prevents protein synthesis and leads to apoptosis in HeLa cells.

  2011cites this paper
• Modulation of Myocardin Function by the Ubiquitin E3 Ligase UBR5*

  2010cites this paper
• Structural Basis of Binding of P-body-associated Proteins GW182 and Ataxin-2 by the Mlle Domain of Poly(A)-binding Protein*

  2010cites this paper
• Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu

  2010cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010influential citation
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  2010cites this paper
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  2009cites this paper
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  2009cites this paper
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  2009cites this paper
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  2008cites this paper
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  2008cites this paper
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  2007cites this paper