Molecular Mechanisms of Obesity, Inflammation and Cancer: The Use of in vitro Model Approaches for Targeted Prevention Strategies

No abstract is available for this paper.

• Publication year

  2010

• Venue

  The Open Obesity Journal

• Publication date

  2010-07-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2174/1876823701002010023
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• The hallmarks of cancer

  2012cited by this paper
• Sentinel Surveillance of Influenza-Like-Illness in Two Cities of the Tropical Country of Ecuador: 2006–2010

  2011cited by this paper
• Adiponectin deficiency does not affect development and progression of spontaneous colitis in IL-10 knockout mice.

  2009cited by this paper
• Novel mechanism for obesity-induced colon cancer progression.

  2009influential reference
• IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.

  2009cited by this paper
• Interleukin-6 (IL-6) released by macrophages induces IL-6 secretion in the human colon cancer HT-29 cell line.

  2009cited by this paper
• The Prostate Specific Membrane Antigen Regulates the Expression of IL-6 and CCL5 in Prostate Tumour Cells by Activating the MAPK Pathways1

  2009cited by this paper
• Inflammation-Associated Serum and Colon Markers as Indicators of Dietary Attenuation of Colon Carcinogenesis in ob/ob Mice

  2009cited by this paper
• Insulin, insulin-like growth factor-I, and risk of breast cancer in postmenopausal women.

  2009cited by this paper
• Effects of adipocyte-secreted factors on cell cycle progression in HT29 cells

  2009cited by this paper
• Interleukin-6 and insulin resistance.

  2009cited by this paper
• Adiponectin Deficiency Limits Tumor Vascularization in the MMTV-PyV-mT Mouse Model of Mammary Cancer

  2009cited by this paper
• Local Inflammation and Hypoxia Abolish the Protective Anticontractile Properties of Perivascular Fat in Obese Patients

  2009cited by this paper
• Metabolic syndrome and risk of cancer mortality in men.

  2009cited by this paper
• Proangiogenic Contribution of Adiponectin toward Mammary Tumor Growth In vivo

  2009cited by this paper
• Serum Adipocytokine Levels in Prostate Cancer Patients

  2009cited by this paper
• Testosterone and obesity in men under the age of 40 years

  2009cited by this paper
• c-Jun NH(2)-terminal kinase mediates leptin-stimulated androgen-independent prostate cancer cell proliferation via signal transducer and activator of transcription 3 and Akt.

  2008cited by this paper
• Adiponectin differentially affects gene expression in human mammary epithelial and breast cancer cells

  2008cited by this paper
• Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor.

  2008cited by this paper
• Adiponectin mediates an antiproliferative response in human MDA-MB 231 breast cancer cells.

  2008cited by this paper
• Adiponectin and its role in cardiovascular diseases.

  2008cited by this paper
• Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal‐transduction pathways

  2008cited by this paper
• The Effects of Adiponectin and Metformin on Prostate and Colon Neoplasia Involve Activation of AMP-Activated Protein Kinase

  2008cited by this paper
• Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.

  2008cited by this paper
• Leptin receptor-related immune response in colorectal tumors: the role of colonocytes and interleukin-8.

  2008cited by this paper
• Adiponectin blocks multiple signaling cascades associated with leptin‐induced cell proliferation in ApcMin/+ colon epithelial cells

  2008cited by this paper
• Involvement of the leptin receptor in the immune response in intestinal cancer.

  2008cited by this paper
• Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition

  2008cited by this paper
• Mitogenic and anti‐apoptotic actions of adipocyte‐derived hormone leptin in prostate cancer cells

  2008cited by this paper
• Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet.

  2008cited by this paper
• Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies

  2008cited by this paper
• Leptin-regulated gene expression in MCF-7 breast cancer cells: mechanistic insights into leptin-regulated mammary tumor growth and progression.

  2008cited by this paper
• Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet.

  2008cited by this paper
• Microarray analysis reveals that leptin induces autocrine/paracrine cascades to promote survival and proliferation of colon epithelial cells in an Apc genotype‐dependent fashion

  2008cited by this paper
• Interleukin-6 stimulation of growth of prostate cancer in vitro and in vivo through activation of the androgen receptor.

  2008cited by this paper
• TGF-β has paradoxical and context dependent effects on proliferation and anoikis in human colorectal cancer cell lines

  2008cited by this paper
• The usefulness of circulating adipokine levels for the assessment of obesity-related health problems

  2008cited by this paper
• Obesity Accelerates Mouse Mammary Tumor Growth in the Absence of Ovarian Hormones

  2008cited by this paper
• Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice.

  2008cited by this paper
• Reducing the weight of cancer: mechanistic targets for breaking the obesity-carcinogenesis link.

  2008cited by this paper
• Cancer progression in the transgenic adenocarcinoma of mouse prostate mouse is related to energy balance, body mass, and body composition, but not food intake.

  2007cited by this paper
• Effect of Adiponectin on Murine Colitis Induced by Dextran Sulfate Sodium

  2007cited by this paper
• Adiposity, the metabolic syndrome, and breast cancer in African-American and white American women.

  2007cited by this paper
• The role of the IGF system in cancer growth and metastasis: overview and recent insights.

  2007cited by this paper
• Adipocytes and preadipocytes promote the proliferation of colon cancer cells in vitro

  2007cited by this paper
• Obesity, metabolic syndrome, and prostate cancer.

  2007cited by this paper
• Obesity-associated improvements in metabolic profile through expansion of adipose tissue.

