The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Immunity

• Publication date

  2002-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S1074-7613(02)00298-4PMID 11970877
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CD8+ lymphocytes from patients with systemic lupus erythematosus sustain, rather than suppress, spontaneous polyclonal IgG production and synergize with CD4+ cells to support autoantibody synthesis.

  2010cited by this paper
• Fas/Fas Ligand Deficiency Results in Altered Localization of Anti-Double-Stranded DNA B Cells and Dendritic Cells1

  2001cited by this paper
• Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

  2001cited by this paper
• Novel Roles for Lyn in B Cell Migration and Lipopolysaccharide Responsiveness Revealed Using Anti-Double-Stranded DNA Ig Transgenic Mice1

  2001cited by this paper
• Impairment of CD8+ T Suppressor Cell Function in Patients with Active Systemic Lupus Erythematosus1

  2001cited by this paper
• Costimulation by B7-1 and B7-2 Is Required for Autoimmune Disease in MRL-Faslpr Mice1

  2000cited by this paper
• FAS Engagement Induces the Maturation of Dendritic Cells (Dcs), the Release of Interleukin (Il)-1β, and the Production of Interferon γ in the Absence of IL-12 during Dc–T Cell Cognate Interaction

  2000cited by this paper
• Autoantibody Responses and Pathology Regulated by B7-1 and B7-2 Costimulation in MRL/lpr Lupus1

  2000cited by this paper
• Virus-Induced Maturation and Activation of Autoreactive Memory B Cells

  2000cited by this paper
• Functional Consequences of the Developmental Arrest and Follicular Exclusion of Anti-Double-Stranded DNA B Cells1

  2000cited by this paper
• B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.

  2000cited by this paper
• Blockade of CD28/CTLA4-B7 pathway prevented autoantibody-related diseases but not lung disease in MRL/lpr mice.

  1999cited by this paper
• B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies.

  1999cited by this paper
• MRL-lpr/lpr Mice Exhibit a Defect in Maintaining Developmental Arrest and Follicular Exclusion of Anti–double-stranded DNA B Cells

  1999cited by this paper
• Chemokines and B-cell homing to follicles.

  1999cited by this paper
• Role of the costimulatory molecule CD28 in the development of lupus in MRL/lpr mice.

  1999cited by this paper
• A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus

  1999cited by this paper
• Dendritic cells undergo rapid apoptosis in vitro during antigen-specific interaction with CD4+ T cells.

  1999cited by this paper
• Visualization of specific B and T lymphocyte interactions in the lymph node.

  1998cited by this paper
• Transgenic expression of Fas in T cells blocks lymphoproliferation but not autoimmune disease in MRL-lpr mice.

  1998cited by this paper
• Anti-CD40L accelerates renal disease and adenopathy in MRL-lpr mice in parallel with decreased thymocyte apoptosis.

  1998cited by this paper
• Rescue of self-reactive B cells by provision of T cell help in vivo

  1998cited by this paper
• Enhanced lymphoproliferation and diminished autoimmunity in CD4-deficient MRL/lpr mice.

  1998cited by this paper
• A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1

  1998cited by this paper
• A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice.

  1998cited by this paper
• Tolerant B Lymphocytes Acquire Resistance to Fas-mediated Apoptosis after Treatment with Interleukin 4 but Not after Treatment with Specific Antigen Unless a Surface Immunoglobulin Threshold Is Exceeded

  1998cited by this paper
• CD22 is a negative regulator of B-cell receptor signalling.

  1997cited by this paper
• Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response.

  1997cited by this paper
• Outer Periarteriolar Lymphoid Sheath Arrest and Subsequent Differentiation of Both Naive and Tolerant Immunoglobulin Transgenic B Cells Is Determined by B Cell Receptor Occupancy

  1997cited by this paper
• Regulation of Anti–double-stranded DNA B Cells in Nonautoimmune Mice: Localization to the T–B Interface of the Splenic Follicle

  1997cited by this paper
• Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures

  1997cited by this paper
• A major T cell determinant from the influenza virus hemagglutinin (HA) can be a cryptic self peptide in HA transgenic mice.

  1997cited by this paper
• Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses.

  1996cited by this paper
• Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor.

  1996cited by this paper
• Anti‐CD4 monoclonal antibody therapy

  1996cited by this paper
• Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires.

  1996cited by this paper
• The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help

  1996cited by this paper
• The phenotype and fate of the antibody‐forming cells of the splenic foci

  1996cited by this paper
• Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells

  1995cited by this paper
• Breakdown of B cell tolerance in a mouse model of systemic lupus erythematosus

  1995cited by this paper
• Light chain contribution to specificity in anti-DNA antibodies.

