Kinetics of human connecting peptide in normal and diabetic subjects.

No abstract is available for this paper.

• Publication year

  1978

• Venue

  Journal of Clinical Investigation

• Publication date

  1978-07-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1172/JCI109106PMID 659633PMCID PMC371754
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The analysis of decay curves.

  1977cited by this paper
• Heterogeneity of circulating C-peptide.

  1977cited by this paper
• C-peptide Response to Glucagon: A Test for the Residual β-cell Function in Diabetes Mellitus

  1977cited by this paper
• Hyperinsulinism of hepatic cirrhosis: Diminished degradation or hypersecretion?

  1977cited by this paper
• C‐PEPTIDE AND INSULIN DURING BLOCKADE OF THE HYPERGLYCAEMIC RESPONSE TO SURGERY BY EPIDURAL ANALGESIA

  1977cited by this paper
• Retention and degradation of 125I-insulin by perfused livers from diabetic rats.

  1976cited by this paper
• Production of antisera to synthetic benzyloxycarbonyl-C-peptide of human proinsulin.

  1976cited by this paper
• Disappearance rate of endogenous human C-peptide from blood

  1976cited by this paper
• Glucagon metabolism in man, studies on the metabolic clearance rate and the plasma acute disappearance time of glucagon in normal and diabetic subjects.

  1976cited by this paper
• Insulin removal by isolated perfused rat liver.

  1976cited by this paper
• Radioimmunological determination of human C-peptide in serum

  1975cited by this paper
• Immunological Half-Life of Porcine Proinsulin C-Peptide

  1975cited by this paper
• Studies on polypeptides. V. Improved synthesis of human proinsulin C-peptide and its benzyloxycarbonyl derivative. Circular dichroism and immunological studies of human C-peptide.

  1975cited by this paper
• Turnover in humans of iodine- and cobalamin-labeled transcobalamin I and of iodine-labeled albumin.

  1975cited by this paper
• Proinsulin, insulin, and C-peptide concentrations in human portal and peripheral blood.

  1975cited by this paper
• Peripheral metabolism of insulin, proinsulin, and C-peptide in the pregnant rat.

  1975cited by this paper
• Metabolism of endogenous proinsulin and insulin in man.

  1974cited by this paper
• The kinetics of insulin metabolism in diabetes mellitus.

  1973cited by this paper
• Effect of intraduodenal glucose administration on hepatic extraction of insulin in the anesthetized dog.

  1973cited by this paper
• Metabolism of proinsulin, insulin, and C-peptide in the rat.

  1973cited by this paper
• Extraction of insulin by liver.

  1973cited by this paper
• [Proinsulin and biosynthesis of insulin].

  1973cited by this paper
• The kinetics of insulin metabolism in diabetes mellitus.

  1973cited by this paper
• A comparative study on the metabolism of human insulin and porcine proinsulin in man.

  1973cited by this paper
• Proinsulin and C-Peptide in Blood

  1972cited by this paper
• Determination of total serum insulin (IRI) in insulin-treated diabetic patients

  1972cited by this paper
• Electrophoretic characterization of circulating human proinsulin and insulin

  1972cited by this paper
• Hypoglycemic activity and immunological half-life of porcine insulin and proinsulin in baboons and swine.

  1971cited by this paper
• Measurement of the insulin delivery rate in man.

  1971cited by this paper
• Human albumin metabolism determined with radioiodinated albumin

  1971cited by this paper
• Clearance of Porcine Insulin, Proinsulin, and Connecting Peptide by the Isolated Rat Liver 1

  1970cited by this paper
• Identification of proinsulin and C-peptide in human serum by a specific immunoassay.

  1970cited by this paper
• Secretion of Proinsulin C-Peptide by Pancreatic β Cells and its Circulation in Blood

  1969cited by this paper
• Proinsulin and the biosynthesis of insulin.

  1969cited by this paper
• Plasma Disappearance Rate of Injected Human Insulin in Juvenile Diabetic, Maturity-onset Diabetic and Nondiabetic Subjects

  1969cited by this paper
• Evidence for proinsulin in human urine and serum.

  1968cited by this paper
• Insulin delivery rate into plasma in normal and diabetic subjects.

  1968cited by this paper
• "Big insulin": a new component of plasma insulin detected by immunoassay.

  1968cited by this paper
• The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma.

