Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single-agent cladribine and with more aggressive behavior.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Blood

• Publication date

  2009-11-19

• Fields of study

  Medicine

• Identifiers
  DOI 10.1182/blood-2009-03-212449PMID 19667403
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Prognostic Value of TP53 Mutations in Chronic Lymphocytic Leukemia Is Independent of Del17p13: Implications for Overall Survival and Chemorefractoriness

  2009cited by this paper
• Long‐term follow‐up of 233 patients with hairy cell leukaemia, treated initially with pentostatin or cladribine, at a median of 16 years from diagnosis

  2009cited by this paper
• High density genome‐wide DNA profiling reveals a remarkably stable profile in hairy cell leukaemia

  2008cited by this paper
• Monoallelic TP53 inactivation is associated with poor prognosis in chronic lymphocytic leukemia: results from a detailed genetic characterization with long-term follow-up.

  2008cited by this paper
• Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines.

  2008cited by this paper
• Selective influences in the expressed immunoglobulin heavy and light chain gene repertoire in hairy cell leukemia

  2008cited by this paper
• Equivalent Efficacy and Lower Toxicity of Subcutaneous Cladribine at Reduced Doses (Five versus Seven Consecutive days) in Hairy Cell Leukemia: An Interim Analysis of the ICGHCL 2004 Protocol by the Italian Cooperative Group on Hcl

  2008cited by this paper
• The role of rituximab in combination with pentostatin or cladribine for the treatment of recurrent/refractory hairy cell leukemia

  2007cited by this paper
• Complete molecular remission induced by concomitant Cladribine – Rituximab treatment in a case of multi-resistant Hairy Cell Leukemia

  2007cited by this paper
• Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

  2007cited by this paper
• Immunotoxins in the treatment of refractory hairy cell leukemia.

  2006cited by this paper
• Somatic hypermutation and VH gene usage in hairy cell leukaemia

  2006cited by this paper
• Meta-analysis of the p53 Mutation Database for Mutant p53 Biological Activity Reveals a Methodologic Bias in Mutation Detection

  2006cited by this paper
• Eradication of minimal residual disease in hairy cell leukemia.

  2006cited by this paper
• Cladribine in a weekly versus daily schedule for untreated active hairy cell leukemia: final report from the Polish Adult Leukemia Group (PALG) of a prospective, randomized, multicenter trial.

  2006influential reference
• Hairy cell leukemia

  2006cited by this paper
• Long remissions in hairy cell leukemia with purine analogs

  2005cited by this paper
• Heterogeneous somatic hypermutation status confounds the cell of origin in hairy cell leukemia.

  2005cited by this paper
• Chronic lymphocytic leukemia: revelations from the B-cell receptor.

  2004cited by this paper
• Towards the pharmacotherapy of hairy cell leukaemia

  2004influential reference
• Hairy cell leukemia: at the crossroad of somatic mutation and isotype switch.

  2004cited by this paper
• Chronic lymphocytic leukemia : revelations from the B-cell receptor

  2004cited by this paper
• Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1).

  2004cited by this paper
• Long-term follow-up of front-line treatment of hairy cell leukemia with 2-chlorodeoxyadenosine.

  2004cited by this paper
• Binet's staging system and VH genes are independent but complementary prognostic indicators in chronic lymphocytic leukemia.

  2003cited by this paper
• VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome.

  2003cited by this paper
• IMGT - the international ImMunoGeneTics information system

  2003cited by this paper
• A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease.

  2003cited by this paper
• Phase 2 study of rituximab in the treatment of cladribine-failed patients with hairy cell leukemia.

  2003cited by this paper
• Extended follow-up of patients with hairy cell leukemia after treatment with cladribine.

  2003cited by this paper
• Rituximab in relapsed or refractory hairy cell leukemia.

