Development of a novel ex vivo porcine skin explant model for the assessment of mature bacterial biofilms

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Wound Repair and Regeneration

• Publication date

  2013-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/wrr.12074PMID 23927831
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Microbial Biofilms

  2011cited by this paper
• Development of a novel, highly quantitative in vivo model for the study of biofilm‐impaired cutaneous wound healing

  2011cited by this paper
• Biofilm maturity studies indicate sharp debridement opens a time- dependent therapeutic window.

  2010cited by this paper
• In vitro and in vivo model systems to study microbial biofilm formation.

  2010cited by this paper
• Human skin wounds: A major and snowballing threat to public health and the economy

  2009cited by this paper
• Biofilms in chronic wounds

  2008influential reference
• Microscopic and physiologic evidence for biofilm‐associated wound colonization in vivo

  2008cited by this paper
• Our historical roots: Dr Richard Drysdale Dakin, DSc, and his solution.

  2008cited by this paper
• Guideline for isolation precautions: preventing transmission of infectious agents in healthcare settings 2007

  2008cited by this paper
• Physiological heterogeneity in biofilms

  2008cited by this paper
• 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care Settings

  2007cited by this paper
• Antimicrobial activity and effectiveness of a combination of sodium hypochlorite and hydrogen peroxide in killing and removing Pseudomonas aeruginosa biofilms from surfaces

  2007cited by this paper
• Preventing pressure ulcers: the goal is zero.

  2007cited by this paper
• Characterization of Temporal Protein Production in Pseudomonas aeruginosa Biofilms

  2005cited by this paper
• Patterns of virulence gene expression differ between biofilm and tissue communities of Streptococcus pyogenes

  2005cited by this paper
• Clinical Care of the Diabetic Foot

  2005cited by this paper
• Bacteria and wound healing

  2004cited by this paper
• Inflammation and Wound Healing: The Role of Bacteria in the Immuno-Regulation of Wound Healing

  2004cited by this paper
• Human Monoclonal Antibodies to Pseudomonas aeruginosa Alginate That Protect against Infection by Both Mucoid and Nonmucoid Strains1

  2004cited by this paper
• Gene expression in Escherichia coli biofilms

  2004cited by this paper
• Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms

  2002cited by this paper
• Effect of flow regime on the architecture of a Pseudomonas fluorescens biofilm.

  2002cited by this paper
• Microbiological methods for testing disinfectant efficiency on Pseudomonas biofilm.

  2001cited by this paper
• Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption.

  2001cited by this paper
• Antibiotic resistance of bacteria in biofilms.

  2001cited by this paper
• THE PIG AS A MODEL FOR HUMAN WOUND HEALING

  2001cited by this paper
• Biofilm penetration and disinfection efficacy of alkaline hypochlorite and chlorosulfamates

  2001cited by this paper
• Quorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms

  2000cited by this paper
• The Global Carbon Metabolism Regulator Crc Is a Component of a Signal Transduction Pathway Required for Biofilm Development by Pseudomonas aeruginosa

  2000cited by this paper
• Bacterial biofilms: a common cause of persistent infections.

  1999influential reference
• LIVE/DEAD BacLight : application of a new rapid staining method for direct enumeration of viable and total bacteria in drinking water.

  1999cited by this paper
• Abiotic Surface Sensing and Biofilm-Dependent Regulation of Gene Expression in Escherichia coli

  1999cited by this paper
• Pseudomonas aeruginosa strains obtained from patients with tracheal, urinary tract and wound infection: variations in virulence factors and virulence genes.

  1999cited by this paper
• REFERENCES CONTENT ALERTS

  1998cited by this paper
• The involvement of cell-to-cell signals in the development of a bacterial biofilm.

  1998cited by this paper
• Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes

  1997cited by this paper
• Microbial biofilms.

  1995cited by this paper
• Pseudomonas aeruginosa and long-term indwelling bladder catheters.

  1988cited by this paper

• Development of Rapid and Economic In Vitro Assay and Biorelevant Ex Vivo Biofilm Inhibition Wound Model to Test the Antibacterial Efficacy of Wound Dressings

  2025cites this paper
• A Novel In Vitro Scrubber Model for Evaluating Wound Cleansing on Biofilms

  2025cites this paper
• Effects of Hxc-T2SS on the Phenotypic Features and Virulence of Pseudomonas aeruginosa PAO1.

