Novel mechanism of resistance to paclitaxel (Taxol) in human K562 leukemia cells by combined selection with PSC 833.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Oncology Research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 8866664
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Substoichiometric binding of taxol suppresses microtubule dynamics.

  1995cited by this paper
• Characterization of a human myeloid leukemia cell line highly resistant to taxol.

  1994cited by this paper
• Characterization of a Taxol‐resistant Human Small‐cell Lung Cancer Cell Line

  1994cited by this paper
• Biweekly paclitaxel (Taxol) and cisplatin in breast and ovarian cancer.

  1994cited by this paper
• Predominant labeling of beta- over alpha-tubulin from porcine brain by a photoactivatable taxoid derivative.

  1994cited by this paper
• Microtubule dynamics in vitro are regulated by the tubulin isotype composition.

  1994cited by this paper
• 3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin.

  1994cited by this paper
• Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine.

  1993cited by this paper
• Two cofactors and cytoplasmic chaperonin are required for the folding of alpha- and beta-tubulin

  1993cited by this paper
• Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations.

  1993cited by this paper
• Modulation of multidrug resistance: at the threshold.

  1993cited by this paper
• Clinical significance of P-glycoprotein in multidrug resistance malignancies.

  1993cited by this paper
• Are tubulin isotypes functionally significant.

  1993cited by this paper
• In vitro assembly of multiprotein complexes containing alpha, beta, and gamma tubulin, heat shock protein HSP70, and elongation factor 1 alpha.

  1993cited by this paper
• Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis.

  1992cited by this paper
• Mechanism of inhibition of cell proliferation by Vinca alkaloids.

  1991cited by this paper
• Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin [corrected].

  1991cited by this paper
• Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein.

  1990cited by this paper
• Taxol: a novel investigational antimicrotubule agent.

  1990cited by this paper
• Induction of erythroid differentiation in human leukemic K-562 cells by membrane-directed action of adriamycin covalently bound to microspheres.

  1990cited by this paper
• Chemosensitivity testing of fresh leukaemia cells using the MTT colorimetric assay

  1989cited by this paper
• Mechanisms by which mammalian cells acquire resistance to drugs that affect microtubule assembly

  1989cited by this paper
• Elimination of permeability mutants from selections for drug resistance in mammalian cells

  1989cited by this paper
• Mechanism of multidrug resistance.

  1988cited by this paper
• Microtubule changes and cytotoxicity in leukemic cell lines treated with taxol.

  1988cited by this paper
• Autoregulated changes in stability of polyribosome-bound beta-tubulin mRNAs are specified by the first 13 translated nucleotides

  1988cited by this paper
• Free intermingling of mammalian beta-tubulin isotypes among functionally distinct microtubules.

  1987cited by this paper
• Multidrug (pleiotropic) resistance in doxorubicin-selected variants of the human sarcoma cell line MES-SA.

  1985cited by this paper
• Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype.

  1985cited by this paper
• Taxol: an antimitotic agent with a new mechanism of action.

  1984cited by this paper
• Sequence of an expressed human beta-tubulin gene containing ten Alu family members.

  1984cited by this paper
• Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines.

  1983cited by this paper
• Diverse mechanisms in the generation of human beta-tubulin pseudogenes.

  1982cited by this paper
• Evidence that a human β-tubulin pseudogene is derived from its corresponding mRNA

  1982cited by this paper
• Isolation of a taxol-resistant Chinese hamster ovary cell mutant that has an alteration in alpha-tubulin.

  1981cited by this paper
• Taxol binds to polymerized tubulin in vitro

  1981cited by this paper
• Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes.

  1980cited by this paper
• CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered beta-tubulin.

  1980cited by this paper

• Key genes and molecular mechanisms related to Paclitaxel Resistance

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  2021cites this paper
• Paclitaxel-Based Chemotherapy Targeting Cancer Stem Cells from Mono- to Combination Therapy

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• β-III tubulin modulates the behavior of Snail overexpressed during the epithelial-to-mesenchymal transition in colon cancer cells.

  2016cites this paper
• Non-adherent culture induces paclitaxel resistance in H460 lung cancer cells via ERK-mediated up-regulation of βIVa-tubulin.

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• Quantitative Proteomic Analysis of Cellular Resistance to the Nanoparticle Abraxane.

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• Mechanisms of Resistance to Cabazitaxel

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• Studying the enhancement of programmed cell death by combined AG1024 and paclitaxel in a model of chronic myelogenous leukemia.

  2014cites this paper
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• Class III b-tubulin overexpression in gynecologic tumors: implications for the choice of microtubule targeted agents?

  2013cites this paper
• Paclitaxel stimulates chromosomal fusion and instability in cells with dysfunctional telomeres: implication in multinucleation and chemosensitization.

  2011cites this paper
• New insights into mechanisms of resistance to microtubule inhibitors.

  2011cites this paper
• Comparative proteomic analysis of paclitaxel sensitive A549 lung adenocarcinoma cell line and its resistant counterpart A549-Taxol

  2011cites this paper
• In-vivo-Testung des "Vascular Disrupting Agents" DMXAA am Modell für neuroendokrine und Nebennieren-Tumore

  2010cites this paper
• A tubulin polymerization microassay used to compare ligand efficacy.

  2010cites this paper
• Highly efficient eradication of intracranial glioblastoma using Eg5 siRNA combined with HVJ envelope

  2009cites this paper
• Cellular mechanisms of resistance to anthracyclines and taxanes in cancer: intrinsic and acquired.