  1995cited by this paper
• Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate.

  1995cited by this paper
• CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

  1995cited by this paper
• Low avidity recognition of a class II-restricted neo-self peptide by virus-specific T cells.

  1995cited by this paper
• Anatomy of autoantibody production: dominant localization of antibody-producing cells to T cell zones in Fas-deficient mice.

  1995cited by this paper
• Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells

  1994cited by this paper
• Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor

  1994cited by this paper
• Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes

  1994cited by this paper
• B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

  1993cited by this paper
• Polyclonal B cell activation arises from different mechanisms in lupus-prone (NZB x NZW)F1 and MRL/MpJ-lpr/lpr mice.

  1993cited by this paper
• Evidence for early onset, polyclonal activation of T cell subsets in mice homozygous for lpr.

  1992cited by this paper
• Anti-CD4 monoclonal antibody therapy suppresses autoimmune disease in MRL/Mp-lpr/lpr mice.

  1992cited by this paper
• In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers

  1992cited by this paper
• Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice

  1991cited by this paper
• Ig H and L chain contributions to autoimmune specificities.

  1991cited by this paper
• Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

  1991cited by this paper
• Breakdown of self-tolerance in anergic B lymphocytes

  1991cited by this paper
• In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations

  1991cited by this paper
• CTLA-4 is a second receptor for the B cell activation antigen B7

  1991cited by this paper
• Autoantibodies in chronic graft versus host result from cognate T-B interactions

  1990cited by this paper
• Endogenous circulating DNA in systemic lupus erythematosus. Occurrence as multimeric complexes bound to histone.

  1990cited by this paper
• Antinuclear antibodies: diagnostic markers for autoimmune diseases and probes for cell biology.

  1989cited by this paper
• The contribution of L3T4+ T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr mice

  1988cited by this paper
• Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

  1988cited by this paper
• Phenotypic, functional, and molecular genetic comparisons of the abnormal lymphoid cells of C3H-lpr/lpr and C3H-gld/gld mice.

  1986cited by this paper
• [4] Graft-versus-host reactions

  1984cited by this paper
• Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases.

  1984cited by this paper
• IMMUNOLOGY OF DNA. III. CRITHIDIA LUCILIAE, A SIMPLE SUBSTRATE FOR THE DETERMINATION OF ANTI‐dsDNA WITH THE IMMUNOFLUORESCENCE TECHNIQUE *

  1975cited by this paper
• A Theory of Self-Nonself Discrimination

  1970cited by this paper
• DISQUISITIONS ON ORIGINAL ANTIGENIC SIN

  1966cited by this paper

• Lowering CD40L expression in Murine Lupus Results in an Increase in Disease Indicators in Female but not Male B6 mice

  2025cites this paper
• Failed Downregulation of PI3K Signaling Makes Autoreactive B Cells Receptive to Bystander T Cell Help.

  2024cites this paper
• Failed down-regulation of PI3K signaling makes autoreactive B cells receptive to bystander T cell help

  2023cites this paper
• Metabolic Modulators in Cardiovascular Complications of Systemic Lupus Erythematosus

  2023cites this paper
• BAFF induces CXCR5 expression during B cell differentiation in bone marrow

  2023cites this paper
• Implications of regulatory T cells in anti-cancer immunity: from pathogenesis to therapeutics

  2022cites this paper
• Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs

  2022cites this paper
• Role of inhibitory B cell co‐receptors in B cell self‐tolerance to non‐protein antigens *

  2022cites this paper
• T cell help in the autoreactive germinal center

  2022cites this paper
• Functional Role of B Cells in Atherosclerosis

  2021cites this paper
• Positive and negative selection shape the human naive B cell repertoire

  2021cites this paper
• Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA.

  2020cites this paper
• A free amino acid‐based diet partially prevents symptoms of cow's milk allergy in mice after oral sensitization with whey

  2020cites this paper
• The role of B cells in heart failure and implications for future immunomodulatory treatment strategies

  2020cites this paper
• Humoral autoimmunity after solid organ transplantation: Germinal ideas may not be natural.

  2020cites this paper
• T follicular regulatory (Tfr) cells: Dissecting the complexity of Tfr‐cell compartments

  2019cites this paper
• Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity

  2019cites this paper
• Modulation of B cell activation threshold mediated by BCR/CD40 costimulation by targeting Cbl-b for ubiquitination

  2019influential citation
• Non-Antibody-Secreting Functions of B Cells and Their Contribution to Autoimmune Disease.

