Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Molecular Oncology

• Publication date

  2012-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.molonc.2012.05.002PMID 22717603PMCID PMC3439602
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells

  2012cited by this paper
• 6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells.

  2011cited by this paper
• Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines

  2011cited by this paper
• The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity

  2010cited by this paper
• Jak2 inhibition deactivates Lyn kinase through the SET–PP2A–SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients

  2009cited by this paper
• Berbamine, a novel nuclear factor κB inhibitor, inhibits growth and induces apoptosis in human myeloma cells

  2009cited by this paper
• Multimodal assessment of protein functional deficiency supports pathogenicity of BRCA1 p.V1688del.

  2009cited by this paper
• The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.

  2009cited by this paper
• Role of myeloid cell leukemia-1 in cell growth of squamous cell carcinoma.

  2009cited by this paper
• Berbamine exhibits potent antitumor effects on imatinib-resistant CML cells in vitro and in vivo

  2009cited by this paper
• Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action

  2009cited by this paper
• Berbamine derivatives: a novel class of compounds for anti-leukemia activity.

  2009cited by this paper
• STATs in cancer inflammation and immunity: a leading role for STAT3

  2009cited by this paper
• Mcl-1 Is Required for Melanoma Cell Resistance to Anoikis

  2009cited by this paper
• Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding.

  2009cited by this paper
• Prolonged PFS after Autologous Stem Cell Transplantation in Follicular Lymphoma Patients: A Long-Term Retrospective Study.

  2008cited by this paper
• Signal Transducer and Activator of Transcription-3: A Molecular Hub for Signaling Pathways in Gliomas

  2008cited by this paper
• Myeloproliferative disorders.

  2008cited by this paper
• A Novel Inhibitor of Signal Transducers And Activators Of Transcription 3 Activation Is Efficacious Against Established Central Nervous System Melanoma and Inhibits Regulatory T Cells

  2008cited by this paper
• Melanoma biology and new targeted therapy

  2007cited by this paper
• Cutaneous Malignant Melanoma

  2006cited by this paper
• The myeloproliferative disorders.

  2006cited by this paper
• Cutaneous malignant melanoma.

  2006cited by this paper
• Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.

  2005cited by this paper
• Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.

  2005cited by this paper
• Targeting STAT3 affects melanoma on multiple fronts

  2005cited by this paper
• Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

  2005cited by this paper
• Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells.

  2005cited by this paper
• A gain-of-function mutation of JAK2 in myeloproliferative disorders.

  2005cited by this paper
• A new modality for immunosuppression: targeting the JAK/STAT pathway

  2004cited by this paper
• Src family kinases, key regulators of signal transduction

  2004influential reference
• The STATs of cancer — new molecular targets come of age

  2004cited by this paper
• Inhibitors of JAKs/STATs and the kinases: a possible new cluster of drugs.

  2004cited by this paper
• Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

  2003cited by this paper
• JAKs, STATs and Src kinases in hematopoiesis

  2002cited by this paper
• Signalling: STATs: transcriptional control and biological impact

  2002cited by this paper
• Transcription factors as targets for cancer therapy

  2002cited by this paper
• Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

  2002cited by this paper
• Cytokine signaling in 2002: new surprises in the Jak/Stat pathway.

  2002influential reference
• Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

  2001cited by this paper
• Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.

  2001cited by this paper
• IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled

  2000cited by this paper
• Activation of Stat3 in v-Src-transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity*

  2000cited by this paper
• Janus kinases: components of multiple signaling pathways

  2000cited by this paper
• Stat3 as an oncogene.

  1999cited by this paper
• Jaks and STATs: biological implications.

  1998cited by this paper
• Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop

  1997cited by this paper
• Constitutive Activation of JAK1 in Src-transformed Cells*

  1997cited by this paper
• Myeloproliferative Disorders

  1975cited by this paper

• α-terpineol induces apoptosis in melanoma cells and its underlying mechanism

  2026cites this paper
• The role of miR‐4284 in cancer progression and therapeutic response: Regulatory mechanisms and clinical implications

  2025cites this paper
• Semisynthesis of bersavine and berbamine derivatives that target the CaMKIIγ:cMyc axis for lymphoma therapy.

  2025cites this paper
• Targeting anticancer immunity in melanoma tumour microenvironment: unleashing the potential of adjuvants, drugs, and phytochemicals

  2024cites this paper
• MiR362-3p Alleviates Osteosarcoma by Regulating the IL6ST/JAK2/STAT3 Pathway in Vivo and in Vitro

  2024cites this paper
• Pharmacological and Therapeutic Potential of Berbamine: A Potent Alkaloid from Genus Berberis.

  2024cites this paper
• Targeting JAK2/STAT3 for the treatment of cancer: A review on recent advancements in molecular development using structural analysis and SAR investigations.

  2024cites this paper
• Berbamine promotes ferroptosis of esophageal squamous cell carcinoma by facilitating USP51-mediated GPX4 ubiquitination and degradation.

