MicroRNA‐21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Hepatology

• Publication date

  2009-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/hep.22838PMID 19296468PMCID PMC3124086
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene

  2008cited by this paper
• Programmed Cell Death 4 (PDCD4) Is an Important Functional Target of the MicroRNA miR-21 in Breast Cancer Cells*

  2008cited by this paper
• miR-21 microRNA expression in human gastric carcinomas and its clinical association.

  2008cited by this paper
• Altered Expression of miR-21, miR-31, miR-143 and miR-145 Is Related to Clinicopathologic Features of Colorectal Cancer

  2008cited by this paper
• MiR-21 Promotes Glioma Invasion by Targeting MMP Regulators.

  2008cited by this paper
• MicroRNA-21 is Overexpressed in Pancreatic Cancer and a Potential Predictor of Survival

  2008cited by this paper
• Cholangiocarcinoma: Advances in pathogenesis, diagnosis, and treatment

  2008cited by this paper
• Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes

  2008cited by this paper
• E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer.

  2008cited by this paper
• MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators

  2008cited by this paper
• MicroRNA-21 targets tumor suppressor genes in invasion and metastasis

  2008cited by this paper
• MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations

  2008cited by this paper
• MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer

  2008cited by this paper
• Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors.

  2008cited by this paper
• Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype.

  2008cited by this paper
• MicroRNA gene expression profile of hepatitis C virus–associated hepatocellular carcinoma

  2007cited by this paper
• mir-29 regulates Mcl-1 protein expression and apoptosis

  2007cited by this paper
• MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer.

  2007cited by this paper
• TIMP-3 gene transfection suppresses invasive and metastatic capacity of human hepatocarcinoma cell line HCC-7721.

  2007cited by this paper
• Cholangiocarcinoma: modern advances in understanding a deadly old disease.

  2006cited by this paper
• Frequent Epigenetic Inactivation of Spleen Tyrosine Kinase Gene in Human Hepatocellular Carcinoma

  2006cited by this paper
• Involvement of programmed cell death 4 in transforming growth factor-β1-induced apoptosis in human hepatocellular carcinoma

  2006cited by this paper
• Implications of micro-RNA profiling for cancer diagnosis

  2006cited by this paper
• Cholangiocarcinoma

  2006cited by this paper
• Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines.

  2006cited by this paper
• miRNAs, cancer, and stem cell division.

  2005cited by this paper
• Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers

  2005cited by this paper
• The epidemiology of cholangiocarcinoma.

  2004cited by this paper
• Surgical Management of Cholangiocarcinoma

  2004cited by this paper
• Programmed cell death protein 4 (pdcd4): A novel target for antineoplastic therapy?

  2003cited by this paper
• Complex roles of tissue inhibitors of metalloproteinases in cancer

  2002cited by this paper
• Aberrant CpG island methylation of multiple genes in intrahepatic cholangiocarcinoma.

  2002cited by this paper
• Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States

  2001cited by this paper
• Treatment of colorectal liver metastases by adenoviral transfer of tissue inhibitor of metalloproteinases-2 into the liver tissue.

  2000cited by this paper
• Hepatology

  1999cited by this paper
• Biliary tract cancers.

  1999cited by this paper
• High level expression of tissue inhibitors of metalloproteinases-1,-2 and -3 in melanoma cells achieved by adenovirus mediated gene transfer.

  1998cited by this paper
• Establishment of a new extrahepatic bile duct carcinoma cell line, TFK-1.

  1995cited by this paper
• Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death.

  1995cited by this paper
• "Natural history" of unresected cholangiocarcinoma: patient outcome after noncurative intervention.

  1995cited by this paper

• Noncoding RNAs: A Novel Frontier in Liver Cancer Research and Therapy: Implications for Precision Oncology.

  2026cites this paper
• A Comprehensive Guide on Epigenetics' Precision Role in Uncommon "Rare" Cancers' Biology and Treatment Frontiers.

