Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.

No abstract is available for this paper.

• Publication year

  1992

• Venue

  Cell

• Publication date

  1992-09-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0092-8674(92)90243-6PMID 1356076
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Suppression of gene amplification in human cell hybrids.

  1992cited by this paper
• The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation.

  1992cited by this paper
• Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

  1992cited by this paper
• Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

  1992cited by this paper
• Alterations of the p53 gene in nasopharyngeal carcinoma

  1992cited by this paper
• Amplification of a gene encoding a p53-associated protein in human sarcomas

  1992cited by this paper
• Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

  1992cited by this paper
• p53 mutations in human cancers.

  1991cited by this paper
• Expression of wild-type p53 in human A673 cells suppresses tumorigenicity but not growth rate.

  1991cited by this paper
• Tumorigenic transformation of spontaneously immortalized fibroblasts from patients with a familial cancer syndrome.

  1991cited by this paper
• The p53 tumour suppressor gene

  1991cited by this paper
• Participation of p53 protein in the cellular response to DNA damage.

  1991cited by this paper
• DNA amplification is rare in normal human cells.

  1990cited by this paper
• p53 functions as a cell cycle control protein in osteosarcomas

  1990cited by this paper
• Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.

  1990cited by this paper
• A deadly inheritance

  1990cited by this paper
• Cancer. A deadly inheritance.

  1990cited by this paper
• Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

  1990cited by this paper
• Normal diploid human and rodent cells lack a detectable frequency of gene amplification.

  1990cited by this paper
• Organization and Nucleotide Sequence of the 3′ End of the Human CAD Gene

  1990cited by this paper
• Suppression of human colorectal carcinoma cell growth by wild-type p53.

  1990cited by this paper
• A genetic model for colorectal tumorigenesis.

  1990cited by this paper
• Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization.

  1990cited by this paper
• Checkpoints: controls that ensure the order of cell cycle events.

  1989cited by this paper
• Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

  1989cited by this paper
• The p53 proto-oncogene can act as a suppressor of transformation.

  1989cited by this paper
• Early dihydrofolate reductase gene amplification events in CHO cells usually occur on the same chromosome arm as the original locus.

  1989cited by this paper
• Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis.

  1989cited by this paper
• Wild-type p53 can inhibit oncogene-mediated focus formation.

  1989cited by this paper
• Increased incidence of CAD gene amplification in tumorigenic rat lines as an indicator of genomic instability of neoplastic cells.

  1989cited by this paper
• Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life

  1988cited by this paper
• The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae.

  1988cited by this paper
• A variation in the structure of the protein-coding region of the human p53 gene.

  1988cited by this paper
• Hamster cells with increased rates of DNA amplification, a new phenotype.

  1987cited by this paper
• Rearrangement of the p53 gene in human osteogenic sarcomas.

  1987cited by this paper
• Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines

  1987cited by this paper
• Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter.

  1987cited by this paper
• Mutant p53 proteins bind hsp 72/73 cellular heat shock-related proteins in SV40-transformed monkey cells.

  1987cited by this paper
• Association of adenovirus early-region 1A proteins with cellular polypeptides

  1986cited by this paper
• Pathogenesis of metastatic disease: implications for current therapy and for the development of new therapeutic strategies.

  1986cited by this paper
• Gene amplification: an example of accelerated evolution in tumorigenic cells.

  1985cited by this paper
• A locus on chromosome 11p with multiple restriction site polymorphisms.

  1984cited by this paper
• Analysis of the gene coding for the murine cellular tumour antigen p53.

  1984cited by this paper
• Properties of single-step mutants of Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate

  1983cited by this paper
• Amplification of a gene coding for human T-cell differentiation antigen

  1983cited by this paper
• Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting.

  1983cited by this paper
• The development of biological diversity and metastatic potential in malignant neoplasms.

  1982cited by this paper
• Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

  1979cited by this paper
• Chromosomes and cancer.

  1977cited by this paper
• The clonal evolution of tumor cell populations.