  2003cited by this paper
• Pathology and Genetics: Tumours of Haematopoietic and Lymphoid Tissues

  2003cited by this paper
• Insight into the potential for DNA idiotypic fusion vaccines designed for patients by analysing xenogeneic anti‐idiotypic antibody responses

  2002cited by this paper
• The natural history and clinico-pathological features of the variant form of hairy cell leukemia

  2001cited by this paper
• Pathology and genetics: Tumours of haematopoietic and lymphoid tissues

  2001cited by this paper
• The occurrence and significance of V gene mutations in B cell-derived human malignancy.

  2001cited by this paper
• Tumor cells of hairy cell leukemia express multiple clonally related immunoglobulin isotypes via RNA splicing.

  2001cited by this paper
• Genomic aberrations and survival in chronic lymphocytic leukemia.

  2000cited by this paper
• p53 gene deletion and trisomy 12 in hairy cell leukemia and its variant.

  1999cited by this paper
• The effect of p53 dysfunction on purine analogue cytotoxicity in chronic lymphocytic leukaemia

  1999cited by this paper
• Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.

  1999cited by this paper
• VH gene expression in hairy cell leukaemia

  1998cited by this paper
• Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine via the Group C protocol mechanism of the National Cancer Institute: a report of 979 patients.

  1998cited by this paper
• The Scripps Clinic experience with 2-chlorodeoxyadenosine in the treatment of hairy cell leukemia.

  1994influential reference
• 2-Chlorodeoxyadenosine: A Newer Purine Analog Active in the Treatment of Indolent Lymphoid Malignancies

  1994cited by this paper
• Flow cytometry of blood and bone marrow cells from patients with hairy cell leukemia: phenotype of hairy cells and lymphocyte subsets after treatment with 2-chlorodeoxyadenosine.

  1994cited by this paper
• Rapid restoration of natural killer activity following treatment with 2‐chlorodeoxyadenosine in 22 patients with hairy‐cell leukemia

  1994cited by this paper
• Results of a salvage regimen in refractory or relapsed non-Hodgkin's lymphoma.

  1994cited by this paper
• p53-dependent apoptosis modulates the cytotoxicity of anticancer agents.

  1993cited by this paper
• Sequential administration of recombinant interferon alpha and deoxycoformycin in the treatment of hairy cell leukaemia

  1992cited by this paper
• Consensus resolution: proposed criteria for evaluation of response to treatment in hairy cell leukemia.

  1987cited by this paper
• Guidelines for the treatment of hairy cell leukemia.

  1987cited by this paper
• [Hairy cell leukemia].

  1983cited by this paper

• Immune activation and microenvironmental crosstalk in hairy cell leukemia.

  2026cites this paper
• The tumor microenvironment in hairy cell leukemia (HCL) and splenic B cell lymphoma with prominent nucleoli (SBLPN)

  2025cites this paper
• Serum soluble interleukin‐2 receptor levels in hairy cell leukaemia as a marker of tumour burden with prognostic value and as a tool for disease monitoring

  2025cites this paper
• An unusual form of BRAF‐V600E mutated hairy cell neoplasm with clinical resistance to BRAF inhibition: Challenging precision medicine

  2024cites this paper
• Recommendations for the Management of Patients with Hairy-Cell Leukemia and Hairy-Cell Leukemia-like Disorders: A Work by French-Speaking Experts and French Innovative Leukemia Organization (FILO) Group

  2024cites this paper
• Hairy cell leukemia 2024: Update on diagnosis, risk‐stratification, and treatment—Annual updates in hematological malignancies

  2024cites this paper
• Fucosyltransferase 3 and 8 promote the metastatic capacity of cancer stem-like cells via CD15s and E-cadherin in esophageal cancer

  2024cites this paper
• Molecular Profiling of Small Mature B Cell Lymphomas; New Insights on Diagnosis and Treatment

  2024cites this paper
• [Updates on hairy cell leukemia (HCL) and HCL-like disorders].

  2024cites this paper
• A Comparative Analysis of the Immunoglobulin Repertoire in Leukemia Cells and B Cells in Chinese Acute Myeloid Leukemia by High-Throughput Sequencing

  2024cites this paper
• Molecular Pathology of Mature Lymphoid Malignancies.