  2026cites this paper
• Non-coding RNAs in alcohol-associated liver disease

  2025cites this paper
• Exploring microRNAs in Bile Duct Stents as Diagnostic Biomarkers for Biliary Pathologies

  2025cites this paper
• Advancing Cholangiocarcinoma Diagnosis: The Role of Liquid Biopsy and CRISPR/Cas Systems in Biomarker Detection

  2025influential citation
• Endoscopic liquid biopsy of bile: superior diagnostic and prognostic performance of bile-derived exosomal miR-21-5p for biliary tract cancers

  2025cites this paper
• MicroRNAs and RNA-Binding Protein-Based Regulation of Bone Metastasis from Hepatobiliary Cancers and Potential Therapeutic Strategies

  2024cites this paper
• Synthetic Circular RNA for microRNA-1269a Suppresses Tumor Progression in Oral Squamous Cell Carcinoma

  2024cites this paper
• Genetic, Epigenetic, and Microenvironmental Drivers of Cholangiocarcinoma.

  2024cites this paper
• MicroRNA-21 in urologic cancers: from molecular mechanisms to clinical implications

  2024cites this paper
• microRNA profiling of exosomes derived from plasma and their potential as biomarkers for Opisthorchis viverrini-associated cholangiocarcinoma.

  2024cites this paper
• Metabolic disorders affecting the liver and heart: therapeutic efficacy of miRNA-based therapies?

  2024cites this paper
• Non-coding RNA and Drug resistance in cholangiocarcinoma

  2023cites this paper
• Circulating microRNAs in gallbladder cancer: Is serum assay of diagnostic value?

  2023cites this paper
• High-Precision Single-Cell microRNA Therapy by a Functional Nanopipette with Sensitive Photoelectrochemical Feedback.

  2023cites this paper
• Small but mighty: How microRNAs drive the deadly progression of cholangiocarcinoma.

  2023cites this paper
• MicroRNA-532 Promotes Proliferation, Metastasis and Autophagy in Esophageal Cancer via Targeting Naked Cuticle 1

  2023cites this paper
• Near-Infrared-Light-Mediated DNA-Logic Nanomachine for Bioorthogonal Cascade Imaging of Endogenous Interconnected MicroRNAs and Metal Ions.

  2022cites this paper
• Circular RNAs in cholangiocarcinoma.

  2022cites this paper
• The Role and Interactions of Programmed Cell Death 4 and its Regulation by microRNA in Transformed Cells of the Gastrointestinal Tract

  2022cites this paper
• Tissue Inhibitor of Metalloproteases 3 (TIMP-3): In Vivo Analysis Underpins Its Role as a Master Regulator of Ectodomain Shedding

  2022cites this paper
• The diagnostic value of serum miR-21 in patients with ovarian cancer: a systematic review and meta-analysis

  2022cites this paper
• Noncoding RNAs in liver cancer patients

  2022cites this paper
• Micro-RNA in Cholangiocarcinoma: Implications for Diagnosis, Prognosis, and Therapy

  2022cites this paper
• Biomarker Study of Cholangiocarcinoma

  2022cites this paper
• CRISPR-Cas14a-integrated strand displacement amplification for rapid and isothermal detection of cholangiocarcinoma associated circulating microRNAs.

  2022cites this paper
• SAHA induce hippo pathway in CCA cells without increasing cell proliferation

  2022cites this paper
• The Role of microRNAs in Cholangiocarcinoma

  2021cites this paper
• Established and Emerging Biomarkers for Prediction, Early Detection, and Prognostication of Cholangiocarcinoma

  2021cites this paper
• Notch Signaling Regulation in HCC: From Hepatitis Virus to Non-Coding RNAs

  2021cites this paper
• Mir-21 Suppression Promotes Mouse Hepatocarcinogenesis

  2021cites this paper
• Circulating microRNAs as biomarkers in bile-derived exosomes of cholangiocarcinoma

  2021cites this paper
• The Investigative Therapeutic Pipeline for Cholangiocarcinoma: Insights from Model Systems

  2021cites this paper
• Biliary Strictures and Cholangiocarcinoma – Untangling a Diagnostic Conundrum

  2021cites this paper
• Pleiotropic Effects of MicroRNA in Health and Disease

  2021cites this paper
• A High-Accuracy Model Based on Plasma miRNAs Diagnoses Intrahepatic Cholangiocarcinoma: A Single Center with 1001 Samples

  2021cites this paper
• Screening and identification of genes associated with cell proliferation in cholangiocarcinoma

  2020cites this paper
• Fabrication of a novel fluorescent polyacrylonitrile electrospun nanofiber for DNA-based optical biosensing of microRNA-21

  2020cites this paper
• Role of noncoding RNAs in cholangiocarcinoma (Review).