  1976cited by this paper

• Comprehensive Genomic Profiling Across Diverse Solid Tumors: A Real-World Experience From India With FoundationOne®CDx Testing.

  2026cites this paper
• HPV16 CpG Methylation Contributes to Cervical Carcinogenesis by Regulating HPV16 Tumorigenesis‐Related Genes

  2025cites this paper
• Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis

  2025cites this paper
• The relationship between p53 and the malignant transformation of nasal inverted papilloma: a meta-analysis

  2025cites this paper
• The R337C mutation in the p53 oligomerization domain affects the regulatory domain and its ability to bind response elements: Evidence based on structural and biophysical studies.

  2025cites this paper
• Comprehensive genomic profiling can predict response to neoadjuvant chemotherapy in triple-negative breast cancer

  2025cites this paper
• Studying Progression from Chronic Injury to Esophageal Adenocarcinoma

  2024cites this paper
• Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?

  2024cites this paper
• Evaluating targeted therapies in older patients with TP53-mutated AML

  2024cites this paper
• ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss.

  2024cites this paper
• Change in p53 nuclear localization in response to extracellular matrix stiffness

  2024cites this paper
• Role of Podoplanin (PDPN) in Advancing the Progression and Metastasis of Glioblastoma Multiforme (GBM)

  2024cites this paper
• Mutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA response

  2024cites this paper
• P53 protein and the diseases in central nervous system

  2023cites this paper
• Escape from Cellular Senescence Is Associated with Chromosomal Instability in Oral Pre-Malignancy

  2023cites this paper
• Targeting p53 pathways: mechanisms, structures and advances in therapy

  2023cites this paper
• A common pathway to cancer: Oncogenic mutations abolish p53 oscillations.

  2022cites this paper
• Empirical single-cell tracking and cell-fate simulation reveal dual roles of p53 in tumor suppression

  2022cites this paper
• Ordered and deterministic cancer genome evolution after p53 loss

  2022cites this paper
• Oncogenic alterations in the p53 pathway abolish oscillatory competence

  2021cites this paper
• Mitochondrial uncoupler MB1-47 is efficacious in treating hepatic metastasis of pancreatic cancer in murine tumor transplantation models

  2021cites this paper
• Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndromes are associated with complex karyotype, monosomal karyotype, TP53 deletion, and TP53 mutations

  2021cites this paper
• Aspergillus fumigatus-derived demethoxyfumitremorgin C inhibits proliferation of PC3 human prostate cancer cells through p53/p21-dependent G1 arrest and apoptosis induction

  2021cites this paper
• Metabolic Control by DNA Tumor Virus-Encoded Proteins

  2021cites this paper
• Effect of Artemisia vulgaris Extract on P53 Expression and Caspase-8 Expression (Study on Adenocarcinoma Mammae C3H Mice Given Adriamycin- Cyclophosphamide Chemotherapy Regimen)

  2021cites this paper
• Oscillatory Dynamics of p53-Mdm2 Circuit in Response to DNA Damage Caused by Ionizing Radiation

  2020cites this paper
• Recombinant human p53 adenovirus injection (rAd-p53) combined with chemotherapy for 4 cases of high-grade serous ovarian cancer.

  2020cites this paper
• Mechanisms Generating Cancer Genome Complexity: Back to the Future

  2020cites this paper
• Interleukin-1α associates with the tumor suppressor p53 following DNA damage

  2020cites this paper
• Computational Approaches to Examine Cellular SignallingNetworks

  2020cites this paper
• Excess DHA Induces Cell Cycle Arrest by Activating the P53/Cycling Pathway in Blunt Snout Bream (Megalobrama amblycephala)

  2020cites this paper
• Mechanisms Underlying Recurrent Genomic Amplification in Human Cancers.

  2020cites this paper
• iAMP21 in acute myeloid leukemia is associated with complex karyotype, TP53 mutation and dismal outcome

  2020cites this paper
• Variable Mutations at the p53-R273 Oncogenic Hotspot Position Leads to Altered Properties

  2019cites this paper
• Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas.

