Transforming Growth Factor Beta Is a Major Regulator of Human Neonatal Immune Responses following Respiratory Syncytial Virus Infection

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Virology

• Publication date

  2010-10-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.01273-10PMID 20926560PMCID PMC3004333
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genetic Susceptibility to Respiratory Syncytial Virus Bronchiolitis in Preterm Children Is Associated With Airway Remodeling Genes and Innate Immune Genes

  2009cited by this paper
• Reovirus Activates Transforming Growth Factor β and Bone Morphogenetic Protein Signaling Pathways in the Central Nervous System That Contribute to Neuronal Survival following Infection

  2009cited by this paper
• Hepatitis C virus core protein triggers hepatic angiogenesis by a mechanism including multiple pathways

  2009cited by this paper
• Transforming growth factor-beta enhances rhinovirus infection by diminishing early innate responses.

  2009cited by this paper
• TGF‐β indirectly favors the development of human Th17 cells by inhibiting Th1 cells

  2009cited by this paper
• Cell Cycle Arrest by Transforming Growth Factor β1 Enhances Replication of Respiratory Syncytial Virus in Lung Epithelial Cells

  2009cited by this paper
• The role of proteases in transforming growth factor-beta activation.

  2008cited by this paper
• Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge

  2007cited by this paper
• Innate immunity of the newborn: basic mechanisms and clinical correlates

  2007cited by this paper
• Immaturity of infection control in preterm and term newborns is associated with impaired toll-like receptor signaling.

  2007cited by this paper
• Transforming growth factor beta enhances respiratory syncytial virus replication and tumor necrosis factor alpha induction in human epithelial cells.

  2007cited by this paper
• TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

  2007cited by this paper
• Respiratory syncytial virus and metapneumovirus

  2007cited by this paper
• Faculty Opinions recommendation of TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology.

  2007cited by this paper
• MyD88-Mediated Instructive Signals in Dendritic Cells Regulate Pulmonary Immune Responses during Respiratory Virus Infection1

  2007cited by this paper
• Respiratory syncytial virus differentially activates murine myeloid and plasmacytoid dendritic cells

  2007cited by this paper
• Decreased expression of tumor necrosis factor family receptors involved in humoral immune responses in preterm neonates.

  2007cited by this paper
• T(H)-17 differentiation: of mice and men.

  2007cited by this paper
• Severe Human Lower Respiratory Tract Illness Caused by Respiratory Syncytial Virus and Influenza Virus Is Characterized by the Absence of Pulmonary Cytotoxic Lymphocyte Responses

  2007cited by this paper
• Differential response of dendritic cells to human metapneumovirus and respiratory syncytial virus.

  2006cited by this paper
• Low expression of the interleukin (IL)‐4 receptor alpha chain and reduced signalling via the IL‐4 receptor complex in human neonatal B cells

  2006cited by this paper
• Innate Immunity of the Human Newborn Is Polarized Toward a High Ratio of IL-6/TNF-α Production In Vitro and In Vivo

  2006cited by this paper
• Association between severe respiratory syncytial virus infection and IL13/IL4 haplotypes.

  2006cited by this paper
• Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

  2006cited by this paper
• Monocyte Toll-Like Receptor 4 Expression and LPS-Induced Cytokine Production Increase during Gestational Aging

  2005cited by this paper
• Inhibition of Toll-Like Receptor 7- and 9-Mediated Alpha/Beta Interferon Production in Human Plasmacytoid Dendritic Cells by Respiratory Syncytial Virus and Measles Virus

  2005cited by this paper
• Mobilization of plasmacytoid and myeloid dendritic cells to mucosal sites in children with respiratory syncytial virus and other viral respiratory infections.

  2005cited by this paper
• JNK Regulates Autocrine Expression of TGF-β1

  2004cited by this paper
• JNK regulates autocrine expression of TGF-beta1.

  2004cited by this paper
• Blood plasmacytoid dendritic cell responses to CpG oligodeoxynucleotides are impaired in human newborns.

  2004cited by this paper
• Neonatal adaptive immunity comes of age

  2004cited by this paper
• Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

  2003cited by this paper
• Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression.

  2003cited by this paper
• Impaired responses to toll-like receptor 4 and toll-like receptor 3 ligands in human cord blood.

  2003influential reference
• Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms.

  2003cited by this paper
• Functional responses of human neonatal B lymphocytes to antigen receptor cross‐linking and CpG DNA

  2003cited by this paper
• Frequencies of dendritic cells (myeloid DC and plasmacytoid DC) and their ratio reduced in pregnant women: comparison with umbilical cord blood and normal healthy adults.