  2020cites this paper
• Molecular heterogeneity in intrahepatic cholangiocarcinoma

  2020cites this paper
• Development of Surface-Enhanced Raman Scattering (SERS)-Based Surface-Corrugated Nanopillars for Biomolecular Detection of Colorectal Cancer

  2020cites this paper
• Pathogenetic Role and Clinical Implications of Regulatory RNAs in Biliary Tract Cancer

  2020cites this paper
• MAb NJ001 inhibits lung adenocarcinoma invasiveness by directly regulating TIMP‐3 promoter activity via FOXP1 binding sites

  2020cites this paper
• Long Noncoding RNAs in Cholangiocarcinoma

  2020cites this paper
• MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases

  2020cites this paper
• Methionine selenium antagonizes LPS‐induced necroptosis in the chicken liver via the miR‐155/TRAF3/MAPK axis

  2020cites this paper
• Galangin Inhibits Cholangiocarcinoma Cell Growth and Metastasis through Downregulation of MicroRNA-21 Expression

  2020cites this paper
• Modulation of Biliary Cancer Chemo‐Resistance Through MicroRNA‐Mediated Rewiring of the Expansion of CD133+ Cells

  2019cites this paper
• miR‐186 modulates hepatocellular carcinoma cell proliferation and mobility via targeting MCRS1‐mediated Wnt/β‐catenin signaling

  2019cites this paper
• Aberrant Methylation of Tumor Suppressive miRNAs in Bile from Patients With Pancreaticobiliary Diseases

  2019cites this paper
• Identification and profiling of microRNAs expressed in oral buccal mucosa squamous cell carcinoma of Chinese hamster

  2019cites this paper
• Common features between neoplastic and preneoplastic lesions of the biliary tract and the pancreas

  2019cites this paper
• TIMP-3 as a therapeutic target for cancer

  2019cites this paper
• Etude de la voie TGFβ dans le cholangiocarcinome intrahépatique : implication des ARN longs non-codants

  2019cites this paper
• Matrisome analysis of intrahepatic cholangiocarcinoma unveils a peculiar cancer-associated extracellular matrix structure

  2019cites this paper
• Pleiotropic microRNA-21 in pulmonary remodeling: novel insights for molecular mechanism and present advancements

  2019cites this paper
• CircPCMTD1 Acts as the Sponge of miR-224-5p to Promote Glioma Progression

  2019cites this paper
• miR-377-3 p suppresses cell proliferation and promotes apoptosis of prostate cancer cells

  2019cites this paper
• Molecular perturbations in cholangiocarcinoma: Is it time for precision medicine?

  2019cites this paper
• Diagnostic and prognostic biomarkers in cholangiocarcinoma

  2019cites this paper
• MicroRNAs derived from urinary exosomes act as novel biomarkers in the diagnosis of intrahepatic cholestasis of pregnancy.

  2019cites this paper
• Circulating inflammation signature predicts overall survival and relapse-free survival in metastatic colorectal cancer

  2019cites this paper
• Biomarkers for the Diagnosis of Cholangiocarcinoma: A Systematic Review.

  2018cites this paper
• Discovery of glycocholic acid and taurochenodeoxycholic acid as phenotypic biomarkers in cholangiocarcinoma

  2018cites this paper
• Diagnostic and prognostic value of microRNAs in cholangiocarcinoma: a systematic review and meta-analysis

  2018cites this paper
• Circulating microRNA-21 as a prognostic, biological marker in cholangiocarcinoma

  2018cites this paper
• Inhibition of miR‐21 ameliorates excessive astrocyte activation and promotes axon regeneration following optic nerve crush

  2018cites this paper
• MicroRNA‐21 and Dicer are dispensable for hepatic stellate cell activation and the development of liver fibrosis

  2018cites this paper
• Programmed cell death 4 overexpression enhances sensitivity to cisplatin via the JNK/c-Jun signaling pathway in bladder cancer.