  2019cites this paper
• Computational Tools for the Untargeted Assignment of FT-MS Metabolomics Datasets

  2019cites this paper
• Comparison of P53 Protein Overexpression With P53 Mutation In Bladder Cancer: Clinical and Biologic Aspects

  2019cites this paper
• Cytogenomic characterization of double minute heterogeneity in therapy related acute myeloid leukemia.

  2019cites this paper
• Carbon-ion irradiation overcomes HPV-integration/E2 gene-disruption induced radioresistance of cervical keratinocytes

  2019cites this paper
• Paradoxical Role for Wild-Type p53 in Driving Therapy Resistance in Melanoma.

  2019cites this paper
• Low folate concentration impacts mismatch repair deficiency in neural tube defects.

  2019cites this paper
• Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation

  2018cites this paper
• C-Myc misregulation triggers complex process of genomic instability

  2018cites this paper
• Immune and genomic signatures in oral (head and neck) cancer

  2018cites this paper
• Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells

  2018cites this paper
• CBP/p300 inhibitor C646 prevents high glucose exposure induced neuroepithelial cell proliferation.

  2018cites this paper
• Patched Domain-containing 4 (PTCH53) Identified in Li-Fraumeni Syndrome Patient-derived Cells

  2018cites this paper
• Potential Anticancer Properties of Osthol: A Comprehensive Mechanistic Review

  2018cites this paper
• Identification of biomarkers of venous thromboembolism by bioinformatics analyses

  2018cites this paper
• Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity

  2017cites this paper
• Mutationsanalyse des Tumorsuppressorgens TP53 bei der akuten myeloischen Leukämie mit komplexem Karyotyp

  2017cites this paper
• Identification of two p53 isoforms from Litopenaeus vannamei and their interaction with NF-κB to induce distinct immune response

  2017cites this paper
• Putting p53 in Context.

  2017cites this paper
• Relevance of chromosomal band 11q13 in oral carcinogenesis: An update of current knowledge.

  2017cites this paper
• Updates from the TP53 universe

  2017cites this paper
• Chromosomes and Chromosomal Instability in Human Cancer

  2017cites this paper
• SLC14A1: a novel target for human urothelial cancer

  2017cites this paper
• Chemical carcinogens and chronic inflammation

  2017cites this paper
• Palindromic amplification of the ERBB2 oncogene in primary HER2-positive breast tumors

  2017cites this paper
• Inflammation and the chemical carcinogen benzo[a]pyrene: Partners in crime.

  2017cites this paper
• Co-Expression Network and Pathway Analyses Reveal Important Modules of miRNAs Regulating Milk Yield and Component Traits

  2017cites this paper
• Chromosomal Instability in Gastric Cancer Biology

  2017cites this paper
• Control mechanisms in germ cells mediated by p53 family proteins

  2017cites this paper
• Treatment of Uterine Sarcoma with rAd-p53 (Gendicine) Followed by Chemotherapy: Clinical Study of TP53 Gene Therapy

  2017cites this paper
• The role of p53 in myelodysplastic syndromes and acute myeloid leukemia: molecular aspects and clinical implications

  2017cites this paper
• Title : Treatment of uterine sarcoma with rAd-p 53 ( Gendicine ® ) followed by chemotherapy-Clinical Study on TP 53 gene therapy

  2017cites this paper
• Myosins as fundamental components during tumorigenesis: diverse and indispensable

  2016cites this paper
• Pulchrin A, a New Natural Coumarin Derivative of Enicosanthellum pulchrum, Induces Apoptosis in Ovarian Cancer Cells via Intrinsic Pathway

  2016cites this paper
• Molecular Features of Urothelial Carcinoma of the Bladder: A Brief Overview With Histologic and Clinical Correlates

  2016cites this paper
• Development of a Chemical Genetic Screen to Determine Synergistic Compounds with Laromustine in Treating Glioblastoma Multiforme Cultured Cells

  2016cites this paper
• SIMULTANEOUS INHIBITION OF DRIVER AND EFFECTOR KINASES PROMOTES POTENT GROWTH ARREST OF AML CELLS IN VITRO AND IN VIVO

  2016cites this paper
• Double minute chromosomes in acute myeloid leukemia, myelodysplastic syndromes, and chronic myelomonocytic leukemia are associated with micronuclei, MYC or MLL amplification, and complex karyotype.

