In Vitro Cell Models of the Human Blood-Brain Barrier: Demonstrating the Beneficial Influence of Shear Stress on Brain Microvascular Endothelial Cell Phenotype

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Blood-Brain Barrier

• Publication date

  2018-12-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/978-1-4939-8946-1_5
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells

  2017cited by this paper
• Staphylococcus aureus‐mediated blood–brain barrier injury: an in vitro human brain microvascular endothelial cell model

  2017cited by this paper
• Tumour necrosis factor‐α‐mediated disruption of cerebrovascular endothelial barrier integrity in vitro involves the production of proinflammatory interleukin‐6

  2016cited by this paper
• The blood-brain barrier endothelium: a target for pro-inflammatory cytokines.

  2015cited by this paper
• Novel Approaches for the Delivery of Biologics to the Central Nervous System

  2015cited by this paper
• The dynamic blood–brain barrier

  2015cited by this paper
• Blood-brain barrier breakdown in the aging human hippocampus.

  2015cited by this paper
• Thrombomodulin regulation in human brain microvascular endothelial cells in vitro: role of cytokines and shear stress.

  2015cited by this paper
• Shear-Dependent Attenuation of Cellular ROS Levels can Suppress Proinflammatory Cytokine Injury to Human Brain Microvascular Endothelial Barrier Properties

  2015cited by this paper
• Cytokine-mediated dysregulation of zonula occludens-1 properties in human brain microvascular endothelium.

  2015cited by this paper
• Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke.

  2014cited by this paper
• In vitro models of the blood-brain barrier for the study of drug delivery to the brain.

  2014cited by this paper
• The impact of microglial activation on blood-brain barrier in brain diseases

  2014cited by this paper
• Novel insights into the development and maintenance of the blood–brain barrier

  2014cited by this paper
• Zebrafish models for translational neuroscience research: from tank to bedside.

  2014cited by this paper
• A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

  2014cited by this paper
• Downregulation of Blood-Brain Barrier Phenotype by Proinflammatory Cytokines Involves NADPH Oxidase-Dependent ROS Generation: Consequences for Interendothelial Adherens and Tight Junctions

  2014cited by this paper
• An in vitro blood-brain barrier model combining shear stress and endothelial cell/astrocyte co-culture.

  2014cited by this paper
• Retinoic Acid Induces Blood–Brain Barrier Development

  2013cited by this paper
• Quantitative atlas of blood-brain barrier transporters, receptors, and tight junction proteins in rats and common marmoset.

  2013cited by this paper
• Establishment of a simplified in vitro porcine blood–brain barrier model with high transendothelial electrical resistance

  2013cited by this paper
• SyM-BBB: a microfluidic Blood Brain Barrier model.

  2013cited by this paper
• Glial‐cell‐mediated re‐induction of the blood‐brain barrier phenotype in brain capillary endothelial cells: A differential gel electrophoresis study

  2013cited by this paper
• Laminin isoforms in endothelial and perivascular basement membranes

  2013cited by this paper
• Functional Characterisation of the Maturation of the Blood-Brain Barrier in Larval Zebrafish

  2013cited by this paper
• Trial Watch: Phase II and Phase III attrition rates 2011–2012

  2013cited by this paper
• Neurovascular unit on a chip: implications for translational applications

  2013cited by this paper
• A Novel Brain Neurovascular Unit Model with Neurons, Astrocytes and Microvascular Endothelial Cells of Rat

  2013cited by this paper
• Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier

  2013cited by this paper
• Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood–brain barrier model for drug permeability studies

  2013cited by this paper
• Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence

  2013cited by this paper
• Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model.

  2013cited by this paper
• The worldwide economic impact of dementia 2010

  2013cited by this paper
• Microglia: Scapegoat, Saboteur, or Something Else?

  2013cited by this paper
• Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro

  2013cited by this paper
• Development, maintenance and disruption of the blood-brain barrier

  2013cited by this paper
• In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish

  2012cited by this paper
• In vitro blood-brain barrier models: current and perspective technologies.

  2012cited by this paper
• The economic cost of brain disorders in Europe

  2012cited by this paper
• Reliable permeability assay system in a microfluidic device mimicking cerebral vasculatures

  2012cited by this paper
• CNS drug development - lost in translation?

  2012cited by this paper
• Zebrafish as a Model to Study Drug Transporters at the Blood–Brain Barrier

  2012cited by this paper
• Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB).

  2012cited by this paper
• Case study: adapting in vitro blood-brain barrier models for use in early-stage drug discovery.

  2012cited by this paper
• Histopathological stainings and definitions of vascular disruptions in the elderly brain.

  2012cited by this paper
• Generation of an Immortalized Murine Brain Microvascular Endothelial Cell Line as an In Vitro Blood Brain Barrier Model

  2012cited by this paper
• BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

  2012cited by this paper
• Transcriptional Profiling of Human Brain Endothelial Cells Reveals Key Properties Crucial for Predictive In Vitro Blood-Brain Barrier Models

  2012cited by this paper
• Comparison of brain capillary endothelial cell-based and epithelial (MDCK-MDR1, Caco-2, and VB-Caco-2) cell-based surrogate blood-brain barrier penetration models.

  2012cited by this paper
• In vitro primary human and animal cell-based blood-brain barrier models as a screening tool in drug discovery.

  2011cited by this paper
• Stabilization of brain microvascular endothelial barrier function by shear stress involves VE‐cadherin signaling leading to modulation of pTyr‐occludin levels

  2011cited by this paper
• Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila

  2011cited by this paper
• The role of shear stress in Blood-Brain Barrier endothelial physiology

  2011cited by this paper
• Modelling the neurovascular unit and the blood-brain barrier with the unique function of pericytes.

