Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Genes & Development

• Publication date

  2002-10-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/GAD.242002PMID 12381667PMCID PMC187458
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2004cited by this paper
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  2002cited by this paper
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  2001influential reference
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001influential reference
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Genetic control of branching morphogenesis.

  1999cited by this paper
• Structure, expression and receptor-binding properties of novel vascular endothelial growth factors.

  1999influential reference
• A requirement for neuropilin-1 in embryonic vessel formation.

  1999influential reference
• Vascular endothelial growth factor (VEGF) and its receptors

  1999cited by this paper
• Multiple developmental roles of VEGF suggested by a LacZ-tagged allele.

  1999cited by this paper
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  1999cited by this paper
• Airway patterning: A paradigm for restricted signalling.

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999influential reference
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  1998cited by this paper
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  1998influential reference
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997influential reference
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  1997influential reference
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  1996influential reference
• The Mouse Gene for Vascular Endothelial Growth Factor

  1996cited by this paper
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  1996influential reference
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  1996cited by this paper
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  1996cited by this paper
• Mapping the distribution of Golgi enzymes involved in the construction of complex oligosaccharides.

  1995influential reference
• Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

  1994influential reference
• A simple and efficient procedure for non-isotopic in situ hybridization to sectioned material.

  1994influential reference
• Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

  1994influential reference
• The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

  1993influential reference
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  1992influential reference
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  1992influential reference
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1987cited by this paper
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  1987cited by this paper
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  1983cited by this paper
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  year unknowncited by this paper

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