  2025cites this paper
• Fungal quorum sensing molecules as potential drugs in the treatment of chronic wounds and their delivery

  2025cites this paper
• A Three-Dimensional Model of Bacterial Biofilms and Its Use in Antimicrobial Susceptibility Testing

  2024cites this paper
• Melaleuca alternifolia essential oil in a natural product-based formulation: Antimicrobial and healing effects in Staphylococcus aureus-infected wounds.

  2024cites this paper
• Development of a Stringent Ex Vivo-Burned Porcine Skin Wound Model to Screen Topical Antimicrobial Agents

  2024cites this paper
• Multi‐drug resistant Staphylococcus epidermidis from chronic wounds impair healing in human wound model

  2024cites this paper
• Estrategias para el manejo de heridas crónicas complicadas con biopelícula de bacterias multirresistentes en equinos: revisión bibliográfica, diagnóstico y protocolo de tratamiento

  2024cites this paper
• A surfactant‐based dressing can reduce the appearance of Pseudomonas aeruginosa pigments and uncover the dermal extracellular matrix in an ex vivo porcine skin wound model

  2023cites this paper
• In vitro laboratory infection research in orthopaedics: Why, when, and how

  2023cites this paper
• Chitosan hydrogels with MK2 inhibitor peptide-loaded nanoparticles to treat atopic dermatitis.

  2023cites this paper
• Photoactivated Gallium Porphyrin Reduces Staphylococcus aureus Colonization on the Skin and Suppresses Its Ability to Produce Enterotoxin C and TSST-1

  2023cites this paper
• Effects of elevated levels of intracellular nitric oxide on Pseudomonas aeruginosa biofilm in chronic skin wound and slow-killing infection models

  2023cites this paper
• Combining SNAPs with antibiotics shows enhanced synergistic efficacy against S. aureus and P. aeruginosa biofilms

  2023cites this paper
• Vitamin K3 (Menadione) is a multifunctional microbicide acting as a photosensitizer and synergizing with blue light to kill drug-resistant bacteria in biofilms.

  2023cites this paper
• Preclinical performance testing of medical devices with antimicrobial effects

  2023cites this paper
• NF-κB signaling pathway mechanism in cow intertoe skin inflammation caused by Fusobacterium necrophorum

  2023cites this paper
• Controlling the structure of supramolecular fibre formation for benzothiazole based hydrogels with antimicrobial activity against methicillin resistant Staphylococcus aureus.

  2023cites this paper
• Standardization of in vitro dual-species biofilms of Staphylococcus pseudintermedius and Malassezia pachydermatis: A strategy to establish an ex vivo biofilm model.

  2023cites this paper
• Development and Characterization of Hydroxyethyl Cellulose-Based Gels Containing Lactobacilli Strains: Evaluation of Antimicrobial Effects in In Vitro and Ex Vivo Models

  2023cites this paper
• Ex vivo wound model on porcine skin for the evaluation of the antibiofilm activity of polyhexamethylene biguanide and ciprofloxacin.

  2023cites this paper
• In vitro and Ex vivo Assessments of the Compatibility of Fibrin Sealant with Antimicrobial Compounds

  2023cites this paper
• Development of In Vitro and Ex Vivo Biofilm Models for the Assessment of Antibacterial Fibrous Electrospun Wound Dressings

  2023cites this paper
• How to study biofilms: technological advancements in clinical biofilm research

  2023cites this paper
• Assessment of antibiotic release and antibacterial efficacy from pendant glutathione hydrogels using ex vivo porcine skin.

  2023cites this paper
• Bactericidal Effect of Iberin Combined with Photodynamic Antimicrobial Chemotherapy Against Pseudomonas aeruginosa Biofilm Cultured on ex vivo Wound Model.

  2023cites this paper
• Biofilm Models: Different Ways of Biofilm Characterization and Drug Discovery

  2023cites this paper
• Liquid crystal nanoparticle platform for increased efficacy of cationic antimicrobials against biofilm infections.