  1967cited by this paper
• Automatic recording apparatus for use in the chromatography of amino acids.

  1958cited by this paper
• On the theory of the indicator-dilution method for measurement of blood flow and volume.

  1954cited by this paper

• Kinetics of insulin and C-peptide and estimation of prehepatic insulin secretion rates after intravenous glucose stimulation using arterial versus venous blood sampling in healthy males

  2024cites this paper
• Urinary C-Peptide to Creatinine Ratio (UCPCR) as Indicator for Metabolic Risk in Apparently Healthy Adults—A BioPersMed Cohort Study

  2023cites this paper
• High doses of exogenous glucagon stimulate insulin secretion and reduce insulin clearance in healthy humans.

  2023cites this paper
• Proinsulin-to-C-Peptide Ratio as a Marker of β-Cell Function in African American and European American Adults.

  2023cites this paper
• Suppression of endogenous insulin secretion by euglycemic hyperinsulinemia.

  2023cites this paper
• Copper(II) Affects the Biochemical Behavior of Proinsulin C-peptide by Forming Ternary Complexes with Serum Albumin.

  2023cites this paper
• Quantifying beta cell function in the preclinical stages of type 1 diabetes

  2023cites this paper
• Multiplexed quantification of insulin and C-peptide by LC-MS/MS without the use of antibodies

  2022cites this paper
• Familial diabetes predisposes PCOS patients to insulin resistance (IR), reproductive impairment and hepatic dysfunction: effects of d-chiro inositol (DCI) and alpha lipoic acid (ALA) administration on hepatic insulin extraction (HIE) index

  2022cites this paper
• The Elusive Cephalic Phase Insulin Response: Triggers, Mechanisms, and Functions.

  2022cites this paper
• Lymphocytes Prediction of Homeostasis Model Assessment of Beta-cells Function (HOMA-B) and C-peptide Level during Pregnancy: New Insight into Beta-cells Proliferation and Insulin Sensitivity

  2022cites this paper
• HIE (hepatic insulin extraction) index in overweight/ obese. PCOS patients with or without familial diabetes

  2022cites this paper
• C-peptide enhances glucagon secretion in response to hyperinsulinemia under euglycemic and hypoglycemic conditions

  2021cites this paper
• Streptozotocin-Induced Diabetes in a Mouse Model (BALB/c) Is Not an Effective Model for Research on Transplantation Procedures in the Treatment of Type 1 Diabetes

  2021cites this paper
• Combination of disease duration‐to‐age at diagnosis and hemoglobin A1c‐to‐serum C‐peptide reactivity ratios predicts patient response to glucose‐lowering medication in type 2 diabetes: A retrospective cohort study across Japan (JDDM59)

  2021cites this paper
• Detection of haemolysis, a frequent preanalytical problem in the serum of newborns and adults

  2020cites this paper
• Can chewing gum be another source of preanalytical variability in fasting outpatients?

  2020cites this paper
• Multilayered Particles Based on Biopolyelectrolytes as Potential Peptide Delivery Systems

  2020cites this paper
• Lower Insulin-Dose Adjusted A1c (IDAA1c) Is Associated With Less Complications in Individuals With Type 1 Diabetes Treated With Hematopoetic Stem-Cell Transplantation and Conventional Therapy

  2019cites this paper
• Assessment of pulsatile insulin secretion derived from peripheral plasma C-peptide concentrations by nonparametric stochastic deconvolution.

  2019cites this paper
• Genomewide association study of C-peptide surfaces key regulatory genes in Indians

  2019cites this paper
• The pharmacokinetics of porcine C‐peptide after intraperitoneal injection

  2019cites this paper
• Optimisation of the Investigation of Antibody-Mediated Dysglycaemia

  2019cites this paper
• Novel Formulations of C-Peptide with Long-Acting Therapeutic Potential for Treatment of Diabetic Complications

  2019cites this paper
• Transcriptome profiling of four candidate milk genes in milk and tissue samples of temperate and tropical cattle

  2019cites this paper
• BIOLOGICAL EFFECTS OF C-PEPTIDE AND PROINSULIN: WE JIBE TOGETHER

  2019cites this paper
• Performance of individually measured vs population‐based C‐peptide kinetics to assess β‐cell function in the presence and absence of acute insulin resistance

  2018cites this paper
• Impact of First Meal Size during Prolonged Sitting on Postprandial Glycaemia in Individuals with Prediabetes: A Randomised, Crossover Study

  2018cites this paper
• Dissection of hepatic versus extra‐hepatic insulin clearance: Ethnic differences in childhood

  2018cites this paper
• Characterisation of preproendothelin-1 derived peptides identifies Endothelin-Like Domain Peptide as a modulator of Endothelin-1

  2017cites this paper
• Hepatic but Not Extrahepatic Insulin Clearance Is Lower in African American Than in European American Women

  2017cites this paper
• Unraveling the aggregation propensity of human insulin C‐peptide

  2017cites this paper
• Utility of C-peptide for a reliable estimate of insulin secretion in children with growth hormone deficiency.