  2024cites this paper
• Berbamine Inhibits the Biological Activities of Prostate Cancer Cells by Modulating the ROS/NF-κB Axis.

  2023cites this paper
• Natural STAT3 inhibitors for cancer treatment: A Comprehensive Literature Review.

  2023cites this paper
• Berbamine targets cancer stem cells and reverses cabazitaxel resistance via inhibiting IGF2BP1 and p‐STAT3 in prostate cancer

  2023cites this paper
• Berbamine dihydrochloride suppresses the progression of colorectal cancer via RTKs/Akt axis.

  2022cites this paper
• Hydroxyzine Induces Cell Death in Triple-Negative Breast Cancer Cells via Mitochondrial Superoxide and Modulation of Jak2/STAT3 Signaling

  2022cites this paper
• Regulation of Cell-Signaling Pathways by Berbamine in Different Cancers

  2022influential citation
• Natural products in suppressing glioma progression: A focus on the role of microRNAs

  2022cites this paper
• Pharmacological Benefits of Miswak Users and Its Impact on COVID-19 Patients – A Review

  2021cites this paper
• Berbamine induced activation of the SIRT1/LKB1/AMPK signaling axis attenuates the development of hepatic steatosis in high-fat diet-induced NAFLD rats.

  2021cites this paper
• Licochalcone H Induces Cell Cycle Arrest and Apoptosis in Human Skin Cancer Cells by Modulating JAK2/STAT3 Signaling

  2021cites this paper
• Berbamine Inhibits Cell Proliferation and Migration and Induces Cell Death of Lung Cancer Cells via Regulating c-Maf, PI3K/Akt, and MDM2-P53 Pathways

  2021cites this paper
• Two Worlds Colliding: The Interplay Between Natural Compounds and Non-Coding Transcripts in Cancer Therapy

  2021cites this paper
• Improving target assessment in biomedical research: the GOT-IT recommendations

  2020cites this paper
• Synthesis and antitumor activity in vitro of novel berbamine derivatives

  2020cites this paper
• Knockdown of Long Non-Coding RNA LOC100132707 Inhibits the Migration of Uveal Melanoma Cells via Silencing JAK2

  2020cites this paper
• Association of Clinicopathologic Features with the Depth of Invasion in Acral Melanoma

  2020cites this paper
• Mechanistic Paradigms of Natural Plant Metabolites as Remedial Candidates for Systemic Lupus Erythromatosus

  2020influential citation
• Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway.

  2020cites this paper
• STAT3 transcription factor as target for anti-cancer therapy

  2020cites this paper
• Circular RNA hsa_circ_0001649 suppresses the growth of osteosarcoma cells via sponging multiple miRNAs

  2020cites this paper
• The Multi-Functional Calcium/Calmodulin Stimulated Protein Kinase (CaMK) Family: Emerging Targets for Anti-Cancer Therapeutic Intervention

  2019cites this paper
• Berberis Plants—Drifting from Farm to Food Applications, Phytotherapy, and Phytopharmacology

  2019cites this paper
• Natural products as important tyrosine kinase inhibitors.

  2019cites this paper
• Lycorine exerts antitumor activity against osteosarcoma cells in vitro and in vivo xenograft model through the JAK2/STAT3 pathway

  2019cites this paper
• Novel synthetic tosyl chloride-berbamine regresses lethal MYC-positive leukemia by targeting CaMKIIγ/Myc axis.

  2019cites this paper
• Salidroside inhibits migration and invasion of poorly differentiated thyroid cancer cells

  2019cites this paper
• Cell-state dynamics and therapeutic resistance in melanoma from the perspective of MITF and IFNγ pathways

  2019cites this paper
• Identification of Chinese Herbal Compounds with Potential as JAK3 Inhibitors

  2019cites this paper
• Berbamine exerts anticancer effects on human colon cancer cells via induction of autophagy and apoptosis, inhibition of cell migration and MEK/ERK signalling pathway.

  2019cites this paper
• The JAK2/STAT3 pathway is involved in the anti‐melanoma effects of atractylenolide I

  2018cites this paper
• Crispenes F and G, cis-Clerodane Furanoditerpenoids from Tinospora crispa, Inhibit STAT3 Dimerization.

  2018cites this paper
• Novel synthetic 4-chlorobenzoyl berbamine inhibits c-Myc expression and induces apoptosis of diffuse large B cell lymphoma cells

  2018cites this paper
• Cardiotoxicity evaluation of nine alkaloids from Rhizoma Coptis

  2018cites this paper
• Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products

  2018cites this paper
• 4-parvifuran inhibits metastatic and invasive actions through the JAK2/STAT3 pathway in osteosarcoma cells

  2017cites this paper
• A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells

  2017cites this paper
• Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma.

  2017cites this paper
• Cucurbitacin B inhibits cell proliferation and induces apoptosis in human osteosarcoma cells via modulation of the JAK2/STAT3 and MAPK pathways.