  2022cites this paper
• Biofilm model on mice skin wounds

  2022cites this paper
• Inhibition of Staphylococcus aureus Biofilm Formation and Virulence Factor Production by Petroselinic Acid and Other Unsaturated C18 Fatty Acids

  2022cites this paper
• Phytopigment Alizarin Inhibits Multispecies Biofilm Development by Cutibacterium acnes, Staphylococcus aureus, and Candida albicans

  2022cites this paper
• A proof‐of‐concept study of the removal of early and late phase biofilm from skin wound models using a liquid acoustic stream

  2022cites this paper
• Effect of Nanosulfur Against Multidrug-Resistant Staphylococcus pseudintermedius and Pseudomonas aeruginosa

  2022cites this paper
• A Bioluminescence-Based Ex Vivo Burn Wound Model for Real-Time Assessment of Novel Phage-Inspired Enzybiotics

  2022cites this paper
• Cerium Nitrate Stiffens In Vitro Skin Models and Reduces Pseudomonas aeruginosa Pathogenicity and Penetration Through Skin Models

  2022cites this paper
• Activity of a hypochlorous acid‐producing electrochemical bandage as assessed with a porcine explant biofilm model

  2022cites this paper
• Efficacy and toxicity of hydrogen peroxide producing electrochemical bandages in a porcine explant biofilm model

  2022influential citation
• Biofilms: Formation, Research Models, Potential Targets, and Methods for Prevention and Treatment

  2022cites this paper
• An in vitro and ex vivo wound infection model to test topical and systemic treatment with antibiotics

  2022cites this paper
• β-Lactamase-Responsive Hydrogel Drug Delivery Platform for Bacteria-Triggered Cargo Release.

  2022cites this paper
• Self-locomotive, antimicrobial microrobot (SLAM) swarm for enhanced biofilm elimination.

  2022cites this paper
• Improved diabetic wound healing by LFcinB is associated with relevant changes in the skin immune response and microbiota

  2021cites this paper
• Antibiofilm activity of chitosan/epsilon‐poly‐L‐lysine hydrogels in a porcine ex vivo skin wound polymicrobial biofilm model

  2021influential citation
• SARS-CoV-2 decontamination of skin with disinfectants active during and after application

  2021cites this paper
• Ex situ model of biofilm‐associated wounds: providing a host‐like environment for the study of Staphylococcus aureus and Pseudomonas aeruginosa biofilms

  2021cites this paper
• Potential of bacteriophages as disinfectants to control of Staphylococcus aureus biofilms

  2021cites this paper
• Early wound bed preparation: irrigation and debridement.

  2021cites this paper
• Transcriptional analysis and target genes discovery of Pseudomonas aeruginosa biofilm developed ex vivo chronic wound model

  2021cites this paper
• Transcriptional analysis and target genes discovery of Pseudomonas aeruginosa biofilm developed ex vivo chronic wound model

  2021cites this paper
• Non-invasive, 3D printed, colourimetric, early wound-infection indicator.

  2021cites this paper
• Mini-review: from in vitro to ex vivo studies: an overview of alternative methods for the study of medical biofilms

  2020cites this paper
• How microbes read the map: Effects of implant topography on bacterial adhesion and biofilm formation.

  2020cites this paper
• Failure of Healing in Chronic Diabetic Wounds: A Case Report.

  2020cites this paper
• An ex vivo cornea infection model

  2020cites this paper
• Evaluation of an Explanted Porcine Skin Model to Investigate Infection with the Dermatophyte Trichophyton rubrum

  2020cites this paper
• Novel Antimicrobial Peptides Formulated in Chitosan Matrices are Effective Against Biofilms of Multidrug-Resistant Wound Pathogens.

  2020cites this paper
• Corrigendum: Bioengineered Platforms for Chronic Wound Infection Studies: How Can We Make Them More Human-Relevant?

  2020cites this paper
• Nanomaterials combination for wound healing and skin regeneration

  2020cites this paper
• A VersaTile-driven platform for rapid hit-to-lead development of engineered lysins

  2020cites this paper
• Cadexomer iodine effectively reduces bacterial biofilm in porcine wounds ex vivo and in vivo

  2019cites this paper
• Antimicrobial assessment of phage therapy using a porcine model of biofilm infection

  2019cites this paper
• The efficacy of topical agents used in wounds for managing chronic biofilm infections: A systematic review.

  2019cites this paper
• Bioengineered Platforms for Chronic Wound Infection Studies: How Can We Make Them More Human-Relevant?