  2019cites this paper
• Regulation of the Germinal Center Response

  2018cites this paper
• Unravelling the role of the microenvironment in chronic lymphocytic leukaemia: T helper cell support of cancer cells

  2018cites this paper
• Autoimmunität und Transplantation

  2018cites this paper
• Regulatory T Cells Control PF4/Heparin Antibody Production in Mice

  2018cites this paper
• Collagen I enhances the efficiency and anti-tumor activity of dendritic-tumor fusion cells

  2017cites this paper
• of Tolerance to Nuclear Antigens Genetic Determination of T Cell Help in Loss

  2017cites this paper
• Direct control of B cells by Tregs: An opportunity for long-term modulation of the humoral response.

  2017cites this paper
• Metformin Suppresses Systemic Autoimmunity in Roquinsan/san Mice through Inhibiting B Cell Differentiation into Plasma Cells via Regulation of AMPK/mTOR/STAT3

  2017influential citation
• Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.

  2017cites this paper
• Human Ig knockin mice to study the development and regulation of HIV‐1 broadly neutralizing antibodies

  2017cites this paper
• Indirect Allospecificity Rejection by Regulatory CD4 T Cells with Abrogation of Antibody-Mediated Allograft

  2017cites this paper
• Immunological tolerance as a barrier to protective HIV humoral immunity.

  2017cites this paper
• Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction

  2016cites this paper
• Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells

  2016cites this paper
• Regulatory T cells in cardiovascular diseases

  2016cites this paper
• T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity.

  2016cites this paper
• Dendritic Cells Regulate Extrafollicular Autoreactive B Cells via T Cells Expressing Fas and Fas Ligand.

  2016cites this paper
• Mechanisms of Peripheral B Cell Tolerance

  2016cites this paper
• Current Treatment, Emerging Translational Therapies, and New Therapeutic Targets for Autoimmune Myasthenia Gravis

  2015cites this paper
• Systemic Lupus Erythematosus: Molecular Mimicry between Anti-dsDNA CDR3 Idiotype, Microbial and Self Peptides—As Antigens for Th Cells

  2015cites this paper
• Humoral autoimmunity: a failure of regulatory T cells?

  2015cites this paper
• Idiotype-Specific Th Cells Support Oligoclonal Expansion of Anti-dsDNA B Cells in Mice with Lupus

  2014cites this paper
• Contribution of Foxp3+ regulatory T cells and myeloid-derived suppressor cells to immune homeostasis in the steady state and under inflammatory conditions

  2014cites this paper
• Regulatory CD4+ T Cells Promote B Cell Anergy in Murine Lupus

  2014cites this paper
• in Mice with Lupus Cells Oligoclonal Expansion of Anti-dsDNA B Idiotype-Specific Th Cells Support

  2014cites this paper
• Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen.

  2014cites this paper
• Anergy in Murine Lupus T Cells Promote B Cell + Regulatory CD4

  2014cites this paper
• Regulation of Type II Responses in Lung Fibrosis and Systemic Autoimmunity: A Dissertation

  2014cites this paper
• [Regulatory lymphocytes: a new cooperation between T and B cells for a better control of the immune response].

  2014cites this paper
• Interleukin 28B Gene Polymorphisms in Hepatitis C Virus-related Cryoglobulinemic Vasculitis

  2014cites this paper
• Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells.

  2013cites this paper
• Chromosome 1 Loci When Expressed on Autoimmunity Driven by 129-Derived Genetic Dissection of Spontaneous

  2013cites this paper
• Rheumatoid Factor B Cell Memory Leads to Rapid, Switched Antibody-Forming Cell Responses

  2013cites this paper
• Regulatory T cells and B cells: implication on autoimmune diseases.

  2013cites this paper
• Foxp3+ Treg cells in humoral immunity

  2013cites this paper
• Excess CD40L does not rescue anti-DNA B cells from clonal anergy.

  2013cites this paper
• Autoantibodies to Harmonin and Villin Are Diagnostic Markers in Children with IPEX Syndrome

  2013cites this paper
• TLR9 Promotes Tolerance by Restricting Survival of Anergic Anti-DNA B Cells, Yet Is Also Required for Their Activation

  2013cites this paper
• L Chain Allelic Inclusion Does Not Increase Autoreactivity in Lupus-Prone New Zealand Black/New Zealand White Mice

  2013cites this paper
• B cell resistance to Fas-mediated apoptosis contributes to their ineffective control by regulatory T cells in rheumatoid arthritis

  2013cites this paper
• Fate determination of mature autoreactive B cells.