  2016cites this paper
• Lean Seafood Intake Reduces Postprandial C-peptide and Lactate Concentrations in Healthy Adults in a Randomized Controlled Trial with a Crossover Design.

  2016cites this paper
• Long-Acting C-Peptide and Neuropathy in Type 1 Diabetes: A 12-Month Clinical Trial

  2016influential citation
• C-peptide as a Therapy for Kidney Disease: A Systematic Review and Meta-Analysis

  2015cites this paper
• Short-term glucagon stimulation test of C-peptide effect on glucose utilization in patients with type 1 diabetes mellitus

  2015cites this paper
• Age‐dependent impairment of glucose tolerance in the 3xTg‐AD mouse model of Alzheimer's disease

  2015cites this paper
• C-peptide: new findings and therapeutic possibilities.

  2015cites this paper
• Effects of different milk proteins on the metabolic response in healthy and prediabetic volunteers

  2015influential citation
• C-peptide: a new potential in the therapy of microvascular complications of Type 1 diabetes?

  2015cites this paper
• Erratum to: Short-term glucagon stimulation test of C-peptide effect on glucose utilization in patients with type 1 diabetes mellitus

  2015cites this paper
• Efficacy of a long‐acting C‐peptide analogue against peripheral neuropathy in streptozotocin‐diabetic mice

  2015cites this paper
• Moderate diet-induced weight loss is associated with improved insulin sensitivity in middle-aged healthy obese Korean women

  2014cites this paper
• Glucose homeostasis and the enteroinsular axis in the horse: a possible role in equine metabolic syndrome.

  2014influential citation
• The Dipeptidyl Peptidase-4 Inhibitor Vildagliptin has the Capacity to Repair β-Cell Dysfunction and Insulin Resistance

  2014cites this paper
• Pancreatic secretion, hepatic extraction, and plasma clearance of insulin from steady-state insulin and C-peptide measurements in critically ill patients

  2014cites this paper
• Physiological effects and therapeutic potential of proinsulin C-peptide.

  2014cites this paper
• Residual C‐peptide in type 1 diabetes: what do we really know?

  2014cites this paper
• Disproportionately elevated proinsulinemia is observed at modestly elevated glucose levels within the normoglycemic range

  2014cites this paper
• Glucose homeostasis and the enteroinsular axis in the horse: a possible role in equine metabolic syndrome.

  2014cites this paper
• Cereal Processing Influences Postprandial Glucose Metabolism as Well as the GI Effect

  2013cites this paper
• Persistent C-peptide: what does it mean?

  2013cites this paper
• Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome

  2013cites this paper
• The pig as an animal model for type 1 Diabetes Mellitus – with focus on carbohydrate and fat metabolism

  2013cites this paper
• Obesity-related markers and breast cancer in CPS-II Nutrition Cohort.

  2013cites this paper
• Correlations between Glucagon Stimulated C-peptide Levels and Microvascular Complications in Type 2 Diabetes Patients

  2012cites this paper
• C-Peptide Versus Insulin: Relationships with Risk Biomarkers of Cardiovascular Disease in Metabolic Syndrome in Young Arab Females

  2012cites this paper
• Population pharmacokinetic/pharmacodynamic modeling of insulin kinetics

  2011cites this paper
• CHAPTER 31 – Type 2 Diabetes Mellitus

  2011cites this paper
• Methodological and Clinical Studies on Insulin Resistance in Childhood

  2011cites this paper
• Significance of plasma C-peptide in obese African American adolescents.

  2011cites this paper
• Intracellular and peptide interactions of C-peptide

  2010cites this paper
• Measurement of C-peptide concentrations and responses to somatostatin, glucose infusion, and insulin resistance in horses.