  2017cites this paper
• Synergistic Antitumor Effects of Berbamine and Paclitaxel through ROS/Akt Pathway in Glioma Cells

  2017cites this paper
• In vitro and in vivo metabolic activation of berbamine to quinone methide intermediate

  2017cites this paper
• Berbamine induces SMMC-7721 cell apoptosis via upregulating p53, downregulating survivin expression and activating mitochondria signaling pathway

  2017cites this paper
• Title A natural product-like JAK 2 / STAT 3 inhibitor induces apoptosisof malignant melanoma cells

  2017cites this paper
• Targeting signal transducers and activators of transcription (STAT) in human cancer by dietary polyphenolic antioxidants.

  2017cites this paper
• Historical Development of STAT3 Inhibitors and Early Results in Clinical Trials

  2016cites this paper
• Curcumin analogue, A13, exhibits anti-leukemia effect via inhibiting STAT3

  2016cites this paper
• Berbamine inhibited the growth of prostate cancer cells in vivo and in vitro via triggering intrinsic pathway of apoptosis

  2016cites this paper
• Salidroside reduces renal cell carcinoma proliferation by inhibiting JAK2/STAT3 signaling

  2016cites this paper
• Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling

  2016cites this paper
• 4-Chlorbenzoyl Berbamine, a Novel Derivative of the Natural Product Berbamine, Potently Inhibits the Growth of Human Myeloma Cells by Modulating the NF-κB and JNK Signalling Pathways

  2016cites this paper
• Huaier aqueous extract inhibits proliferation and metastasis of tuberous sclerosis complex cell models through downregulation of JAK2/STAT3 and MAPK signaling pathways.

  2016cites this paper
• Artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably Suppresses Hepatocellular Carcinoma.

  2016cites this paper
• Novel harmine derivatives for tumor targeted therapy

  2015cites this paper
• Glucose-6-phosphate dehydrogenase and NADPH oxidase 4 control STAT3 activity in melanoma cells through a pathway involving reactive oxygen species, c-SRC and SHP2.

  2015cites this paper
• Cancer Therapy with Phytochemicals: Present and Future Perspectives.

  2015cites this paper
• Lentiginoses in polycythemia vera patient: Is there a role for JAK2 (V617F) mutation?

  2015cites this paper
• Review Cancer Therapy with Phytochemicals : Present and Future Perspectives

  2015cites this paper
• Anticancer effect of salidroside on colon cancer through inhibiting JAK2/STAT3 signaling pathway.

  2015cites this paper
• Glucose-6-phosphate dehydrogenase and NADPH oxidase 4 control STAT 3 activity in melanoma cells through a pathway involving reactive oxygen species , cSRC and SHP 2

  2015cites this paper
• A mechanistic study on the anti-melanoma action of quercetin

  2015cites this paper
• A map describing the association between effective components of traditional Chinese medicine and signaling pathways in cancer cells in vitro and in vivo.

  2014cites this paper
• Natural products and their derivatives regulating the janus kinase/signal transducer and activator of transcription pathway

  2014cites this paper
• Targeting constitutively-activated STAT3 in hypoxic ovarian cancer, using a novel STAT3 inhibitor

  2014cites this paper
• A Novel Berbamine Derivative Inhibits Cell Viability and Induces Apoptosis in Cancer Stem-Like Cells of Human Glioblastoma, via Up-Regulation of miRNA-4284 and JNK/AP-1 Signaling

  2014cites this paper
• Electrospray ionization mass spectrometry probing of binding affinity of berbamine, a flexible cyclic alkaloid from traditional Chinese medicine, with G-quadruplex DNA.

  2014cites this paper
• Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening

  2014cites this paper
• A review on berbamine a - a potential anticancer drug.

  2014cites this paper
• A millet bran-derived peroxidase inhibits cell migration by antagonizing STAT3-mediated epithelial-mesenchymal transition in human colon cancer

  2014cites this paper
• Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH‑SY5Y human neuroblastoma cells.

  2014cites this paper
• Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling.

  2014cites this paper
• A sesquiterpene lactone antrocin from Antrodia camphorata negatively modulates JAK2/STAT3 signaling via microRNA let-7c and induces apoptosis in lung cancer cells.

  2013cites this paper
• Therapeutic modulators of STAT signalling for human diseases

  2013cites this paper
• A novel synthetic analog of Militarin, MA-1 induces mitochondrial dependent apoptosis by ROS generation in human lung cancer cells.

  2013influential citation
• Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway.

  2013cites this paper
• Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca2+/Calmodulin-Dependent Protein Kinase II

  2013cites this paper
• Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca 2þ /Calmodulin-

  2013cites this paper
• Léky přírodního původu a jejich potenciální protinádorový účinek

  2013cites this paper
• A novel synthetic derivative of the natural product berbamine inhibits cell viability and induces apoptosis of human osteosarcoma cells, associated with activation of JNK/AP-1 signaling

  2013cites this paper
• Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells

  2012cites this paper