  2003cited by this paper
• Differences in participation of innate and adaptive immunity to respiratory syncytial virus in adults and neonates.

  2003cited by this paper
• A common haplotype of interleukin-4 gene IL4 is associated with severe respiratory syncytial virus disease in Korean children.

  2002cited by this paper
• Mechanism of Transforming Growth Factor β–induced Inhibition of T Helper Type 1 Differentiation

  2002cited by this paper
• SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.

  2002cited by this paper
• The Transcription Factor T-bet Regulates Mucosal T Cell Activation in Experimental Colitis and Crohn's Disease

  2002cited by this paper
• Mechanism of Transforming Growth Factor (cid:2) –induced Inhibition of T Helper Type 1 Differentiation

  2002cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Cutting Edge: TGF-β Inhibits Th Type 2 Development Through Inhibition of GATA-3 Expression

  2000cited by this paper
• TGF‐β1 down‐regulates Th2 development and results in decreased IL‐4‐induced STAT6 activation and GATA‐3 expression

  2000cited by this paper
• Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease.

  2000cited by this paper
• Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus

  2000cited by this paper
• Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease

  2000cited by this paper
• Interleukin-4 Diminishes CD8+ Respiratory Syncytial Virus-Specific Cytotoxic T-Lymphocyte Activity In Vivo

  1999cited by this paper
• Intracellular IFN-gamma expression in natural killer cells precedes lung CD8+ T cell recruitment during respiratory syncytial virus infection.

  1998cited by this paper
• Flow cytometric characterization of human umbilical cord blood lymphocytes: immunophenotypic features.

  1998cited by this paper
• CD8+ T cells control Th2‐driven pathology during pulmonary respiratory syncytial virus infection

  1997cited by this paper
• Transforming growth factor-beta 1 in asthma. Measurement in bronchoalveolar lavage fluid.

  1997cited by this paper
• Influenza virus neuraminidase activates latent transforming growth factor beta

  1996cited by this paper
• Phenotypic and functional immaturity of human umbilical cord blood T lymphocytes.

  1992cited by this paper
• Age-related changes in human blood lymphocyte subpopulations.

  1992cited by this paper
• Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice.

  1991cited by this paper
• Transforming growth factor beta 1 suppresses acute and chronic arthritis in experimental animals.

  1991cited by this paper
• Transforming growth factor beta 1, a potent chemoattractant for human neutrophils, bypasses classic signal-transduction pathways.

  1991cited by this paper
• Respiratory syncytial virus infection in anti-mu-treated mice

  1991cited by this paper
• Tumour necrosis factor triggers granulocytes to internalize complement-coated virus particles.

  1991cited by this paper
• Immaturity of the human splenic marginal zone in infancy. Possible contribution to the deficient infant immune response.

  1989cited by this paper
• Fetal and neonatal development of human spleen: an immunohistological study.

  1987cited by this paper
• Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth

  1986cited by this paper
• Respiratory syncytial virus infection of human mononuclear leukocytes in vitro and in vivo.

  1985cited by this paper
• Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group, and maternal antibody level.

  1981cited by this paper
• Serum Complement Levels in Infancy: Age Related Changes

  1979cited by this paper
• Transforming Growth Factor (cid:2) Enhances Respiratory Syncytial Virus Replication and Tumor Necrosis Factor Alpha Induction in Human Epithelial Cells (cid:1)

  year unknowncited by this paper

• Deciphering the Role of Macrophages in RSV Infection and Disease

  2025cites this paper
• Differential anti-viral response to respiratory syncytial virus A in preterm and term infants

  2024cites this paper
• The role of dendritic cells in respiratory viral infection

  2024cites this paper
• Inhibiting retinoic acid signaling in dendritic cells suppresses respiratory syncytial virus infection through enhanced antiviral immunity

  2024cites this paper
• Chronic developmental hypoxia alters rat lung immune cell transcriptomes during allergic airway inflammation

  2023cites this paper
• Micro-Players of Great Significance—Host microRNA Signature in Viral Infections in Humans and Animals

  2022cites this paper
• Neonatal Immune Responses to Respiratory Viruses

  2022cites this paper
• RGD‐binding integrins and TGF‐β in SARS‐CoV‐2 infections – novel targets to treat COVID‐19 patients?

  2021cites this paper
• The developing T-cell compartment of the neonatal lung orchestrates an atypical response to respiratory syncytial virus

  2020cites this paper
• Contribution of Dendritic Cells in Protective Immunity against Respiratory Syncytial Virus Infection

  2020cites this paper
• The specific features of the developing T cell compartment of the neonatal lung are a determinant of respiratory syncytial virus immunopathogenesis

  2020cites this paper
• Influenza infected newborn and adult monkeys exhibit a strong primary antibody response to hemagglutinin stem.