  2010influential citation
• DIABETIC STUDIES The Review of Anti-Inflammatory Properties of C-Peptide

  2010cites this paper
• Studies of gastric motility in health and diabetes.

  2009cites this paper
• Anti-inflammatory properties of C-Peptide.

  2009cites this paper
• A numerical deconvolution method to estimate C-peptide secretion in humans after an intravenous glucose tolerance test.

  2009cites this paper
• Variation of Fasting Serum C-Peptide Level After Admission in Japanese Patients with Type 2 Diabetes Mellitus

  2009cites this paper
• A Minimal C-Peptide Sampling Method to Capture Peak and Total Prehepatic Insulin Secretion in Model-Based Experimental Insulin Sensitivity Studies

  2009cites this paper
• Exercício e diabetes mellitus tipo 2

  2009cites this paper
• Ethnic and gender differences regarding the insulin-blood pressure relationship.

  2009cites this paper
• Murder by insulin: suspected, purported and proven-a review.

  2009cites this paper
• Age-dependent relationship of fasting C-peptide concentration and insulin secretion in non-obese subjects with normal glucose tolerance.

  2009cites this paper
• Insulin and C-peptide secretory responses to glucagon in man: studies on the dose-response relationships.

  2009cites this paper
• Reduced postprandial proinsulinaemia and 32–33 split proinsulinaemia after a mixed meal in type 2 diabetic patients following sensitization to insulin with pioglitazone

  2008cites this paper
• Measures of beta-cell function during the oral glucose tolerance test, liquid mixed-meal test, and hyperglycemic clamp test.

  2008cites this paper
• The effect of exercise on the absorption of inhaled human insulin in healthy volunteers.

  2008cites this paper
• LIVER FAT IN THE METABOLIC SYNDROME AND TYPE 2 DIABETES

  2008cites this paper
• Urinary C-peptide of insulin as a non-invasive marker of energy balance in wild orangutans.

  2008cites this paper
• Effect of muscular exercise on plasma C-peptide and insulin in obese non-diabetics and diabetics, type II.

  2008cites this paper
• Clamp-like Index : a Novel , Highly Sensitive Insulin Sensitivity Index to Calculate Hyperinsulinemic Clamp Glucose Infusion Rates from Oral Glucose Tolerance Test in Nondiabetic Humans

  2007cites this paper
• The Clamp-Like Index

  2007cites this paper
• Effect of liver fat on insulin clearance.

  2007cites this paper
• High Resolution Clinical Model-Based Assessment of Insulin Sensitivity

  2007cites this paper
• Targeting vesicular monoamine transporter Type 2 for noninvasive PET-based β-cell mass measurements

  2007cites this paper
• Current progress in non-invasive imaging of beta cell mass of the endocrine pancreas.

  2006cites this paper
• Acute effects of C-peptide on gastric emptying in longstanding type 1 diabetes

  2006cites this paper
• Acute effects of C-peptide on gastric emptying in longstanding type 1 diabetes

  2006cites this paper
• Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes

  2006cites this paper
• Aspects on the psychopharmacology of cholecystokinin

  2005cites this paper
• Subtle hyperproinsulinaemia characterises the defective insulin secretory capacity in offspring of glutamic acid decarboxylase antibody-positive patients with latent autoimmune diabetes mellitus in adults.

  2005cites this paper
• Basal and 24-h C-peptide and insulin secretion rate in normal man

  2005influential citation
• Pharmacokinetics and metabolic effects of glibenclamide and glipizide in type 2 diabetics

  2004cites this paper
• Use of the Göttingen minipig as a model of diabetes, with special focus on type 1 diabetes research.

  2004cites this paper
• Potent activation of multiple signalling pathways by C-peptide in opossum kidney proximal tubular cells

  2004cites this paper
• The transient effect of strict glycaemic control on B cell function in newly diagnosed Type 1 (insulin-dependent) diabetic patients

  2004cites this paper
• Insulin Minimal Model Indexes and Secretion: Proper Handling of Uncertainty by a Bayesian Approach

  2004cites this paper
• Effect of beta-blocking drugs on beta-cell function and insulin sensitivity in hypertensive non-diabetic patients

  2004cites this paper
• The Effect of Aging on Glucose Tolerance and B Cell Secretion in Man Wpływ wieku na tolerancję glukozy i czynność wydzielniczą komórek B wysp trzustkowych

  2004cites this paper