  2024cites this paper
• Untangling hairy cell leukaemia (HCL) variant and other HCL‐like disorders: Diagnosis and treatment

  2023cites this paper
• BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes

  2023cites this paper
• Long-term follow-up of patients with hairy cell leukemia in the south of Iran

  2023cites this paper
• Immunoglobulin genes and stereotyped antigenic receptors in chronic lymphocytic leukemia and other lymphoproliferative diseases

  2023cites this paper
• 毛细胞白血病诊断与治疗中国指南（2023年版）

  2023cites this paper
• Hairy cell leukaemia with unusual BRAF mutations

  2023cites this paper
• Hairy Cell Leukemia (HCL) and HCL Variant: Updates and Spotlights on Therapeutic Advances

  2022cites this paper
• Updates in hairy cell leukemia (HCL) and variant-type HCL (HCL-V): rationale for targeted treatments with a focus on ibrutinib

  2022cites this paper
• Deciphering Genetic Alterations of Hairy Cell Leukemia and Hairy Cell Leukemia-like Disorders in 98 Patients

  2022cites this paper
• Immunophenotypic Analysis of Hairy Cell Leukemia (HCL) and Hairy Cell Leukemia-like (HCL-like) Disorders

  2022cites this paper
• Novel targeted treatments in hairy cell leukemia and other hairy cell-like disorders

  2022cites this paper
• It's a BRAF new world for hairy cell leukemia.

  2022cites this paper
• Long-term follow-up of cladribine treatment in hairy cell leukemia: 30-year experience in a multicentric Italian study

  2022cites this paper
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  2022cites this paper
• Management of Relapsed Hairy Cell Leukemia: A Systematic Review of Novel Agents and Targeted Therapies.

  2021cites this paper
• Molecular Pathology of Mature Lymphoid Malignancies.

  2021cites this paper
• [Hairy cell leukemia: What are the best treatment options for relapsed or refractory patients?]

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• Diagnostic and therapeutic challenges in hairy cell leukemia-variant: where are we in 2021?

  2021cites this paper
• Massive Splenomegaly and Pancytopenia: It’s a Hairy Situation

  2020cites this paper
• Hairy Cell Leukaemia: From Hairy Beginnings to a BRAF New World

  2020cites this paper
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  2020cites this paper
• MAP-Kinase-Driven Hematopoietic Neoplasms: A Decade of Progress in the Molecular Age.

  2020cites this paper
• Prognostic Value of Baseline Serum Lactate Dehydrogenase Level in Patients With Hairy Cell Leukemia.

  2020cites this paper
• Biology and Treatment of Hairy Cell Leukemia

  2020cites this paper
• Hairy Cell Leukemia

  2020cites this paper
• Massive splenomegaly in hairy cell leukemia causing urinary retention

  2020cites this paper
• Moxetumomab pasudotox for hairy cell leukemia: preclinical development to FDA approval.

  2019cites this paper
• BRAF in the cross-hairs

  2019cites this paper
• Hairy cell leukemia: 2020 update on diagnosis, risk stratification, and treatment

  2019cites this paper
• Outcomes and second neoplasms in hairy cell leukemia: A retrospective cohort.

  2019cites this paper
• No Loose Ends: A Review of the Pharmacotherapy of Hairy Cell and Hairy Cell Leukemia Variant

  2019cites this paper
• Hairy cell leukemia 2018 Update on diagnosis, risk-stratification, and treatment

  2019cites this paper
• [Cladribine in treatment of 5 patients with hairy cell leukemia].

  2018cites this paper
• 克拉屈滨治疗毛细胞白血病五例报告并文献复习

  2018cites this paper
• BRAFV600E mutation in hairy cell leukemia: A single-center experience

  2018cites this paper
• Molecular Diagnostics in Hematologic Malignancies

  2018cites this paper
• New generation sequencing of targeted genes in the classical and the variant form of hairy cell leukemia highlights mutations in epigenetic regulation genes

  2018cites this paper
• Hairy cell leukemia 2018: Update on diagnosis, risk‐stratification, and treatment

  2017cites this paper
• Ibrutinib for relapsed refractory hairy cell leukemia variant

  2017cites this paper
• Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia.