  2011cited by this paper
• In vitro modeling of the blood-brain barrier: simplicity versus complexity.

  2011cited by this paper
• A Dynamic in vitro BBB Model for the Study of Immune Cell Trafficking into the Central Nervous System

  2011cited by this paper
• Quantitative membrane protein expression at the blood-brain barrier of adult and younger cynomolgus monkeys.

  2011cited by this paper
• Review: Leucocyte–endothelial cell crosstalk at the blood–brain barrier: A prerequisite for successful immune cell entry to the brain

  2011cited by this paper
• Blood-brain barrier P450 enzymes and multidrug transporters in drug resistance: a synergistic role in neurological diseases.

  2011cited by this paper
• Zebrafish model of the blood-brain barrier: morphological and permeability studies.

  2011cited by this paper
• Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in an in Vitro Blood-Brain Barrier Model*

  2011cited by this paper
• Blood-brain Barrier Disruption is Involved in Seizure and Hemianopsia in Nonketotic Hyperglycemia

  2011cited by this paper
• Review: Molecular pathogenesis of blood–brain barrier breakdown in acute brain injury

  2011cited by this paper
• Claudin-1 induced sealing of blood–brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis

  2011cited by this paper
• How well can in vitro brain microcapillary endothelial cell models predict rodent in vivo blood-brain barrier permeability?

  2011cited by this paper
• A differential proteomic approach identifies structural and functional components that contribute to the differentiation of brain capillary endothelial cells.

  2011cited by this paper
• Claudin‐5a in developing zebrafish brain barriers: another brick in the wall

  2010cited by this paper
• Slow integration leads to persistent action potential firing in distal axons of coupled interneurons

  2010cited by this paper
• Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury

  2010cited by this paper
• Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE.

  2010cited by this paper
• Pericytes regulate the blood–brain barrier

  2010cited by this paper
• ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders

  2010cited by this paper
• Shear stress and the endothelial transport barrier.

  2010cited by this paper
• Structure and function of the blood-brain barrier.

  2010cited by this paper
• Validation of in vitro cell-based human blood-brain barrier model using clinical positron emission tomography radioligands to predict in vivo human brain penetration.

  2010cited by this paper
• Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach.

  2010cited by this paper
• Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

  2010cited by this paper
• Pericytes are required for blood–brain barrier integrity during embryogenesis

  2010cited by this paper
• Reproductive age-related changes in the blood brain barrier: expression of IgG and tight junction proteins.

  2009cited by this paper
• Closing the gap between the in-vivo and in-vitro blood-brain barrier tightness.

  2009cited by this paper
• A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes.

  2009cited by this paper
• Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human.

  2009cited by this paper
• Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy.

  2009cited by this paper
• Maintaining blood–brain barrier integrity: Pericytes perform better than astrocytes during prolonged oxygen deprivation

  2009cited by this paper
• Vascular mechanobiology: endothelial cell responses to fluid shear stress.

  2009cited by this paper
• Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport

  2009cited by this paper
• Signaling mechanism of extracellular RNA in endothelial cells

  2009cited by this paper
• Blood-brain barrier: ageing and microvascular disease--systematic review and meta-analysis.

  2009cited by this paper
• Control of the Blood–Brain Barrier by Glucocorticoids and the Cells of the Neurovascular Unit

  2009cited by this paper
• Toward an improved prediction of human in vivo brain penetration

  2008cited by this paper
• Influence of basolateral condition on the regulation of brain microvascular endothelial tight junction properties and barrier function.

  2008cited by this paper
• Pericytes: pluripotent cells of the blood brain barrier.

  2008cited by this paper
• The human brain endothelial cell line hCMEC/D3 as a human blood‐brain barrier model for drug transport studies

  2008cited by this paper
• Activation of β‐catenin signalling by GSK‐3 inhibition increases p‐glycoprotein expression in brain endothelial cells

  2008cited by this paper
• An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening.

  2008cited by this paper
• Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation.

  2008cited by this paper
• Astroglia: not just glue.

  2008cited by this paper
• Effect of nicotine and polyaromtic hydrocarbons on cerebral endothelial cells

  2008cited by this paper
• Hyperosmotic stress induces Axl activation and cleavage in cerebral endothelial cells

  2008cited by this paper
• Blood-brain barrier tight junction permeability and ischemic stroke.

  2008cited by this paper

• A microfluidic biomimetic system from the blood-brain barrier to activated microglia towards anti-Mesial Temporal Lobe Epilepsy drug screening

  2025influential citation
• In‐vitro Assessment of BCRP‐Mediated Efflux of Antiseizure Medications in Human Blood‐Brain Barrier Cell Model

  2025cites this paper
• Advances and Challenges of Bioassembly Strategies in Neurovascular In Vitro Modeling: An Overview of Current Technologies with a Focus on Three-Dimensional Bioprinting

  2024cites this paper
• Experimental Models to Study the Functions of the Blood–Brain Barrier

  2023cites this paper
• In Vitro Blood-Brain Barrier Models for Neuroinfectious Diseases: A Narrative Review

  2023cites this paper
• Astrocytes and human artificial blood-brain barrier models

  2022cites this paper
• Advances on fluid shear stress regulating blood-brain barrier.

  2020cites this paper
• Bioreactors in tissue engineering: mimicking the microenvironment

  2020cites this paper
• Advances in 3D neural, vascular and neurovascular models for drug testing and regenerative medicine.

  2020cites this paper
• In vitro Models of the Blood-Brain Barrier: Building in physiological complexity.

  2020cites this paper