Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Circulation

• Publication date

  2013-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCULATIONAHA.112.000116PMID 23616627PMCID PMC3661714
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Workflow and Scan Protocol Considerations for Integrated Whole-Body PET/MRI in Oncology

  2012influential reference
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  2011influential reference
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  2011influential reference
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  2010cited by this paper
• Monocytes: protagonists of infarct inflammation and repair after myocardial infarction.

  2010influential reference
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• Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.

  2010influential reference
• Knocking down barriers: advances in siRNA delivery

  2009cited by this paper
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• Activatable Magnetic Resonance Imaging Agent Reports Myeloperoxidase Activity in Healing Infarcts and Noninvasively Detects the Antiinflammatory Effects of Atorvastatin on Ischemia-Reperfusion Injury

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• Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

  2008cited by this paper
• Macrophage roles following myocardial infarction.

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  2008cited by this paper
• Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.

  2008cited by this paper
• The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

  2007cited by this paper
• Magnetic and fluorescent nanoparticles for multimodality imaging.

  2007cited by this paper
• Cardiovascular MRI: its current and future use in clinical practice

  2007cited by this paper
• Mechanisms of Post-Infarct Left Ventricular Remodeling.

  2007cited by this paper
• Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates.

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  2006influential reference
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  2004cited by this paper
• Novel Factor XIII Probes for Blood Coagulation Imaging

  2003cited by this paper
• Extracellular matrix remodeling following myocardial injury

  2003cited by this paper
• The inflammatory response in myocardial infarction.

  2002cited by this paper
• The Journal of Experimental Medicine

  2000cited by this paper

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  2021cites this paper
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  2021cites this paper
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