  2017cites this paper
• How I manage patients with hairy cell leukaemia

  2017cites this paper
• Hairy Cell Leukemia, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.

  2017cites this paper
• Splenectomy for Haematological Disorders

  2017cites this paper
• p53 dysregulation in B-cell malignancies: More than a single gene in the pathway to hell.

  2017cites this paper
• Diagnostic Applications of Nuclear Medicine: Leukemias

  2016cites this paper
• B-cell receptor signaling in chronic lymphocytic leukemia and other B-cell malignancies.

  2016cites this paper
• Long‐term durable remission by cladribine followed by rituximab in patients with hairy cell leukaemia: update of a phase II trial

  2016cites this paper
• Leucémie à tricholeucocytes

  2016cites this paper
• Hairy cell leukemia: Past, present and future.

  2015cites this paper
• Racial Differences in the Overall Survival of Hairy Cell Leukemia in the United States: A Population-Based Analysis of the Surveillance, Epidemiology, and End Results Database.

  2015cites this paper
• NCCN Clinical Practice Guidelines in Oncology ( NCCN Guidelines ) ® Non-Hodgkin ’ s Lymphomas

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  2015cites this paper
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  2015cites this paper
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• Clinical features and diagnosis of hairy cell leukemia.

  2015cites this paper
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  2015cites this paper
• Long-term follow-up after purine analogue therapy in hairy cell leukaemia

  2015cites this paper
• The importance of the tissue microenvironment in hairy cell leukemia.

  2015cites this paper
• Chemoimmunotherapy for hairy cell leukemia.

  2015cites this paper
• Historical overview of hairy cell leukemia.

  2015cites this paper
• Hairy cell leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

  2015cites this paper
• [Chronic B-cell lymphoproliferative disorders with hairy cells].

  2015cites this paper
• Hairy cell leukaemia-variant: Disease features and treatment.

  2015cites this paper
• Recent advances in diagnosis and treatment of hairy cell leukemia

  2015cites this paper
• Hematological malignancies of the lymph nodes

  2015cites this paper
• Current and emerging treatment options for hairy cell leukemia

  2015cites this paper
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  2014cites this paper
• Recommendations of the SFH (French Society of Haematology) for the diagnosis, treatment and follow-up of hairy cell leukaemia

  2014cites this paper
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  2014cites this paper
• Hairy cell leukemia: short review, today's recommendations and outlook

  2014cites this paper
• Hairy cell leukemia: a ‘hair-raising’ update

  2014cites this paper
• TP53 Somatic Mutations: Prognostic and Predictive Value in Human Cancers

  2013cites this paper
• Genome‐wide high resolution DNA profiling of hairy cell leukaemia

  2013cites this paper
• Cladribine with Immediate Rituximab for the Treatment of Patients with Variant Hairy Cell Leukemia

  2013cites this paper
• Orphan drugs for the treatment of hairy cell leukemia

  2013cites this paper
• Białaczka włochatokomórkowa oporna na standardową terapię analogiem puryn – opis przypadku i przegląd piśmiennictwa

  2013cites this paper
• Nouveautés sur les hémopathies lymphoïdes chroniques B matures

  2013cites this paper
• Étude des hémopathies malignes avec cellules chevelues

  2013cites this paper
• Hairy Cell Leukemia

  2013cites this paper
• Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biologic and clinical features.

  2012cites this paper
• Hematologic improvement after flavopiridol treatment of pentostatin and rituximab refractory hairy cell leukemia

  2012cites this paper
• A Canadian perspective on bendamustine for the treatment of chronic lymphocytic leukemia and non-Hodgkin lymphoma.

  2012cites this paper
• B-cell prolymphocytic leukemia and hairy cell leukemia: new advances in biology and treatment

  2012cites this paper
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  2012cites this paper
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  2011cites this paper
• HAIRY CELL LEUKEMIA: REVIEW

  2011cites this paper