  2007cited by this paper
• The oligomeric structure of high molecular weight adiponectin

  2007cited by this paper
• Metabolic syndrome, hyperinsulinemia, and colon cancer: a review.

  2007cited by this paper
• TGF-β signaling alterations and susceptibility to colorectal cancer

  2007cited by this paper
• TGF-beta signaling alterations and susceptibility to colorectal cancer.

  2007cited by this paper
• Adiponectin deficiency protects mice from chemically induced colonic inflammation.

  2007cited by this paper
• Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells.

  2007cited by this paper
• Leptin acts as a mitogenic and antiapoptotic factor for colonic cancer cells

  2007cited by this paper
• The anti-apoptotic and growth stimulatory actions of leptin in human colon cancer cells involves activation of JNK mitogen activated protein kinase, JAK2 and PI3 kinase/Akt

  2007cited by this paper
• Stage matters: choosing relevant model systems to address hypotheses in diet and cancer chemoprevention research.

  2006cited by this paper
• The insulin-like growth factor-I receptor gene: a downstream target for oncogene and tumor suppressor action.

  2006cited by this paper
• Molecular links between obesity and breast cancer.

  2006cited by this paper
• The metabolic syndrome: A high-risk state for cancer?

  2006cited by this paper
• Adiponectin and cancer: a systematic review

  2006cited by this paper
• Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice.

  2006cited by this paper
• Expression of IGF-I, IGF-II, and IGF-IR in gallbladder carcinoma. A systematic analysis including primary and corresponding metastatic tumours

  2006cited by this paper
• Obesity, Diabetes, and Risk of Prostate Cancer: Results from the Prostate Cancer Prevention Trial

  2006cited by this paper
• TGF-beta as a T cell regulator in colitis and colon cancer.

  2006cited by this paper
• Leptin and cancer

  2006cited by this paper
• Adiponectin as a growth inhibitor in prostate cancer cells.

  2006cited by this paper
• Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min/+) colon epithelial cell line.

  2006influential reference
• Leptin induces an Apc genotype-associated colon epithelial cell chemokine production pattern associated with macrophage chemotaxis and activation.

  2006cited by this paper
• Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice.

  2006cited by this paper
• Leptin stimulates the proliferation of human colon cancer cells in vitro but does not promote the growth of colon cancer xenografts in nude mice or intestinal tumorigenesis in ApcMin/+ mice

  2005cited by this paper
• Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6

  2005cited by this paper
• Adiponectin Inhibits Cell Proliferation by Interacting with Several Growth Factors in an Oligomerization-dependent Manner*

  2005cited by this paper
• Sex Steroid Hormones and the Androgen Receptor Gene CAG Repeat and Subsequent Risk of Prostate Cancer in the Prostate-Specific Antigen Era

  2005cited by this paper
• Leptin, Insulin-Like Growth Factor-1, and Insulin-Like Growth Factor-2 Are Mitogens in ApcMin/+ but not Apc+/+ Colonic Epithelial Cell Lines

  2005influential reference
• Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6.

  2005cited by this paper
• Circulating Levels of Insulin-like Growth Factors, their Binding Proteins, and Breast Cancer Risk

  2005cited by this paper
• A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer

  2005cited by this paper
• A Prospective Study of C-Peptide, Insulin-like Growth Factor-I, Insulin-like Growth Factor Binding Protein-1, and the Risk of Colorectal Cancer in Women

  2005cited by this paper
• Adipocytokines: leptin--the classical, resistin--the controversical, adiponectin--the promising, and more to come.

  2005cited by this paper
• Adipose tissue, adipokines, and inflammation.

  2005cited by this paper
• The endocrine function of adipose tissue: an update

  2005cited by this paper
• Connexin43 is overexpressed in ApcMin/+‐mice adenomas and colocalises with COX‐2 in myofibroblasts

  2005cited by this paper
• Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell

  2005cited by this paper
• Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells.

  2004cited by this paper
• Enhanced Expression of Leptin and Leptin Receptor (OB-R) in Human Breast Cancer

  2004cited by this paper
• Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis.

  2004cited by this paper
• Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

  2004cited by this paper
• Cancer: An inflammatory link

  2004cited by this paper
• Adipokines: inflammation and the pleiotropic role of white adipose tissue

  2004cited by this paper
• Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cells.

  2004cited by this paper
• Leptin induces cell migration and the expression of growth factors in human prostate cancer cells.

  2004cited by this paper
• Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels.

  2004cited by this paper
• Crosstalk Between the Insulin-Like Growth Factors and Estrogens in Breast Cancer

  2004cited by this paper
• Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition

  2004cited by this paper
• At the crossroads of inflammation and cancer.

  2004cited by this paper
• Adipose tissue and adipokines: for better or worse.

  2004cited by this paper
• Obesity, adipocytokines, and insulin resistance in breast cancer

  2004cited by this paper
• Leptin Counteracts Sodium Butyrate-induced Apoptosis in Human Colon Cancer HT-29 Cells via NF-κB Signaling*

  2004influential reference
• Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors.

  2004cited by this paper

• Inflammatory cytokines in the pathogenesis of cardiovascular disease and cancer

  2020cites this paper
• How the association between obesity and inflammation may lead to insulin resistance and cancer.

  2019cites this paper
• Adipokines and Obesity Are Associated with Colorectal Polyps in Adult Males: A Cross-Sectional Study

  2014cites this paper
• Metabolic syndrome and colorectal cancer: a review

  2013cites this paper
• The Role of Immune System in the Patho- genesis of Multiple Sclerosis

  2013cites this paper