  2016cites this paper
• Protective effects of Selenium and/or Melatonin against Cadmium Chloride induced Chromosomal aberrations in Swiss Albino mice Mus musculus BALB/c

  2016cites this paper
• Clinicopathologic and immunohistochemical characteristics of gastric adenocarcinoma with enteroblastic differentiation: a study of 29 cases

  2016cites this paper
• Recombinant Newcastle disease virus expressing P53 demonstrates promising antitumor efficiency in hepatoma model

  2016cites this paper
• Genome Stability Requires p53.

  2016cites this paper
• Engineering targeted chromosomal amplifications in human breast epithelial cells

  2015cites this paper
• An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma

  2015cites this paper
• The Pyridone-Annelated Isoindigo (5‘-Cl) Induces Apoptosis, Dysregulation of Mitochondria and Formation of ROS in Leukemic HL-60 Cells

  2015cites this paper
• Performance of the HPV-16 L1 methylation assay and HPV E6/E7 mRNA test for the detection of squamous intraepithelial lesions in cervical cytological samples.

  2015cites this paper
• Introduction to the molecular basis of cancer metabolism and the Warburg effect

  2015cites this paper
• Antiproliferative activity of the isoindigo 5'-Br in HL-60 cells is mediated by apoptosis, dysregulation of mitochondrial functions and arresting cell cycle at G0/G1 phase.

  2015cites this paper
• High-throughput genotyping of CRISPR/Cas9-mediated mutants using fluorescent PCR-capillary gel electrophoresis

  2015cites this paper
• Interaction between ATM Kinase and p53 in determining glioma radiosensitivity

  2015cites this paper
• Recombinant Newcastle Disease virus Expressing IL15 Demonstrates Promising Antitumor Efficiency in Melanoma Model

  2015cites this paper
• The Anticancer Activity of the Substituted Pyridone-Annelated Isoindigo (5'-Cl) Involves G0/G1 Cell Cycle Arrest and Inactivation of CDKs in the Promyelocytic Leukemia Cell Line HL-60

  2015cites this paper
• Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

  2015cites this paper
• The General Information of the Tumor Suppressor Gene p53 and the Protein p53

  2015cites this paper
• Replication fork integrity and intra-S phase checkpoint suppress gene amplification

  2015cites this paper
• Stereodivergent total synthesis of chlorofusin and its all seven chromophore diastereomers

  2015cites this paper
• p53-dependent expression of CXCR5 chemokine receptor in MCF-7 breast cancer cells

  2015cites this paper
• Immunohistochemical Localization of Aspergillus and p53 in Human Lung Tissues

  2015cites this paper
• Synchronization in stress p53 network.

  2015cites this paper
• Molecular Biology of Urothelial Cancer

  2015cites this paper
• MLL gene amplification in acute myeloid leukemia and myelodysplastic syndromes is associated with characteristic clinicopathological findings and TP53 gene mutation.

  2015cites this paper
• The influence of p53 status on the cytotoxicity of fluorinated pyrimidine L-nucleosides.

  2015cites this paper
• Development of siRNA payloads to target KRAS-mutant cancer.

  2014influential citation
• Transcriptional regulators TRIM28, SETDB1, and TP53 are aberrantly expressed in porcine embryos produced by in vitro fertilization in comparison to in vivo- and somatic-cell nuclear transfer-derived embryos

  2014cites this paper
• In vitro cytotoxicity of Artemisia vulgaris L. essential oil is mediated by a mitochondria-dependent apoptosis in HL-60 leukemic cell line

  2014cites this paper
• DNA Damage Response Genes and the Development of Cancer Metastasis

  2014cites this paper