Iron homeostasis—Achilles’ heel of Aspergillus fumigatus?

Highlights • Aspergillus fumigatus uses extracellular siderophores for uptake and intracellular siderophores for storage and trafficking of iron. • Intracellular siderophore-mediated iron handling is important for germination, development, and antioxidative defense. • Extra- and intracellular siderophores are crucial for virulence of A. fumigatus and a variety of other fungal species. • The regulator HapX mediates adaptation to iron starvation by activating iron uptake and repressing iron consumption. • HapX is crucial for virulence of A. fumigatus and a variety of other fungal species.

• Publication year

  2011

• Venue

  Current Opinion in Microbiology

• Publication date

  2011-08-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.mib.2011.06.002PMID 21724450PMCID 3162135
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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