The association between inflammation and cancer was discovered as early as 1863 by Rudolf Virchow (Fig. 5.1) (Virchow 1863), who first described the presence of a leukocyte infiltrate in tumor tissues (Balkwill and Mantovani 2001). Individuals affected by chronic inflammatory pathologies have increased risk of cancer development, since they lead to the release of proinflammatory cytokines, creating a favourable microenvironment for tumor progression and metastasis (Balkwill et al. 2005). Examples include viral infection with hepatitis B and C for liver cancer; papilloma virus for cervix carcinoma; bacterial infections, such as Helicobacter pylori for gastric cancer or lymphoma; parasites, such as Schistosoma for bladder cancer. It is thought that Helicobacter pylori infection leads to the formation of Helicobacter pylori reactive T cells, which in turn cause polyclonal B-cell proliferation. In some patients viral integrations causes secondary rearrangements of chromosomes, including multiple deletions that may harbor unknown suppressor genes.
ABSTRACT
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- Publication year
2017
- Venue
Unknown venue
- Publication date
2017-06-09
- Fields of study
Biology, Medicine
- Identifiers
- External record
- Source metadata
Semantic Scholar
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