  2013cites this paper
• Rapid , Switched Antibody-Forming Cell Rheumatoid Factor B Cell Memory Leads to

  2013cites this paper
• Required for Their Activation Survival of Anergic Anti-DNA B Cells , Yet Is TLR 9 Promotes Tolerance by Restricting Shlomchik

  2013cites this paper
• Excess CD40L does not rescue anti-DNA B cells from clonal anergy

  2013cites this paper
• Function through Multiple Mechanisms Controls Regulatory T Cell Number and Murine Lupus Susceptibility Locus Sle1a

  2013cites this paper
• Black/New Zealand White Mice Autoreactivity in Lupus-Prone New Zealand L Chain Allelic Inclusion Does Not Increase

  2013cites this paper
• This information is current as Mouse Model of Autoimmune Arthritis Determines Regulatory T Cell Activity in a Requirement for Diverse TCR Specificities

  2012cites this paper
• Evaluation of Natural Regulatory T Cells in Subjects with Selective IgA Deficiency: From Senior Idea to Novel Opportunities

  2012cites this paper
• Deletion and anergy of polyclonal B cells specific for ubiquitous membrane-bound self-antigen

  2012cites this paper
• The Pathophysiology of Preeclampsia Involves Altered Levels of Angiogenic Factors Promoted by Hypoxia and Autoantibody-Mediated Mechanisms1

  2012cites this paper
• Expansion of follicular helper T cells in the absence of Treg cells: Implications for loss of B‐cell anergy

  2012cites this paper
• Cutting Edge: In the Absence of Regulatory T Cells, a Unique Th Cell Population Expands and Leads to a Loss of B Cell Anergy

  2012cites this paper
• Requirement for Diverse TCR Specificities Determines Regulatory T Cell Activity in a Mouse Model of Autoimmune Arthritis

  2012cites this paper
• Regulatory T cells use programmed death 1 ligands to directly suppress autoreactive B cells in vivo

  2012cites this paper
• Humoral autoimmunity in transplantation

  2012cites this paper
• Increased levels of rheumatoid factors after TNF inhibitor in rheumatoid arthritis

  2012cites this paper
• B Cell Tolerance and Positive Selection in Lupus

  2012cites this paper
• macrophage clearance increased frequency of apoptotic lymphocytes and a defect in is coincident with an lpr Fas Autoreactive MZ and B-1 B-cell activation by

  2012cites this paper
• T regulatory cells participate in the control of germinal centre reactions

  2011cites this paper
• Chapter 13 – Origins of Antinuclear Antibodies

  2011cites this paper
• T regulatory cells and the germinal center

  2011influential citation
• T regulatory cells participate in the control of germinal centre

  2011cites this paper
• GM-CSF-induced regulatory T cells selectively inhibit anti-acetylcholine receptor-specific immune responses in experimental myasthenia gravis.

  2011cites this paper
• Treg cells: patrolling a dangerous neighborhood

  2011cites this paper
• Contrasting effects of TNF and anti‐TNF on the activation of effector T cells and regulatory T cells in autoimmunity

  2011cites this paper
• Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis

  2011cites this paper
• Long-Lived Plasma Cells Autoimmunity by Suppressing the Regulatory T Cells Control Humoral

  2010cites this paper
• The U1‐snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases

  2010cites this paper
• TNF-alpha: an activator of CD4+FoxP3+TNFR2+ regulatory T cells.

  2010cites this paper
• B-cell anergy is maintained in anti-DNA transgenic NZB/NZW mice.

  2010cites this paper
• ICOS expression by effector T cells influences the ability of regulatory T cells to inhibit anti-chromatin B cell responses in recipient mice.

  2010influential citation
• Mouse Models of Systemic Lupus Erythematosus Reveal a Complex Pathogenesis

  2010cites this paper
• Humoral autoimmunity and transplant vasculopathy: when allo is not enough.

  2010cites this paper
• Cellular mechanisms of TNF function in models of inflammation and autoimmunity.

  2010cites this paper
• This information is current as Development of Long-Lived Plasma Cells Autoimmunity by Suppressing the Regulatory T Cells Control Humoral + Foxp 3

  2010cites this paper
• Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage.

  2010cites this paper
• Altered B Cell Development and Anergy in the Absence of Foxp3

  2010cites this paper
• Separate checkpoints regulate splenic plasma cell accumulation and IgG autoantibody production in Lyn‐deficient mice

  2010cites this paper
• Immune dysregulation of pemphigus in humans and mice

  2010cites this paper
• The effect of T cell receptor specificity on CD4+CD25+ regulatory T cell function in an autoimmune setting

  2010cites this paper
• CD4+CD25+ regulatory T cells in autoimmune arthritis

  2010cites this paper