  2008cites this paper
• Melanoma cell sensitivity to Docetaxel‐induced apoptosis is determined by class III β‐tubulin levels

  2008cites this paper
• Resistance to Microtubule-Targeting Drugs

  2008cites this paper
• Differential Activity of Caspase-3 Regulates Susceptibility of Lung and Breast Tumor Cell Lines to Paclitaxel

  2008cites this paper
• Microtubule Stabilizing Agents

  2008cites this paper
• Mechanisms of Resistance to Drugs That Interfere with Microtubule Assembly

  2008cites this paper
• Sensitivity Alkaloid Vinca-Tubulin in β Class II and Class IVb Tubulin-Targeted Drug Action : Functional Significance of Updated

  2008cites this paper
• Tubulin-targeted drug action: functional significance of class ii and class IVb beta-tubulin in vinca alkaloid sensitivity.

  2008cites this paper
• Class III β-Tubulin Isotype Predicts Response in Advanced Breast Cancer Patients Randomly Treated Either with Single-Agent Doxorubicin or Docetaxel

  2008cites this paper
• Paclitaxel And Docetaxel Resistance: Molecular Mechanisms and Development of New Generation Taxanes

  2007cites this paper
• Heightened Sensitivity to Paclitaxel in Class IVa β-Tubulin-transfected Cells Is Lost as Expression Increases*

  2007cites this paper
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  2007cites this paper
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  2007cites this paper
• Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of β-tubulin (Asp26Glu) and less stable microtubules

  2006cites this paper
• Combretastatin A-4 resistance in H460 human lung carcinoma demonstrates distinctive alterations in beta-tubulin isotype expression.

  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2005cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
• Different Effects of Vinblastine on the Polymerization of Isotypically Purified Tubulins from Bovine Brain

  2003cites this paper
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  2003cites this paper
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  2003cites this paper
• SOLVING THE PROBLEM OF MULTIDRUG RESISTANCE: ABC TRANSPORTERS IN CLINICAL ONCOLOGY

  2003cites this paper
• Expression of class III beta-tubulin reduces microtubule assembly and confers resistance to paclitaxel.

  2003cites this paper
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  2002cites this paper
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  2002cites this paper
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  2001cites this paper
• Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics

  2001cites this paper
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  2001cites this paper
• Mechanisms of taxotere-related drug resistance in pancreatic carcinoma.

  2001cites this paper
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  2001cites this paper
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  2001cites this paper
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  2001cites this paper
• Abundant expression of the microtubule-associated protein, ensconsin (E-MAP-115), alters the cellular response to Taxol.

  2001cites this paper
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  2001cites this paper
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  2001cites this paper
• The role of β-tubulin isotypes in resistance to antimitotic drugs

  2001cites this paper
• Research Article

  2001cites this paper
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  2000cites this paper
• Resistance to arsenite modulates levels of α-tubulin and sensitivity to paclitaxel in Leishmania donovani

  2000cites this paper
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  2000cites this paper
• Proteolysis of microtubule associated protein 2 and sensitivity of pancreatic tumours to docetaxel

  2000cites this paper
• Taxol Resistance

  2000cites this paper
• Chapter 14. Antimitotic Agents

  1999cites this paper
• Characterization of paclitaxel (Taxol) sensitivity in human glioma- and medulloblastoma-derived cell lines.

  1999cites this paper
• A β-Tubulin Leucine Cluster Involved in Microtubule Assembly and Paclitaxel Resistance* 210

  1999cites this paper
• Increased intracellular cAMP renders HL-60 cells resistant to cytotoxicity of taxol.

  1999cites this paper
• Antisense oligonucleotides to class III β-tubulin sensitize drug-resistant cells to Taxol

  1999cites this paper
• Mechanisms of action of and resistance to antitubulin agents: microtubule dynamics, drug transport, and cell death.

  1999cites this paper
• Overexpression of class I, II or IVb beta-tubulin isotypes in CHO cells is insufficient to confer resistance to paclitaxel.

  1999cites this paper
• A new PCR MIMIC strategy to quantify low mdr1 mRNA levels in drug resistant cell lines and AML blast samples.

  1999cites this paper
• Tau expression in model adenocarcinomas correlates with docetaxel sensitivity in tumour-bearing mice.

  1998cites this paper
• Use of drugs to study role of microtubule assembly dynamics in living cells.

  1998cites this paper
• Potential interactions between antitubulin agents and temperature: implications for modulation of multidrug resistance.

  1998cites this paper
• Preferential Binding of E7010 to Murine β3‐Tubulin and Decreased β3‐Tubulin in E7010‐resistant Cell Lines

  1998cites this paper
• Microtubules and actin filaments: dynamic targets for cancer chemotherapy.

  1998cites this paper
• The biology of ovarian cancer.

  1998cites this paper
• Upregulation of caveolin‐1 and caveolae organelles in Taxol‐resistant A549 cells

  1998cites this paper
• Epothilones: novel microtubule-stabilising agents.

  1997cites this paper
• Paclitaxel-resistant Human Ovarian Cancer Cells Have Mutant β-Tubulins That Exhibit Impaired Paclitaxel-driven Polymerization*

  1997cites this paper
• Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes.

  1997cites this paper
• Comparative antitumor efficacy of docetaxel and paclitaxel in nude mice bearing human tumor xenografts that overexpress the multidrug resistance protein (MRP)

  1997cites this paper
• Taxol differentially modulates the dynamics of microtubules assembled from unfractionated and purified beta-tubulin isotypes.

  1997cites this paper
• Differential expression of tubulin isotypes during the cell cycle.

  1996cites this paper