  2019cites this paper
• An Equine Wound Model to Study Effects of Bacterial Aggregates on Wound Healing

  2019cites this paper
• Peptides and their effect on wound healing

  2019cites this paper
• Effects and efficacy of different sterilization and disinfection methods on electrospun drug delivery systems.

  2019cites this paper
• General Assembly, Research Caveats: Proceedings of International Consensus on Orthopedic Infections.

  2019cites this paper
• In vitro and ex vivo systems at the forefront of infection modeling and drug discovery

  2018cites this paper
• Options and Limitations in Clinical Investigation of Bacterial Biofilms

  2018cites this paper
• Preclinical models for wound-healing studies

  2018cites this paper
• Electrical stimulation disrupts biofilms in a human wound model and reveals the potential for monitoring treatment response with volatile biomarkers

  2018cites this paper
• Validation of biofilm formation on human skin wound models and demonstration of clinically translatable bacteria-specific volatile signatures

  2018cites this paper
• A Surfactant-Based Dressing to Treat and Prevent Acinetobacter baumannii Biofilms.

  2018cites this paper
• Effectiveness of a monofilament wound debridement pad at removing biofilm and slough: ex vivo and clinical performance.

  2018cites this paper
• R ESEARCH C AVEATS

  2018cites this paper
• Electrical stimulation disrupts biofilms in a human wound model and reveals the potential for monitoring treatment response with volatile biomarkers: ES disrupts biofilm and VOC allows monitoring

  2018cites this paper
• Evaluation of short exposure times of antimicrobial wound solutions against microbial biofilms: from in vitro to in vivo

  2017cites this paper
• Advances in Microbiology, Infectious Diseases and Public Health

  2017cites this paper
• Antimicrobial and Anti-Biofilm Medical Devices: Public Health and Regulatory Science Challenges

  2017cites this paper
• The microbiome of diabetic foot ulcers and the role of biofilms

  2017cites this paper
• A surfactant‐based wound dressing can reduce bacterial biofilms in a porcine skin explant model

  2017influential citation
• Nitroxoline: a broad-spectrum biofilm-eradicating agent against pathogenic bacteria.

  2017cites this paper
• Growth of MRSA and Pseudomonas aeruginosa in a fine-celled foam model containing sessile commensal skin bacteria

  2016cites this paper
• Activity of Norspermidine on Bacterial Biofilms of Multidrug-Resistant Clinical Isolates Associated with Persistent Extremity Wound Infections.

  2016influential citation
• Diphenyl diselenide derivatives inhibit microbial biofilm formation involved in wound infection

  2016cites this paper
• Detection of Biofilm in Wounds as an Early Indicator for Risk for Tissue Infection and Wound Chronicity

  2016cites this paper
• Clinical investigation of biofilm in non-healing wounds by high resolution microscopy techniques.

  2016cites this paper
• In Vitro and In Vivo Biofilm Wound Models and Their Application.

  2016cites this paper
• COMBINATORIAL EFFECT OF D-AMINOACIDS AND TETRACYCLINE AGAINST PSEUDOMONAS AERUGINOSA BIOFILM

  2016cites this paper
• Clove bud oil reduces kynurenine and inhibits pqs A gene expression in P. aeruginosa

  2016cites this paper
• Comparing the Effectiveness of Polymer Debriding Devices Using a Porcine Wound Biofilm Model

  2016cites this paper
• for Optimizing Outcomes in the Management of Biofilm to Promote Healing of Chronic Wounds

  2016cites this paper
• Bilayered skin-substitute technology for the treatment of diabetic foot ulcers: current insights

  2016cites this paper
• Advances in Microbiology, Infectious Diseases and Public Health

  2016cites this paper
• From Single Cells to Engineered and Explanted Tissues: New Perspectives in Bacterial Infection Biology.

  2015cites this paper
• In vitro activity of Melaleuca alternifolia (tea tree) oil on filamentous fungi and toxicity to human cells.

  2015influential citation
• Lactobacillus crispatus inhibits growth of Gardnerella vaginalis and Neisseria gonorrhoeae on a porcine vaginal mucosa model

  2015cites this paper
• A Novel Model of Chronic Wounds: Importance of Redox Imbalance and Biofilm-Forming Bacteria for Establishment of Chronicity

  2014cites this paper
• Biofilms and Wounds: An Identification Algorithm and Potential Treatment Options

  2014cites this paper