  2018cites this paper
• The Association of BRAF V600E Mutation With Tissue Inhibitor of Metalloproteinase-3 Expression and Clinicopathological Features in Papillary Thyroid Cancer

  2018cites this paper
• Epigenetic regulation of miR-200 as the potential strategy for the therapy against triple-negative breast cancer.

  2018cites this paper
• Delivery of MicroRNA with CXCR4-Targeted Nanoparticles in Metastatic Cancer Treatment

  2018influential citation
• Prognostic and Predictive Epigenetic Biomarkers in Oncology

  2018cites this paper
• Synthetic Circular RNA Functions as a miR-21 Sponge to Suppress Gastric Carcinoma Cell Proliferation

  2018cites this paper
• miRNA-21 ablation protects against liver injury and necroptosis in cholestasis

  2018cites this paper
• Noncoding RNA in Cholangiocarcinoma

  2018cites this paper
• NcRNAs and Cholangiocarcinoma

  2018cites this paper
• Modulating Hallmarks of Cholangiocarcinoma

  2018cites this paper
• Role of PDCD4 in inflammation and tumors: a double-edged sword

  2018cites this paper
• Identification of microRNAs as biomarkers for cholangiocarcinoma detection: A diagnostic meta-analysis.

  2017cites this paper
• MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma

  2017cites this paper
• Pronostic du cholangiocarcinome intrahépatique réséqué

  2017cites this paper
• Molecular Mechanisms Driving Cholangiocarcinoma Invasiveness: An Overview.

  2017cites this paper
• The search for novel diagnostic and prognostic biomarkers in cholangiocarcinoma.

  2017cites this paper
• Emerging molecular targets and therapy for cholangiocarcinoma

  2017cites this paper
• MicroRNAs and extracellular vesicles in cholangiopathies.

  2017cites this paper
• Up-regulation of lncRNA CASC9 promotes esophageal squamous cell carcinoma growth by negatively regulating PDCD4 expression through EZH2

  2017cites this paper
• Epigenome dysregulation in cholangiocarcinoma.

  2017cites this paper
• Roles of microRNAs in psoriasis: Immunological functions and potential biomarkers

  2017cites this paper
• miR-21 and KLF4 jointly augment epithelial-mesenchymal transition via the Akt/ERK1/2 pathway

  2017cites this paper
• Plasma levels of the tissue inhibitor matrix metalloproteinase-3 as a potential biomarker in oral cancer progression

  2017cites this paper
• Regulation of EMT by STAT3 in gastrointestinal cancer (Review).

  2017cites this paper
• miR-21, An Oncogenic Target miRNA for Cancer Therapy: Molecular Mechanisms and Recent Advancements in Chemo and Radio-resistance.

  2017cites this paper
• miR-21 inhibition of LATS1 promotes proliferation and metastasis of renal cancer cells and tumor stem cell phenotype

  2017cites this paper
• Downregulation of PDCD4 by miR-21 suppresses tumor transformation and proliferation in a nude mouse renal cancer model

  2017cites this paper
• Gene expression, regulation of DEN and HBx induced HCC mice models and comparisons of tumor, para-tumor and normal tissues

  2017cites this paper
• Delivery of miR-200c Mimic with Poly(amido amine) CXCR4 Antagonists for Combined Inhibition of Cholangiocarcinoma Cell Invasiveness.

  2016cites this paper
• MicroRNAs in cholangiopathies: Potential diagnostic and therapeutic tools.

  2016cites this paper
• Circulating Plasma Levels of MicroRNA-21 and MicroRNA-221 Are Potential Diagnostic Markers for Primary Intrahepatic Cholangiocarcinoma

  2016cites this paper
• A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion

  2016cites this paper