Dysfunctional brain dynamics and their origin in Lewy body dementia

Julia Schumacher,Luis R. Peraza,M. Firbank,Alan J. Thomas,Marcus Kaiser,P. Gallagher,J. O'Brien,A. Blamire,John-Paul Taylor

Published 2019 in Brain : a journal of neurology

ABSTRACT

See Jeganathan and Breakspear (doi:10.1093/brain/awz132) for a scientific commentary on this article. Schumacher et al. report a marked and generalised slowing of whole-brain EEG dynamics in Lewy body dementia that distinguishes it from Alzheimer’s disease and healthy ageing. The slowing is related to a loss of dynamic interaction between basal ganglia-thalamic networks and large-scale cortical networks, and may contribute to fluctuating cognition.

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