  2020cites this paper
• Lack of Activation Marker Induction and Chemokine Receptor Switch in Human Neonatal Myeloid Dendritic Cells in Response to Human Respiratory Syncytial Virus

  2019influential citation
• Regulatory cytokine function in the respiratory tract

  2019cites this paper
• Determining Immune and miRNA Biomarkers Related to Respiratory Syncytial Virus (RSV) Vaccine Types

  2019cites this paper
• Host Components Contributing to Respiratory Syncytial Virus Pathogenesis

  2019cites this paper
• Immune-Modulation by the Human Respiratory Syncytial Virus: Focus on Dendritic Cells

  2019cites this paper
• Altered regulatory cytokine profiles in cases of pediatric respiratory syncytial virus infection

  2018cites this paper
• TGF-β1 Suppresses the Type I IFN Response and Induces Mitochondrial Dysfunction in Alveolar Macrophages

  2018cites this paper
• Neonatal Immunity, Respiratory Virus Infections, and the Development of Asthma

  2018cites this paper
• Notch Ligand Delta-like 4 (Dll4) Induces Epigenetic Mechanism in Regulatory T Cell FunctionDuring Pulmonary Viral Infection

  2018cites this paper
• Peripheral blood microRNAs expression is associated with infant respiratory syncytial virus infection

  2017cites this paper
• Airway epithelial cell and macrophage regulation of pulmonary immunity

  2017cites this paper
• Unique aspects of the perinatal immune system

  2017cites this paper
• Pulmonary immunity to viruses.

  2017cites this paper
• Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children

  2017cites this paper
• P244 Serum YKL-40 levels may help distinguish exacerbation of post-infectious bronchiolitis obliterans from acute bronchiolitis in young children

  2017cites this paper
• 122 – Host Defense Mechanisms Against Viruses

  2017cites this paper
• Peripheral blood microRNAs expression is associated with infant respiratory syncytial virus infection.

  2017cites this paper
• Autophagy, TGF-β, and SMAD-2/3 Signaling Regulates Interferon-β Response in Respiratory Syncytial Virus Infected Macrophages

  2016cites this paper
• A curated transcriptome dataset collection to investigate the functional programming of human hematopoietic cells in early life

  2016cites this paper
• Short report Open Access

  2015cites this paper
• Human respiratory syncytial virus non-structural protein NS1 modifies miR-24 expression via transforming growth factor-β.

  2015cites this paper
• Identification and characterization of transforming growth factor β induced gene (TGFBIG) from Branchiostoma belcheri: insights into evolution of TGFBI family.

  2014cites this paper
• Alveolar macrophages contribute to the pathogenesis of human metapneumovirus infection while protecting against respiratory syncytial virus infection.

  2014cites this paper
• Maternal inflammation modulates infant immune response patterns to viral lung challenge in a murine model

  2014cites this paper
• Cord blood CD4(+)CD25(+) regulatory T cells fail to inhibit cord blood NK cell functions due to insufficient production and expression of TGF-beta1.

  2014cites this paper
• Immunity to RSV in Early-Life

  2014cites this paper
• Combining Single RNA Sensitive Probes with Subdiffraction-Limited and Live-Cell Imaging Enables the Characterization of Virus Dynamics in Cells

  2013cites this paper
• Consequences of immature and senescent immune responses for infection with respiratory syncytial virus.

  2013cites this paper
• Th17 Lymphocytes in Respiratory Syncytial Virus Infection

  2013influential citation
• The Innate Immune System of the Perinatal Lung and Responses to Respiratory Syncytial Virus Infection

  2013cites this paper
• Pattern recognition receptors for respiratory syncytial virus infection and design of vaccines.

  2012cites this paper
• Glucocorticoid-resistant asthma and novel anti-inflammatory drugs.

  2012cites this paper
• Characterization of Memphis 37 strain of human respiratory syncytial virus in neonatal lambs

  2012cites this paper
• Respiratory Syncytial Virus Regulates Human MicroRNAs by Using Mechanisms Involving Beta Interferon and NF-κB

  2012cites this paper
• Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis

  2012cites this paper
• Respiratory syncytial virus infection and immunity

  2012influential citation
• Perinatal Lamb Model of Respiratory Syncytial Virus (RSV) Infection

  2012influential citation
• Krüppel-like factor 6 regulates transforming growth factor-β gene expression during human respiratory syncytial virus infection

  2011cites this paper
• Diagnostic Value of Homocysteine and Other Preeclampsia Markers: Relationship with Severity

  2011cites this paper
• Respiratory Syncytial Virus Infection in Adults

  2011cites this paper